Clinical trial on the effects of thalidomide on hemoglobin synthesis in patients with moderate thalassemia intermedia
AbstractTo investigate the efficacy and safety of thalidomide in patients with thalassemia intermedia (TI). Patients with a confirmed diagnosis of TI who met the trial criteria and signed consent forms were prescribed oral thalidomide 50  mg qn for 3 months from February 2017. Complete blood counts, Hb analysis, and liver and kidney functions were monitored monthly during treatment and any differences were compared before and after treatment. Patients with Hb increments>  2.0 g/dL were termed main responders (MaR), and those with Hb increments between 1.0 and 2.0 g/dL as minor responders (MiR)...
Source: Annals of Hematology - June 22, 2018 Category: Hematology Source Type: research

Efficacy and safety of resveratrol, an oral hemoglobin F-augmenting agent, in patients with beta-thalassemia intermedia
AbstractRecently, resveratrol showed induction of γ-globin mRNA synthesis in human erythroid precursors and reducing oxidative stress in red cells of thalassemia patients in many in vitro studies. We aimed to investigate the efficacy and safety of resveratrol, for the first time, in non-transfusion-dependent beta-thalassemia intermedia (B-TI) in S outhern Iran. In this double-blind randomized clinical trial, 54 patients with B-TI were investigated during 6 months betweenOctober 2016 and March 2017. Patients were randomly allocated into three groups by simple randomization method. Group 1 (hydroxyurea (HU) and pl...
Source: Annals of Hematology - June 21, 2018 Category: Hematology Source Type: research

The effect of desferrioxamine chelation versus no therapy in patients with non transfusion-dependent thalassaemia: a multicenter prospective comparison from the MIOT network
AbstractWe prospectively assessed by magnetic resonance imaging (MRI) the advantages of desferrioxamine (DFO) with respect to the absence of chelation therapy in non transfusion-dependent thalassaemia (NTDT) patients. We considered 18 patients non-chelated and 33 patients who received DFO alone between the two MRI scans. Iron overload was assessed by the T2* technique. Biventricular function parameters were quantified by cine sequences. No patient treated with DFO had cardiac iron. At baseline, only one non-chelated patient showed a pathological heart T2* value (
Source: Annals of Hematology - June 21, 2018 Category: Hematology Source Type: research

Cytogenetic clonal heterogeneity is not an independent prognosis factor in 15 –60-year-old AML patients: results on 1291 patients included in the EORTC/GIMEMA AML-10 and AML-12 trials
AbstractThe presence of cytogenetic clonal heterogeneity has been associated with poor prognosis in patients with acute myeloid leukemia (AML). Here, we reassessed this association. The study cohort consisted of all patients with an abnormal karyotype randomized in the EORTC/GIMEMA AML-10 and AML-12 trials. Abnormal karyotypes were classified as no subclones present (cytogenetic abnormality in a single clone), defined subclones present (presence of one to three subclones), and composite karyotypes (CP) (clonal heterogeneity not allowing enumeration of individual subclones). The main endpoints were overall survival (OS) and...
Source: Annals of Hematology - June 20, 2018 Category: Hematology Source Type: research

Major bleeding in a patient with warfarin-hypersensitive and factor IX propeptide variant, p.Ala37Thr, who was treated with a direct oral anti-Xa inhibitor
(Source: Annals of Hematology)
Source: Annals of Hematology - June 19, 2018 Category: Hematology Source Type: research

Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency —a case report and comprehensive review of the literature
AbstractRecently, an immunodeficiency syndrome caused by guanine-adenine-thymine-adenine 2 (GATA2) deficiency has been described. The syndrome is characterized by (i) typical onset in early adulthood, (ii) profound peripheral blood cytopenias of monocytes, B lymphocytes, and NK cells, (iii) distinct susceptibility to disseminated non-tuberculous mycobacterial (NTM) and other opportunistic infections (particularly human papillomavirus), and (iv) a high risk of developing hematologic malignancies (myelodysplastic syndromes (MDS); acute myeloid leukemias (AML)). Considerable clinical heterogeneity exists among patients withGA...
Source: Annals of Hematology - June 13, 2018 Category: Hematology Source Type: research

