Mediterranean Journal of Hematology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Therapy-related myeloid neoplasms: predisposition and clonal evolution
Therapy-related Myeloid Neoplasm (t-MN) represents one of the worst long-term consequences of cytotoxic therapy for primary tumors and autoimmune disease. Poor survival and refractoriness to current treatment strategies characterize affected patients from a clinical point of view. In our aging societies, where newer therapies and ameliorated cancer management protocols are improving the life expectancy of cancer patients, therapy-related Myeloid Neoplasms are an emerging problem. Although several research groups have contributed to characterizing the main risk factors in t-MN development, the multiplicity of primary tumors...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Emiliano Fabiani, Dr. Falconi, Dr. Cristiano, Dr. Hajrullaj, Dr. Falconi, Prof. Leone, Prof. Voso Source Type: research

Liver disease & sickle cell disease: autoimmune hepatitis more than a coincidence; a systematic literature review.
In patients with SCD, chronic liver damage is a common manifestation. More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. Autoimmune hepatitis (AIH) is a rare disease that appears to occur more commonly in the sickle cell disease (SCD) population than in the general population. There are many schools of thought as to why this is the case, including the phosphatidylserine hypothesis, the heme...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Kelvin Lynch, Andrea Mega, Andrea Piccin, Massimo Daves, Helen Fogarty Source Type: research

Kinetics and role of pancreatic stone protein and midregional proadrenomedullin as predictors of sepsis and bacteremia in children with haematological malignancies.
Conclusions: Both PSP and MR-proADM are promising biomarkers for early diagnosis of sepsis during FN episodes in children with haematological malignancies. PSP has the higher sensitivity and specificity. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Vasiliki Antari, Lemonia Skoura, Athanasios Tragiannidis, Emmanuel Hatzipantelis, Vasiliki-Regina Tsinopoulou, Konstantina Papakonstantinou, Efthimia Protonotariou, Assimina Galli-Tsinopoulou Source Type: research

A rare immune-related mesenteric and retroperitoneal serositis in a multirefractory Hodgkin lymphoma patient successfully treated with chylolymphostatic surgery
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Matteo D ' Addona, Luca Pezzullo, Corradino Campisi, Corrado Cesare Campisi, Valentina Giudice, Vincenzo Ciccone, Roberto Guariglia, Bianca Serio, Carmine Selleri Source Type: research

Car-t cell therapy in large b cell lymphoma
Large B-cell lymphomas (LBCLs) are among the most frequent (about 30%) non-Hodgkin ’s lymphoma. Despite the aggressive behavior of these lymphomas, more than 60% of patients can be cured with first-line chemoimmunotherapy using the R-CHOP regimen. Patients with refractory or relapsing disease show a poor outcome even when treated with second-line therapies.CD19-targeted chimeric antigen receptor (CAR) T-cells are emerging as an efficacious second-line treatment strategy for patients with LBCL. Three CD19-CAR-T-cell products received FDA and EMA approval. The use of CAR-T cell therapy has also been explored for the t...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Ugo Testa, Dr. Germana Castelli, Giuseppe Leone, Elvira Pelosi, Dr. Germana Castelli, Prof. Hohaus Source Type: research

Evaluating the use of meropenem in hematologic patients with febrile neutropenia
ConclusionsOur results support the safe reduction of the use of meropenem by changing the empiric treatment protocol for patients with hematologic malignancy and febrile neutropenia. As this study showed a lower resistance frequency to piperacillin/tazobactam than to ceftazidime, this antibiotic is the recommended alternative. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: R.A. Stuurman, E. Jong, P.C.R. Godschalk, M.F. Corsten, J.E. Nagtegaal Source Type: research

Impact of Sars-CoV-2 prophylaxis with tixagevimab-cilgavimab in high-risk patients with B-cell malignancies: a single-center retrospective study.
Severe Acute Respiratory Syndrome CoronaVirus ‐2 (SARS‐CoV‐2) infection can result in different clinical manifestations (COVID-19), starting from asymptomatic disease to life threatening respiratory insufficiency. Onco-haematologic patients are at higher risk to develop severe COVID-19. In particular, patients affected by lymphoproliferat ive diseases, given the impaired cell-mediated and antibody-mediated immunity and treatment toxicity, develop more often a symptomatic and a more serious disease of Covid-19. Various therapeutic and prophylactic agents are being used against COVID‐19 such as antiviral drugs, vacci...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Giovanni Manfredi Assanto ,, Matteo Totaro , Poggiali Rebecca, Delli Paoli Adele, Annechini Giorgia, D ’Elia Gianna Maria, Aji Francesco, Petrucci Luigi, Fazio Francesca, Del Giudice Ilaria, Martelli Maurizio, Micozzi Alessandra, Giuseppe Gentile Source Type: research

