Vascular Nanomedicine: Current Status, Opportunities, and Challenges
Semin Thromb Hemost DOI: 10.1055/s-0039-1692395The term “nanotechnology” was coined by Norio Taniguchi in the 1970s to describe the manipulation of materials at the nano (10−9) scale, and the term “nanomedicine” was put forward by Eric Drexler and Robert Freitas Jr. in the 1990s to signify the application of nanotechnology in medicine. Nanomedicine encompasses a variety of systems including nanoparticles, nanofibers, surface nano-patterning, nanoporous matrices, and nanoscale coatings. Of these, nanoparticle-based applications in drug formulations and delivery have emerged as the most utilized...
Source: Seminars in Thrombosis and Hemostasis - June 14, 2019 Category: Hematology Authors: Sun, Michael Sen Gupta, Anirban Tags: Review Article Source Type: research

Clinical Application of Thromboelastography/Thromboelastometry (TEG/TEM) in the Neonatal Population: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0039-1692210Hemostasis is a dynamic age-related process, which gradually evolves from fetal life throughout childhood until adulthood. Although at birth there is a hemostatic deficit of most coagulation factors, studies have shown that this “hemostatic immaturity” is functionally counterbalanced in healthy term or preterm newborns. This delicate hemostatic balance is, however, deranged in sick neonates, resulting in an enhanced risk of hemorrhage and/or thrombosis. In critically ill neonates, conventional coagulation tests do not seem to provide reliable information or indicat...
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: Konstantinidi, Aikaterini Sokou, Rozeta Parastatidou, Stavroula Lampropoulou, Katerina Katsaras, George Boutsikou, Theodora Gounaris, Antonios K. Tsantes, Argyrios E. Iacovidou, Nicoletta Tags: Review Article Source Type: research

Tissue Factor-Negative Cell-Derived Microparticles Play a Distinctive Role in Hemostasis: A Viewpoint Review
Semin Thromb Hemost DOI: 10.1055/s-0039-1688570Circulating cell-derived microparticles (MPs) exhibit procoagulant activity and have been investigated for a possible role in some human pathologies. However, their potential role in hemostasis has been neglected and often denied. This review brings to attention a specific body of direct clinical evidence supporting an important but distinctive role of MPs in hemostasis. Evidence for a role of MPs in hemostasis includes: (1) two congenital bleeding disorders attributed to impaired release of MPs; (2) two recent studies of trauma patients relating naturally elevated endogenous ...
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: Horstman, Lawrence L. McCauley, Robert F. Jy, Wenche Ahn, Yeon S. Tags: Review Article Source Type: research

Investigation of Possible Herb  − Drug Interactions for the Treatment of Cardiovascular Diseases
Semin Thromb Hemost DOI: 10.1055/s-0039-1692211 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: Zuo, Huali L. Yang, Fengqing Q. Hu, Yuanjia J. Tags: Letter to the Editor Source Type: research

Comment on: Inherited Thrombophilia and Pregnancy Complications: Should We Test?
Semin Thromb Hemost DOI: 10.1055/s-0039-1692214 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: Ruiz-Arg üelles, Guillermo J. Tags: Letter to the Editor Source Type: research

Comment on “Investigation of Possible Herb − Drug Interactions for the Treatment of Cardiovascular Diseases”
Semin Thromb Hemost DOI: 10.1055/s-0039-1692212 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: McEwen, Bradley J. Tags: Letter to the Editor Source Type: research

Reply to Comment on: Inherited Thrombophilia and Pregnancy Complications: Should We Test?
Semin Thromb Hemost DOI: 10.1055/s-0039-1692213 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 13, 2019 Category: Hematology Authors: Arachchillage, Deepa R.J. Makris, Mike Tags: Letter to the Editor Source Type: research

Emerging Paradigms of Thrombosis and Cancer (Part I): The yin yang Relationship between Thrombosis and Cancer
Semin Thromb Hemost 2019; 45: 319-320 DOI: 10.1055/s-0039-1688496 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 3, 2019 Category: Hematology Authors: Kwaan, Hau C. Lindholm, Paul F. Tags: Preface Source Type: research