Diagnosis of Richter transformation in chronic lymphocytic leukemia: histology tips the scales
In conclusion, our findings confirm the central role of tissue biopsy in the diagnostic work up in case of clinically suspected RT. (Source: Annals of Hematology)
Source: Annals of Hematology - June 12, 2018 Category: Hematology Source Type: research

Fludarabine and busulfan plus low-dose TBI as reduced intensity conditioning in older patients undergoing allogeneic hematopoietic cell transplant for myeloid malignancies
AbstractWe have been using a combination of fludarabine/busulfan plus low-dose total body irradiation (TBI) as the reduced-intensity conditioning (RIC) regimen for patients age ≥ 60 years undergoing allogeneic hematopoietic cell transplantation (HCT) for myeloid malignancies. We retrospectively analyzed outcomes of 116 older patients (median age 64 years) who underwent HCT from 2006 to 2015 for myeloid malignancies, including acute myeloid leukemia (AML) in first com plete remission (CR1). On univariate analysis, overall survival (OS) for the cohort at 3 years was 33% (95% CI 25–42). Cumulati...
Source: Annals of Hematology - June 11, 2018 Category: Hematology Source Type: research

Treating synchronous bilateral ocular adnexal marginal zone lymphoma: the consortium for improving survival of lymphoma study
AbstractBoth-side synchronous involvement has been reported to account for 7 –24% of ocular adnexal marginal zone lymphoma (OAML). We conducted a retrospective analysis to identify the clinical features and treatment outcomes of synchronous bilateral OAML (SB-OAML) by treatment modality. We analyzed patients with a histologic diagnosis of SB-OAML, excluding metachronous bi lateral involved OAML. We enrolled a total of 95 patients for this analysis, 36 males and 59 females; the median patient age was 42 years (range 16–77 years). Eleven (11.6%) patients had been treated with chemotherapy or chemo-immun...
Source: Annals of Hematology - June 11, 2018 Category: Hematology Source Type: research

Comparative analysis of azacitidine and intensive chemotherapy as front-line treatment of elderly patients with acute myeloid leukemia
AbstractThe present observational study aimed to compare the efficacy of azacitidine (AZA) and intensive chemotherapy (IC) in elderly patients with untreated acute myeloid leukemia (AML), diagnosed according to WHO criteria. In the two groups, we evaluated complete remission (CR), overall survival (OS), and disease-free survival (DFS). The AZA group included 89 patients; median age was 73  years (range 61–80) and median white blood cell count (WBCc) 2.5 × 109/L (range 0.27 –83), 45% of the patients had BM blasts ≥ 30%, and 44 (49%) had a secondary AML (sAML). Karyotype was eva...
Source: Annals of Hematology - June 10, 2018 Category: Hematology Source Type: research

Efficacy and safety of mesenchymal stromal cells for the prophylaxis of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials
In conclusion, this meta-analysis demonstrated that MSC infusion is an effective and safe prophylactic strategy for cGVHD in patients with hematological malignancies undergoing allo-HSCT. (Source: Annals of Hematology)
Source: Annals of Hematology - June 8, 2018 Category: Hematology Source Type: research

Red blood cells metabolome changes upon treatment with different X-ray irradiation doses
AbstractThe upholding of red blood cells (RBC) quality and the removal of leukocytes are two essential issues in transfusion therapy. Leukodepletion provides optimum results, nonetheless there are cases where irradiation is recommended for some groups of hematological patients such as the ones with chronic graft-vs-host disease, congenital cellular immunodeficiency, and hematopoietic stem cell transplant recipients. The European guidelines suggest irradiation doses from 25 to 50 Gray (G γ). We evaluated the effect of different prescribed doses (15 to 50 Gγ) of X-ray irradiation on fresh leukodepleted RBCs bags ...
Source: Annals of Hematology - June 7, 2018 Category: Hematology Source Type: research

