Successful Outcomes of Severe COVID-19 in Patient with Chronic Lymphocytic Leukemia: Diagnostic Challenges in Immunocompromised Hosts
We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis, treatment and specimens sampling pitfalls. This case highlights the importance of a comprehensive diagnostic approach of pneumonia in immunocompromised hosts, including timely and safe bronchoscopy, because the broad differential diagnosis, more challenging with the current outbreak of COVID-19. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Alexandre Malek Source Type: research

Acquired haemophilia a: an intriguing disease
Acquired Haemophilia A is a rare acquired bleeding disorder caused by autoantibodies directed against Factor VIII, which neutralize FVIII activity. These inhibitors differ from alloantibodies against FVIII which can occur in congenital Haemophilia A after repeated exposures to plasma-derived or recombinant FVIII products. In most cases the disease occurs suddenly in subjects without personal or familiar history of bleedings, with symptoms that may be mild, moderate or severe. However, only laboratory alterations are present in   ̴ 30% of patients. The incidence varies from 1 to 4 cases per million/year; more tha...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Maria Gabriella Mazzucconi, Erminia Baldacci, Antonietta Ferretti, Cristina Santoro Source Type: research

Cobalamin deficiency in the elderly
Older people are at risk for cobalamin (vitamin B12) deficiency because of a number of common disorders (e.g. autoimmune gastritis) and drugs (e.g. antacids) that may alter its absorption and utilization. The prevalence of cobalamin deficiency increases with age, resulting particularly elevated in frail and institutionalized subjects. At variance with common sense, the diagnosis is far from simple and requires a high degree of suspicion, due to heterogeneity and non-specificity of the signs and symptoms, ranging from macrocytosis (with or without anemia) to neuropsychiatric manifestations, that characterize several other a...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Giacomo Marchi, Fabiana Busti, Acaynne Lira Zidanes, Alice Vianello, Domenico Girelli Source Type: research

Children in Coronaviruses ’ Wonderland: What Clinicians Need to Know
Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, and pneumonia. Among the seven coronaviruses that affect humans, (SARS)-CoV, the Middle East respiratory syndrome (MERS)-CoV and the most recent coronavirus disease 2019 (COVID-19) represent potential life-threatening diseases worldwide. In adults they may cause severe pneumonia that evolve in distress respiratory ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Giuseppe Lassandro, Valentina  Palladino, Anna Amoruso, Viviana Palmieri, Giovanna Russo, Paola Giordano Source Type: research

Iron deficiency anemia in children residing in high and low-income countries: risk factors, prevention, diagnosis and therapy
Iron deficiency and iron deficiency anemia (IDA) affect approximately two billion people worldwide and most of them reside in low- and middle-income countries. In these countries, additional causes of anemia include parasitic infections like malaria, other nutritional deficiencies, chronic diseases, hemoglobinopathies and lead poisoning. Maternal anemia in resource-poor nations is associated with low birth weight, increased perinatal mortality and decreased work productivity. Maintaining a normal iron balance in these settings is challenging, as iron-rich foods with good bioavailability are of animal origin that are expens...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: ELPIS MANTADAKIS Source Type: research

Impressive continuous complete response after mogamulizumab in a heavily pre-treated S ézary syndrome patient
Conclusions: mogamulizumab is an anti-CCR4 monoclonal antibody that can induce long lasting response also in very heavily pre-treated patients not responding to any previous treatment. The extraordinary characteristic of our patient is that she is still in CR after 2.5 years since treatment discontinuation. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Pier Luigi Zinzani, Ginevra Lolli, Beatrice Casadei, Lisa Argnani, Laura Nanni, Michele Cavo Source Type: research

Focusing On A Unique Innate Memory Cell Population Of Natural Killer Cells In The Fight Against COVID-19: Harnessing The Ubiquity Of Cytomegalovirus Exposure
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: SUPARNO CHAKRABARTI Source Type: research

