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Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO)
We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult patients with newly diagnosed AML at 63 centers in Germany and Austria were followed within the AMLSG BiO registry (NCT01252485). Between January 1, 2012, and December 31, 2014, data of 3525 patients with AML (45% women) were collected. The median age was 65  years (range 18–94). The comparison of age-specific AML incidence rates with epidemiological cancer registries revealed excellent coverage in patients
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Effect of thrombopoietin receptor agonists on leukocyte and haematopoietic stem and progenitor cells in the peripheral blood of patients with immune thrombocytopenic purpura
AbstractThe thrombopoietin receptor agonists (TPO-RAs), romiplostim and eltrombopag, stimulate megakaryopoiesis and thereby increase platelet counts. Both drugs are increasingly used in the treatment of immune thrombocytopenic purpura (ITP). To assess the effect of TPO-RAs on trilineage haematopoiesis, colony-forming cell (CFC) assays were performed on peripheral blood mononuclear cells of 8 healthy donors and 52 ITP patients. Additionally, we revaluated the regular and complete blood counts (CBCs) performed during romiplostim therapy in 45 patients and the CBCs performed in 9 patients during eltrombopag therapy. The clono...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

The progress and current status of immunotherapy in acute myeloid leukemia
AbstractRecently, there has been remarkable progress in basic and preclinical studies of acute myeloid leukemia (AML). The improved outcomes of AML can largely be attributed to advances in supportive care and hematopoietic cell transplantation as opposed to conventional chemotherapy. However, as the 5-year survival rate remains low due to a high incidence of relapse, novel and effective treatments are urgently needed. Increasing attention is focusing on identifying suitable immunotherapeutic strategies for AML. Here, we describe the immunological features, mechanisms of immune escape, and recent progress in immunotherapy f...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Novel agent-based salvage autologous stem cell transplantation for relapsed multiple myeloma
AbstractHigh-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard frontline therapy for multiple myeloma (MM). Therapeutic options for patients with relapsed MM after ASCT include novel agents in different combos, salvage ASCT (sASCT), and allogeneic transplant, with no unique standard of care. We retrospectively analyzed 66 MM patients who relapsed after up-front single or double ASCT(s) and received novel agent-based sASCT at five Italian centers. Median event-free survival from up-front ASCT(s) to first relapse (EFS1) was 44  months. Seventy-three percent of patients received sASC...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Efficacy and prognosis of antiviral therapy on hepatitis C following treatment of lymphoma in HCV-positive diffuse large-cell lymphoma
AbstractThe purpose of this study is to study the usefulness of post-remission antiviral therapy in cases of HCV-RNA-positive diffuse large-cell lymphoma. Antiviral therapy against HCV was performed after remission using CHOP or CHOP-like chemotherapy in combination with rituximab in five successive cases of HCV-RNA-positive diffuse large-cell lymphoma. The control groups consisted of a group of HCV-RNA-positive diffuse large-cell lymphoma cases prior to this trial (control 1), and a group of cases that tested negative for HIV, HCV, and HBV (control 2). All the cases were in remission at the time of initial treatment. Ther...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

VEGF, ANGPT1, ANGPT2, and MMP-9 expression in the autologous hematopoietic stem cell transplantation and its impact on the time to engraftment
In this study, we aimed at exploring mutual correlations of bone marrow niche cytokines involved in the homing and mobilization of hematopoietic stem cells, as well as in angiogenesis. The aim of our study was to evaluate levels of cytokines: VEGF, angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2), and matrix metalloproteinase 9 (MMP-9) during autologous HSCT and to examine their influence on hematological recovery. Forty-three patients with hematological malignancies (33 multiple myeloma, 10 lymphoma) were enrolled in the study. Plasma samples were taken at five time points: before conditioning treatment (BC), on transplan...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Therapy-related acute myeloid leukemia with inv(16) after successful therapy for de novo acute myeloid leukemia with t(8;21)
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Relapsed subcutaneous panniculitis-like T cell lymphoma: role of haploidentical hematopoietic stem cell transplant
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Congenital dyserythropoietic anemia type II mimicking hereditary spherocytosis in Indian patient with SEC23B -Y462C mutations
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation
In conclusion, we found that the measurement of sTREM-1 concentration at presentation of febrile neutropenia is not useful to identify bacterial bloodstream infections and critically ill patients. PCT and IL-8 are useful biomarkers for the early identification of critically ill patients, compared to CRP and sTREM-1 in febrile neutropenia. PCT or IL-8 in combination with clinical parameters should be considered in routine measurement to identify critically ill patients as early as possible. (Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