Clinical characteristics and treatment outcome of an 86-year-old patient with acute myeloid leukaemia with acute promyelocytic-like morphology and uncommon RARA fusion variant
(Source: Annals of Hematology)
Source: Annals of Hematology - June 5, 2018 Category: Hematology Source Type: research

Myeloid neoplasms with t(16;21)(q24;q22)/ RUNX1-RUNX1T3 mimics acute myeloid leukemia with RUNX1-RUNX1T1
AbstractChromosome translocation t(16;21)(q24;q22)/RUNX1-RUNX1T3 is an infrequent but recurrent chromosomal abnormality identified in myeloid neoplasms, with only 25 cases have been reported to date. Here, we report eight cases (six women and two men) of myeloid neoplasms associated with t(16;21)(q24;q22): five with therapy-related myeloid neoplasms, two with relapsed acute myeloid leukemia (AML), and one with blast phase of chronic myeloid leukemia. Morphologic and immunophenotypic features include granulocytic dysplasia, blasts with prominent perinuclear hof, large orange-pink granules, long and slim Auer rods, and aberr...
Source: Annals of Hematology - June 5, 2018 Category: Hematology Source Type: research

Long-term outcomes of total body irradiation plus cyclophosphamide versus busulfan plus cyclophosphamide as conditioning regimen for acute lymphoblastic leukemia: a comparative study
In conclusion, high-dose TBI is feasible in younger patients providing better survival. The choice between TBI- or Bu-conditioning regimens remains challenging. (Source: Annals of Hematology)
Source: Annals of Hematology - June 5, 2018 Category: Hematology Source Type: research

Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study
AbstractDespite recent advances, chemoimmunotherapy remains a standard for fit previously untreated chronic lymphocytic leukaemia patients. Lenalidomide had activity in early monotherapy trials, but tumour lysis and flare proved major obstacles in its development. We combined lenalidomide in increasing doses with six cycles of fludarabine and rituximab (FR), followed by lenalidomide/rituximab maintenance. In 45 chemo-naive patients, included in this trial, individual tolerability of the combination was highly divergent and no systematic toxicity determining a maximum tolerated dose was found. Grade 3/4 neutropenia (71%) wa...
Source: Annals of Hematology - June 4, 2018 Category: Hematology Source Type: research

Outcome of gastrointestinal graft-versus-host disease according to the treatment response
In conclusion, patients with GI-GVHD who failed to respond to the first-line treatment had inferior survival. However, later improvement may be observed without additional immunosuppressant other than steroid among patients who initially do not respond to steroid therapy. It is important to repeat colonoscopy in patients with refractor y GI-GVHD to monitor the activity of GVHD. (Source: Annals of Hematology)
Source: Annals of Hematology - June 2, 2018 Category: Hematology Source Type: research

Hyperfibrinogenemia is a poor prognostic factor in diffuse large B cell lymphoma
AbstractDiffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphomas worldwide. Previous studies indicated that hyperfibrinogenemia was a poor predictor in various tumors. The purpose of our study was to evaluate the prognostic effect of hyperfibrinogenemia in DLBCL. Data of 228 patients, who were diagnosed with DLBCL in our hospital between May 2009 and February 2016, were analyzed retrospectively. The Kaplan-Meier method and Cox regression were performed to find prognostic factors associated with progression-free survival (PFS) and overall survival (OS). Receiver operator characteristic (ROC)...
Source: Annals of Hematology - June 2, 2018 Category: Hematology Source Type: research