A seroprevalence of hbv, hcv and hiv-1 and correlation with molecular markers among multi-transfused thalassemia patients in western india
Conclusion:Prevalence of HCV among multi-transfused Beta-thalassemia patients is significantly higher than the normal population. On the other hand, the study showed low prevalence of HBV. Therefore, a follow-up schedule and administration of booster dose of HBV vaccine is strongly recommended for thalassemia patients. To the best of our knowledge, this is the foremost work that shows prevalence of HIV, HBV and HCV in thalassemia patients using both serology and molecular markers in Western India. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Kanchan Mishra, Avani Shah, Krima Patel, Kanjaksha Ghosh, Sumit Bharadva Source Type: research

Association of VDBP rs4701 variant, but not VDR/RXR- α over-expression with bone mineral density in pediatric β-Thalassemia patients
Introduction: The reduced rate of bone formation despite the availability of vitamin D has been reported in β-thalassemia.  This suggests genetic factors together with environmental one can be implicated in this condition. Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. To this end, this study aims to analyzeVDR...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Shaimaa Sahmoud, Mostafa Ibrahim, Eman Toraih, Noha Kamel, Manal Fawzy, Samar Elfiky Source Type: research

Health-related quality of life in thai children with thalassemia as evaluated by pedsql and eq-5d-y: a single center experience
Conclusion:HRQoL scores of our pediatric thalassemia patients had improved from the previous decade, and these findings may represent our better standard of care. Some sociodemographic and clinical characteristics may present negative impacts on HRQoL. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Pacharapan Surapolchai, Phakatip Sinlapamongkolkul Source Type: research

The First Case of Concomitant Mycobacterium genavense lymphadenitis and EBV-positive lymphoproliferative disorder
This is the first case of concurrentMycobacterium genavense lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history.M. genavense infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce theM. genavense lymphadenitis. This case highly alerts clinicians the immunosuppressive sta...
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Yusuke Ito, Kensuke Takaoka, Kazuhiro Toyama, Yoshitaka Wakabayashi, Aya Shinozaki-Ushiku, Aiko Okazaki, Kinuyo Chikamatsu, Satoshi Mitarai, Tetsuo Ushiku, Mineo Kurokawa Source Type: research

Burkitt lymphoma as fourth neoplasia in a patient affected by Cowden Syndrome with a novel PTEN germline pathogenic variant
x (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 28, 2020 Category: Hematology Authors: Eugenio Galli, Francesco D ’Alò, Annarosa Cuccaro, Eleonora Alma, Elena Maiolo, Fulvia Brugnoletti, Luigi Maria Larocca, Marcella Zollino, Andrea Paolo Bacigalupo, Stefan Hohaus Source Type: research

Clinical usefulness of brochoalveolar lavage in the management of pulmonary infiltrates in adults with haematological malignancies and stem cell transplantation
Conclusions: Infection was the leading cause of pulmonary infiltrates in patients with hematologic malignancies and stem cell transplantation. BAL was a useful decision-making diagnostic tool, with minor adverse events (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Laura Jorge, Diego Torres, Agust ín Languasco, Pablo Rodriguez, Pablo Bonvehí, Elena Temporiti, Silvia Relloso, Cristina Videla, Fabián Herrera Source Type: research

Delivery in asymptomatic Italian woman with SARS-CoV-2 infection.
We report a case of a 33-year-old Italian pregnant at 40 weeks of gestation affected by asymptomatic SARS-CoV-2 infection delivering a healthy baby with no evidence of Coronavirus Disease 2019 (COVID-19). Vaginal delivery was uncomplicated, the breastfeeding was permitted under strict measures of infection control. The breast milk was negative for SARS-CoV-2. Control at 7 and 15 days indicated mother and baby good clinical condition, no signs of neonatal infection demonstrated by news oropharyngeal and rectal swab test negative for SARS-CoV-2. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Giuseppe Vittorio De Socio, Lisa Malincarne, Saverio Arena, Stefania Troiani, Sara Benedetti, Barbara Camilloni, Giorgio Epicoco, Antonella Mencacci, Daniela Francisci Source Type: research

