How I treat febrile neutropenia
This article reviews my approach to the evaluation and treatment of febrile neutropenic patients. Key topics discussed include antibacterial and antifungal prophylaxis, the initial workup for fever, the choice of the empiric antibiotic regimen and its modifications, and criteria for discontinuation. For each of these questions, I review the literature and present my perspective. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Marcio Nucci Source Type: research

Comment on “Worldwide Distribution of PK Deficiency: the Defect Seems Mainly Concentrated in West African Countries and the United States.”
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Stefano Barco Source Type: research

Parvovirus B19 infection in a patient with common variable immunodeficiency
n/a (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Magda Zanelli, Loredana Reggiani, Francesca Sanguedolce, Maurizio Zizzo, Giovanni Martino, Angelo Genua, Stefano Ascani Source Type: research

Mental well-being in patients with transfusion-dependent anemias and hemochromatosis during the SARS-CoV-2 pandemic
Since February 2020 the SARS-CoV-2 virus pandemic caused the reduction of spaces and medical and nurse staff dedicated to outpatients because of the urgent needs in the intensive, sub-intensive, and ward units in Lombardia region in Italy. In our Centre we regularly follow patients with hereditary anemias (ThSA), and hemochromatosis (HH). We aimed to evaluate these patients ’ emotional responses during the pandemic through online survey. 44 ThSA (55%) and 54 HH (54%) answered the questionnaire. Both ThSA and HH reported high level of anxiety, worries and concern regarding SARS-Cov-2 pandemic that was the sum of sever...
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Rachele Piperno, Gabriella Bertazioli, Ravasi Giulia, Raffaella Mariani, Alberto Piperno Source Type: research

Mild clinical course of COVID-19 infection in chronic myeloid leukemia (CML) patients receiving tyrosine kinase inhibitors (TKIs) without interruption
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Judit Demeter, Julia Weisinger, Zsolt Nagy Source Type: research

First Tunisian cluster admissions of critically ill patients with multisystem inflammatory syndrome in children (MIS-C)
Conclusion: We reported here the first Tunisian cluster admissions of 8 critically ill children with MIS-C to highlight the increase of a new severe emerging disease with an evidence of prior COVID-19 infection in older children. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: aida borgi Source Type: research

First-phase insulin response (FPIR) to intravenous glucose tolerance test (IVGTT), insulin sensitivity and long-term follow-up in ?- transfusion-dependent thalassemia (TDT) normoglycemic patients with reduced insulin secretion to oral glucose tolerance t
Conclusions:These data demonstrated, for the first time, a progressive deterioration in glucose homeostasis in?-TDT subjectswith NGT and hypoinsulinemia.Thus, we considerthat variations of insulin sensitivitycould possibly have an impact on glucose tolerance in adult patients with TDT. Further investigations should focus on factors that might positively influence insulin sensitivity, including nutrition, drugs and physical activity. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Vincenzo De Sanctis Source Type: research

Diagnostic accuracy of clinical tool ‘STOPS’ and Serum Procalcitonin for optimizing antibiotic therapy in Neonatal Sepsis
Conclusion:Identifying abnormal STOPS parameters was superior to PCT alone in EONS and as good as PCT in LONS. The ‘STOPS’ tool allows early identification of neonates with no sepsis thereby optimizing antibiotic use. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Vishal Vishnu Tewari Source Type: research

Real world data on characteristics and management of community patients receiving anticoagulation therapy who presented with acute bleeding to the emergency department at a regional Australian hospital: A prospective observational study.
Objective:To study patients receiving anticoagulants with or without antiplatelet therapy presenting at a regional Australian hospital with bleeding. The main aims are to explore: (1) patients ’ characteristics and management provided; (2) association between the type of anticoagulant and antiplatelet agent used and the requirement of reversal; (3) and the length of hospital stay (LoS) in conjunction with bleeding episode and management.Methods:A prospective cross-sectional review of medical records of all patients who presented at a tertiary referral centre with bleeding while receiving anticoagulation the...
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Fayez Hanna, Annemarie Hyppa, Ajay Prakash, Usira Vithanarachchi, Hizb U Dawar, Zar Sanga, George Olabode, Hamish Crisp, Professor Alhossain A. Khalafallah Source Type: research

