Efficacy of prophylactic antibiotics for the prevention of neutropenic fever in patients with multiple myeloma receiving high-dose cyclophosphamide for stem cell mobilization
AbstractHigh-dose cyclophosphamide (HD-Cy) (3 g/m2) plus granulocyte colony-stimulating factor (G-CSF) is a very effective regimen for peripheral blood stem cell (PBSC) mobilization. Unfortunately, it is associated with an increased risk of neutropenic fever (NF). We analyzed the effect of NF on PBSC apheresis results and the efficacy of prophylactic antibiotics for the prevention of NF associated with HD-Cy plus G-CSF for PBSC mobilization in patients with newly diagnosed multiple myeloma (MM). First, patients were divided into NF ( +) and NF ( −) groups according to whether they suffered from NF during mobilizat...
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation
AbstractAlthough it is known that BK polyomavirus (BKPyV) causes hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of BKPyV viremia has not been fully evaluated. We retrospectively analyzed the results of quantitative polymerase chain reaction (PCR) evaluations for detecting BKPyV in the whole blood samples of patients undergoing allogeneic HSCT during the period from January 2010 to June 2020 at a single institute, Tokyo Medical and Dental University. BKPyV was detected in the blood of 28 of the 107 evaluated patients, and the cumulative incidence of was 2...
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Is eryptosis druggable?
(Source: Annals of Hematology)
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Concomitant large deletion and de novo duplication of factor VIII gene in an Indian patient with severe Hemophilia A
(Source: Annals of Hematology)
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Effective treatment of pleural effusion in chronic lymphocytic leukemia with acalabrutinib: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Correction to: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Correction to: Sutimlimab improves quality of life in patients with cold agglutinin disease: results of patientreported outcomes from the CARDINAL study
(Source: Annals of Hematology)
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Comparable outcomes of allogeneic peripheral blood versus bone marrow hematopoietic stem cell transplantation from a sibling donor for pediatric patients
In this study, we showed no significant differences in EFS, OS, TRM, and GVHD, except for acute GVHD grades II–IV, between BMT and PBSCT from sibling donors, using ATG (a total of 7.5 mg/kg). Therefore, PB collection, which is less invasive for donors and less labor-intensive for doctors, could also be considered an acceptable SC sour ce for sibling donor HSCT in children. (Source: Annals of Hematology)
Source: Annals of Hematology - April 10, 2024 Category: Hematology Source Type: research
Bibliometric analysis of worldwide research on Polycythemia Vera in the 21st century
AbstractPolycythemia vera (PV) is a myeloproliferative tumor with low incidence and complex symptoms, affecting patients' quality of life and shortening their life span. Since the beginning of the 21st century, there has been an update but a need for uniform consensus regarding diagnosing and treating PV. With the continued interest of researchers in this field, a bibliometric study of PV is necessary. This paper aims to analyze articles on PV through bibliometric software to provide collaborative information and new ideas for researchers in this field. We collected PV-related publications in the Web of Science Core Collec...
Source: Annals of Hematology - April 9, 2024 Category: Hematology Source Type: research
Could it be VEXAS?
We report the case of the youngest patient described with VEXAS syndrome associated with MDS-IB1, successfully treated with azacitidine-venetoclax and allogeneic stem cell transplant. (Source: Annals of Hematology)
Source: Annals of Hematology - April 9, 2024 Category: Hematology Source Type: research
Thiotepa-busulfan-fludarabine-based conditioning as a promising approach prior to allogeneic hematopoietic stem cell transplantation in patients with blastic plasmacytoid dendritic cell neoplasm
AbstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive myeloid malignancy associated with a poor prognosis. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has emerged as a potential treatment strategy for BPDCN, standardized conditioning regimens remain lacking. In this manuscript, we present two cases of BPDCN that were treated with a thiotepa-busulfan-fludarabine (TBF)-based conditioning regimen prior to allo-HSCT. Both cases demonstrated complete remission post-transplantation, sustained donor chimerism, and remission maintenance, suggesting the potential efficacy ...
Source: Annals of Hematology - April 8, 2024 Category: Hematology Source Type: research
Impact of genotype on multi-organ iron and complications in patients with non-transfusion-dependent β-thalassemia intermedia
AbstractWe evaluated the impact of the genotype on clinical and hematochemical features, hepatic and cardiac iron levels, and endocrine, hepatic, and cardiovascular complications in non-transfusion-dependent (NTD) β-thalassemia intermedia (TI) patients. Sixty patients (39.09 ± 11.11 years, 29 females) consecutively enrolled in the Myocardial Iron Overload in Thalassemia project underwent Magnetic Resonance Imaging to quantify iron overload, biventricular function parameters, and atrial areas and to det ect replacement myocardial fibrosis. Three groups of patients were identified: homozygous β+ (N = 18), heteroz...
Source: Annals of Hematology - April 6, 2024 Category: Hematology Source Type: research
Efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation treatment for adolescent and adult Tlymphoblastic leukemia /lymphoma: a large cohort multicenter study in China
In conclusion, Allo-HSCT could be an effective consolidation therapy not just for patients with CR, but also for those who achieved PR. The prognosis is significantly improved by obtaining MRD negative prior to allogeneic transplantation. (Source: Annals of Hematology)
Source: Annals of Hematology - April 6, 2024 Category: Hematology Source Type: research
Quality of life after immune suppressive therapy in aplastic anemia
In conclusion, patients with AA continue to experience psycholo gical and physical effects despite successful IST. (Source: Annals of Hematology)
Source: Annals of Hematology - April 5, 2024 Category: Hematology Source Type: research
Hepatotoxicity as dose-limiting toxicity of the combination of bosutinib and atezolizumab in patients with chronic myeloid leukemia. Results of the ZEROLMC study
AbstractIn the field of chronic myeloid leukemia (CML), new strategies are needed to increase the rate of successful treatment discontinuations, a crucial goal in this disease. Anti-PD-L1 checkpoint inhibitors are a promising therapeutic approach in CML after the demonstration of an increase of these inhibitory molecules in patients with CML. A phase Ib/II (NCT04793399, registration date March 11, 2021) open-label exploratory trial has been conducted to evaluate the safety of atezolizumab, a humanized anti-PD-L1 antibody, in combination with bosutinib in patients with newly diagnosed chronic phase CML. A total of 36 patien...
Source: Annals of Hematology - April 3, 2024 Category: Hematology Source Type: research