At least partial hematological response after first cycle of treatment predicts organ response and long-term survival for patients with AL amyloidosis receiving bortezomib-based treatment
AbstractAL amyloidosis is a rare plasma cell dyscrasia characterized by multi-organ involvement and poor prognosis. We retrospectively evaluated the organ response (OR) and long-term survival of newly diagnosed AL amyloidosis patients who received first-line bortezomib-containing induction therapy, aiming to identify the clinical indication of a 50% reduction in the difference between involved and uninvolved free light chains (dFLC) after first cycle of treatment. Among the 89 patients included, 78.7% had cardiac involvement and 42.7% were diagnosed with 2004 Mayo stage III disease, while 75.3% of patients achieved a hemat...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Leonine facies due to Sezary syndrome: complete clinical, radiologic, and molecular remission with alemtuzumab
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

High level of soluble interleukin-2 receptor in serum predicts treatment resistance and poor progression-free survival in multiple myeloma
AbstractThe IL-2/IL-2 receptor (IL-2R) system plays a central role in maintaining normal T cell immunity, and its disturbance is associated with several hematologic disorders. Studies have found in several types of lymphoma that abnormal amounts of soluble IL-2R (sIL-2R) may result in imbalance of the IL-2/IL-2R system and hence of the T cell immunoregulation. Whether the level of sIL-2R in blood could predict treatment outcomes or not needs to be investigated in multiple myeloma (MM) patients. The level of sIL-2R in serum was measured using enzyme-linked immunosorbent assay (ELISA) in 81 patients with newly diagnosed MM. ...
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Cytogenetic evidence for the clonal hematopoietic cell origin of alveolar macrophages in myelodysplastic syndrome-associated pulmonary alveolar proteinosis
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Interleukin-6 in idiopathic multicentric Castleman ’s disease after long-term tocilizumab
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Rare gene variants in a patient with azathioprine-induced lethal myelosuppression
(Source: Annals of Hematology)
Source: Annals of Hematology - November 16, 2017 Category: Hematology Source Type: research

Patient characteristics and outcomes in adolescents and young adults with classical Philadelphia chromosome-negative myeloproliferative neoplasms
AbstractLittle is known about the outcomes of Philadelphia-negative myeloproliferative neoplasms (MPNs) in adolescents and young adults (AYA). We reviewed all patients with essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) treated at our institution from 1988 to 2016 who were aged 16 to 39  years (AYA) and described their outcomes in comparison to older MPN population. Of 2206 patients, 185 (8.3%) were identified as AYA: 105 (57%) ET, 43 (23%) PV, and 37 (20%) MF. The median age was 33 years [range, 16–39], and median follow-up time 3 years [range, 0.04–25].JAK2 allel...
Source: Annals of Hematology - November 15, 2017 Category: Hematology Source Type: research

Clinical predictors of Stenotrophomonas maltophilia bacteremia in adult patients with hematologic malignancy
AbstractStenotrophomonas maltophilia (SM) has emerged as an important nosocomial pathogen with high morbidity and mortality. Because of its unique antimicrobial susceptibility pattern, appropriate antimicrobial therapy for SM bacteremia is still challenging, especially in immunocompromised patients. The present study was performed to assess clinical predictors of SM bacteremia in adult patients with hematologic malignancy. From 2006 through 2016, a case-control study was performed at a tertiary-care hospital. Case patients were defined as SM bacteremia in patients with hematologic malignancy. Date- and location-matched con...
Source: Annals of Hematology - November 14, 2017 Category: Hematology Source Type: research

Delayed recovery of serum immunoglobulin G is a poor prognostic marker in patients with follicular lymphoma treated with rituximab maintenance
AbstractClinical trials involving various treatment schedules for rituximab maintenance have been conducted for patients with follicular lymphoma (FL) and have not confirmed their impact on serum immunoglobulin (sIg) levels until the completion of maintenance. However, the long-term use of rituximab is a concern because of circulating plasma cell-depletion risk, suggesting that the mechanism of change in sIg levels after RM has not been determined. Additionally, the relationship between host humoral immunity and the prognosis of patients with B cell malignancies has not been determined. We retrospectively investigated data...
Source: Annals of Hematology - November 14, 2017 Category: Hematology Source Type: research