Elevated P-Selectin in Severe Covid-19: Considerations for therapeutic options
CONCLUSION:Elevation of P-selectin suggests a central role of platelet endothelium interaction as part of the multifaced pathogenic mechanism of COVID-19 leading to the local activation of hemostatic system forming pulmonary thrombi. Further work is necessary to determine the therapeutic role of antiplatelets agents or of the anti P-selectin antibody Crizanlizumab. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Chiara Agrati, Veronica Bordoni, alessandra sacchi, germana grassi, nicola petrosillo, emanuele nicastri, franca del nonno, giampiero d ' offizi, fabrizio palmieri, luisa marchioni, maria rosaria capobianchi, andrea antinori, giuseppe ippolito, Michele Bi Source Type: research

DNA Repair Genes and Chronic Myeloid Leukemia: XPD (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (1394) Gene Polymorphisms
No Abstract required (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Istemi SERIN, Mustafa PEHLIVAN, Kursat OZDILLI, Fatma OGUZ SAVRAN, Gaye TOMATIR, Sacide PEHLIVAN Source Type: research

Prognostic Impact Of Baseline Immunologic Profile In Aggressive B-cell Non-Hodgkin ’s Lymphomas
Not requested (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Safaa M. Ramadan Source Type: research

Cover
Printable Cover Vol 13, Year 2021 (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2021 Category: Hematology Authors: Francesco Guidi Source Type: research

The INFLUENCE OF NUTRITION ON DISEASE SEVERITY AND HEALTH-RELATED QUALITY OF LIFE IN ADULTS WITH SICKLE CELL DISEASE
Conclusion: Patients with sickle cell disease have various degrees of macro and micro deficiencies, which increase SCD severity and hospitalizations and reduce the health-related quality of life. Early diagnosis and prompt correction of macro and micronutrient deficiencies need to be incorporated in the standard of care of SCD patients to improve the disease outcomes.  (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2021 Category: Hematology Authors: Sanaa Kamal, Moheyeldeen Mohamed Naghib, Jamaan Al Zahrani, Huda Hassan, Karim Abdel Aziz Moawado, Omar Arrahman Source Type: research

Socioeconomic status is globally a prognostic factor for overall survival of multiple myeloma patients; synthesis of studies and review of the literature
Socioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations has a higher prevalence of multiple myeloma and worst survival, a gap that widens over time.Methods: We performed a meta-analysis of 16 studies (registries and cohorts) reporting survival data of myeloma patients according to SES. Ten studies reported Hazzard Ratio (HR) (95 % CI) and 16 studies reported p values. We combined the HR from 10 studies and by using the Mosteller-Bush formula we performed the synthesis of p values according to the area of the globe.Results: A combination o...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Stergios Intzes, Marianthi Symeonidou, Konstantinos Zagoridis, Aikaterini Pentidou, Spanoudakis Emmanouil Source Type: research

Worldwide distribution of prekallikrein (PK) deficiency: the defect seems mainly concentrated in West African countries and in the United States
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Antonio Girolami, Silvia Ferrari Source Type: research

Clinical and laboratory features of Hemoglobin La Desirade variant in association with sickle cell and alpha thalassemia genes
AbstractHemoglobin La Desirade (Hb La Desirade) is an unstable hemoglobin variant characterized by amino acid Alanine (Ala) replacing Valine (Val) at position 129 (H7) in the beta chain. Hb La Desirade exhibits a decreased oxygen affinity and normal heme-heme interaction. Interestingly, on analysis by standard electrophoresis, it migrates in the same region as normal HbA, and HbA actually represents a combination of HbA and Hb La Desirade together. This variant was reported as compound heterozygous with other Hemoglobin variants such as HbS, HbC or beta thalassemia, and more recently with Southeast Asian ovalocytosis and H...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Salam Alkindi, Dr. , Mr. , Mr. , prof. , Dr. , Dr. , Dr. Source Type: research