Elevated expression of the EZH2 gene in CALR -mutated patients with primary myelofibrosis
AbstractPrimary myelofibrosis (PMF) is one of the BCR/ABL-negative myeloproliferative neoplasms (MPNs), characterized by the diffuse fibrous hyperproliferation, bone marrow osteosclerosis, extramedullary hematopoiesis, and marked splenomegaly. The patients with PMF have an insidious onset, a long duration of clinical course, and the deteriorated quality of life. It has been reported that theCALR gene 9 exon mutations were detected in 25 –30% PMF patients, particularly as high as 80% in theJAK2/MPL-negative ones. As the second most common mutation inBCR/ABL-negative MPNs,CALR mutation has been included in the latest W...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Role of minimal residual disease in the management of acute myeloid leukemia —a case-based discussion
AbstractAML is stratified into risk-categories based on cytogenetic and molecular features that prognosticate survival and facilitate treatment algorithms, though there is still significant heterogeneity within risk groupings with regard to risk of relapse and prognosis. The ambiguity regarding prognosis is due in large part to the relatively outdated criteria used to determine response to therapy. Whereas risk assessment has evolved to adopt cytogenetic and molecular profiling, response criteria are still largely determined by bone marrow morphologic assessment and peripheral cell count recovery. Minimal residual disease ...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Survival analysis of patients with Hodgkin lymphoma who failed high dose chemotherapy and autologous stem cell transplant
AbstractHodgkin lymphoma (HL) patients failing after high dose chemotherapy (HDC) and auto-SCT have a poor outcome. Some patients may still benefit from further treatments. From 1996 to 2016, 137 HL patients (39.5%) out of 347 transplanted experienced post auto-SCT failure. Males/female 61%:39%, median age at auto-SCT 23.4  years and median follow-up 55.6 months (9–153). Type of failure was progressive (46%), relapsed (35%) or persistent disease/refractory disease (19%). Median overall survival (OS) from the time of failure is 20 months; 35 patients (25.5%) are alive. One hundred and four patients rece...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Altered microRNA expression profile in the peripheral lymphoid compartment of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw
AbstractBisphosphonates are formidable inhibitors of osteoclast-mediated bone resorption employed for therapy of multiple myeloma (MM) subjects with osteolytic lesions. Osteonecrosis of the jaw (ONJ) is an uncommon drug-induced adverse event of these agents. MicroRNAs (miRNAs) are a group of small, noncoding RNAs nucleotides, which are essential post-transcriptional controllers of gene expression. They have a central role in the normal bone development. The goal of our study was to investigate 18 miRNAs, whose targets were previously validated and described in MM subjects without ONJ, in peripheral lymphocytes of MM subjec...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Consensus statement for cancer patients requiring intensive care support
AbstractThis consensus statement is directed to intensivists, hematologists, and oncologists caring for critically ill cancer patients and focuses on the management of these patients. (Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Clinical utility of miR-143/miR-182 levels in prognosis and risk stratification specificity of BFM-treated childhood acute lymphoblastic leukemia
AbstractAlthough childhood acute lymphoblastic leukemia (ALL) is characterized by high remission rates, there are still patients who experience poor response to therapy or toxic effects due to intensive treatment. In the present study, we examined the expression profile of miR-143 and miR-182 in childhood ALL and evaluated their clinical significance for patients receiving Berlin –Frankfurt–Münster (BFM) protocol. Bone marrow specimens from 125 childhood ALL patients upon diagnosis and the end-of-induction (EoI; day 33), as well as from 64 healthy control children undergone RNA extraction, polyadenylation,...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Unmet supportive care needs of haematological cancer survivors: rural versus urban residents
This study compared among rural and urban haematological cancer survivors the most common “high/very high” unmet supportive care needs and the unmet need scores for five domains (information,financial concerns,access and continuity of care,relationships andemotional health). Survivors ’ socio-demographics, rurality, cancer history and psychological factors associated with each unmet need domain were also explored. A total of 1511 haematological cancer survivors were recruited from five Australian state cancer registries and 1417 (1145 urban, 272 rural) allowed extraction of the ir residential postcode fro...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Lymphoma-like monoclonal B cell lymphocytosis in a patient population: biology, natural evolution, and differences from CLL-like clones
AbstractHigh-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1 –4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrospectively evaluated 33 L-MBL cases within our hospital population and compared them to 95 subjects with CLL-like MBL (C-MBL). Diagnoses of L-MBL were based on asymptomatic B cell clones with Matutes score
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Salvage regimens using conventional chemotherapy agents for relapsed/refractory adult AML patients: a systematic literature review
AbstractPrognosis in relapsed and refractory acute myeloid leukemia (R/R AML) patients is dismal, with no satisfactory and standard salvage chemotherapy regimen. We performed a systematic review in order to analyze the clinical outcomes reported with conventional chemotherapy schemes in adult patients with R/R AML. To have a better understanding of the R/R ground, we included studies in R/R AML adult population at any disease stage (i.e., primary refractory as well as first relapse or beyond). Study selection included a total number of 157 out of 850 records, with a wide variety of schedules. Furthermore, only 24 studies w...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids
AbstractWe aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion of LOHC after allo-HSCT were enrolled in this study. The median time from allo-HSCT to the occurrence of LOHC was 29 (range, 4 –155) days. Pathogens identified in blood and/or urine samples from 143 patients were mostly viruses. All of the patients with LOHC received intravenous fluid hydra...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Association of bone marrow fibrosis with inferior survival outcomes in chronic myelomonocytic leukemia
AbstractThe impact of bone marrow fibrosis grade on the prognosis of patients with chronic myelomonocytic leukemia (CMML) remains controversial. Therefore, we examined the records of 82 patients diagnosed with CMML at our institution and summarized baseline characteristics and molecular profiles by subgroups of absent or mild (grades 0/1) and moderate (grade 2) fibrosis. Cox proportional hazards models were constructed to assess the prognostic significance of fibrosis grade. Grade 2 fibrosis was identified in 63 patients (76.8%), grade 1 in 16 patients (19.5%), and grade 0 in 3 patients (3.7%). Grade 2 fibrosis was associa...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Histological transformation of MALT lymphoma to plasma cell leukemia after rituximab-containing therapy
(Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Langerhans cell histiocytosis and primary hemophagocytic lymphohistiocytosis with persistent clonal T-large granular lymphocyte proliferation
(Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

