Editorial Board
(Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - April 24, 2024 Category: Hematology Source Type: research
Table of Contents
(Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - April 24, 2024 Category: Hematology Source Type: research
A Novel Frameshift Mutation(HBA2:C.337delC) Associated With α-Thalassemia Trait Detected by Next-Generation Sequencing in Southern China
. (Source: Hemoglobin)
Source: Hemoglobin - April 24, 2024 Category: Hematology Authors: Lei PanYan WangHaiying LinXiufa ZhangRui ZhangDepartment of Medical Genetics and Prenatal Diagnosis, Baoan Women ’s and Children’s Hospital, Shenzhen, China Source Type: research
Lack of mTORC2 signalling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
J Leukoc Biol. 2024 Apr 23:qiae084. doi: 10.1093/jleuko/qiae084. Online ahead of print.ABSTRACTThe Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes ...
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Aline Ignacio Marcella Cipelli Tatiane Takiishi Cristhiane Favero Aguiar Fernanda Fernandes Terra Bruno Ghirotto Eloisa Martins Silva Angela Castoldi Yuli Thamires Magalh ães Tiago Antonio Barbara Nunes Padovani Meire Ioshie Hiyane Vinicius Andrade-Olive Source Type: research
Comprehensive Analysis of Immune Signatures in Primary Biliary Cholangitis and Autoimmune Hepatitis
In conclusion, our analyses reveal that PBC and AIH share similarities and differences regarding to immune profiles. And γδ T, TIGIT+Vδ2 T, and Tfh1 cell frequencies are potential noninvasive immunological markers that can differentiate PBC from AIH.PMID:38652703 | DOI:10.1093/jleuko/qiae085 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - April 23, 2024 Category: Hematology Authors: Xiaoxue Yang Jiawei Li Meiling Ren Xuemei Pan Huiling Liu Jie Jiang Man Li Zhe Yang Bingyu Han Lina Ma Jianlei Hao Yuanyuan Duan Zhinan Yin Yan Xu Zheng Xiang Bin Wu Source Type: research
Absence of evidence of transfusion transmission risk of Creutzfeldt-Jakob disease in the United States: Results froma 28-year lookback study
We report on a 28-year lookback study of recipients of blood from donors who subsequently developed CJD.METHODS: Patients with diagnosed CJD and a history of blood donation were identified. Blood centers were asked to provide information about the distribution of the donations and consignees were requested to provide information about the recipients of the donations. Vital status of each available recipient was determined and, if deceased, the reported cause(s) of death were obtained primarily from the National Death Index. All recipients included in the study database contributed person-time up to the last recorded review...
Source: Transfusion - April 23, 2024 Category: Hematology Authors: Lauren A Crowder Roger Y Dodd Lawrence B Schonberger Source Type: research
How do we leverage data through replication and warehousing to meet blood collection and transfusion service needs
DISCUSSION: Data replication and warehousing can empower BCTS analytic offerings not otherwise natively available through one's CIS to improve patient care and laboratory operations.PMID:38650378 | DOI:10.1111/trf.17845 (Source: Transfusion)
Source: Transfusion - April 23, 2024 Category: Hematology Authors: Justin E Juskewitch Lynne Briggs Jenna Khan Patrick C Mathias Terri S Coyle Vicki L Courson James T Hansen Nageswar Madde Mandy F O'Leary Hamilton C Tsang AABB Information Systems Committee Source Type: research
Identification of a novel c.77T & gt;G mutation on the ABO*B.01 allele associated with a B subtype
Transfusion. 2024 Apr 22. doi: 10.1111/trf.17832. Online ahead of print.NO ABSTRACTPMID:38650375 | DOI:10.1111/trf.17832 (Source: Transfusion)
Source: Transfusion - April 23, 2024 Category: Hematology Authors: Xiao Hao Xueqin Diao Congcong Cui Yihua Lv Yueqin Liu Huiwen Bi Source Type: research
Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation
CONCLUSION: Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.PMID:38653482 | DOI:10.1055/a-2311-0117 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Pengyu Zhang Saskia von Ungern-Sternberg Luisa Hastenplug Fiorella Solari Albert Sickmann Marijke Kuijpers Johan Wm Heemskerk Ulrich Walter Kerstin Jurk Source Type: research
A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura
CONCLUSION: The USTMA Mortality Index was acceptable for predicting mortality due to acute iTTP in the USTMA registry, but not sensitive enough to rule out death. Identifying patients at high risk of iTTP-related mortality may help individualize care and ultimately improve iTTP survival outcomes. Further studies are needed to provide external validation. Our model is one of many recent examples where machine learning models may show promise in clinical prediction tools in healthcare.PMID:38651093 | PMC:PMC11033197 | DOI:10.1016/j.rpth.2024.102388 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Chong Zhang Angela P Presson Shruti Chaturvedi Ana G Antun Andrew M Farland Ryan Woods Ara Metjian Yara A Park Gustaaf de Ridder Briana Gibson Raj S Kasthuri Darla K Liles Frank Akwaa Todd Clover Lisa Baumann Kreuziger Meera Sri Source Type: research
Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated β cell dysfunction
Volume 16, Issue 1, December 2024 . (Source: Islets)
Source: Islets - April 23, 2024 Category: Hematology Authors: LilyAnne M. GrieveAbhya RaniGary T. ZeRuthDepartment of Biological Sciences, Murray State University, Murray, KY, USA Source Type: research
Platelet activity, coagulation, and fibrinolysis in long-term users of anabolic-androgenic steroids compared to strength-trained athletes
This study aimed to assess platelet activation and aggregation, coagulation, and fibrinolysis, in long-term AAS users compared to non-using strength-trained athletes. (Source: Thrombosis Research)
Source: Thrombosis Research - April 23, 2024 Category: Hematology Authors: Tea S ætereng Fyksen, Ingebjørg Seljeflot, Paul Vanberg, Dan Atar, Sigrun Halvorsen Source Type: research
A Retrospective Analysis of BCR-ABL-1 Kinase Domain Mutations in Frontline TKI Resistant Chronic Myeloid Leukemia Patients: A Single Centre Experience
AbstractCML is a commonly diagnosed myeloproliferative neoplasm in India. Tyrosine kinase inhibitors (TKIs) are the current standard of care for management of CML. Mutations in Tyrosine kinase Domain (TKD) result in resistance to TKIs. The aim of this study is to evaluate the pattern of TKD mutations in CML patients having inadeq uate response or resistance to first line TKIs and to analyse the outcome of CML patients with and without mutations. It is a retrospective observational study. Medical records of 1633 CML patients from year 2014 to 2021 were analysed. Out of these 108 patients (6.6%) lost their response or d...
Source: Indian Journal of Hematology and Blood Transfusion - April 23, 2024 Category: Hematology Source Type: research
Adult Langerhans Cell Histiocytosis Presenting With Skin Lesions, Sclerosing Cholangitis and Pneumothorax
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 23, 2024 Category: Hematology Source Type: research
Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways
AbstractThe interaction between programmed cell death ligand 1 (PD-L1), which is expressed on the surface of tumor cells, and programmed cell death 1 (PD-1), which is expressed on T cells, impedes the effective activation of tumor antigen-specific T cells, resulting in the evasion of tumor cells from immune-mediated killing. Blocking the PD-1/PD-L1 signaling pathway has been shown to be effective in preventing tumor immune evasion. PD-1/PD-L1 blocking antibodies have garnered significant attention in recent years within the field of tumor treatments, given the aforementioned mechanism. Furthermore, clinical research has su...
Source: Experimental Hematology and Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
