Bendamustine-120 plus rituximab therapy for relapsed or refractory follicular lymphoma: a multicenter phase II study
AbstractThe optimal dose, schedule, and other aspects of bendamustine plus rituximab treatment remain unclear for patients with relapsed or refractory follicular lymphoma (FL). Herein, we analyzed the efficacy of bendamustine combined with rituximab (RB-120) treatment for Japanese patients with relapsed or refractory FL. This phase II clinical trial included patients with relapsed or refractory FL who received 375  mg/m2 rituximab on day 1 and 120  mg/m2 bendamustine on days 2 and 3 every 28  days for up to 6 cycles. The primary endpoint was the overall response rate (ORR), and the secondary endpoints i...
Source: Annals of Hematology - July 8, 2019 Category: Hematology Source Type: research

Successful treatment of nasal-type extra-nodal natural killer/T cell lymphoma with simultaneous involvement of the thyroid, liver, and pancreas
(Source: Annals of Hematology)
Source: Annals of Hematology - July 6, 2019 Category: Hematology Source Type: research

An uncommon cause of acute hypoxaemic respiratory failure during haematopoietic stem cell transplantation
(Source: Annals of Hematology)
Source: Annals of Hematology - July 5, 2019 Category: Hematology Source Type: research

Bronchoscopic features, associations, and outcomes of organizing pneumonia following allogeneic hematopoietic stem cell transplantation
AbstractOrganizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass opacities. Bronchoalveolar lavage (BAL) was performed on 14 patients with five having lymphocytosis (>  25% lymphocytes), three with eosinophilia (>  5% eosinophils), three with neutrophilia (>  30% neutrophils), and three with normal cell counts. Flow cytometry was analyz...
Source: Annals of Hematology - July 4, 2019 Category: Hematology Source Type: research

Impairment of lung diffusion capacity —a new consequence in the long-term childhood leukaemia survivors
AbstractChildhood leukaemia survivors (CLS) are known to have developed long-term impairment of lung function. The reasons for that complication are only partially known. The aims of this study were to assess pulmonary function in CLS and identify (1) risk factors and (2) clinical manifestations for the impairment of airflow and lung diffusion. The study group included 74 CLS: 46 treated with chemotherapy alone (HSCT −), 28 with chemotherapy and haematopoietic stem cell transplantation (HSCT+), and 84 healthy subjects (control group (CG)). Spirometry and diffusion limit of carbon monoxide (DLCO) tests were performed ...
Source: Annals of Hematology - July 2, 2019 Category: Hematology Source Type: research

Pediatric Langerhans cell histiocytosis: the impact of mutational profile on clinical progression and late sequelae
AbstractLangerhans cell histiocytosis (LCH) is a clonal histiocytic disorder with recurrent mutations ofBRAF andMAP2K1, but data on the impact of genetic features on progression and long-term sequelae are sparse. Cases of pediatric LCH with long-term follow-up from our institution were analyzed for mutations inBRAFV600 andMAP2K1 exons 2 and 3 by immunostaining with mutation-specific VE1 antibody, as well as allele-specific PCR and sequencing, respectively. Clinical and follow-up data were obtained from our files and a questionnaire sent to all former patients. Sixteen of 37 (43%) evaluable cases showedBRAFV600E, one case a...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

The platelet NLRP3 inflammasome is upregulated in a murine model of pancreatic cancer and promotes platelet aggregation and tumor growth
AbstractPlatelets are activated in solid cancers, including pancreatic ductal adenocarcinoma (PDA), a highly aggressive malignancy with a devastating prognosis and limited therapeutic options. The mechanisms by which activated platelets regulate tumor progression are poorly understood. The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome is a key inflammatory mechanism recently identified in platelets, which controls platelet activation and aggregation. In an orthotopic PDA mouse model involving surgical implantation of Panc02 murine cancer cells into the tail of the pancreas, we show...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