Coronavirus disease 2019 (COVID-19) severity in patients with thalassemias: A Nationwide Iranian Experience
None (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Mehran Karimi, Sezaneh Haghpanah , Azita Azarkeivan , Sara Matin, Arash Safaei, Vincenzo De Sanctis Source Type: research

Thalassemia carrier detection among pregnant women
This study aimed to re-assess the validity of the various erythrocyte indices in determining ?-thalalssemia carrier among pregnant women in a low resource setting area. An analytic study was performed, comparing conventional cut-off various erythrocyte indices with new modified cut-offs by Kumaret al. The concordance analysis was calculated with Mentzer Index (MI) as reference. The validity of erythrocyte indices against hemoglobin (Hb) A2 were analysed, confirmed by molecular examination for ?- and common ?-Globin South East Asia population. Of 102 pregnant women, 34% was still anemic after completion of 90 iron pills. Th...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Edhyana Sahiratmadja, Merry M.V. Seu, Ita M. Nainggolan, Johanes C. Mose, Ramdan Panigoro Source Type: research

Elevated serum pentraxin-3 levels is positively correlated to disease severity and coagulopathy in covid-19 patients
AbstractBACKGROUND Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and is associated with coagulopathy. Pentraxin-3(PTX3) participates in innate resistance to infections and plays a role in thrombogenesis.PURPOSE The present study aimed to investigate the role of PTX3 in coagulopathy in patients with COVID-19.METHODSA retrospective study including thirty-nine COVID-19 patients enrolled in Hunan, China were performed. The patients were classified into the D-dimer_L (D-dimer?1mg/L) and D-dimer_H (D-dimer?1mg/L) groups basing on the plasma D-dimer levels on admission. Serum PTX3 levels were detected by enz...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Ming Tong, Ying Xiong, Chen Zhu, Hong Xu, Qing Zheng, Changping Hu, Yu Jiang, Lianhong Zou, Xiaolin Xiao, Fang Chen, Yimin Zhu Source Type: research

The importance of targeted next-generation sequencing usage in cytogenetically normal myeloid malignancies
In this study, we analyzed 100 patients who admitted to Medical Genetics Laboratory within different type of myeloid malignancies. We highlighted the possible diagnostic algorithm for cytogenetically normal cases. We applied NGS 141 gene panel for cytogenetically normal patients and we detected two or more pathogenic variations in 61 out of 100 patients (61%). The pathogenic variation detection rate of NGS varies in disease groups: AML were 85% and MDS were 23%. Here, we identified 24 novel variation out of total pathogenic variations in myeloid malignancies. A total 18 novel variation were identified in AML and 6 novel va...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Emine Atli, Hakan Gurkan, Engin Atli, Hakki Onur Kirkizlar, Sinem Yalcintepe, Selma Demir, Ufuk Demirci, Damla Eker, Cisem Mail, Rasime Kalkan, Ahmet Muzaffer Demir Source Type: research

Real-world outcome in the pre-car-t era of myeloma patients qualifying for car-t cell therapy
Conclusion:Myeloma patients refractory after at least three lines of anti-CD38/PI/IMID treatment have a poor prognosis with a PFS of 6.6 months and OS of 13.5 months. These data may serve as reference to compare the potential benefit of CAR-T treatment in this group of myeloma patients when available in the near future. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Ulrike Bacher, Simon Brechb ühl, Barbara Jeker, Thomas Pabst Source Type: research