Sclerosing mesenteritis as a presentation of myelodysplastic syndrome (MDS) with improvement following treatment targeted at MDS
(Source: Annals of Hematology)
Source: Annals of Hematology - November 13, 2017 Category: Hematology Source Type: research

A patient with acquired factor X deficiency and metastatic transitional cell carcinoma of the bladder: is there a link between metastasis and factor deficiency in solid tumors?
(Source: Annals of Hematology)
Source: Annals of Hematology - November 13, 2017 Category: Hematology Source Type: research

Is it possible to improve prognostic value of NCCN-IPI in patients with diffuse large B cell lymphoma? The prognostic significance of comorbidities
AbstractThe prognostic value of the International Prognostic Index (IPI) has been re-evaluated in the rituximab-treated diffuse large B cell lymphoma (DLBCL) patients. Accordingly, National Comprehensive Cancer Network-IPI (NCCN-IPI) has been introduced to estimate prognosis of DLBCL patients. However, comorbidities that frequently affect elderly DLBCL patients were not analyzed. The aim of this study was to evaluate the prognostic significance of comorbidities using Charlson Comorbidity Index (CCI) in 962 DLBCL patients. According to CCI, majority of patients (73.6%) did not have any comorbidity, while high CCI ( ≥&nbs...
Source: Annals of Hematology - November 12, 2017 Category: Hematology Source Type: research

Infusion of leukocytes from HLA haplo-identical familial donors as an adjuvant in the HLH-2004 protocol to treat the virus-associated adult hemophagocytic lymphohistiocytosis: a retrospective study of 26 patients
AbstractAdult hemophagocytic lymphohistiocytosis (HLH) is a fatal disease with poor survival and a limited role of drug therapies. To help to recognize virus and enhance survival, we infused leukocytes derived from human leukocyte antigen (HLA) haplo-identical familial donors to patients. We retrospectively investigated 26 adult virus-associated hemophagocytic syndrome (VAHS) patients ’ medical records from 2006–2017. Eleven of the 26 patients accepted relatives’ derived leukocytes infusions in addition to drug therapies recommended in the HLH-2004 protocol. The leukocyte doses ranged from 0.75 to 3.30&ti...
Source: Annals of Hematology - November 12, 2017 Category: Hematology Source Type: research

PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas
AbstractTumor cells can evade immune surveillance through overexpressing the ligands of checkpoint receptors on tumor cells or adjacent cells, leading T cells to anergy or exhaustion. Growing evidence of the interaction between tumor cells and microenvironment promoted the emergence of immune-checkpoint blockade. By targeting programmed cell death-1 (PD-1) pathway, cytotoxic activity of T cell is enhanced significantly and tumor cell lysis is induced subsequently. Currently, various antibodies against PD-1 and programmed death-ligand 1 (PD-L1) are under clinical studies in lymphomas. In this review, we outline the rational...
Source: Annals of Hematology - November 11, 2017 Category: Hematology Source Type: research

Simultaneous occurrence of two distinct leukemic clones with PML-RAR α and RUNX1-RUNX1T1 in a case of acute myeloid leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - November 9, 2017 Category: Hematology Source Type: research

Correction to: Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates
AbstractFigure 1c. is with numeric error. The error can not result in any change of discussion and conclusion. The proper figures corresponding to Fig 1c are in supplement file, see figure 5 and 6. (Source: Annals of Hematology)
Source: Annals of Hematology - November 9, 2017 Category: Hematology Source Type: research

Chemotherapy-related anemia
(Source: Annals of Hematology)
Source: Annals of Hematology - November 4, 2017 Category: Hematology Source Type: research

Clinical features of hematological disorders with increased large granular lymphocytes (LGLs): a retrospective study
(Source: Annals of Hematology)
Source: Annals of Hematology - November 2, 2017 Category: Hematology Source Type: research