SARS-CoV-2 (COVID-19) and Chronic Myeloid Leukemia (CML): a case report and review of ABL kinase involvement in viral infection
no abstract availableAknowledgements:We thank professor Nathan Tubliz, dept. Biology, University of Oregon, for his insightful support. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Elisabetta Abruzzese, luigia luciano, Francesco D ' Agostino, Malgorzata Monika Trawinska, Fabrizio Pane, Paolo de Fabritiis Source Type: research

Extending Long Term Follow-up of Patient With Acute Myeloid Leukemia after Autologous Stem Cell Transplantation: disclosing late mortality and causes of death.
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Federica Sor à, Patrizia Chiusolo, luca laurenti, idanna innocenti, francesco autore, andrea corbingi, andrea corbingi, sabrina giammarco, elisabetta metafuni, andrea bacigalupo, simona sica Source Type: research

Current issues and options for hormonal contraception in adolescents and young adult women with sickle cell disease: an update for health care professionals
This article provides an overview of the present knowledge for the use of contraceptives in women with SCD. We believe that the collaboration between health care professionals (hematologists, obstetricians, endocrinologists, and primary care providers) can play a major role in identifying the safer contraceptive method to abolish the risks of unintended pregnancy and preserve the health status of patients with SCD. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Vincenzo De Sanctis Source Type: research

Covid-19 and Children with Immune Thrombocytopenia: emerging issues
Letter to Editor (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Giuseppe Lassandro, Valentina Palladino, Viviana Palmieri, Anna Amoruso, Giovanni Del Vecchio, Paola Giordano Source Type: research

The efficacy and safety of intralesional sodium stibogluconate for the treatment of cutaneous Leishmaniasis in children under the age of two years
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Nawfal R Hussein, ibrahim naqid, Haval Salih Source Type: research

Isavuconazole therapy of disseminated and encephalic Saprochaete capitata infection in an acute myeloid leukemia patient treated with midostaurin.
CONCLUSION this case illustrates the feasibility of isavuconazole therapy in the treatment of aS.capitata infection when co-administered with midostaurin. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 28, 2020 Category: Hematology Authors: Salvatore Perrone, Chiara Lisi, Elettra Ortu La Barbera, Cristina Luise, Miriam Lichtner, Corrado Girmenia, Giuseppe Cimino Source Type: research

Limiting the Impact of Methicillin Resistant Staphylococcus Aureus in Patients Undergoing Haploidentical Transplantation
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: SUPARNO CHAKRABARTI, Sarita Rani Jaiswal, Gitali Bhagwati Source Type: research

The COST-UTILITY ANALYSIS OF FOUR CHELATION REGIMENS FOR Β-THALASSEMIA MAJOR: A CHINESE PERSPECTIVE
Conclusions: DFP was the most cost-effective chelation regimen for β-thalassemia major patients, followed by DFO+DFP, DFO and DFX. Using DFP as the primary treatment regimen may potentially result in cost-savings and QALY gains for the Chinese healthcare system. To increase these benefits, the Chinese government and clinicians should lower drug costs, increase dru g utility and reduce mortality and morbidity. Changes in influential parameters easily affect the results of DFO+DFP versus DFP and of DFP versus DFO; clinicians should focus on such parameters and adjust the regimens accordingly. (Source: Mediterranean Jour...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Jialian Li Source Type: research

Hematopoietic stem cell transplantation in egypt challenges and opportunities
Hematopoietic stem cell transplantation (HSCT) is now an established treatment modality with definitive indications for many hematological disorders. However, this line of treatment requires tremendous resources, and it becomes increasingly difficult for transplanters  practicing in the developing world to reconcile the difference between what is possible and what is available. On the basis of 30 years of experience and more than 4250 transplants , this article will focus on the challenges faced our HSCT program and how they were solved. The HSCT program in Egypt started in 1989 on a narrow scale and since that time w...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Hossam Kamel Mahmoud, Gamaleldin Mohamed Fathy, Alaa Elhaddad, Omar Abdelrahman Fahmy, Mohamed Abdelmooti, Raafat Abdelfattah, Mahmoud Tarek Sayed Ahmed Bokhary Source Type: research