A Comprehensive Overview of Coagulation Factor V and Congenital Factor V Deficiency
Semin Thromb Hemost DOI: 10.1055/s-0039-1687906Coagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the prothrombinase complex, which is critical for progressing clot formation. FV deficiency is a rare bleeding disorder with an estimated incidence of one per 1 million in the general population. The disorder is manifested with a wide array of clinical bleeding events. The most common bleeding features of FV deficiency are mucosal bleedings. Life-threatening manifestations are rarely seen in this disorder. FV deficiency is diagnosed using routine coagulation tests and FV activity assay....
Source: Seminars in Thrombosis and Hemostasis - May 23, 2019 Category: Hematology Authors: Tabibian, Shadi Shiravand, Yavar Shams, Mahmood Safa, Majid Gholami, Mohammad Saeed Heydari, Farshad Ahmadi, Abbas Rashidpanah, Jamal Dorgalaleh, Akbar Tags: Review Article Source Type: research

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review
Semin Thromb Hemost DOI: 10.1055/s-0039-1688497The relationship between malignancy and coagulopathy is one that is well documented yet incompletely understood. Clinicians have attempted to quantify the hypercoagulable state produced in various malignancies using common coagulation tests such as prothrombin time, activated partial thromboplastin time, and platelet count; however, due to these tests' focus on individual aspects of coagulation during one specific time point, they have failed to provide clinicians the complete picture of malignancy-associated coagulopathy (MAC). Viscoelastic tests (VETs), such as thromboelasto...
Source: Seminars in Thrombosis and Hemostasis - May 20, 2019 Category: Hematology Authors: Walsh, Mark Moore, Ernest E. Moore, Hunter Thomas, Scott Lune, Stefani Vande Zimmer, David Dynako, Joseph Hake, Daniel Crowell, Zachary McCauley, Ross Larson, Emilee E. Miller, Michael Pohlman, Tim Achneck, Hardean E. Martin, Peter Nielsen, Nathan Shariff Tags: Review Article Source Type: research

Statins for Preventing Venous Thrombosis: For or Against?
Semin Thromb Hemost DOI: 10.1055/s-0039-1687912 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 17, 2019 Category: Hematology Authors: Lippi, Giuseppe Favaloro, Emmanuel J. Tags: Commentary Source Type: research

Gene Therapy: Paving New Roads in the Treatment of Hemophilia
Semin Thromb Hemost DOI: 10.1055/s-0039-1688445Hemophilia is a monogenic disease with robust clinicolaboratory correlations of severity. These attributes coupled with the availability of experimental animal models have made it an attractive model for gene therapy. The road from animal models to human clinical studies has heralded significant successes, but major issues concerning a previous immunity against adeno-associated virus and transgene optimization remain to be fully resolved. Despite significant advances in gene therapy application, many questions remain pertaining to its use in specific populations such as those ...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Yamaguti-Hayakawa, Gabriela G. Ozelo, Margareth C. Tags: Review Article Source Type: research

Oncogenes and Clotting Factors: The Emerging Role of Tumor Cell Genome and Epigenome in Cancer-Associated Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0039-1687891There are emerging linkages between biological and genetic aspects of cancer progression and the mechanisms of cancer-associated thrombosis. It is argued that reciprocal influences between cancer cells, their associated vascular stroma, and the hemostatic system may shape the mechanism of coagulopathy. In this regard, glioblastoma multiforme offers a paradigm where the prevalent occurrence of local microthrombosis and peripheral venous thromboembolism can be linked to the profiles of oncogenic driver mutations and their impact on the expression of coagulation-related genes (co...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Tawil, Nadim Bassawon, Rayhaan Rak, Janusz Tags: Review Article Source Type: research

Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0039-1687895It has been long-established that cancer and thrombosis are linked, but the exact underlying pathological mechanism remains to be unraveled. As the initiator of the coagulation cascade, the transmembrane glycoprotein tissue factor (TF) has been intensely investigated for its role in cancer-associated thrombosis and cancer progression. TF expression is regulated by both specific oncogenes and environmental factors, and it is shown to regulate primary growth and metastasis formation in a variety of cancer models. In clinical studies, TF has been shown to be overexpressed in most...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Rondon, Araci M. R. Kroone, Chantal Kapteijn, Maaike Y. Versteeg, Henri H. Buijs, Jeroen T. Tags: Review Article Source Type: research

