Presenting Characteristics, Treatment Patterns, and Outcomes among Patients with Venous Thromboembolism during Hospitalization for COVID-19
This study provides characteristics and early outcomes of patients diagnosed with acute VTE during hospitalization for COVID-19. Additional studies are needed to identify the optimal strategies to prevent VTE and to mitigate adverse outcomes associated. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 21, 2020 Category: Hematology Authors: Fern ández-Capitán, Carmen Barba, Raquel D íaz-Pedroche, María del Carmen Sig üenza, Patricia Demelo-Rodriguez, Pablo Siniscalchi, Carmine Pedrajas, Jos é María Farf án-Sedano, Ana I. Olivera, Pavel Eduardo G ómez-Cuervo, Covadonga Llamas, Pilar Tags: Review Article Source Type: research

Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials
Semin Thromb Hemost DOI: 10.1055/s-0040-1716874Thrombotic cardiovascular disease (myocardial infarction [MI], stroke, and venous thromboembolism [VTE]) remains a major cause of death and disability. Sulodexide is an oral glycosaminoglycan containing heparan sulfate and dermatan sulfate. We conducted a systematic review and meta-analysis to determine the cardiovascular efficacy, and safety of sulodexide versus control in randomized controlled trials (RCTs). We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for RCTs reporting cardiovascular outcomes in patients receiving sulodexide versus co...
Source: Seminars in Thrombosis and Hemostasis - October 21, 2020 Category: Hematology Authors: Bikdeli, Behnood Chatterjee, Saurav Kirtane, Ajay J. Parikh, Sahil A. Andreozzi, Giuseppe M. Desai, Nihar R. Francese, Dominic P. Gibson, C Michael Piazza, Gregory Goldhaber, Samuel Z. Eikelboom, John W. Krumholz, Harlan M. Stone, Gregg W. Tags: Review Article Source Type: research

Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk
Semin Thromb Hemost DOI: 10.1055/s-0040-1714140Combined oral contraceptives (COCs) induce several changes in the levels of coagulation factors. The levels of procoagulant factors are often increased, while levels of anticoagulant factors are decreased. Fibrinolysis is also affected, even if the effect seems to be more counterbalanced by opposite regulation of profibrinolytic and antifibrinolytic factors. These effects on hemostasis are more pronounced with third- or fourth-generation COC compared with second-generation COC. Venous thromboembolism (VTE) risk increases when multiple risk factors, including genetic and enviro...
Source: Seminars in Thrombosis and Hemostasis - October 20, 2020 Category: Hematology Authors: Douxfils, Jonathan Morimont, Laure Bouvy, C éline Tags: Review Article Source Type: research

Maintaining Hemostasis and Preventing Thrombosis in Coronavirus Disease 2019 (COVID-19) —Part I
Semin Thromb Hemost 2020; 46: 757-762 DOI: 10.1055/s-0040-1717139 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 20, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

Anabolic –Androgenic Steroid Abuse Impairs Fibrin Clot Lysis
Semin Thromb Hemost DOI: 10.1055/s-0040-1714398Abuse of anabolic–androgenic steroids (AASs) is suspected to increase the risk of cardiovascular disease (CVD) and cardiovascular mortality in otherwise healthy individuals. AAS abuse may increase the incidence of CVD by altering the hemostatic balance toward a procoagulant state. Studies on the effect of AAS abuse on the fibrinolytic system, however, have either demonstrated a profibrinolytic effect or no effect of AAS abuse, but the overall effect of AAS on fibrinolysis has not been addressed so far. This cross-sectional study investigated the effect of AAS on fibrin c...
Source: Seminars in Thrombosis and Hemostasis - October 4, 2020 Category: Hematology Authors: Sidelmann, Johannes Jakobsen Gram, J ørgen Brodersen Rasmussen, Jon J. Kistorp, Caroline Tags: Review Article Source Type: research

Hormonal Contraceptives and the Risk of Venous Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0040-1715793The risk of venous thrombosis (VT) varies according to the type of progestogen that is found in combined oral contraceptives (COCs). When combined with the estrogen component ethinylestradiol (EE), the androgenic progestogens are better able to counteract the EE-induced stimulation of liver proteins and hence are associated with a twofold decreased risk of VT compared with non- or antiandrogenic progestogens, which exert limited counteraction of EE. Because EE is responsible for the increased risk, novel estrogens such as estradiol were developed and seem to have a lower risk ...
Source: Seminars in Thrombosis and Hemostasis - October 4, 2020 Category: Hematology Authors: Khialani, Deeksha Rosendaal, Frits Vlieg, Astrid van Hylckama Tags: Review Article Source Type: research

