Mediterranean Journal of Hematology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Thalidomide ameliorates erythropoiesis and iron homeostasis in transfusion-dependent β-thalassemia
This study investigated the effects of thalidomide treatment on hematologic, er ythropoietic, and iron-status parameters in 22 patients with transfusion-dependent β-thalassemia (TDT). Thalidomide significantly improved anemia endpoints, including increases in hemoglobin (p<0.001), red blood cells (p<0.001), and hematocrit (p<0.001), as well as reducing erythropoietin levels (p=0.033) and ameliorating erythropoiesis. Thalidomide treatment significantly reduced serum iron levels (p=0.018) and transferrin saturation (p=0.039) and increased serum transferrin levels (p=0.030). Thalidomide had no observed effect on ser...
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Kun Yang, Jian Xiao Source Type: research

A case of central venous catheter-related Candida parapsilosis fungemia evolved to disseminated infection in a neutropenic patient with blast crisis of chronic myeloid leukemia.
Central venous catheter-related infections are of particular importance in onco-hematological patients.Candidaparapsilosis is generally reported as a mild pathogen, however it is able to effectively colonize intravascular devices and potentially give rise to sustained fungemias. Here we report a case of invasive, potentially lethalC. parapsilosis disseminated infection in a neutropenic patient affected by chronic myeloid leukemia with blast crisis. We underline the importance of removing the central venous catheter as potential source of infection as soon as possible during the course of candidemia, and not replacing it wi...
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Elena Amabile, Matteo Totaro, Luca Cappelli, Clara Minotti, Alessandra Micozzi Source Type: research

Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa
ConclusionThe proper supply of blood was impacted by the COVID-19 pandemic meanwhile replacement donations had contributed to limiting the damage observed with blood shortages. However, the significant differences noted on the seroprevalences of transfusion-transmissible infections between voluntary non-paid donors and family/replacement donors strengthens WHO recommendations for the selection of volunteer non-paid donors to lower transfusion-transmissible HBV in sub Saharan Africa.          (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Macoura GADJI, Dr , Dr , Prof. Source Type: research

How we prevented an anti-P1 mediated hemolytic transfusion reaction
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Beatrice Borsellino, Tiziano Martini, Rino Biguzzi, Irene Francesconi, Maria Federica Curr à, Sabrina Lelli Source Type: research

Hemophagocytic lymphohistiocytosis secondary to refractory acute myeloid leukemia resolved after second line treatment with azacitidine plus venetoclax
Hemophagocytic lymphohistiocytosis (HLH), also defined as hemophagocytic syndrome (HPS), represents a potentially life-threatening hyperinflammatory syndrome, characterized by impaired function of cytotoxic T lymphocytes, natural killer cells and macrophages. The main clinical features of HLH are prolonged fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. Secondary HLH typically occurs in conjunction with severe infections, malignancies or autoimmune disorders and intensive chemotherapy, potentially complicating treatment of acut...
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Claudio Fozza Source Type: research

Kinetics and role of pancreatic stone protein and midregional proadrenomedullin as predictors of sepsis and bacteremia in children with haematological malignancies.
Conclusions: Both PSP and MR-proADM are promising biomarkers for early diagnosis of sepsis during FN episodes in children with haematological malignancies. PSP has the higher sensitivity and specificity. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Vasiliki Antari, Lemonia Skoura, Athanasios Tragiannidis, Emmanuel Hatzipantelis, Vasiliki-Rengina Tsinopoulou, Konstantina Papakonstantinou, Efthimia Protonotariou, Assimina Galli-Tsinopoulou Source Type: research

A multicenter icet-a study on age at menarche and menstrual cycles in patients with transfusion-dependent thalassemia (tdt) who started early chelation therapy with different chelating agents.
Conclusions: Early chelation does not necessary correlate with efficient chelation during pubertal age. Delayed menarche, related to high SF levels, was still frequent in most Centers and was a forerunner of irregular menstrual cycles, SA and associated complications. Neglecting the importance of adherence to iron chelation therapy (ICT), despite innovative and expensive therapies, may lead to complications and decreased quality of life. Key words: Transfusion-dependent thalassemia, menarche, menstrual cycles, iron chelation therapy (ICT), iron overload, adherence to treatment.  (Source: Mediterranean Journal of ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: SALVATORE DI MAIO, VINCENZO DE SANCTIS, PIERLUIGI MARZUILLO, CHRISTOS KATTAMIS, SHAHINA DAAR, MEHERAN KARIMI, SAKI FOROUGH, ATANAS BANKEV, VALERIA KALEVA, SOTEROULA CHRISTOU, CARMELO FORTUGNO, POLYXENI DELAPORTA, ASHRAF T SOLIMAN , PLOUTARCHOS TZOULIS Source Type: research