Ultrasound Microbubbles for Diagnosis and Treatment of Cardiovascular Diseases
Semin Thromb Hemost DOI: 10.1055/s-0039-1688492Ultrasound (US) imaging of heart and major arteries and veins is among the most frequently used diagnostic techniques applied in humans. Conventional cardiovascular US sessions include anatomical B-mode and functional M-, pulsed-wave- and Doppler mode, which have their limitations in both precise cardiac chambers' delineation and small vessel imaging. The introduction of contrast-enhanced US, employing microbubble suspensions as contrast agent, has enabled a better delineation of heart chambers, the visualization of myocardial microvasculature, and the atherosclerotic plaque n...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Rix, Anne Curaj, Adelina Liehn, Elisa Kiessling, Fabian Tags: Review Article Source Type: research

Shear-, Sound-, and Light-Sensitive Nanoparticles for Thrombolytic Drug Delivery
Semin Thromb Hemost DOI: 10.1055/s-0039-1688490Thrombotic diseases, as potentially induced by blood clots or vascular embolization, frequently occur with high rates of mortalities worldwide. Current drug thrombolysis, a primary clinical therapy, may increase fatal risk of hemorrhage when thrombolysis agents become systemically distributed. Given current thrombolysis limitations, some novel drug delivery systems based on nanoparticles have been recently exploited to achieve a more controlled release of loaded thrombolytic agents, able to respond to environmental changes, and resulting in a safer thrombolysis. In this review...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Qu, Shu Ding, Xingwei Tags: Review Article Source Type: research

Statin Therapy to Revert Hypercoagulability and Prevent Venous Thromboembolism: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0039-1687911Venous thromboembolism (VTE) causes a major disease burden worldwide, so that effective preventive measures are warranted. Although oral anticoagulation is effective in preventing VTE episodes, bleeding complications are a major concern that may lead to treatment avoidance. Statin therapy, which is widely used for prevention of arterial cardiovascular disease, is a promising alternative treatment for VTE prophylaxis, as the drug may affect hemostasis without increasing the risk of bleeding. In the past years, clinical studies have suggested that statins can interfere with bloo...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Orsi, Fernanda A. Cannegieter, Suzanne C. Lijfering, Willem M. Tags: Review Article Source Type: research

Hemostatic Abnormalities in Dementia: A Systematic Review and Meta-Analysis
Semin Thromb Hemost DOI: 10.1055/s-0039-1688444Alzheimer's disease (AD) is considered the most frequent cause of dementia. It is known that vascular risk factors play an important role in the development and progression of this condition. Alterations in vascular walls represent documented findings in patients with AD and other dementias affecting elderly people. The authors performed a systematic review and meta-analysis, aiming to synthesize observational studies that evaluated how the hemostatic system may contribute to cognitive decline in the elderly, using papers published until April 2018 and as indexed in Medline (P...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Loures, Cristina de Mello Gomide Duarte, Rita Carolina Figueiredo Silva, Marcos Vin ícius Ferreira Cicarini, Walter Batista de Souza, Leonardo Cruz Caramelli, Paulo Borges, Karina Braga Gomes Carvalho, Maria das Gra ças Tags: Review Article Source Type: research

Next-Generation Sequencing and Emerging Technologies
Semin Thromb Hemost DOI: 10.1055/s-0039-1688446Genetic sequencing technologies are evolving at a rapid pace with major implications for research and clinical practice. In this review, the authors provide an updated overview of next-generation sequencing (NGS) and emerging methodologies. NGS has tremendously improved sequencing output while being more time and cost-efficient in comparison to Sanger sequencing. The authors describe short-read sequencing approaches, such as sequencing by synthesis, ion semiconductor sequencing, and nanoball sequencing. Third-generation long-read sequencing now promises to overcome many of the...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Kumar, Kishore R. Cowley, Mark J. Davis, Ryan L. Tags: Review Article Source Type: research

Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis
Semin Thromb Hemost DOI: 10.1055/s-0039-1687894There is a strong relationship between tissue factor (TF) and cancer. Many cancer cells express high levels of both full-length TF and alternatively spliced (as) TF. TF expression in cancer is associated with poor prognosis. In this review, the authors summarize the regulation of TF expression in cancer cells and the roles of TF and asTF in tumor growth and metastasis. A variety of different signaling pathways, transcription factors and micro ribonucleic acids regulate TF gene expression in cancer cells. The TF/factor VIIa complex enhances tumor growth by activating protease-a...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Hisada, Yohei Mackman, Nigel Tags: Review Article Source Type: research