Uterine intravascular lymphoma as a cause of fever of unknown origin
AbstractPrimary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant18FDG uptake on18FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had ...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates
(Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations
This study is to retrospectively evaluate the prevalence ofMYD88 andCD79B mutations and the clinicopathologic characteristics of patients with primary diffuse large B cell lymphoma (DLBCL) of the female genital tract and breast. The characteristics, treatments, and outcomes of 19 patients diagnosed with primary DLBCL of the female genital tract and breast, who had formalin-fixed and paraffin-embedded tissues obtained from diagnostic samples diagnosed between January 2004 and June 2016, were analyzed retrospectively. Nineteen female patients (7 with primary breast and 12 with primary female genital tract DLBCL) were include...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Clinical outcomes in patients with diffuse large B cell lymphoma with a partial response to first-line R-CHOP chemotherapy: prognostic value of secondary International Prognostic Index scores and Deauville scores
AbstractAfter introducing a rituximab-containing chemoimmunotherapy (R-CHOP) for diffuse large B cell lymphoma (DLBCL), a partial response (PR) which is regarded as treatment failure is still observed. To investigate the prognostic factors for the DLBCL patients with a PR to R-CHOP, we retrospectively evaluated 758 newly diagnosed DLBCL patients. After R-CHOP, 88 (11.6%) achieved a PR. Three-year progression-free and overall survival rates measured from the date of PR achievement (PFS2 and OS2) were 57.4 and 67.8%, respectively. The secondary International Prognostic Index (IPI2) scores after R-CHOP were low (0 –1) i...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation
AbstractTaste disorders are one of the most common complications in patients undergoing allogeneic hematopoietic cell transplantation (HCT). They persist in some patients as a late complication 3  months or more after HCT. Therefore, we conducted a cross-sectional study to evaluate the prevalence and predictive factors of late taste disorders, with the help of a self-reporting and closed-ended questionnaire, which was distributed among 91 patients in our institute. The median age at this st udy was 50 (range, 25–69) years. The median follow-up period was 54 (range, 3–234) months after HCT. Taste disorders ...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia
This study further illustrates the diversity of genomic lesions and underlying molecular mechanisms leading to α-thalassemia. (Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Encouraging results with the compassionate use of hydralazine/valproate (TRANSKRIP ™) as epigenetic treatment for myelodysplastic syndrome (MDS)
AbstractThe hypomethylating agents azacytidine and decitabine are unaffordable for many patients with MDS. The combination of the DNA methyltransferase inhibitor hydralazine and the histone deacetylase inhibitor valproate has shown preliminary efficacy in MDS. The aim of this study is to evaluate the clinical efficacy and safety of hydralazine/valproate in a case series of MDS patients treated in a compassionate manner. Hydralazine was dosed according to the acetylation genotype of patients (slow acetylators 83  mg daily; fast acetylators 182 mg daily), and valproate was dosed at 30 mg/kg/day. Both drugs wer...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Therapeutic decision-making in elderly patients with acute myeloid leukemia: conventional intensive chemotherapy versus hypomethylating agent therapy
This study was noteworthy because it assessed prognostic factors that would help to select elderly patients who could expect actual benefits from undergoing the different t herapeutic options available, especially HMA therapy. (Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Effectivity of a modified Sanz risk model for early death prediction in patients with newly diagnosed acute promyelocytic leukemia
In conclusion, we proposed a modified Sanz risk model as a useful predictor of early death risk in patients with APL. (Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Progression of liver fibrosis can be controlled by adequate chelation in transfusion-dependent thalassemia (TDT)
AbstractA substantial proportion of patients with transfusion-dependent beta-thalassemia major suffer from chronic liver disease. Iron overload resulting from repeated transfusions and HCV infection has been implicated in the development of liver fibrosis. Hepatic siderosis and fibrosis were assessed in 99 transfusion-dependent thalassemia (TDT) patients using transient elastography (TE) and liver iron concentration (LIC) assessed by T2*MRI at baseline and after 4  years. Data were analyzed retrospectively. At baseline, the overall mean liver stiffness measurement (LSM) was 7.4 ± 3.2 kPa and the ...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Durable remission is achievable with localized treatment and reduction of immunosuppression in limited stage EBV-related plasmablastic lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Effects of realgar (As 4 S 4 ) on degradation of PML-RARA harboring acquired arsenic-resistance mutations
(Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