Diagnosis and prognosis evaluation of severe pneumonia by lung ultrasound score combined with serum inflammatory markers
Conclusion:LUS combined with serum inflammatory indicators (IL-6, IL-10, TNF- α, CRP and NLR) can differentiate the severity and prognosis of severe pneumonia, which may be a new direction for the diagnosis of severe pneumonia and guide early clinical intervention. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Bo Fu, Peng Zhang, JunHua Zhang Source Type: research

NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2
Conclusion: Our study suggested that the mutations as K337D and G392D modulate the stability of nsp2 and tracking viral evolution should be implemented and vaccine development updated.s 51.08. The results revealed that 8 of the 17 nsp2 mutations (R207C, T224I, G262V, T265I, K337D, N348S, G392D, and I431M) were missense. One deletion was also found in nsp2. Among nsp2 missense mutations studied, K337D and G392D increased structural stability while the others decreased it. The homology-designed models demonstrated that the homologies were comparable to the sequences of the Wuhan-HU-1 virus.Conclusion: Our study suggested tha...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 16, 2023 Category: Hematology Authors: Mohsen Nakhaei, Zohreh-Al-Sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd, Hedyeh Askarpour, Nasir Source Type: research

Justification of universal iron supplementation for infants 6-12 months in regions with a high prevalence of thalassemia
Conclusions: Both thalassemia and IDA are endemic to Southeast Asia. Infants with thalassemia minor, particularly with Hb E and a-thalassemia traits, are at risk of IDA. Our short-term universal iron supplementation program for 6 to 12-month old infants does not appear to increase the risk of those with thalassemia minor developing iron overload in the future. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2023 Category: Hematology Authors: Phakatip Sinlapamongkolkul, Pacharapan Surapolchai, Vip Viprakasit Source Type: research

Correlation of transient elastography with liver iron concentration, and serum ferritin levels in patients with transfusion-dependent thalassemia major patients from oman
Conclusion: We observed that in transfusion dependent β thalassemia major patients there was a significant correlation with the TE measured by ultrasound transient elastography, and LIC by MRI as well as SF levels but not with the fibrosis-4 (FIB-4) score. Key Words: Serum ferritin; Fibrosis-4; Transfusion-dependent beta-thalassemia; Transient elastography; Magnetic resonance imaging (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2023 Category: Hematology Authors: Hammad Khan, Vinodh Panjwani, Sara Al Rahbi, Abubakr Eltigani , Rizwan Qureshi, Khaleeq Unnisa, Najmus Sehar, Alok Mittal, Anil Pathare Source Type: research

Multiparametric flow cytometry refines risk stratification in newly diagnosed multiple myeloma patients
Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of surface antigens. Our study aimed at describing the antigenic profile detected by MFC in a series of newly diagnosed MM patients to correlate the level of expression with other features of the disease. Between April 2018 and June 2022, 84 consecutive MM patients were studied at presentation. CD56 and CD117 were commonly detected, while CD45, CD28, CD20, CD19, CD13 and CD33 were...
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2023 Category: Hematology Authors: Francesca Fazio, Gianfranco Lapietra, Maria Zaira Limongi, Stefania Intoppa, Maria Laura Milani, Alfonso Piciocchi, Maurizio Martelli, Anna Guarini, Robin Fo à, Maria Stefania De Propris, Maria Teresa Petrucci Source Type: research

Preliminary study of scd14 and scd163 as predictors of disease severity and icu admission in covid-19: relation to hematological parameters, blood morphological changes and inflammatory biomarkers
Conclusion: High sCD163 and sCD14 levels, hematological parameters, and blood morphology reflect monocyte activation in COVID-19 infection. sCD163 is a potential marker of disease severity. These findings support further study of therapeutics targeting macrophage activity in COVID-19 patients with high sCD163 levels. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2023 Category: Hematology Authors: hend Attia Source Type: research

HEMOGLOBIN H DISEASE AND GROWTH: A COMPARATIVE STUDY OF DHbH AND NDHbH PATIENTS
Conclusions: NDHbH patients exhibited lower hemoglobin levels and more pronounced splenomegaly than DHbH patients. Growth failure can occur in both HbH types but appears more prevalent in NDHbH. Close monitoring of growth velocity is essential, and early treatment interventions may be required to prevent growth failure. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2023 Category: Hematology Authors: Issanun Hunnuan, Kleebsabai SAnpakit, Ornsuda Lertbannaphong, Jassada Buaboonnam Source Type: research