Hematopoietic stem cell transplantation in egypt challenges and solutions
Hematopoietic stem cell transplantation (HSCT) is now an established treatment modality with definitive indications for many hematological disorders. However, this line of treatment requires tremendous resources, and it becomes increasingly difficult for transplanters  practicing in the developing world to reconcile the difference between what is possible and what is available. On the basis of 30 years of experience and more than 4250 transplants , this article will focus on the challenges faced our HSCT program and how they were solved. The HSCT program in Egypt started in 1989 on a narrow scale and since that time w...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Hossam Kamel Mahmoud, Gamaleldin Mohamed Fathy, Alaa Elhaddad, Omar Abdelrahman Fahmy, Mohamed Abdelmooti, Raafat Abdelfattah, Mahmoud Tarek Sayed Ahmed Bokhary Source Type: research

Lyon-university hospital experience with gemtuzumab ozogamicin therapy in acute myeloid leukemia: a ‘real-life’ study
One-hundred and four adults with newly diagnosed or relapsed/refractory acute myeloid leukemia (AML) were treated with fractionated doses of gemtuzumab ozogamicin (GO) at one-single French center over a 10-year period. We attempted to define predictive factors for response and survival. The overall response rate was 70% (86% in newly diagnosed and 67% in relapsed/refractory AML). Disease-free survival (DFS) and overall survival at 3 years after GO treatment was 31% and 29%, respectively. Mortality during induction was 7%. Among remitters, allogeneic hematopoietic stem cell transplantation can be performed in 33 cases (45%)...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Xavier Thomas, Marica Laurino, sandrine loron, marie-virginie larcher, ga ëlle fossard, mohamed elhamri, alexandre deloire, marie balsat, fiorenza barraco, hélène labussière, sophie ducastelle, myriam renault, eric wattel, maël heiblig, gilles salles Source Type: research

Thalidomide for patients with thalassemia intermedia: a retrospective multicenter clinical study
Conclusion: Thalidomide had significant therapeutic effects on patients with TI, and the response was sustained with acceptable short-term and long-term adverse reactions. While these preliminary results support the potential long-term efficacy and safety of thalidomide as a therapeutic agent for TI, several issues need to be addressed before its application in the clinic. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Kun Yang, Yi Wu, Yali Zhou, Tianhong Zhou, Li Wang, Zhili Geng, Xiaolin Yin Source Type: research

Calreticulin mutation survey by high resolution melting method associated with unique presentations in essential thrombocythemic patients
Somatic mutations of exon 9 of calreticulin gene (CALR) were diagnosis and prognosis importance found in patients with JAK2V617F-negative essential thrombocythemia (ET). We survey CALR and JAK2 mutations in our ET patients and study the relationship between mutations and clinical presentations.A total of 60 ET patients were enrolled in the study, and CALR mutations were studied by high resolution melting (HRM) methods and sequencing in JAK2V617F-negative group retrospectively. Clinical manifestations were reviewed retrospectively from chart records.Twenty-one CALR mutations showed eight types of specific melting curves det...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 27, 2020 Category: Hematology Authors: Yi-Chang Liu, Ching-Ping Lee, Tsung-Jang Yeh, Yuh-Ching Gau, Chieh-Yu Hsieh, Ya-Lun Ke, Jeng-Shiun Du, Ming-Hui Lin, Hui-Ching Wang, Shih-Hao Tang, Shih-Feng Cho, Jui-Feng Hsu, Samuel Yien Hsiao, Chin-Mu Hsu, Hui-Hua Hsiao Source Type: research

Cover
Printable Cover Vol 12, Year 2020 (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - March 14, 2020 Category: Hematology Authors: Francesco Guidi Source Type: research