The impact of stem cell transplantation on the natural course of peripheral T-cell lymphoma: a real-world experience
In this study, a significant benefit of intending first-line autoSCT over non-transplant induction in patients with ALK-PTCL did not emerge. Most patients fail first-line treatment and have a p oor outlook if salvage alloSCT cannot be performed. (Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Rhu-Epo down-regulates pro-tumorigenic activity of cancer-associated fibroblasts in multiple myeloma
AbstractWe have previously demonstrated that recombinant human erythropoietin (rHuEpo) is involved in the regulation of the angiogenic response in multiple myeloma (MM) through a direct effect on macrophages and endothelial cells isolated from the bone marrow of patients with MM. The aim of the present study was designed to determine the effects of rHuEpo on cancer-associated fibroblasts (CAFs) from monoclonal gammopathy of undetermined significance (MGUS) and MM patients by means of in vitro and in vivo assays. rHuEpo treatment reduces the expression of mRNA levels of fibroblast activation markers, namely alpha smooth act...
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Higher Sclerostin/ SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis
(Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Correction to: MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia
The original version of this article contained a mistake. The name of Magnus Bj örkhom should have been Magnus Björkholm. (Source: Annals of Hematology)
Source: Annals of Hematology - May 30, 2018 Category: Hematology Source Type: research