Tumors: Wounds That Do Not Heal —A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting
Semin Thromb Hemost DOI: 10.1055/s-0039-1687908Similarities between solid tumor stroma generation, wound healing, chronic inflammation, and associated inflammatory diseases have prompted interest from the time of Virchow. However, it was not until the 1970s that these entities were shown to share important molecular mechanisms. Foundational to all of them is the initiating role of vascular endothelial growth factor (VEGF-A) in increasing vascular permeability to plasma and plasma proteins. Extravasated plasma activates the tissue factor clotting pathway, leading to extravascular deposition of a fibrin gel. Fibrin serves in...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Dvorak, Harold F. Tags: Review Article Source Type: research

Primary Prevention of Cardiovascular Events with Aspirin: Toward More Harm than Benefit —A Systematic Review and Meta-Analysis
Semin Thromb Hemost DOI: 10.1055/s-0039-1687905Primary prevention of cardiovascular events with aspirin remains controversial, as the risk of bleeding might outweigh the benefits. Recently, new evidence has emerged from the ARRIVE (Aspirin to Reduce Risk of Initial Vascular Events), ASCEND (A Study of Cardiovascular Events in Diabetes), and ASPREE (Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly) trials. The aim of this study was to perform a systematic review and meta-analysis of aspirin's efficacy and safety in the primary prevention of cardiovascular events in healthy individuals and in in...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Christiansen, Mikael Grove, Erik Lerkevang Hvas, Anne-Mette Tags: Review Article Source Type: research

Vascular Disease and Dementia: Lipoprotein(a) as a Neglected Link
Semin Thromb Hemost DOI: 10.1055/s-0039-1687907 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 16, 2019 Category: Hematology Authors: Lippi, Giuseppe Danese, Elisa Favaloro, Emmanuel J. Tags: Letter to the Editor Source Type: research

Thrombotic Microangiopathy in Cancer
Semin Thromb Hemost DOI: 10.1055/s-0039-1687893Thrombotic microangiopathy (TMA) is a rare but often devastating complication of cancer and cancer treatment. The syndrome is defined by thrombocytopenia (i.e., a platelet count of  30% decrease from baseline), microangiopathic hemolytic anemia, and some evidence of organ damage. Among the nine recognized groups of disorders causing TMA, the focus of this article will be on cancer and cancer treatment-related causes of TMA. This review will discuss the pathophysiology of TMA in cancer, chemotherapy-associated TMA, transplant-associated TMA, and newer therapeutic ...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Weitz, Ilene Ceil Tags: Review Article Source Type: research

Venous Thromboembolism in Brain Tumors: Risk Factors, Molecular Mechanisms, and Clinical Challenges
Semin Thromb Hemost DOI: 10.1055/s-0039-1688493Venous thromboembolism (VTE) is a common complication in patients with primary brain tumors, with up to 20% of patients per year having a VTE event. Clinical risk factors for VTE include glioblastoma subtype, paresis, or surgery. Furthermore, specific factors playing a role in tumor biology were recently identified to predispose to prothrombotic risk. For instance, mutations in the isocitrate dehydrogenase 1 (IDH1) gene, which occurs in a subgroup of glioma, correlate with risk of VTE, with low incidence in patients with presence of an IDH1 mutation compared with those with ID...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Riedl, Julia Ay, Cihan Tags: Review Article Source Type: research

Genetic Techniques Used in the Diagnosis of Inherited Platelet Disorders
Semin Thromb Hemost DOI: 10.1055/s-0039-1687888Recent advances in genetic analysis are bringing huge benefits to patients with rare genetic disorders, including those with inherited disorders of platelet number and function. Modern clinical hematological practice now has a range of genetic techniques available to enable the precision diagnosis of inherited platelet disorders (IPDs). There are some features of this disparate group of inherited disorders that present specific challenges to establishing an accurate genetic diagnosis. This review aims to introduce the techniques that are relevant for the genetic diagnosis of I...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Mumford, Andrew D. Westbury, Sarah K. Tags: Review Article Source Type: research

The Epidemiology of Cancer-Associated Venous Thromboembolism: An Update
This article will focus on an update regarding the epidemiology of cancer-associated thrombosis (CT). The authors will describe factors associated with CT risk including cancer type and stage at the time of diagnosis, race and ethnicity, and cancer-directed therapy. In addition, recurrent thrombosis and the effect of thromboembolism on survival in cancer patients will also be addressed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Mahajan, Anjlee Brunson, Ann White, Richard Wun, Ted Tags: Review Article Source Type: research