Discovery of type 3 von willebrand disease in a cohort of patients with suspected hemophilia a in c Ôte d’ivoire
AbstractAim : Type 3 von Willebrand disease (VWD) is the most severe form of VWD, characterized by a near-total absence of von Willebrand factor (vWF) leading to a huge deficiency in plasmatic factor VIII (FVIII). VWD may be confused with hemophilia A, sometimes leading to misdiagnosis. The purpose of this work was to finalize the biological diagnosis of patients with FVIII activity deficiency in Abidjan, in order to guide the best type of management.Methods: We conducted a cross-sectional descriptive study from June 2018 to April 2019. Forty-nine patients, all of whom had lower FVIII levels or had been referred for b...
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Adia Eus èbe Adjambri, Sylvie Bouvier, Roseline N ' guessan, Emma N ’draman-Donou, Mireille Yayo-Ayé, Marie-France Meledje, Missa Louis Adjé, Duni Sawadogo Source Type: research

Archi-Prevaleat project. A National Register of color-Doppler ultrasonography of the epi-aortic vessels in Patients Living with HIV
Persons Living with HIV (PLWH) are at higher risk of cardiovascular disease (CVD) than the general population. Carotid ultrasound is a non-invasive diagnostic tool, aimed at the assessment of vascular anatomy and function.  Our present aim is to generate a National Register of color-Doppler ultrasonography (Archi-Prevaleat) to better evaluate the characteristics of vascular lesions in PLWH on a large number of data. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: S Martini, S Ferrara, C Bellacosa, B M Ceresia, F Taccari, G Di Filippo, A Tartaglia, G Gaeta, Paolo Maggi Source Type: research

Development of an improved epstein-barr virus (ebv) neutralizing antibody assay to facilitate development of a prophylactic gp350-subunit ebv vaccine
No licensed vaccine is available for prevention of EBV-associated diseases, and robust, sensitive, and high-throughput bioanalytical assays are needed to evaluate immunogenicity of gp350 subunit-based candidate EBV vaccines. Here we have developed and improved analytical tools for such a vaccine ’s pre-clinical and clinical validation including a gp350-specific antibody detection assay and an EBV-GFP based neutralization assay for measuring EBV specific antibodies in human donors. The sensitivity of our previously published high-throughput EBV-GFP fluorescent focus (FFA)-based neutralizat ion assay was further improv...
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Hui Liu, Henry H. Balfour, Gregory M. Hayes Source Type: research

The impact of chemotherapy after pediatric malignancy on humoral immunity to vaccine-preventable diseases
Conclusions: We confirm that seroprotection for vaccine-preventable diseases is affected by treatment for pediatric malignancy. A single booster dose of vaccine might be a practical way to restore vaccine immunity in patients after chemotherapy.  (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Chiara Garonzi, Rita Balter, Gloria Tridello, Anna Pegoraro, Manuela Pegoraro, Monia Pacenti, Novella Scattolo, Simone Cesaro Source Type: research

The impact of chemotherapy and hematopoietic stem cell transplantation on humoral immunity to vaccine-preventable diseases
CONCLUSIONSWe confirm that seroprotection for vaccine-preventable disease is affected by treatment for pediatric malignancy. A single booster dose of vaccine might be a practical way to restore vaccine immunity in patients after chemotherapy. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Chiara Garonzi, Rita Balter, Gloria Tridello, Anna Pegoraro, Manuela Pegoraro, Monia Pacenti, Novella Scattolo, Simone Cesaro Source Type: research

Fine mapping of Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency in rural area of South West Odisha using the clinical, hematological and molecular approach
Conclusion: The cumulative prevalence of G6PD deficiency the present is below the estimated national prevalence. G6PD deficiency was higher in tribes as compared to non-tribes. Rare G6PD Kaiping and G6PD Union variants have been identified. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Ravindra Kumar, MPSS Singh, Soumendu Mahapatra, Sonam Chourasia, Malay Kumar Tripathi, John Oommen, Praveen Kumar Bharti, Rajasubramaniam Shanmugam Source Type: research

Characteristics and prognosis of hepatocellular carcinoma in multi-transfused patients with thalassemia major. Experience of a single tertiary center.
Conclusions: In conclusion, BCLC staging is the main prognostic factor of survival in patients with TM who develop HCC, with a median survival time of six months. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Nikolaos Papadopoulos, Dimitrios Kountouras, Katerina Malagari, Maria Tampaki, Maria Theochari, John Koskinas Source Type: research