CSF3R mutations were associated with an unfavorable prognosis in patients with acute myeloid leukemia with CEBPA double mutations
AbstractThe aim of this study was to explore the clinical features and prognostic significance ofCSF3R mutations in AML patients withCEBPA double mutations (CEBPAdm). One hundred one AML patients withCEBPAdm were retrospectively analyzed in this study. Mutation status ofCSF3R gene, clinical features, and long-term outcomes were analyzed. The frequency ofCSF3R mutations in patients withCEBPAdm was 19.80% (20/101). Patients withCSF3R mutations were associated with a lower platelet (u = 2.728,P = 0.006) and higher leukocytes (u = 3.178,P = 0.001) compared with those with...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis
AbstractRecent evidence suggests that renal dysfunction may be a direct consequence of primary myelofibrosis (PMF). We performed a retrospective analysis of 100 patients with previously untreated PMF, receiving frontline treatment with single agent ruxolitinib, and compared them to 105 patients, receiving frontline treatment with a non-ruxolitinib-based therapy, matched by age, sex, DIPSS plus, and estimated glomerular filtration rate (eGFR). Use of ruxolitinib associated with a significantly higher rate of renal improvement (RI)  > 10% (73% vs 50%,p = 0.01) confirmed on multivariate analysis (MV...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

The benefit of chronic graft-versus-host disease in patients with acute myeloid leukemia relapsed after allogeneic stem cell transplantation
AbstractTo investigate the effect of chronic graft-versus-host disease (cGVHD) on the outcomes of acute myeloid leukemia (AML) patients who relapsed after allogenic hematopoietic cell transplantation, we performed a retrospective analysis on 218 patients with a median follow-up of 21.4 (3.4 –179.6) months. A total of 103 patients developed cGVHD, with a 2-year cumulative incidence of 48.9% (95% CI 42.1–55.7%). The estimated 3-year overall survival was 85.7% (95% CI 75.7–95.7%), 48.8% (95% CI 31.7–66.0%), and 54.1% (95% CI 44.3–63.8%) for patients with limited cGVHD, extensiv e cGVHD, and ...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin
In this study, we aimed to explore therapeutic approaches and outcomes in patients with extranasal NKTCL in current clinical practice. A data set of patients with newly diagnosed NKTCL who were diagnosed at 31 institutes in Japan between 2000 and 2013 was used for analysis. The patients ’ fitness for steroid, methotrexate, ifosfamide,l-asparaginase, and etoposide (SMILE) chemotherapy was assessed using the major inclusion criteria of the SMILE phase 2 study. Of 358 patients, 47 (13%) had extranasal NKTCL. The most frequent extranodal sites of involvement in extranasal NKTCL were skin/subcutaneous tissue (n =&t...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Characterization of deletional and non-deletional alpha globin variants in a large cohort from Spain between 2009 and 2014
AbstractThe hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. They are among the most common inherited diseases around the world. Those that produce abnormal hemoglobin are called structural hemoglobinopathies while thalassemia is another type of disorder that is caused by a defect in the gene production of the globin chains. In a study ambispective comprising 1623 patients, 153 subjects showed an abnormal hemoglobin and 1470 with hypochromic and microcytic anemia, and of these 1470, 23 patients were studied fo...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Interim PET-CT –guided therapy in elderly patients with Hodgkin lymphoma—a retrospective national multi-center study
AbstractHodgkin lymphoma (HL), a disease of mostly young patients, also peaks in the elderly. Despite the profound improvement in the outcome of young patients, in the elderly, 5-year progression-free survival (PFS) rates are under 70%. Interim PET-CT (iPET) is known to be highly predictive for PFS in young HL patients, but it has not been sufficiently validated in the elderly patient population. In this multi-center collaboration, all consecutive elderly patients (age  ≥ 60) diagnosed with HL between 1998 and 2016 were retrospectively reviewed. Baseline characteristics, outcome measures, and iPET results,...
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Diffuse large B cell lymphoma with chromosomal translocation t(14;19)(q32;q13) occurring in IgG4-related disease
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