A novel heterozygous ALAS2 mutation in a female with macrocytic sideroblastic anemia resembling myelodysplastic syndrome with ring sideroblasts: a case report and literature review
(Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Predictors of early mortality after rabbit antithymocyte globulin as first-line treatment in severe aplastic anemia
This study was designed to identify the risk factors for early mortality and overall survival (OS) after rabbit ATG in patients with SAA. We retrospectively reviewed 185 patients with SAA who underwent rabbit ATG and cyclosporine. The incidence of death in 3  months following rabbit ATG therapy was 15.1% (28/185). Early mortality was mainly related to infectious complications, despite adequate antibiotic and/or antifungal treatment. Age>  35 years (odds ratio [OR] 5.06,P = 0.001) and baseline absolute neutrophil count (ANC) ≤ 0.1 × 109/L (OR 7.64,P   35 yea...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Somatic mutations of calreticulin in patients with myelodysplastic/myeloproliferative neoplasms-unclassifiable
(Source: Annals of Hematology)
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Evaluation of the Greek TranQol: a novel questionnaire for measuring quality of life in transfusion-dependent thalassemia patients
AbstractThe aim of our study was to evaluate the Greek version of the transfusion-dependent quality of life (TranQol) questionnaire and report our experience of using this novel disease-specific quality of life (QoL) measure in patients with transfusion-dependent thalassemia (TDT). The TranQol and SF-36v2 questionnaires were administered to 94 adult TDT patients with a mean age of 32.1  years (SD = 7, range = 19–58), recruited from the Adult Thalassemia Unit of Hippokration General Hospital of Thessaloniki, Greece. The TranQol was evaluated in terms of construct validity, reliability, and res...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

PD-L1 expression correlates with VEGF and microvessel density in patients with uniformly treated classical Hodgkin lymphoma
AbstractRecent studies have reported the associations between programmed death-ligand 1 (PD-L1) or PD-L2/PD-1 pathways and pro-angiogenic genes including hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) in several malignancies. However, no study has examined the relationship or prognostic implication of PD-L1, PD-L2, PD-1, VEGF expression, and microvessel density (MVD) in classical Hodgkin lymphoma (cHL) patients. Diagnostic tissues from 109 patients with doxorubicin, bleomycin, vinblastine, and dacarbazine-treated cHL were evaluated retrospectively by immunohistochemical analysis for PD-L1, P...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Life-threatening bleeding episodes in primary immune thrombocytopenia: a single-center retrospective study of 169 inpatients
AbstractBleeding is the most important clinical outcome in patients with immune thrombocytopenia (ITP), and the goal of therapy in such cases is to treat or prevent bleeding. The frequency of and risk factors for bleeding events in ITP have only recently been identified in several large-scale studies. However, there is little published information about severe life-threatening bleeding in ITP. To clarify the clinical features of life-threatening bleeding in patients with primary ITP, we systematically reviewed the medical records of all ITP patients that were admitted to our hospital between January 1, 1992, and December 3...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

The impact of antimicrobial prophylaxis in morbidity and infections during azacitidine treatment
AbstractThe clinical consequences of the infectious events in patients receiving azacitidine are poorly documented. Likewise, the role of primary antimicrobial prophylaxis is unknown. In this retrospective, single-center study, we compare the impact of prophylaxis on the incidence of infection and morbidity in all consecutive higher-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) patients, during the first 4 azacitidine cycles. Seventy-six patients, corresponding to 283 azacitidine cycles, were studied. There were infectious events in 43% of the patients. Development of infections led to more hospital ...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation
AbstractTransplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but severe complication in patients undergoing allogeneic stem cell transplantation (allo-SCT). However, the mechanism is unclear. From 2011 to 2014, 20 patients with TA-TMA, 20 patients without, and 54 patients with various other complications, including veno occlusive disease (VOD), graft-versus-host disease (GVHD), and infection, were recruited in the study. Plasma vWF antigen (vWFAg), vWF activity (vWFAc), andADAMTS13 activity were determined in these patients by ELISAs and FRETS-vWF73 assay, respectively. Plasma C3b, sC5b-9, and CH50...
Source: Annals of Hematology - October 18, 2017 Category: Hematology Source Type: research

Current prognostic and predictive factors in follicular lymphoma
AbstractFollicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day prognostic tools. In this review, we attempt to summarize the evidence concerning prognostic and predictive factors in FL, including (1) pre-treatment factors, from baseline clinical characteristics and imaging tests to histological grade, the microenvironment and genomic abnormalities; (2) post-treatment f...
Source: Annals of Hematology - October 14, 2017 Category: Hematology Source Type: research

Systemic trichosporonosis mimicking disseminated varicella zoster viral infection during blinatumomab therapy
(Source: Annals of Hematology)
Source: Annals of Hematology - October 14, 2017 Category: Hematology Source Type: research