Oral high-dose sucrosomial iron vs intravenous iron in sideropenic anemia patients intolerant/refractory to iron sulfate: a multicentric randomized study
AbstractIron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who are refractory/intolerant to oral iron sulfate. However, the intravenous way of iron administration requires several precautions; as the in-hospital administration requires a resuscitation service, as imposed in Europe by the European Medicine Agency, it is very expensive and negatively affects patien...
Source: Annals of Hematology - December 2, 2020 Category: Hematology Source Type: research

Treatment patterns and bleeding outcomes in persons with severe hemophilia A and B in a real-world setting
AbstractThe current standard of care treatment for severe hemophilia A and B (SHA and SHB) is the prophylactic intravenous replacement of coagulation factor VIII or IX (FVIII/FIX) to prevent spontaneous bleeding. Persons with hemophilia without prophylactic treatment receive therapy in case of bleeding, i.e., on demand. To assess treatment patterns, utilization of products, and bleeding outcomes in a real-world cohort of persons with SHA and SHB, defined as FVIII or FIX activity
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Reduced renal function strongly affects survival and thrombosis in patients with myelofibrosis
AbstractWe retrospectively investigated a cohort of 176 myelofibrosis patients (128 primary-PMF; 48 secondary-SMF) from five hematology centers. The presence of chronic kidney disease (CKD) was determined in addition to other clinical characteristics. CKD was present in 26.1% of MF patients and was significantly associated with older age (P   0.05 for all analyses). The presence of CKD was significantly associated with shorter time to arterial (HR = 3.49;P = 0.041) and venous thrombosis (HR = 7.08;P = 0.030) as well as with shorter overall survival (HR 2...
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Validation and comparison of prognostic values of GNRI, PNI, and CONUT in newly diagnosed diffuse large B cell lymphoma
AbstractDiffuse large B cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin lymphoma. Emerging evidence indicates that poor nutritional status determined with nutritional indices such as geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), and controlling nutritional status score (CONUT) was associated with poor prognosis of DLBCL. We conducted this multicenter retrospective study to validate and compare prognostic values of the three indices in 615 newly diagnosed DLBCL patients. The overall survival (OS) in patients with poor nutritional status determined with each of these nut...
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Reevaluation of reference values for bone marrow differential counts in 236 healthy bone marrow donors
This study largely confirms the results for cell counts in normal human bone marrow available from previous reports and provides some insights into factors that affect individual c ell populations. It also reveals substantial variability among even experienced investigators in cytological diagnoses. (Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Prognostic value of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in multiple myeloma patients treated with thalidomide-based regimen
AbstractNeutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) are considered as laboratory markers of inflammation. They can be potentially useful in predicting the course of multiple neoplasms including selected hematological cancers. The aim of the study was to assess the value of NLR and PLR in predicting the effects of therapy and prognosis in multiple myeloma patients treated with thalidomide-based regimen. The study group consisted of 100 patients treated with the first line CTD (cyclophosphamide, thalidomide, and dexamethasone) chemotherapy. The NLR and PLR were calculated before treatment....
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Genetic research and clinical analysis of deletional Chinese G γ + ( A γδβ) 0 -thalassemia and Southeast Asian HPFH in South China
AbstractChineseGγ+(Aγδβ)0-thalassemia and SEA-HPFH are the most common types of β-globin gene cluster deletion in Chinese population. The aim of the study was to analyze clinical features of deletional ChineseGγ+(Aγδβ)0-thalassemia and Southeast Asian hereditary persistence of fetal hemoglobin (SEA-HPFH) in South China. A total of 930 subjects with fetal hemoglobin (HbF) level ≥ 2% were selected on genetic research of ChineseGγ+(Aγδβ)0-thalassemia and SEA-HPFH. The gap polymerase chain reaction was performed to identify the deletions. One hundred ...
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Pediatric recurrent Rosai-Dorfman disease with germline heterozygous SLC29A3 and somatic MAP2K1 mutations
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

IL-1R blockade is not effective in patients with hematological malignancies and severe SARS-CoV-2 infection
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Living donor kidney transplantation is an effective option of renal replacement therapy in patients with light-chain amyloidosis (AL)
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Rare synchronous co-existence of acute myeloid leukemia and hairy cell leukemia in a same patient
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Early-stage mantle cell lymphoma —a rare entity with special characteristics and needs for treatment
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Venetoclax monotherapy for cutaneous blastic plasmacytoid dendritic cell neoplasm
(Source: Annals of Hematology)
Source: Annals of Hematology - November 23, 2020 Category: Hematology Source Type: research