A novel nucleotide substitution in the 5 ′ untranslated region of ANKRD26 gene is associated with inherited thrombocytopenia: a report of two new families
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Efficacy and safety of oral deferasirox treatment for transfusional iron overload in pure red cell aplasia patients after allogeneic stem cell transplantation
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

The prognostic value of geriatric nutritional risk index in patients with follicular lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

EBV-positive mucocutaneous ulcer within colonic diverticulitis mimicking diffuse large B cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Geriatric nutritional risk index (GNRI) just before allogeneic hematopoietic stem cell transplantation predicts transplant outcomes in patients older than 50  years with acute myeloid leukemia in complete remission
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Multidimensional radar dot-plots, do we need it for the screening of acute promyelocytic leukemia?
(Source: Annals of Hematology)
Source: Annals of Hematology - June 25, 2019 Category: Hematology Source Type: research

Pyoderma gangrenosum: a too often overlooked facultative paraneoplastic disease
(Source: Annals of Hematology)
Source: Annals of Hematology - June 22, 2019 Category: Hematology Source Type: research

Clinical characteristics and outcomes of primary adrenal diffuse large B cell lymphoma in a large contemporary cohort: a SEER-based analysis
AbstractPrimary adrenal lymphoma (PAL) is an extremely rare lymphoma, and the most common histologic type is diffuse large B cell lymphoma (DLBCL). Primary adrenal DLBCL has a quite poor prognosis, but the prognostic determinants are rarely reported. With the Surveillance, Epidemiology, and End Results (SEER) program, we collected the demographic, clinical, therapeutic information of patients with primary adrenal DLBCL from 1983 to 2015. The Kaplan-Meier method was used to obtain overall survival (OS) and cause-specific survival (CSS) curves. The prognostic values of OS and CSS were assessed using Cox proportional hazards ...
Source: Annals of Hematology - June 21, 2019 Category: Hematology Source Type: research

Variants in ARID5B gene are associated with the development of acute lymphoblastic leukemia in Mexican children
AbstractA high impact ofARID5B SNPs on acute lymphoblastic leukemia (ALL) susceptibility has been described in Hispanic children; therefore, it is relevant to know if they influence the high incidence of childhood-ALL in Mexicans. Seven SNPs (rs10821936, rs10994982, rs7089424, rs2393732, rs2393782, rs2893881, rs4948488) ofARID5B were analyzed in 384 controls and 298 ALL children using genomic DNA and TaqMan probes. The SNPs were analyzed for deviation of Hardy-Weinberg equilibrium; Fisher ’s exact test was used to compare the genotypic and allelic frequencies between controls and patients. The association between SNP...
Source: Annals of Hematology - June 21, 2019 Category: Hematology Source Type: research

BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome
AbstractMyelodysplastic syndromes are clonal hematopoietic stem cell disorders characterized by cytopenia and intramedullary apoptosis. BCL-2 Ovarian Killer (BOK) is a pro-apoptotic member of the BCL-2 family of proteins which, when stabilized from endoplasmic reticulum-associated degradation (ERAD), induces apoptosis in response to ER stress. Although ER stress appropriately activates the unfolded protein response (UPR) in BOK-disrupted cells, the downstream effector signaling that includes ATF4 is defective. We used Nup98-HoxD13 (NHD13) transgenic mice to evaluate the consequences of BOK loss on hematopoiesis and leukemo...
Source: Annals of Hematology - June 16, 2019 Category: Hematology Source Type: research