Prevalence of serious bacterial infections in children with sickle cell disease at king abdulaziz hospital, al ahsa
Conclusion: It appears that in the current era, less than 10% of febrile children with sickle cell disease in our center are diagnosed with a SBI. Over an 11-year period, there were no sequelae or deaths from SBI. Given these excellent outcomes, outpatient ceftriaxone should be considered for febrile well appearing children with sickle cell disease if they have no apparent source and parents are judged to be reliable. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Manal Alsaif, Joan Robinson, Moshtag Abdulbaqi, Mustafa Aghbari, Khalid Al Noaim, Muneera Alabdulqader Source Type: research

Social and financial barriers to optimum tki treatment in patients with chronic myeloid leukemia- a knowledge-attitudes-practices study from india
Conclusion: Cost of treatment, lack of widespread availability of hematology services and poor patient awareness are significant barriers to optimum treatment of CML in low and middle income countries. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Naveen Gupta, Manoranjan Mahapatra, Tulika Seth, Seema Tyagi, Sudha Sazawal, Renu Saxena Source Type: research

Simple peripheral blood smear findings of covid-19 patients provide information about the severity of the disease and the duration of hospital stay.
BackroundData about the morphological changes of Covid-19 infection in peripheral blood smear are limited and association with clinical severity of the disease are not known yet. We aimed to examine the characteristics of the cells detected in the pathological rate and / or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in Covid-19 patients.MethodsClinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with Covid-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compar...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Ilhami Berber, Ozlem Cagasar, Ahmet Sar ıcı, Nurcan Kirici Berber, Ismet Aydogdu, Asli Yildirim, Harika Gozde Gocukara Bag, Leman Acun Delen, Ozkan Ulutas Source Type: research

Hematology patient protection during the covid-19 pandemic in italy: a nationwide nursing survey
Discussion:. Low variability in patient protection strategies was observed, meaning that national recommendations were effective. However, some critical issues emerged regarding the management of infected healthcare professionals and their contacts. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Stefano Botti, Nicola Serra, Fausto Castagnetti, Sabina Chiaretti, Nicola Mordini, Gianpaolo Gargiulo, Laura Orlando Source Type: research

The hematological parameters and biochemical markers of iron status in alfa-thalassemia 3.7kb deletion from metropolitan region of manaus, amazonas, brazil.
Background:Alpha Thalassemia (a-thal) is a heterogeneous group of hereditary alterations caused by deletions that affect alpha regulatory genes and the 3.7Kb deletion is the most frequent worldwide. In Brazil, the prevalence ranges from 20% and 35%, depending mainly on race, being more predominant in Afro-descendants.Purpose: The aim was to determine ?-thal -?3.7Kb and -?4.2Kb deletions, estimating their frequency in individuals from five regions of Amazon.Methods:Volunteers (individuals>18 years old, of both genders) blood samples (n=1809) were collected from march 2014 to september 2017, at hospitals and/or health cen...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: Fernanda Cozendey Anselmo, Abdou Gafar Soumanou , Cleidiane de Aguiar Ferreira , Flora Maia Viga Sobrinha, Ana Caroline Santos Castro, Rafael Oliveira Brito, Adolfo Jos é Mota, Marilda de Souza Gonçalves, Jose Pereira Moura Neto Source Type: research

Donor kir3dl1/receptor hla-bw4-80i combination reduces acute leukemia relapse after umbilical cord blood transplantation without in vitro t-cell depletion
This study aimed to investigate graft-resistant leukemia after transplantation and compared specific genotypes of killer immunoglobulin-like receptors (KIRs) in donors and human leukocyte antigen ligands in patients.Methods: We retrospectively analyzed 232 patients with acute leukemia from a single center. Patients had undergone UCBT with myeloablative conditioning and without anti-thymocyte globulin. We identified the KIR genotypes of cord blood donors using polymerase chain reaction with sequence-specific primers. All of the donors contained KIR3DL1.Results:The patients were divided into three groups according to the HLA...
Source: Mediterranean Journal of Hematology and Infectious Diseases - December 31, 2020 Category: Hematology Authors: xinchen fang, Xiaoyu zhu, Baolin Tang, Kaidi Song, Kaidi Song, Wen Yao, Xiang Wan, Huilan Liu, Zimin Sun, Jun Peng Source Type: research