Correction to: The classic prognostic factors in advanced Hodgkin ’s lymphoma patients are losing their meaning at the time of pet-guided treatments
In the article entitled “The classic prognostic factors in advanced Hodgkin’s lymphoma patients are losing their meaning at the time of Pet-guided treatments”, the affiliation of Armando Santoro should be corrected as follows: (Source: Annals of Hematology)
Source: Annals of Hematology - November 21, 2020 Category: Hematology Source Type: research

R-CHOEP14 in younger high-risk patients with large B cell lymphoma: an effective front-line regimen with cardiac toxicity: a real-life, single-center experience
AbstractCurrently, there is no consensus regarding optimal front-line treatment for younger high-risk patients with large B cell lymphoma. American recommendations list only R-CHOP as standard, while European also include R-ACVBP and R-CHOEP14. We have been routinely using the latter regimen at our institution since 2011 and performed this retrospective real-life single-center study to analyze outcomes. Between September 2011 and April 2019, 66 newly diagnosed patients aged 18 to 60 years with B-large cell lymphoma and high-risk age-adjusted International Prognostic Index score were scheduled to receive 6 or 8 cycles of bi...
Source: Annals of Hematology - November 20, 2020 Category: Hematology Source Type: research

Effects of three months of treatment with vitamin E and N-acetyl cysteine on the oxidative balance in patients with transfusion-dependent β-thalassemia
AbstractOxidative stress is a major mechanism contributing to the progression of β-thalassemia. To assess the effect of vitamin E and N-acetyl cysteine (NAC) as antioxidant agents on total oxidative stress (TOS) status and total antioxidant capacity (TAC) in patients with transfusion-dependent β-thalassemia (TDT). In this open-label randomized controlled trial, from May to Aug ust 2019, 78 eligible patients with TDT over the age of 18 were enrolled. All patients were registered at the Thalassemia Clinic of Shiraz University of Medical Sciences in Southern Iran. Patients were randomly allocated to the NAC group (1...
Source: Annals of Hematology - November 20, 2020 Category: Hematology Source Type: research

Direct oral anticoagulants (DOAC) for prevention of recurrent arterial or venous thromboembolic events (ATE/VTE) in myeloproliferative neoplasms
AbstractIn patients withBCR-ABL-negative myeloproliferative neoplasms (MPN), arterial or venous thromboembolic events (ATE/VTE) are a major burden. In order to control these complications, vitamin K antagonists (VKA) are widely used. There is no robust evidence supporting the use of direct oral anticoagulants (DOAC) in MPN patients. We therefore compared the efficacy and safety of both anticoagulants in 71 cases from a cohort of 782 MPN patients. Seventy-one of 782 MPN patients (9.1%) had ATE/VTE with nine ATE (12.7%) and 62 VTE (87.3%). Forty-five of 71 ATE/VTE (63.4%) were treated with VKA and 26 (36.6%) with DOAC. The d...
Source: Annals of Hematology - November 20, 2020 Category: Hematology Source Type: research

Skin changes in hairy cell leukemia
AbstractSkin lesions have been reported in about 10 –12% of hairy cell leukemia (HCL) patients. Most are etiologically related to autoimmune or infectious processes, although secondary cutaneous neoplasms and drug-induced lesions are also reported. However, leukemia cutis with the direct infiltration of the skin by leukemic cells is extremely rare in HCL patients. This paper reviews the epidemiology, pathogenesis, clinical symptoms, diagnosis, and approach to treating skin lesions in HCL. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skin lesions, leukemia cutis, ...
Source: Annals of Hematology - November 20, 2020 Category: Hematology Source Type: research

Acknowledgement to referees
(Source: Annals of Hematology)
Source: Annals of Hematology - November 20, 2020 Category: Hematology Source Type: research

High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease
AbstractAntithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We conducted a single-center, retrospective study to analyze the association of acute GVHD requiring systemic corticosteroid (SC-aGVHD) with absolute lymphocyte counts (ALC) before the administration of ATG or conditioning in 53 patients with HLA-matched PBSCT using low-dose thymoglobulin (2 mg/kg) after myeloablative conditioning. The cumulative incidence of SC-aGVHD wa...
Source: Annals of Hematology - November 19, 2020 Category: Hematology Source Type: research

Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas
This study evaluated the efficacy and toxicity of BuEAM as a high-dose regimen for ASCT in patients with T-cell lymphomas. The high-dose chemotherapy at seven centers in Korea included Bu (3.2 mg/kg IV qd from day 6 to day 5), E (200 mg/m2 IV bid on day 4 and day 3), A (1 g/m2 IV qd on day 4 and day 3), and M (140 mg/m2 IV qd on day 2). Eighty-one patients were enrolled in this study. The main subtypes were peripheral T-cell lymphoma, not other specified (n = 32, 39.5%), NK/T-cell lymphoma (n = 22, 27.5%), and angioimmunoblastic T-cell lymphoma (n = 12, 14.8%). Upfront and salvage ASCTs were performed in 65 (80.2%) and 16 ...
Source: Annals of Hematology - November 17, 2020 Category: Hematology Source Type: research

Questioning the association between ABO type and outcomes in patients with COVID-19
(Source: Annals of Hematology)
Source: Annals of Hematology - November 17, 2020 Category: Hematology Source Type: research

Cutaneous marginal zone lymphoma following anthrax vaccination
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2020 Category: Hematology Source Type: research

Treatment of myeloid malignancies relapsing after allogeneic hematopoietic stem cell transplantation with venetoclax and hypomethylating agents —a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group
AbstractTreatment of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT) remains a great challenge. Aiming to evaluate the combination of venetoclax and hypomethylating agents (HMAClax) for the treatment of relapse of myeloid malignancies after alloHSCT, we retrospectively collected data from 32 patients treated at 11 German centers. Venetoclax was applied with azacitidine (n = 13) or decitabine (n = 19); 11 patients received DLI in addition. HMAClax was the first salvage therapy in 8 patients. The median number of cycles per patient was 2 (1 –19). All but 1 patient had grade 3/4 neutropenia. ...
Source: Annals of Hematology - November 16, 2020 Category: Hematology Source Type: research

Blood and platelet transfusion from a donor with presymptomatic Covid-19
(Source: Annals of Hematology)
Source: Annals of Hematology - November 13, 2020 Category: Hematology Source Type: research

Venetoclax and azacytidine combination is an effective bridge to transplant strategy in relapsed/refractory acute myeloid leukemia patients
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2020 Category: Hematology Source Type: research

A new parameter in multiple myeloma: CYP3A4*1B single nucleotide polymorphism
This study demonstrated that CYP3A4*1B NN genotype, which is an important cytochrome p450 member for the treatment of MM, was 41.666-fold protective for OS and 3.144-fold protective for PFS. It was shown in this study for the first time in the literature as a valuable contribution. (Source: Annals of Hematology)
Source: Annals of Hematology - November 10, 2020 Category: Hematology Source Type: research

Hemolytic crisis in a patient treated with eculizumab for paroxysmal nocturnal hemoglobinuria possibly triggered by SARS-CoV-2 (COVID-19): a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - November 10, 2020 Category: Hematology Source Type: research

Correction of iron deficiency in hospitalized heart failure patients does not improve patient outcomes
AbstractHeart failure (HF) has an estimated prevalence of 1 –2% in the world’s population and up to 10% of patients age 65 and above. Iron deficiency (ID) in HF has been shown to be an independent contributor of increased mortality and poorer quality of life and has been associated with increased rates of hospitalization. Estimates are varied, but it is believed that as many as 30–83% of HF patients have ID, often without overt anemia, therefore making diagnosis more difficult. Well-established large studies have shown intravenous iron (IVFe) supplementation in HF patients is superior to an oral route, th...
Source: Annals of Hematology - November 9, 2020 Category: Hematology Source Type: research

Analysis of real-world data in patients with relapsed/refractory diffuse large B cell lymphoma who received salvage chemotherapy in the rituximab era
In conclusion, we found that the clinical outcome of patients with relapsed/refractory DLBCL in the rituximab era was unsatisfactory. Further improvements in treatment strategies, including novel agents, are needed. (Source: Annals of Hematology)
Source: Annals of Hematology - November 9, 2020 Category: Hematology Source Type: research

Clinical association between thyroid disease and immune thrombocytopenia
This study demonstrated that thyroid diseases were commonly found in patients with ITP. Treatment of the underlying thyroid disease may improve thrombocytopenia. (Source: Annals of Hematology)
Source: Annals of Hematology - November 9, 2020 Category: Hematology Source Type: research

Ixazomib and lenalidomide maintenance therapy in multiple myeloma
(Source: Annals of Hematology)
Source: Annals of Hematology - November 8, 2020 Category: Hematology Source Type: research

Carfilzomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma patients: the real-life experience of Rete Ematologica Pugliese (REP)
AbstractCarfilzomib, lenalidomide, and dexamethasone (KRd) have been approved for the treatment of relapsed and refractory multiple myeloma (RRMM) based on ASPIRE clinical trial. However, its effectiveness and safety profile in real clinical practice should be further assessed. We retrospectively evaluated 130 consecutive RRMM patients treated with KRd between December 2015 and August 2018, in 9 Hematology Departments of Rete Ematologica Pugliese (REP). The overall response rate (ORR) was 79%, with 37% complete response (CR). Treatment with KRd led to an improvement in response regardless of age, refractory disease, and nu...
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

COVID-19 in cancer patients: clinical characteristics and outcome —an analysis of the LEOSS registry
AbstractIntroductionSince the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk.Patients and methodsWe retrospectively analyzed a cohort of 435 cancer patients and 2636 non-cancer patients with confirmed SARS-CoV-2 infection, enrolled between March 16 and August 31, 2020. Data on socio-demographics, comorbidities, cancer-related features and infection course were collected. Age-, sex- a...
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

Analysis of the impact of adherence to guidelines and expert advice in patients with myelodysplastic syndromes
AbstractThe European Leukemia Net (ELN) guidelines for treatment of myelodysplastic syndromes (MDS) connect heterogeneous MDS subgroups with a number of therapeutic options ranging from best supportive care to allogeneic stem cell transplantation (alloSCT). However, it is currently unknown whether adherence to guideline recommendations translates into improved survival. The sizeable database of the Duesseldorf MDS Registry allowed us to address this question. We first performed a retrospective analysis including 1698 patients (cohort 1) to whom we retrospectively applied the ELN guidelines. We compared patients treated acc...
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

Ruxolitinib is an effective salvage treatment for multidrug-resistant graft-versus-host disease after haploidentical allogeneic hematopoietic stem cell transplantation without posttransplant cyclophosphamide
AbstractThe purpose of our study is to identify the efficacy of ruxolitinib in human leukocyte antigen (HLA) haploidentical hematopoietic stem cell transplantation (haplo-HSCT) recipients with multidrug-resistant (MDR)-graft-versus-host disease (GVHD,n = 34). MDR-GVHD was defined as GVHD showing no improvement after at least 3 types of treatments. The median number of previous GVHD-therapies was 4 for both MDR-acute GVHD (aGVHD) and MDR-chronic GVHD (cGVHD). For MDR-aGVHD (n = 15), the median time to response was 10 days (range 2 to 65), and the overall response rate (ORR) was 60.0% (9/15), including 40.0% (6/15) complete ...
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

Congenital dyserythropoietic anemia types Ib, II, and III: novel variants in the CDIN1 gene and functional study of a novel variant in the KIF23 gene
AbstractCongenital dyserythropoietic anemias (CDA) are disorders characterized by ineffective erythropoiesis and morphological anomalies in erythrocytes and erythroblasts. The purpose of this study is to identify the gene variants in patients diagnosed with CDA. We analyzed five unrelated patients and two siblings with a targeted panel of genes to CDA:CDAN1,CDIN1,SEC23B,KIF23,KLF1, andGATA1 genes. We found three novel variants in theCDIN1 gene (p.Leu136Val, p.Tyr247Cys, and p.Ile273Thr), four known variants in theSEC23B gene (p.Arg14Trp, p.Arg554Ter, p.Asp239Gly, and p.Ser436Leu), and one novel variant in theKIF23 gene (p....
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

Clonal IgH gene rearrangements identify Richter ’s transformation to diffuse large B cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - November 7, 2020 Category: Hematology Source Type: research

Catching the clinical and biological diversity for an appropriate therapeutic approach in systemic mastocytosis
AbstractSystemic mastocytosis (SM) is a rare disease calling for integrated approaches involving onco-hematologic competences for appropriate clinical management and treatment. The wide variability of manifestations and disease course claims for an accurate risk stratification, currently relying on the appraisal of the benefit/risk ratio of treatment modalities within indolent and advanced variants according to WHO classification. More objective parameters are progressively incorporated and integrated into comprehensive models, on which to support the adoption of therapeutic strategies, since the mere clinical distinction ...
Source: Annals of Hematology - November 6, 2020 Category: Hematology Source Type: research

Repeated ruptures of corpus luteum in a female patient with alpha1-antitrypsin Pittsburgh
(Source: Annals of Hematology)
Source: Annals of Hematology - November 6, 2020 Category: Hematology Source Type: research

Plasma hemoglobin in COVID-19: authors ’ reply
(Source: Annals of Hematology)
Source: Annals of Hematology - November 6, 2020 Category: Hematology Source Type: research