Allogeneic hematopoietic cell transplantation for patients with a history of multiple relapses of acute myeloid leukemia
This study retrospectively analyzed outcomes of allogeneic hematopoietic cell transplantation (HCT) for 192 adults with AML in third or subsequent complete remission (CR3+), 300 in second relapse (REL2), and 50 in third or subsequent relapse (REL3+) who were enrolled in a Japanese nationwide transplantation registry. The study population included patients undergoing umbilical cord blood transplantation, but not those undergoing haploidentical HCT. Patients transplanted in CR3+ had better survival than those transplanted in REL2 and REL3+ (48%, 21%, and 12% at 4  years;P 
Source: Annals of Hematology - June 15, 2019 Category: Hematology Source Type: research

Modified cladribine, cytarabine, and G-CSF as a salvage regimen in patients with relapsed/refractory acute myeloid leukemia: a bridge to myeloablative allogeneic hematopoietic stem cell transplantation
AbstractPatients with primary refractory or early relapsed acute myeloid leukemia (AML) have a dismal prognosis, and the treatment options for these patients are limited. The present study retrospectively examined the efficacy and toxicities of the combination of cladribine 5  mg/m2 per day and intermediate-dose cytarabine 1  g/m2 per day for 5  days and granulocyte colony–stimulating factor (G-CSF) as a salvage treatment in 36 patients with relapsed/refractory AML. Among these, 32 patients had de novo AML, and the remaining 4 patients had secondary AML. The median age for the study cohort was 45.8&nbs...
Source: Annals of Hematology - June 14, 2019 Category: Hematology Source Type: research

Efficacy and safety of ruxolitinib and hydroxyurea combination in patients with hyperproliferative myelofibrosis
We report here 53 myelofibrosis patients that received a combination of hydroxyurea and ruxolitinib because of uncontrolled myeloproliferation. Both drugs were administered outside clinical trials. At 48  weeks, a significant reduction in leucocyte and platelet counts was observed (p = 0.02 andp = 0.04, respectively). Additionally, the spleen volume decreased from a median value of 10 cm below the left costal margin (range, 0–10) to 6 cm (range, 0–15). The rate of spleen response increased from 14% at the start of the combination to 45% after 48 weeks. The safety prof...
Source: Annals of Hematology - June 14, 2019 Category: Hematology Source Type: research

Association of alpha hemoglobin –stabilizing protein (AHSP) gene mutation and disease severity among HbE—beta thalassemia patients
This study documents that among the HbE beta thalassemia patients with varying severity, an exon mutation in AHSP is significantly prevalent only among the TDT group. Further understanding of the mechanism will shed light upon the impact of AHSP in modifying the disease severity in thalassemia. (Source: Annals of Hematology)
Source: Annals of Hematology - June 13, 2019 Category: Hematology Source Type: research

Venetoclax in patients with acute myeloid leukemia refractory to hypomethylating agents —a multicenter historical prospective study
AbstractPatients with acute myeloid leukemia (AML) who progress after exposure to hypomethylating agents (HMA) have a dismal prognosis. We hypothesized that the addition of venetoclax, a BCL-2 inhibitor, to AML patients who previously failed HMA might overcome resistance. Adult patients ( ≥ 18 years) with AML were eligible if leukemia relapsed after, or was refractory to HMA. In general, in addition to venetoclax, patients continued HMA or other low-intensity therapies. Patients who previously underwent allogeneic hematopoietic cell transplantation (HCT) were also eligible. Data were analyzed in November 201...
Source: Annals of Hematology - June 11, 2019 Category: Hematology Source Type: research

Helicobacter pylori ( HP ) infection alone, but not HP -induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan
AbstractInfection withHelicobacter pylori (H.pylori) is associated with an increased risk of gastric malignant lymphoma. The chronic inflammation of gastric mucosa byH.pylori infection induces lymphomagenesis. Although this chronic mucosal inflammation also results in atrophic gastritis, evidence supporting the possible significance of atrophic gastritis in gastric lymphomagenesis is scarce. Here, to evaluate the association between gastric mucosal atrophy and the risk of gastric lymphoma, we conducted a matched case-control study at Aichi Cancer Center focusing on the attribution ofH.pylori infection status and pepsinogen...
Source: Annals of Hematology - June 8, 2019 Category: Hematology Source Type: research