Disseminated Intravascular Coagulation in Cancer: An Update
Semin Thromb Hemost DOI: 10.1055/s-0039-1687890Cancer often leads to the activation of coagulation, manifesting as disseminated intravascular coagulation (DIC) in its most extreme form. DIC is characterized by systemic intravascular coagulation activation (leading to deposition of intravascular platelets and fibrin) and simultaneous consumption of coagulation proteins and thrombocytes (which may cause bleeding complications). The clinical course of DIC in patients with malignancies is typically less intense compared with DIC complicating alternative clinical settings, including systemic inflammatory responses following inf...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Levi, Marcel Tags: Review Article Source Type: research

Fibrin and Fibrinolysis in Cancer
Semin Thromb Hemost DOI: 10.1055/s-0039-1688495In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations have supported this concept, showing that many hemostatic factors including fibrinogen, fibrin, and components of the fibrinolytic system have indeed a complex interaction with cancer growth and metastasis. Fibrin promotes cell migration by providing a matrix for tumor cell migration and by interactions with adhesive molecules and integrins. Fibrin-containing vascular endothelial growth factor pr...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Kwaan, Hau C. Lindholm, Paul F. Tags: Review Article Source Type: research

Thrombotic Complications in Gliomas
Semin Thromb Hemost DOI: 10.1055/s-0039-1687892Arterial and venous thromboses are common in glioma patients, both in the perioperative period and throughout the course of the disease. High-grade glioma patients harbor underlying hypercoagulability, which predisposes these high-risk patients with prolonged immobility and neurologic deficits to thrombotic events. Despite the high incidence and recurrent nature of these complications, there is no standardized approach to the management of glioma patients, and many challenges remain. Historically, the perceived risk of intracranial and intratumoral hemorrhage limited the use o...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Czap, Alexandra L. Becker, Ashley Wen, Patrick Y. Tags: Review Article Source Type: research

Genetic and Molecular Testing in Thrombosis and Hemostasis: Informing Surveillance, Treatment, and Prognosis
Semin Thromb Hemost DOI: 10.1055/s-0038-1677020The understanding of molecular mechanisms brought about by the rapid expansion of gene sequencing has helped to characterize molecular interactions underpinning normal hemostasis and identify inherited and acquired risks for thrombosis and hemorrhage. The widespread availability of molecular testing may serve to replace some currently available investigations with more precise diagnostic tools and add to phenotypic tests. Molecular studies will increasingly enable prenatal diagnosis, confirm difficult diagnostic challenges, early intervention, and assist in prognostication. Th...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Crispin, Philip Koo, Ray Mun Tags: Review Article Source Type: research

Update on Molecular Testing in von Willebrand Disease
This article discusses the pros and cons of molecular testing in VWD considering the experience obtained through the multicenter project “Molecular and Clinical Profile of VWD in Spain (PCM-EVW-ES).” [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Batlle, Javier P érez-Rodríguez, Almudena Corrales, Irene Borr às, Nina Costa Pinto, Joana L ópez-Fernández, María Fernanda Vidal, Francisco Tags: Review Article Source Type: research

Molecular Diagnosis of Inherited Coagulation and Bleeding Disorders
Semin Thromb Hemost DOI: 10.1055/s-0039-1687889Diagnosis of inherited bleeding disorders (IBDs) remains challenging, especially in the case of inherited platelet disorders, due to the heterogeneity of the clinical and laboratory phenotype, the limited specificity of platelet function tests, and the large number of potential culprit genes. Unraveling the underlying molecular defect provides the definitive diagnosis of IBDs, facilitating prognosis and clinical care, which are especially important for severe clinical syndromes and those that may be associated with an increased risk of malignancy. Until recently, Sanger sequen...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Bastida, Jos é María Benito, Roc ío Lozano, Mar ía Luisa Mar ín-Quilez, Ana Janusz, Kamila Mart ín-Izquierdo, Marta Hern ández-Sánchez, Jesús Palma-Barqueros, Veronica Hern ández-Rivas, Jesús María Rivera, Jos é Gonz ález-Porras, José Ramó Tags: Review Article Source Type: research