PROLIFERATION AND APOPTOSIS OF B-CELL LYMPHOMA CELLS UNDER TARGETED REGULATION OF FOXO3 BY miR-155
This study aimed to explore the proliferation and apoptosis of B-cell lymphoma cells under targeted regulation of FOXO3 by miR-155. We analyzed the differences between B-cell lymphoma cells and B lymphocytes in expressions of miR-155 and FOXO3, explored the effects of miR-155 on proliferation and apoptosis of B-cell lymphoma cells, and relevant mechanisms, and also analyzed the relationship between expressions of miR-155 and FOXO3 in 42 patients with diffuse large B-cell lymphoma (DLBCL) and clinical characteristics of them. B-cell lymphoma cells showed a higher expression of miR-155 and a low expression of FOXO3 than B lymphocytes (both P
Source: Mediterranean Journal of Hematology and Infectious Diseases - November 2, 2020 Category: Hematology Authors: Xiaoqiang Zheng, Hongbing Rui, Ying Liu, Jinfeng Dong Source Type: research

The Outcome of Six Patients with COVID-19 Infection and Multiple Myeloma. A Case Series and Literature Review
No abstract, as A letter to the Editor. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Hesham Elsabah, Mahmood B. Aldabt, Ruba Taha, Dina Sameh Soliman, Halima Elomri, Feryal Ibrahim Source Type: research

Seroprevalence of anti SARS-CoV2 antibodies in Umbrian persons living with HIV
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: chiara papalini, Francesco Paciosi, Elisabetta Schiaroli, Sara Pierucci, chiara Busti, Silvia Bozza, Antonella Mencacci, Daniela Francisci Source Type: research

The significance of purity: Leukaemias involving the erythroid lineage
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Prof. Vincenzo Liso, Prof. Arcangelo Liso, Prof. Gina Zini Source Type: research

“Hemolysis, or not Hemolysis, that is the question”. Use of hydroxychloroquine in a patient with COVID-19 infection and G6PD deficiency.
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: NICOLA SGHERZA, Lidia Dalfino, Antonio Palma, Angelantonio Vitucci, Daniela Campanale, Salvatore Grasso, Pellegrino Musto Source Type: research

The COVID-19 in Omani children with chronic Hemato-oncology diseases
No abstract. This is a letter to the editor (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Laila Al Yazidi Source Type: research

Npm1 mutated, bcr-abl1 positive myeloid neoplasms: review of literature
Break point cluster region - Abelson (BCR-ABL1) chimeric protein and mutated Nucleophosmin (NPM1) are often present in hematological cancers, but they rarely coexist in the same disease. Both anomalies are considered founder mutations causing inhibition of differentiation and apoptosis, but BCR-ABL1 could act as a secondary mutation conferring a proliferative advantage to a pre-neoplastic clone. The 2016 World Health Organization (WHO) classification lists the provisional acute myeloid leukemia (AML) with BCR-ABL1, which must be diagnosed differentially from the rare blast phase (BP) onset of a chronic myeloid leukemia (CM...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Gianfranco Catalano, Pasquale Niscola, Cristina Banella, Daniela Diverio, Malgorzata Monika Trawinska , Stefano Fratoni, Rita Iazzoni, Paolo de Fabritiis, Elisabetta abruzzese, Nelida Ines Noguera Source Type: research

Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia of the elderly: review of the literature and perspectives.
Acute myeloid leukemia (AML) in adults older than 60 years old has a poor prognosis. Elderly patients often present with comorbidities and an adverse biology of the disease, with higher genetic risk and chemoresistance.  Allogeneic hematopoietic stem cell transplantation (HSCT) can be an effective treatment, and can improve overall survival (OS).Intensive chemotherapy (IC) before HSCT and  myeloablative conditioning regimens can produce significant toxicity and transplant-related mortality (TRM). Reduced-intensity conditioning (RIC) or non-myeloablative (NMA) regimens appear to preserve the graft-versus-leukemia ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Gabriele Magliano, Andrea Bacigalupo Source Type: research