Hyperfibrinolysis in Patients with Solid Malignant Neoplasms: A Systematic Review
In conclusion, primary hyperfibrinolysis induced by solid malignant neoplasms is a rare but potentially life-threatening condition that should be considered, especially in patients with metastatic disease presenting with serious, spontaneous subcutaneous bleedings. A standardized diagnostic strategy is strongly needed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 22, 2020 Category: Hematology Authors: Winther-Larsen, Anne Sandfeld-Paulsen, Birgitte Hvas, Anne-Mette Tags: Review Article Source Type: research

New-Onset Atrial Fibrillation in Sepsis: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0040-1714400Atrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF includ...
Source: Seminars in Thrombosis and Hemostasis - September 22, 2020 Category: Hematology Authors: Aibar, Jesus Schulman, Sam Tags: Review Article Source Type: research

Periodontal Disease and Venous Thromboembolism
Semin Thromb Hemost DOI: 10.1055/s-0040-1714399 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 22, 2020 Category: Hematology Authors: Lippi, Giuseppe Nocini, Riccardo Favaloro, Emmanuel J. Tags: Letter to the Editor Source Type: research

Viscoelastic Tests as Point-of-Care Tests in the Assessment and Management of Bleeding and Thrombosis in Liver Disease
Semin Thromb Hemost 2020; 46: 704-715 DOI: 10.1055/s-0040-1715475Viscoelastic point-of-care (VET POC) tests provide a global assessment of hemostasis and have an increasing role in the management of bleeding and blood component delivery across several clinical settings. VET POC tests have a rapid turnaround time, provide a better overall picture of hemostasis, predict bleeding more accurately than conventional coagulation tests, and reduce blood component usage and health care costs. Despite commonly having abnormal conventional coagulation tests, most patients with chronic liver disease have a “rebalanced” hem...
Source: Seminars in Thrombosis and Hemostasis - September 14, 2020 Category: Hematology Authors: Janko, Natasha Majeed, Ammar Kemp, William Roberts, Stuart K. Tags: Review Article Source Type: research

Bleeding and Thrombosis in Patients with Liver Diseases
Semin Thromb Hemost 2020; 46: 653-655 DOI: 10.1055/s-0040-1715453 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 14, 2020 Category: Hematology Authors: Lisman, Ton Intagliata, Nicolas M. Tags: Preface Source Type: research

Hemostasis and Liver Regeneration
Semin Thromb Hemost 2020; 46: 735-742 DOI: 10.1055/s-0040-1715450The liver is unique in its remarkable regenerative capacity, which enables the use of liver resection as a treatment for specific liver diseases, including removal of neoplastic liver disease. After resection, the remaining liver tissue (i.e, liver remnant) regenerates to maintain normal hepatic function. In experimental settings as well as patients, removal of up to two-thirds of the liver mass stimulates a rapid and highly coordinated process resulting in the regeneration of the remaining liver. Mechanisms controlling the initiation and termination of regen...
Source: Seminars in Thrombosis and Hemostasis - September 8, 2020 Category: Hematology Authors: Starlinger, Patrick Luyendyk, James P. Groeneveld, Dafna J. Tags: Review Article Source Type: research

Netting Liver Disease: Neutrophil Extracellular Traps in the Initiation and Exacerbation of Liver Pathology
Semin Thromb Hemost 2020; 46: 724-734 DOI: 10.1055/s-0040-1715474The liver plays a vital role in the immune system. Its unique position in the portal circulation and the architecture of the hepatic sinusoids, in combination with the wide-ranged population of immunocompetent cells, make the liver function as an immune filter. To aid in pathogen clearance, once challenged, the liver initiates the rapid recruitment of a wide variety of inflammatory cells, including neutrophils. These neutrophils, in conjunction with platelets, facilitate the release of neutrophil extracellular traps (NETs), which are web-like structures of de...
Source: Seminars in Thrombosis and Hemostasis - September 8, 2020 Category: Hematology Authors: Meijenfeldt, Fien A. von Jenne, Craig N. Tags: Review Article Source Type: research