Primary Thrombophilia XIV: Worldwide Identification of Sticky Platelet Syndrome
Semin Thromb Hemost DOI: 10.1055/s-0039-1688498 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 30, 2019 Category: Hematology Authors: Vallejo-Villalobos, Mar ía Fernanda Gomez-Cruz, Gisela Berenice Cantero-Fortiz, Yahveth Olivares-Gazca, Juan Carlos Olivares-Gazca, Mauricio Murrieta-Alvarez, Iv án Reyes-Nu ñez, Virginia Ruiz-Arg üelles, Guillermo J. Tags: Letter to the Editor Source Type: research

Innovations in Thrombosis and Hemostasis: A Glimpse Towards the Future of Diagnostic Analyzers
Semin Thromb Hemost 2019; 45: 225-227 DOI: 10.1055/s-0039-1683844 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 3, 2019 Category: Hematology Authors: Van Cott, Elizabeth M. Smock, Kristi J. Lippi, Giuseppe Tags: Preface Source Type: research

2019 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost 2019; 45: 215-224 DOI: 10.1055/s-0039-1683841 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 3, 2019 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Flow Devices to Assess Platelet Function: Historical Evolution and Current Choices
Semin Thromb Hemost DOI: 10.1055/s-0039-1683840Platelet function testing, which began more than a hundred years ago, is a time-consuming and uncertain process. Simulating hemostasis and the blood vessel microenvironment in vitro is challenging, which poses a difficulty for diagnosing platelet dysfunction and mild von Willebrand disease (VWD). In an effort to simulate the rheological microenvironment within blood vessels, several blood flow devices have been introduced since the 1980s. These devices are capable of reproducing the shear rates found in arterioles and venules, and of incorporating endothelial cell monolayers a...
Source: Seminars in Thrombosis and Hemostasis - March 25, 2019 Category: Hematology Authors: Silva, Raisa Cintra Lomanto Santos Grabowski, Eric Franklin Tags: Review Article Source Type: research

Recent Advances in Mainstream Hemostasis Diagnostics and Coagulation Testing
Semin Thromb Hemost DOI: 10.1055/s-0038-1676579The authors provide a narrative review of mainstream hemostasis analyzers. The review is presented in two parts. In the first part, the authors give voice to several internationally representative manufacturers of mainstream hemostasis analyzers. They ask these manufacturers to (1) answer a series of survey questions that may otherwise reflect common questions asked by users or potential users of their equipment, (2) provide a bullet list of their main focus areas, and (3) provide other information in regard to their instrumentation. The authors then offer their own personal p...
Source: Seminars in Thrombosis and Hemostasis - March 25, 2019 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Review Article Source Type: research

Comprehensive Coagulation Profiling at the Point-of-Care Using a Novel Laser-Based Approach
Semin Thromb Hemost DOI: 10.1055/s-0039-1683842Delays in identifying internal bleeding are life-threatening, thus underscoring the need for rapid and comprehensive coagulation profiling at the bedside. The authors review a novel optical coagulation profiler that measures several coagulation metrics including prothrombin time, activated clotting time, clot polymerization rate (α-angle), clot stiffness (maximum amplitude), fibrinolysis (LY), and platelet function, using a single multifunctional instrument. The optical profiler is based on the principles of Laser Speckle Rheology that quantifies tissue viscoelasticity f...
Source: Seminars in Thrombosis and Hemostasis - March 18, 2019 Category: Hematology Authors: Nadkarni, Seemantini K. Tags: Review Article Source Type: research

Novel Coagulation Analyzers in Development: A Glimpse toward the Future of Microfluidics
Semin Thromb Hemost DOI: 10.1055/s-0039-1683843Coagulation diagnostic testing in pediatric patients currently requires large volume blood sampling and is performed on analyzers that are not well-suited for multiplexed assays on a given sample. For patients who require serial testing at regular intervals, repetitive phlebotomy leads to iatrogenic anemia and need for blood transfusions. Over the past decade, novel microfluidic platforms have been developed that allow for complex multiplexed assays to be performed on small sample volumes, near patient, with high fidelity. In the next few years, these devices will be introduce...
Source: Seminars in Thrombosis and Hemostasis - March 18, 2019 Category: Hematology Authors: Emani, Sitaram M. Tags: Review Article Source Type: research

Recent Advances in Thrombosis and Hemostasis —Part IV
Semin Thromb Hemost 2019; 45: 130-131 DOI: 10.1055/s-0039-1678721 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 1, 2019 Category: Hematology Authors: Schulman, Sam Tags: Preface Source Type: research