The PARTIAL ACHIEVEMENT OF THE 90-90-90 UNAIDS TARGET IN A COHORT OF HIV INFECTED PATIENTS FROM CENTRAL ITALY.
ConclusionsUNAIDS goal was very far to be reached. The main challenges were unreturned tests as well as the retention in ART. Rapid tests for a test-treat strategy and frequent phone communications in the first ART years could facilitate UNAIDS target achievement. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Elisabetta Schiaroli Source Type: research

MicroRNA-181a-3p as a diagnostic and prognostic biomarker for acute myeloid leukemia
Conclusions: MiR-181a-3p may be clinically useful as a disease marker for AML, and enhanced the prediction of patient outcomes to chemotherapy. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2020 Category: Hematology Authors: Xiaoling Ma Source Type: research

Hepatic Infiltration with Malignant T-cells Manifesting as Impending Acute Liver failure in Mycosis Fungoides with Large Cell Transformation
Here we described a patient with a history of mycosis fungoides who developed large cell transformation manifesting with generalized erythroderma, lymphocytosis, lymphadenopathy and impending acute liver failure (ALF). Three-phase computed tomography of the liver showed neither mass nor hepatomegaly. Liver biopsy confirmed infiltration with malignant CD4+ clonal T-cells. Combination chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP) resulted in the recovery of liver function and resolution of skin involvement. In Foundation Medicine Hematology Gene Panel, 31 genetic alterations with 11 clinically relevant mu...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Successful planned pregnancy through vitrified-warmed embryo transfer in a woman with chronic myeloid leukemia: case report and literature review
A 35-year-old female patient with chronic myeloid leukemia wanted to have a child. She had been treated with imatinib and had achieved major molecular remission, after which imatinib was intentionally discontinued and interferon- α treatment was initiated. After three failed cycles of artificial insemination with her husband’s semen, the patient underwent treatment with assisted reproductive technology. After two cycles ofin vitro fertilization, two embryos (8-cell stage and blastocyst) were cryopreserved. The patient again had elevatedBCR/ABL mRNA levels; thus, infertility treatment was discontinued. After 18 ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Chronic-graft-versus-host-disease-related polymyositis: a 17-months-old child with a rare and late complication of haematopoietic stem cell transplantation.
Conclusions:This is the first case of cGVHD-related-polymyositis described in a pediatric patient which was successfully treated with rituximab. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

The prognostic significance of tet2 single nucleotide polymorphism in egyptian chronic myeloid leukemia
Background:Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm. The pathogenesis of CML is based on the oncoprotein termed BCR ‐ABL1. TET2 initiates DNA demethylation and is frequently mutated in hematological malignancies including CML.(1) The relation between TET2 acquisition and CML transformation and/or imitinab resistance is needed to be investigated.(2)Aim: To evaluate Ten Eleven Translocation 2 gene (TET2) single nucleotide polymorphism (SNP) (rs2454206, rs34402524, rs61744960) in chronic myeloid leukemia (CML) in relation to the disease prognostic criteria.Materials& Method: The study included 84 ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Candidemia in patients with acute leukemia: analysis of seven years ’ experience at a single center in
The study of candidemia in Chinese leukemia patients has been limited. This retrospective study aims to investigate the characteristics and prognostic factors of candidemia among leukemia patients in a Chinese chemotherapy center.From 2009 to 2015, 30 isolates of candidemia were detected in 19 patients with acute leukemia after chemotherapy. The overall incidence of candidemia was 2.12 episode per 1000 admissions.Candida tropicalis was the most commonCandida species (n = 17; 89.5%), followed byCandida albicans (n = 2; 10.5%). The most common underlying disease was acute myeloid leukemia (94.7%) and induction chemotherapy p...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Cardiovascular risk in essential thrombocythemia and polycythemia vera: thrombotic risk and survival
In this study we evaluated the impact that CV.R plays on thrombotic risk and survival in patients with PV and ET. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