Identification of predictive factors for overall survival at baseline and during azacitidine treatment in high-risk myelodysplastic syndrome patients treated in the clinical practice
AbstractThe outcome of high-risk myelodysplastic syndrome (MDS) patients treated with 5-azacitidine (5-AZA) in the real-life setting remains largely unknown. We evaluated 110 MDS patients (IPSS intermediate 2/high) treated outside of clinical trials at a single institution between September 2003 and January 2017. Median duration of therapy was 9.5 cycles. The overall survival (OS) of the whole cohort was 66.1% at 1  year and 38.3% at 2 years. No differences in terms of OS were observed with regard to gender (p  = 0.622) and age at baseline (  75 years,p = 0.075). According to...
Source: Annals of Hematology - June 5, 2019 Category: Hematology Source Type: research

Correction to: Brentuximab vedotin use in a jaundiced case with resistant Hodgkin lymphoma
The original version of this article contained a mistake in one of the author names. Cem Irili should have been Cem Mirili. (Source: Annals of Hematology)
Source: Annals of Hematology - June 3, 2019 Category: Hematology Source Type: research

ImmunoglobulinG4-related disease mimicking lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - June 1, 2019 Category: Hematology Source Type: research

Prevalence of extramedullary hematopoiesis, renal cysts, splenic and hepatic lesions, and vertebral hemangiomas among thalassemic patients: a retrospective study from the Myocardial Iron Overload  in Thalassemia (MIOT) network
AbstractWe determined the prevalence of incidental extracardiac findings (IEF) at Magnetic Resonance Imaging (MRI) potentially related to anemia and hypoxia in age- and sex-matched populations (N = 318) with thalassemia major (TM) and thalassemia intermedia (TI) enrolled in the Myocardial Iron Overload in Thalassemia network. Overall, IEFs were detected in 33.3% and 25.8% of patients with TI and TM, respectively (P = 0.114). TI and TM patients had elevated but comparable prevalence of renal, splenic and liver cysts, and vertebral hemangiomas while TI patients had a significant higher frequency o...
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Phase II clinical trial of pazopanib in patients with acute myeloid leukemia (AML), relapsed or refractory or at initial diagnosis without an intensive treatment option (PazoAML)
AbstractWe evaluated pazopanib (800  mg orally QD) in patients not eligible for intensive treatment with relapsed/refractory AML or at initial diagnosis. Patients receiving pazopanib for> 14 days were analyzed for safety, tolerability, and efficacy. Co-primary endpoints were cumulative response rate and reduction of bone marrow microvessel density. Twenty patients (median age 76 years, range 52–86) were treated. Fifteen had relapsed/refractory and five had newly diagnosed AML. Median ECOG performance status was 1 (range 1–3). Four patients had adverse, 15 intermediate, and 1 patient fav...
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Progressive multifocal leukoencephalopathy developing after obinutuzumab treatment for chronic lymphocytic leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Primary hepatic marginal B cell lymphoma of mucosa-associated lymphoid tissue (MALT) and non-alcoholic steatohepatitis (NASH): more than a coincidence?
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Ceftazidime-avibactam for gram-negative multidrug-resistant bacteria in hematological patients: a single-center experience
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Uncommon lymphoplasmacytic lymphoma with IgA paraproteinemia: a challenging clinical diagnosis solved by MYD88 mutation analysis
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Diffuse large B cell lymphoma and schistosomiasis: a rare simultaneous occurrence
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Clinical efficacy of bortezomib and lenalidomide in blastic plasmacytoid dendritic cell neoplasm
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Nivolumab as a safe and effective treatment in an HIV patient with refractory Hodgkin lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Locally distributed multicentric plasmacytomas in the ileum secondary to lymphoma chemoimmunotherapy
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Retrospective analysis of thiamine deficiency in allogeneic stem cell transplant patients
(Source: Annals of Hematology)
Source: Annals of Hematology - May 11, 2019 Category: Hematology Source Type: research