Diagnosis and prognosis evaluation of severe pneumonia by lung ultrasound score combined with serum inflammatory markers.
Conclusion:LUS combined with serum inflammatory indicators (IL-6, IL-10, TNF- α, CRP and NLR) can differentiate the severity and prognosis of severe pneumonia, which may be a new direction for the diagnosis of severe pneumonia and guide early clinical intervention. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Bo Fu, Peng Zhang, JunHua Zhang Source Type: research

Evaluating the use of meropenem in hematologic patients with febrile neutropenia
ConclusionsOur results support the safe reduction of the use of meropenem by changing the empiric treatment protocol for patients with hematologic malignancy and febrile neutropenia. As this study showed a lower resistance frequency to piperacillin/tazobactam than to ceftazidime, this antibiotic is the recommended alternative. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: R.A. Stuurman, E. Jong, P.C.R. Godschalk, M.F. Corsten, J.E. Nagtegaal Source Type: research

Impact of Sars-CoV-2 prophylaxis with tixagevimab-cilgavimab in high-risk patients with B-cell malignancies: a single-center retrospective study.
Severe Acute Respiratory Syndrome CoronaVirus ‐2 (SARS‐CoV‐2) infection can result in different clinical manifestations (COVID-19), starting from asymptomatic disease to life threatening respiratory insufficiency. Onco-haematologic patients are at higher risk to develop severe COVID-19. In particular, patients affected by lymphoproliferat ive diseases, given the impaired cell-mediated and antibody-mediated immunity and treatment toxicity, develop more often a symptomatic and a more serious disease of Covid-19. Various therapeutic and prophylactic agents are being used against COVID‐19 such as antiviral drugs, vacci...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Giovanni Manfredi Assanto ,, Matteo Totaro , Poggiali Rebecca, Delli Paoli Adele, Annechini Giorgia, D ’Elia Gianna Maria, Aji Francesco, Petrucci Luigi, Fazio Francesca, Del Giudice Ilaria, Martelli Maurizio, Micozzi Alessandra, Giuseppe Gentile Source Type: research

Car-t cell therapy in large b cell lymphoma
Large B-cell lymphomas (LBCLs) are among the most frequent (about 30%) non-Hodgkin ’s lymphoma. Despite the aggressive behavior of these lymphomas, more than 60% of patients can be cured with first-line chemoimmunotherapy using the R-CHOP regimen. Patients with refractory or relapsing disease show a poor outcome even when treated with second-line therapies.CD19-targeted chimeric antigen receptor (CAR) T-cells are emerging as an efficacious second-line treatment strategy for patients with LBCL. Three CD19-CAR-T-cell products received FDA and EMA approval. The use of CAR-T cell therapy has also been explored for the t...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Ugo Testa, Dr. Germana Castelli, Giuseppe Leone, Elvira Pelosi, Dr. Germana Castelli, Prof. Hohaus Source Type: research

Therapy-related myeloid neoplasms: predisposition and clonal evolution
Therapy-related Myeloid Neoplasm (t-MN) represents one of the worst long-term consequences of cytotoxic therapy for primary tumors and autoimmune disease. Poor survival and refractoriness to current treatment strategies characterize affected patients from a clinical point of view. In our aging societies, where newer therapies and ameliorated cancer management protocols are improving the life expectancy of cancer patients, therapy-related Myeloid Neoplasms are an emerging problem. Although several research groups have contributed to characterizing the main risk factors in t-MN development, the multiplicity of primary tumors...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Emiliano Fabiani, Dr. Falconi, Dr. Cristiano, Dr. Hajrullaj, Dr. Falconi, Prof. Leone, Prof. Voso Source Type: research

Liver disease & sickle cell disease: autoimmune hepatitis more than a coincidence; a systematic literature review.
In patients with SCD, chronic liver damage is a common manifestation. More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. Autoimmune hepatitis (AIH) is a rare disease that appears to occur more commonly in the sickle cell disease (SCD) population than in the general population. There are many schools of thought as to why this is the case, including the phosphatidylserine hypothesis, the heme...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Kelvin Lynch, Andrea Mega, Andrea Piccin, Massimo Daves, Helen Fogarty Source Type: research

A rare immune-related mesenteric and retroperitoneal serositis in a multirefractory Hodgkin lymphoma patient successfully treated with chylolymphostatic surgery
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Matteo D ' Addona, Luca Pezzullo, Corradino Campisi, Corrado Cesare Campisi, Valentina Giudice, Vincenzo Ciccone, Roberto Guariglia, Bianca Serio, Carmine Selleri Source Type: research

A novel ALAS2 mutation causes congenital sideroblastic anemia
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: Kun Yang Source Type: research