The evolving pharmacotherapeutic landscape for the treatment of sickle cell disease
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapiesare needed. During the last five years the landscape of the pharmacotherapy of SCD has changed dramatically. Currently, there are at least 50 drugs that have been used or under consideration to use for the treatment of SCD. These fall into 3 categories: the first category includes the three drugs (Hydroxyurea, L-Glutamine and Crizanlizumab tmca) that have been approved by the United States Food and Drug Administration (FDA) based on successful clinical t...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

The history of deferiprone (l1) and the complete treatment of iron overload in thalassaemia
Deferiprone (L1) was originally designed, synthesised and screened in vitro and in vivo in 1981 by Kontoghiorghes G J following his discovery of the novel alpha-ketohydroxypyridine class of iron chelators (1978-1981), which were intended for clinical use. The journey through the years for the treatment of thalassaemia with L1 has been a very difficult one with intriguing turn of events, which continue until today. Despite many complications, such as the wide use of L1 suboptimal dose protocols, the aim of chelation therapy- namely the complete removal of excess iron in thalassaemia major patients, has been achieved followi...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Molecular mechanisms of inhibitor development in hemophilia
The development of neutralizing antibodies in hemophilia is a serious complication of factor replacement therapy. These antibodies, also known as “inhibitors”, significantly increase morbidity within the hemophilia population and lower the quality of life for these patients. People with severe hemophilia A have an overall 25-40% lifetime risk of inhibitor development, compared to that of 5-15% lifetime risk in those with moderate/mild hem ophilia A. The risk is lower in hemophilia B population (about 1-5%) and occurrence of inhibitors is almost only seen in patients with severe hemophilia B. The understanding o...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Concise review on the frequency, major risk factors and surveillance of hepatocellular carcinoma (hcc) in Β-thalassemias: past, present and future perspectives
Due to the recent alarming increase in the incidence of hepatocellular carcinoma (HCC) in thalassemias, the aim of the present report is to review briefly the frequency, the major risk factors and the surveillance of HCC in β-thalassemias. Over the past 33 years, 153 cases of HCC were reported in patients with thalassemia, mainly in Italy, and Greece. Among HCV-infected patients additional factors promoting development of  HCC, included: advanced age, male sex, chronic hepatitis B (CHB) coinfection, and iron overload. For early diagnosis of HCC sequential ultrasound screening  is recommended  especially...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2019 Category: Hematology Source Type: research

Febrile neutropenia in acute leukemia. epidemiology, etiology, pathophysiology and treatment
Acute leukemias are a group of aggressive malignant diseases associated with a high degree of morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are highly susceptible to infectious diseases due to factors related to the disease itself, factors attributed to treatment, and specific individual risk factors in each patient. Patients with chemotherapy-induced neutropenia are at particularly high risk, and microbiological agents include viral, bacterial and fungal agents. The etiology is often unknown in infectious complications, although adequate patient ev...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 30, 2019 Category: Hematology Source Type: research

Sepsis in acute leukemia; epidemiology; pathophysiology, etiology and treatment
Acute leukemia is a group of aggressive malignant diseases, associated with a high degree of both morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are highly susceptible to diseases both due to factors related to the disease itself, factors attributed to treatment and specific individual risk factors in each individual patient. Patients with chemotherapy induced neutropenia are at particularly high risk, and microbiological agents include viral, bacterial and fungal agents. The etiology is often unknown in infectious complications, although adequate pa...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 30, 2019 Category: Hematology Source Type: research

Ultrasound as first line step in anaemia diagnostics
This review covers the role of ultrasonography as an essential non-invasive diagnostic approach when facing patients with anemia, a common clinical problem. Abdomen ultrasound is well recognized as a first-line examination in the setting of blood loss, both acute and chronic. Less is clear about the additional opportunities, given by ultrasound in anemia, due to the many other possible causes.Here we provide information on the utility of ultrasound in different contexts and a practical guide for clinicians facing anemic patients (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2019 Category: Hematology Source Type: research