Outcome predictors after retransplantation in relapsed acute lymphoblastic leukemia: a multicenter, retrospective study
We examined 55 recipients who underwent multiple allo-HCTs during 2006 –2018. The 2-year overall survival (OS), progression-free survival (PFS), and non-relapse mortality rates were 35.9%, 29.1%, and 23.6%, respectively. We observed a trend of better outcome in Ph + ALL (n = 22) patients compared with non-Ph ALL (n = 33) patients; the 2-year PFS was 40.9% versus 21.2%, indicating a beneficial effect of more potent second- or third-generation tyrosine kinase inhibitors. Univariate analysis revealed that late relapse after the previous transplant was the only significant predicto...
Source: Annals of Hematology - November 5, 2020 Category: Hematology Source Type: research

Effective treatment with imatinib for acute B-lymphoblastic leukaemia with EBF1-PDGFRB fusion
(Source: Annals of Hematology)
Source: Annals of Hematology - November 5, 2020 Category: Hematology Source Type: research

Prognostic value of 25-hydroxy vitamin D in extranodal NK/T cell lymphoma
In conclusion, our study proved that 25-(OH)D deficiency was associated with inferior survival outcome of ENKTL patients. (Source: Annals of Hematology)
Source: Annals of Hematology - November 2, 2020 Category: Hematology Source Type: research

Post-transplant cyclophosphamide for GVHD prophylaxis compared to ATG-based prophylaxis in unrelated donor transplantation
In this study, PTCy combined with additional immunosuppression after MUD/mMUD HSCT showed a reduction of aGVHD rate with safety results comparable to those obtained with the ATG-based prophylaxis. (Source: Annals of Hematology)
Source: Annals of Hematology - November 2, 2020 Category: Hematology Source Type: research

Plasma cell myeloma with pure lymphocyte-like morphology
(Source: Annals of Hematology)
Source: Annals of Hematology - November 2, 2020 Category: Hematology Source Type: research

Analysis of blood stream infections, antibiograms and clinical outcomes in haematological patients with febrile neutropenia: data from a tertiary care haematology institute in India
In this study, we audited the clinical and microbiological data of febrile neutropenic episodes occurring at a tertiary care haematology institution. Three hundred and ninety-three febrile neutropenic episodes occurring in 123 patients over a 1-year period were analysed for microbial profile, sensitivity and resistance patterns, and finally clinical outcomes. Gram-negative bacilli (GNB) blood stream infections (46.9%) were more prevalent as compared to gram-positive infections (41.9%). Overall mortality due to complicated neutropenic sepsis was 19.5% (24/123 patients). Increased resistance to carbapenems, beta-lactam beta-...
Source: Annals of Hematology - November 2, 2020 Category: Hematology Source Type: research

Correction to: Eltrombopag is effective in patients with relapse/refractory aplastic anemia —report from a single center in China
The article “Eltrombopag is effective in patients with relapse/refractory aplastic anemia—report from a single center in China”. (Source: Annals of Hematology)
Source: Annals of Hematology - November 2, 2020 Category: Hematology Source Type: research

Hepatitis B reactivation in hematopoietic stem cell transplanted patients: 20 years of experience of a single center from a middle endemic country
This study analyzes the incidence of reactivation of HBV infections in HSCT patients in a middle endemic country like Turkey. Five hundred and sixty-one HSCT patients from 1994 to 2015 were retrospectively evaluated. Sixty-six patients had a serologic feature of HBV infection. Fifteen patients were hepatitis B surface antigen (HBsAg)-positive patients (3 allogeneic and 12 autologous) while 51 of them were anti-hepatitis B core IgG (anti-HBc IgG)-positive patients (22 allogeneic and 29 autologous). Although under lamivudine prophylaxis, reactivation was seen in three of 12 (25%) chronic HBV (HBsAg positive) patients who rec...
Source: Annals of Hematology - October 6, 2020 Category: Hematology Source Type: research

A retrospective analysis on anti-CD20 antibody –treated Epstein–Barr virus–related posttransplantation lymphoproliferative disorder following ATG-based haploidentical T-replete hematopoietic stem cell transplantation
AbstractPosttransplantation lymphoproliferation disorder (PTLD) is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Anti-CD20 antibody is the most widely used antibody to eliminate infected B cells. Few studies have focused on prognostic factors predicting the outcome of EBV (Epstein –Barr virus)-PTLD. We conducted a retrospective analysis of 2571 haplo-HSCTs performed between 2010 and 2017 at the Peking University Institute of Hematology; seventy patients who had been treated with rituximab for PTLD were enrolled. The overall EBV-related PTLD frequency was 3.1%. With a median fol...
Source: Annals of Hematology - October 6, 2020 Category: Hematology Source Type: research