SARS-CoV-2 INFECTED PATIENTS: FROM A HEMATOLOGIST PERSPECTIVE
Conclusion:Until more data arises, the summary we provide can be used by hematologists to better understand hemostasis in COVID-19 infected patients.We are in need for more studies to define appropriate management plans in the setting of hematologic findings.  (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Firas Kreidieh, Sally Temraz Source Type: research

ACTIVIN RECEPTOR LIGAND FOR THR TREATMENT OF BETA-THALASSEMIA: a SERENDIPITOUS DISCOVERY
b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins. Alpha globin excess causes oxidative stress, RBCs membrane damage, premature death of late-stage erythroid precursors, resulting in ineffective erythropoiesis.The transforming growth factor b (TGF-b) superfamily signaling acts on biological processes, such as cell quiescence, apoptosis, proliferation, differentiation, and migration, and also plays an important role in the regulation of hematopoiesis. This pathway can lose its physiologic reg...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Irene Motta, Valentina Brancaleoni, Isabella Nava, Paola Delbini, Lorena Duca Source Type: research

High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles
Antiphospholipid antibodies (APAs) are developed antibodies to the phospholipid surfaces or to the proteins binding to phospholipids. Increased PS-expressed red blood cells (RBC) may be a risk factor in APAs development. There were only a few studies reported on APAs in thalassemia, and their associations to PS-expressing microparticles (MPs), remain unknown. The presence of antiphospholipid antibodies (APAs) in pediatric thalassemia patients and their associations with phosphatidylserine (PS)- expressing microparticles (MPs), a previously unexplored relationship, were the aims of this report. We identified that positive A...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Jitlada Chinsuwan, Phatchanat Klaihmon, Praguywan Kadegasem, Ampaiwan Chuansumrit, Anucha Soisamrong, Kovit Pattanapanyasat, Pakawan Wongwerawattanakoon, Nongnuch Sirachainan Source Type: research

The diagnostic pitfalls of mucormycosis
ConclusionsThis case showed that also intensive chemotherapy with rituximab may represent a risk factor for mucormycosis infection. Liposomal amphotericin B and surgery  remain  key tools  for a successful treatment of this aggressive disease.  (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Margherita Mauro, Giuliana Lo Cascio, Rita Balter, Ada Zaccaron, Elisa Bonetti, Virgina Vitale, Matteo Chinello, Massimiliano De Bortoli, Paolo Brazzarola, Costanza Bruno, Simone Cesaro Source Type: research

Perpheral blood cell mitochondrial dysfunction in myelodysplastic syndromecan be improved by a combination of coenzyme q10 and carnitine
Structural mitochondrial abnormalities as well as genetic aberrations in mitochondrial proteins have been known in Myelodysplastic syndrome (MDS) , yet there is currently little data regarding the metabolic properties and energy production of MDS cells. In the current study we used state-of-the-art methods to assess OXPHOS in peripheral blood cells obtained from MDS patients and healthy controls We then assessed the effect of food supplements- Coenzyme Q10 and carnitine on mitochondrial function and hematological response .We show here for the first time that in low risk MDS there is a significant impairment of mitochondri...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Kalman Filanovsky, Michal Haran, Vita Mirkin, Andrei Braester, Olga Shevetz, Anfisa Stanevsky, Erica Sigler, Ekaterina Votinov, Yehudit Zalzman-Amir, Alain Berrebi, Atan Gross, Lev Shvidel Source Type: research

The Outcome of six patients with COVID-19 infection and Multiple Myeloma. A Case Series and Literature Review
No abstract, as A letter to the Editor. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Hesham Elsabah, Mahmood B. Aldabt, Ruba Taha, Dina Sameh Soliman, Halima Elomri, Feryal Ibrahim Source Type: research