2018 Eberhard F. Mammen Award Announcements: Part II —Young Investigator Awards
Semin Thromb Hemost 2019; 45: 123-129 DOI: 10.1055/s-0039-1678722 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 1, 2019 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Thromboprophylaxis in Patients with Acute Spinal Cord Injury: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0039-1678720Patients with acute spinal cord injury (SCI) have the highest risk of venous thromboembolism (VTE) among hospitalized patients. The incidence of total deep vein thrombosis ranges from 50 to 100% in untreated patients and pulmonary embolism is the third most common cause of mortality in these patients. The pathophysiology of the increased risk of VTE is explained by venous stasis after injury, endothelial vessel wall injury from surgery, and a hypercoagulable state associated with trauma. The current thromboprophylaxis options are limited, with low-molecular-weight heparin (LMW...
Source: Seminars in Thrombosis and Hemostasis - February 11, 2019 Category: Hematology Authors: Piran, Siavash Schulman, Sam Tags: Review Article Source Type: research

Management of Patients Taking Oral Anticoagulants Who Need Urgent Surgery for Hip Fracture
Semin Thromb Hemost DOI: 10.1055/s-0039-1678718The number of hip fractures in anticoagulated patients is predicted to increase, due to people living longer. However, evidence regarding urgent perioperative management of elderly patients with hip fracture who take oral anticoagulants (vitamin K antagonists or direct oral anticoagulants) is scarce. In this article, the authors present a narrative review of the evidence to date supporting the urgent management of hip fracture in anticoagulated elderly patients. They discuss the complexity of managing the high risk of procedure-related bleeding and, at the same time, the high ...
Source: Seminars in Thrombosis and Hemostasis - February 11, 2019 Category: Hematology Authors: Grandone, Elvira Ostuni, Angelo Tiscia, Giovanni L. Marongiu, Francesco Barcellona, Doris Tags: Review Article Source Type: research

To Maintain or Cease Non –Vitamin K Antagonist Oral Anticoagulants Prior to Minimal Bleeding Risk Procedures: A Review of Evidence and Recommendations
Semin Thromb Hemost DOI: 10.1055/s-0039-1678719For procedures associated with minimal bleeding risk, there are data and experience to support the practice of continuing vitamin K antagonists rather than interrupting therapy, to prevent exposing patients to the undue risk of developing thromboembolism during anticoagulation cessation. Despite the increasing use of non–vitamin K oral anticoagulants (NOACs), there is little evidence to guide the management of these drugs around minimal bleeding risk procedures. This review examines and discusses the major society guidelines and recommendations addressing the management ...
Source: Seminars in Thrombosis and Hemostasis - February 11, 2019 Category: Hematology Authors: Brennan, Yvonne Favaloro, Emmanuel J. Curnow, Jennifer Tags: Review Article Source Type: research

Analytical Assessment of the New Roche Cobas t 711 Fully Automated Coagulation Analyzer
In conclusion, the results of this preliminary evaluation demonstrate that PT, APTT, and fibrinogen on cobas t 711 coagulation analyzer displays excellent performance for routine use in clinical laboratories. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 30, 2019 Category: Hematology Authors: Lippi, Giuseppe Salvagno, Gian Luca Gelati, Matteo Poli, Giovanni Giavarina, Davide Favaloro, Emmanuel J. Tags: Review Article Source Type: research

Editorial Compilation VI
Semin Thromb Hemost 2019; 45: 005-009 DOI: 10.1055/s-0038-1677462 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 30, 2019 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

Welcome to Seminars in Thrombosis and Hemostasis 2019 –New (2017) Impact Factor and Most Highly Cited Papers
Semin Thromb Hemost 2019; 45: 001-004 DOI: 10.1055/s-0038-1677460 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 30, 2019 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Erratum: Inherited Thrombophilia and Pregnancy Complications: Should We Test?
Semin Thromb Hemost DOI: 10.1055/s-0039-1678545 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 22, 2019 Category: Hematology Authors: Arachchillage, Deepa R.J. Makris, Mike Tags: Erratum Source Type: research

Erratum: Quebec Platelet Disorder: Update on Pathogenesis, Diagnosis, and Treatment
Semin Thromb Hemost DOI: 10.1055/s-0038-1625972 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 14, 2019 Category: Hematology Authors: Hayward, Catherine P.M. Rivard, Georges E. Tags: Erratum Source Type: research