Immunomodulatory drugs and the risk of serious infection in multiple myeloma: systematic review and meta-analysis of randomized and observational studies
AbstractThe effect of immunomodulatory drugs (IMiDs) on serious infection remains uncertain. We therefore conducted a systematic review and meta-analysis to assess the possible impact of IMiDs on serious infection in patients with multiple myeloma (MM). We searched randomized controlled trials (RCTs) and observational studies from databases that addressed the effect of IMiDs on serious infection in patients with MM. We pooled data from RCTs and observational studies separately and used the GRADE approach to rate the quality of evidence. Rates in patients with individual IMiDs at different treatment status ranged from 7.00 ...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants
AbstractThe aims of this study were to describe hepcidin levels and to assess their associations with iron status and the main variants in theHFE gene in healthy and full-term newborns during the first year of life, as a longitudinal study conducted on 140 infants. Anthropometric and biochemical parameters, hepcidin, hemoglobin (Hb), serum ferritin (SF), transferrin saturation (TS), mean corpuscular volume (MCV), and C-reactive protein (CRP), were assessed in 6- and 12-month-olds. Infants were genotyped for the three mainHFE variants: C282Y, H63D, and S65C. Hepcidin levels increased from 6 to 12  months of age (43.7&t...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL)
AbstractMixed phenotype acute leukemia (MPAL) is an uncommon diagnosis, representing only about 2 –5% of acute leukemia cases. The blast cells of MPAL express multilineage immunophenotypic markers and may have a shared B/T/myeloid phenotype. Due to historical ambiguity in the diagnosis of MPAL, the genetics and clinical features of this disease remain poorly characterized. Based on the 2008 an d 2016 World Health Organization classifications, myeloid lineage is best determined by presence of myeloperoxidase, while B and T lymphoid lineages are demonstrated by CD19 and cytoplasmic CD3 expression. MPAL typically carrie...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Genome-wide genotype-based risk model for survival in core binding factor acute myeloid leukemia patients
AbstractThe present study attempted to build a single nucleotide polymorphism (SNP)-based risk model for predicting overall survival (OS) and event-free survival (EFS) in patients with core binding factor acute myeloid leukemia (CBF-AML). Adopting genome-wide SNP array using Affymetrix SNP array 6.0, we analyzed 868,157 SNPs with respect to OS and EFS in 104 patients with CBF-AML. Significant SNPs were identified from single SNP analysis. The risk model was constructed with incorporation of six SNPs and three clinical factors (age, c-kit exon 17 mutation, and LDH) for OS and six SNPs and three clinical factors (age, WBC, a...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation
In this study, using multiparameter flow cytometry (FCM), we investigate the impact of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) mutation. A total of 20 patients who received HLA-matched sibling donor transplantation (MSDT) and 63 patients who received unmanipulated haploidentical hematopoietic stem cell transplantation (haplo-HSCT) were enrolled. Patients were classified into four groups based on the status of pre-FCM: group 1 with positive pre-FCM before MSDT, group 2 with negative pre-...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Acquired long QT syndrome during conditioning for allogeneic stem cell transplantation —are we aware of this side effect?
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy
AbstractRecent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients. PFS was evaluated accordingly to Kaplan-Meier method. Higher NLR was associated to ad...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Concurrent mucosa-associated lymphoid tissue lymphoma with diffuse large B-cell lymphoma transformation and Hodgkin lymphoma of the neck
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

High proportion of TAFRO syndrome in Thai adult Castleman ’s disease patients: a 10-year experience
AbstractCastleman ’s disease (CD) is a rare lymphoproliferative disorder, and its prevalence in Thailand is not known. This 10-year period study investigated the prevalence of CD in Thailand, and the clinical characteristics and outcomes of Thai CD patients, with special focus on the existence and prevalence of TAF RO syndrome. TAFRO syndrome is defined as CD with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Thirty-three CD patients diagnosed and treated at Siriraj Hospital during January 2007 to December 2016 were included. The prevalence of CD was 1.4 per 1,000,000 patients/10 ye ar...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Mutational analysis aids the diagnosis of primary myelofibrosis with atypical morphology
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma
AbstractThe geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

High PD-L1 expression predicts poor prognosis in diffuse large B-cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma
AbstractIn our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56.3%) in partial remission (PR), and five (31.2%) with active disease. The patients were transplanted from an HLA-identical (n = 7) from a mismatched (n = 1) or haploidentical (n = 1) sibling, from matched unrelated donor (n = 5), or from a single cord blood unit (n = 2). Conditioning regimen was standard myeloablative in 6 pa...
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

The potential role of clarithromycin addition to lenalidomide and dexamethasone therapy (BiRd) in multiple myeloma
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research

Extramedullary involvement of the stomach presenting as multiple white elevations in the initial diagnosis of chronic myeloid leukemia treated with dasatinib
(Source: Annals of Hematology)
Source: Annals of Hematology - April 20, 2018 Category: Hematology Source Type: research