Seroprevalence of anti SARS-CoV2 antibodies in Umbrian persons living with HIV
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: chiara papalini, Francesco Paciosi, Elisabetta Schiaroli, Sara Pierucci, chiara Busti, Silvia Bozza, Antonella Mencacci, Daniela Francisci Source Type: research

The significance of purity: Leukaemias involving the erythroid lineage
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Prof. Vincenzo Liso, Prof. Arcangelo Liso, Prof. Gina Zini Source Type: research

“Hemolysis, or not Hemolysis, that is the question”. Use of hydroxychloroquine in a patient with COVID-19 infection and G6PD deficiency.
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: NICOLA SGHERZA, Lidia Dalfino, Antonio Palma, Angelantonio Vitucci, Daniela Campanale, Salvatore Grasso, Pellegrino Musto Source Type: research

The COVID-19 in Omani children with chronic Hemato-oncology diseases
No abstract. This is a letter to the editor (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Laila Al Yazidi Source Type: research

Npm1 mutated, bcr-abl1 positive myeloid neoplasms: review of literature
Break point cluster region - Abelson (BCR-ABL1) chimeric protein and mutated Nucleophosmin (NPM1) are often present in hematological cancers, but they rarely coexist in the same disease. Both anomalies are considered founder mutations causing inhibition of differentiation and apoptosis, but BCR-ABL1 could act as a secondary mutation conferring a proliferative advantage to a pre-neoplastic clone. The 2016 World Health Organization (WHO) classification lists the provisional acute myeloid leukemia (AML) with BCR-ABL1, which must be diagnosed differentially from the rare blast phase (BP) onset of a chronic myeloid leukemia (CM...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Gianfranco Catalano, Pasquale Niscola, Cristina Banella, Daniela Diverio, Malgorzata Monika Trawinska , Stefano Fratoni, Rita Iazzoni, Paolo de Fabritiis, Elisabetta abruzzese, Nelida Ines Noguera Source Type: research

Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia of the elderly: review of the literature and perspectives.
Acute myeloid leukemia (AML) in adults older than 60 years old has a poor prognosis. Elderly patients often present with comorbidities and an adverse biology of the disease, with higher genetic risk and chemoresistance.  Allogeneic hematopoietic stem cell transplantation (HSCT) can be an effective treatment, and can improve overall survival (OS).Intensive chemotherapy (IC) before HSCT and  myeloablative conditioning regimens can produce significant toxicity and transplant-related mortality (TRM). Reduced-intensity conditioning (RIC) or non-myeloablative (NMA) regimens appear to preserve the graft-versus-leukemia ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Gabriele Magliano, Andrea Bacigalupo Source Type: research

SARS-CoV-2 INFECTED PATIENTS: FROM A HEMATOLOGIST PERSPECTIVE
Conclusion:Until more data arises, the summary we provide can be used by hematologists to better understand hemostasis in COVID-19 infected patients.We are in need for more studies to define appropriate management plans in the setting of hematologic findings.  (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Firas Kreidieh, Sally Temraz Source Type: research

ACTIVIN RECEPTOR LIGAND FOR THR TREATMENT OF BETA-THALASSEMIA: a SERENDIPITOUS DISCOVERY
b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins. Alpha globin excess causes oxidative stress, RBCs membrane damage, premature death of late-stage erythroid precursors, resulting in ineffective erythropoiesis.The transforming growth factor b (TGF-b) superfamily signaling acts on biological processes, such as cell quiescence, apoptosis, proliferation, differentiation, and migration, and also plays an important role in the regulation of hematopoiesis. This pathway can lose its physiologic reg...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 27, 2020 Category: Hematology Authors: Irene Motta, Valentina Brancaleoni, Isabella Nava, Paola Delbini, Lorena Duca Source Type: research