Gender differences in determinants of iron-deficiency anemia: a population-based study conducted in four European countries
AbstractIron-deficiency anemia (IDA) was the main condition contributing to higher rates of years lived with disabilities in women in 2016. To date, few studies have investigated gender differences in determinants of IDA in Europe. The aim of the present study was to evaluate the determinants of IDA among females and males in four European countries. IDA determinants were estimated using multivariable Cox regression based on information gathered from national primary care databases, namely Italy (for years 2002 –2013), Belgium, Germany, and Spain (for years 2007–2012). Adjusted hazard ratios (aHR) with 95% conf...
Source: Annals of Hematology - May 9, 2019 Category: Hematology Source Type: research

First-line therapy for T cell lymphomas: a retrospective population-based analysis of 906 T cell lymphoma patients
AbstractPeripheral T cell lymphomas (PTLs) have a globally poor prognosis. The CHOP regimen shows insufficient efficacy; first-line consolidation with autologous stem cell transplantation (auto-SCT) is a promising strategy but has never been confirmed by randomized data. We analyzed retrospectively 906 patients diagnosed with PTL between 1999 and 2015. Chemotherapy was given to 862 patients, and 412 of them were
Source: Annals of Hematology - May 8, 2019 Category: Hematology Source Type: research

Improving the safety of CAR-T cell therapy by controlling CRS-related coagulopathy
AbstractThe CD19-targeted chimeric antigen receptor T cell (CAR-T) therapy has been widely proved effective on relapsed and refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL). Meanwhile, CAR-T therapy-related toxicities, including cytokine release syndrome (CRS) and neurological toxicities, are drawing researchers ’ attention. In addition, our research team notices that coagulopathy and even disseminated intravascular coagulation (DIC) are common problems during CAR-T therapy. In our phase 1/2 clinical trial (NCT02965092), 53 r/r B-ALL patients underwent leukapheresis on day − 11 and received l...
Source: Annals of Hematology - May 4, 2019 Category: Hematology Source Type: research

PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression
AbstractSymptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic MM. To investigate SMM microenvironment modifications, we studied 16 patients diagnosed at our hospital. Eight of them (group A) developed MM within 2  years from diagnosis while the others (group B) had stable SMM. Samples were bone marrow biopsies at diagnosis and after 2 years (±&thi...
Source: Annals of Hematology - May 3, 2019 Category: Hematology Source Type: research

Incidence, risk factors and outcomes of sinusoidal obstruction syndrome after haploidentical allogeneic stem cell transplantation
AbstractHepatic sinusoidal obstruction syndrome (SOS) has been rarely studied after haploidentical donor (HID) allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a retrospective multicentre study on patients with SOS after allo-HSCT in China. The incidence, risk factors, and outcomes were compared between HID HSCT and matched related donor (MRD) HSCT. SOS developed in 0.4% of patients (HIDs: 0.4%, MRDs: 0.5%,p = 0.952) at a median time of 21.50 days (range, 1–55) after allo-HSCT (HIDs: 24 days, MRDs: 20 days,p = 0.316). For patients diagnosed with S...
Source: Annals of Hematology - May 3, 2019 Category: Hematology Source Type: research

Evaluation of the Revised International Staging System (R-ISS) in Japanese patients with multiple myeloma
AbstractIn spite of recent development in the treatment armamentarium for multiple myeloma, overall survival (OS) still depends on risk status and sensitivity to treatment of each patient. We have evaluated the clinical relevance of the Revised International Staging System (R-ISS) by comparing it with the original ISS in 718 Japanese patients. The distribution of patients according to response was similar between the ISS and R-ISS stages. Treatment response was greatly influenced by initial treatment modalities and deeper response was observed more frequently in transplanted patients. The R-ISS discriminated the difference...
Source: Annals of Hematology - May 2, 2019 Category: Hematology Source Type: research