Severe neonatal thrombocytopenia due to anti-HPA-4b alloantibodies: Third report described in a Caucasian mother
CONCLUSION: We described the third case of anti-HPA-4b alloantibody discovered in a Caucasian mother. This case strengthens the need for reference laboratory to genotype a panel of HPA alleles reflecting local genetic population diversity and for crossmatch of maternal serum with fresh paternal platelets in clinical suspected cases of neonatal alloimmune thrombocytopenia.PMID:38693097 | DOI:10.1111/trf.17863 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Rachel Petermann Fr édéric Bianchi Loubna Saib Nicolas Ferr é Nathalie Francelle Olivier Oudin Christophe Chenet Yasmine Mammasse Vincent Jallu Am élie Chaussade Antonin Cornu Laureline Dubray Agn ès Mailloux Source Type: research
Measuring the effectiveness of online search ads on blood donor recruitment and donation
CONCLUSION: We developed a method for determining the effectiveness of online search ads on donation outcomes. Rewards/promotions messaging was most effective at recruiting first-time donors. Our methodology is generalizable to different blood centers to explore messaging effectiveness among their unique communities.PMID:38693096 | DOI:10.1111/trf.17850 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Duncan C McElfresh Jennifer Bennet Kay Enriquez Tho D Pham Source Type: research
Survival of transfused red blood cells from a donor with alpha-thalassemia trait in a recipient with sickle cell disease
We present one recipient, a pediatric patient with SCD and splenectomy who received two RBC units with aliquots from each unit labeled at distinct biotin densities (2 and 18 μg/mL biotin). One donor unit was identified to have microcytosis (MCV 68.5 fL after biotinylation); whole blood sample obtained at a subsequent donation showed 2-gene deletion alpha-thalassemia trait (ɑ-3.7kb/ɑ-3.7kb) and normal serum ferritin. G6PD activity was >60% of normal mean for both. The RBCs with alpha-thalassemia RBC had accelerated clearance and increased surface phosphatidylserine post-transfusion, as compared with the normocytic RBC...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Marianne E M Yee Mischa L Covington Patricia E Zerra James W McCoy Kirk A Easley Clinton H Joiner Janetta Bryksin Richard O Francis Christopher M Lough Niren Patel Abdullah Kutlar Cassandra D Josephson John D Roback Sean R Stowell Ross M Fasano Source Type: research
Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments
CONCLUSION: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH)2 and TAP, It is conceivable to acknowledge that GA could be used as an intracanal medicaments for revascularization process of necrotic immature teeth.CLINICAL SIGNIFICANCE: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors...
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Mohammad A Alrashidi Manal F Badawi Mohamed G Elbeltagy Amany E Badr Source Type: research
Brentuximab Vedotin Plus Ibrutinib in Relapsed and Refractory Hodgkin Lymphoma
DISCUSSION: The combination of BV and ibrutinib was active in r/r HL; however, given significant toxicity, it cannot be recommended for future development.PMID:38693037 | DOI:10.1016/j.clml.2024.03.013 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - May 1, 2024 Category: Cancer & Oncology Authors: Matthew Mei Ni-Chun Tsai Joycelynne Palmer Saro Armenian Robert Chen Steven Rosen Stephen Forman Leslie Popplewell Larry Kwak Peter Martin Kami Maddocks David Bond Alex F Herrera Source Type: research
The PI3K signaling pathway; from normal lymphopoiesis to lymphoid malignancies
Expert Rev Anticancer Ther. 2024 May 1. doi: 10.1080/14737140.2024.2350629. Online ahead of print.ABSTRACTINTRODUCTION: As a vital mechanism of survival, lymphopoiesis requires the collaboration of different signaling molecules to orchestrate each step of cell development and maturation. The PI3K pathway is considerably involved in the maturation of lymphatic cells and therefore, its dysregulation can immensely affect human well-being and cause some of the most prevalent malignancies. As a result, studies that investigate this pathway could pave the way for a better understanding of the lymphopoiesis mechanisms, the undesi...
Source: Expert Review of Anticancer Therapy - May 1, 2024 Category: Cancer & Oncology Authors: Bahareh Kashani Zahra Zandi Atieh Pourbagheri-Sigaroodi Amir-Mohammad Yousefi Seyed H Ghaffari Davood Bashash Source Type: research
Positive anti-nuclear antibody in patients with polyclonal hypergammaglobulinemia suggests the presence of multiple distinct comorbidities
Conclusion These results establish a previously underappreciated unique immunological state of multimorbidity in PHGG and indicate that the gamma-globulin levels and ANAs could serve as markers for the clinical assessment of comorbidities in PHGG.PMID:38692914 | DOI:10.2169/internalmedicine.3594-24 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yasutaka Masuda Ken Morita Mineo Kurokawa Source Type: research
Publisher Correction: Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis
Pediatr Res. 2024 Apr 30. doi: 10.1038/s41390-024-03176-6. Online ahead of print.NO ABSTRACTPMID:38693279 | DOI:10.1038/s41390-024-03176-6 (Source: Pediatric Research)
Source: Pediatric Research - May 1, 2024 Category: Pediatrics Authors: Qingqi Chong Zhiru Wang Ting Guo Liaoran Zhang Li Lu Cheng Cai Xiaohui Gong Zhibao Lv Qingfeng Sheng Source Type: research
Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research
Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
Survival of transfused red blood cells from a donor with alpha-thalassemia trait in a recipient with sickle cell disease
We present one recipient, a pediatric patient with SCD and splenectomy who received two RBC units with aliquots from each unit labeled at distinct biotin densities (2 and 18 μg/mL biotin). One donor unit was identified to have microcytosis (MCV 68.5 fL after biotinylation); whole blood sample obtained at a subsequent donation showed 2-gene deletion alpha-thalassemia trait (ɑ-3.7kb/ɑ-3.7kb) and normal serum ferritin. G6PD activity was >60% of normal mean for both. The RBCs with alpha-thalassemia RBC had accelerated clearance and increased surface phosphatidylserine post-transfusion, as compared with the normocytic RBC...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Marianne E M Yee Mischa L Covington Patricia E Zerra James W McCoy Kirk A Easley Clinton H Joiner Janetta Bryksin Richard O Francis Christopher M Lough Niren Patel Abdullah Kutlar Cassandra D Josephson John D Roback Sean R Stowell Ross M Fasano Source Type: research
Measuring the effectiveness of online search ads on blood donor recruitment and donation
CONCLUSION: We developed a method for determining the effectiveness of online search ads on donation outcomes. Rewards/promotions messaging was most effective at recruiting first-time donors. Our methodology is generalizable to different blood centers to explore messaging effectiveness among their unique communities.PMID:38693096 | DOI:10.1111/trf.17850 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Duncan C McElfresh Jennifer Bennet Kay Enriquez Tho D Pham Source Type: research