Catheter-Directed Thrombolysis in a Patient with Severe COVID-19 Pneumonia on Extracorporeal Membrane Oxygenation
Semin Thromb Hemost DOI: 10.1055/s-0040-1715457 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 3, 2020 Category: Hematology Authors: Padley, Guy J. Desai, Shivani S. Weaver, Chrissy Price, Laura C. Arachchillage, Deepa J. Ridge, Carole A. Tags: Letter to the Editor Source Type: research

Coronavirus (COVID-19), Coagulation, and Exercise: Interactions That May Influence Health Outcomes
Semin Thromb Hemost DOI: 10.1055/s-0040-1715094The proinflammatory cytokine storm associated with coronavirus disease 2019 (COVID-19) negatively affects the hematological system, leading to coagulation activation and endothelial dysfunction and thereby increasing the risk of venous and arterial thrombosis. Coagulopathy has been reported as associated with mortality in people with COVID-19 and is partially reflected by enhanced D-dimer levels. Poor vascular health, which is associated with the cardiometabolic health conditions frequently reported in people with severer forms of COVID-19, might exacerbate the risk of coagulo...
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Zadow, Emma Kate Wundersitz, Daniel William Taylor Hughes, Diane Louise Adams, Murray John Kingsley, Michael Ian Charles Blacklock, Hilary Anne Wu, Sam Shi Xuan Benson, Amanda Clare Dutheil, Fr édéric Gordon, Brett Ashley Tags: Review Article Source Type: research

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies
Semin Thromb Hemost DOI: 10.1055/s-0040-1715456Coronavirus disease 2019 (COVID-19) may have a wide spectrum of clinical presentations, leading in some cases to a critical condition with poor long-term outcomes and residual disability requiring post-acute rehabilitation. A major concern in severe COVID-19 is represented by a concomitant prothrombotic state. However, contrasting data are available about the prevalence of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE). A detailed search on the association of COVID-19 with thromboembolic complications was conducted in the main...
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Di Minno, Alessandro Ambrosino, Pasquale Calcaterra, Ilenia Di Minno, Matteo Nicola Dario Tags: Review Article Source Type: research

Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)
Semin Thromb Hemost DOI: 10.1055/s-0040-1715454 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Henry, Brandon Michael Benoit, Stefanie W. Hoehn, Jonathan Lippi, Giuseppe Favaloro, Emmanuel J. Benoit, Justin L. Tags: Letter to the Editor Source Type: research

Pulmonary Megakaryocytes in Coronavirus Disease 2019 (COVID-19): Roles in Thrombi and Fibrosis
Semin Thromb Hemost DOI: 10.1055/s-0040-1714274 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Thachil, Jecko Lisman, Ton Tags: Commentary Source Type: research

Perspectives on Platelet Heterogeneity and Host Immune Response in Coronavirus Disease 2019 (COVID-19)
Semin Thromb Hemost DOI: 10.1055/s-0040-1715093 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Parra-Izquierdo, Iv án Aslan, Joseph E. Tags: Commentary Source Type: research

Does Chronic Treatment with Oral Anticoagulants Ameliorate the Clinical Course of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Coronavirus Disease 2019 (COVID-19)?
Semin Thromb Hemost DOI: 10.1055/s-0040-1715091 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Harenberg, Job Bauersachs, Rupert Ageno, Walter Tags: Commentary Source Type: research

COVID-19 and Sex-/Gender-Specific Differences: Understanding the Discrimination
Semin Thromb Hemost DOI: 10.1055/s-0040-1715455 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 2, 2020 Category: Hematology Authors: Amgalan, Ariunzaya Malinowski, Ann Kinga Othman, Maha Tags: Commentary Source Type: research

Hematology Laboratory Abnormalities in Patients with Coronavirus Disease 2019 (COVID-19)
Semin Thromb Hemost DOI: 10.1055/s-0040-1715458Over the past few months, Coronavirus Disease 2019 (COVID-19) has spread across much of the world leading to a pandemic. Many infected individuals do not experience signs or symptoms, or experience only mild symptoms, whilst a subset experience severe disease, which is often fatal. A number of laboratory tests have been found to be abnormal in hospitalized patients, and some studies suggest some of these tests can predict an unfavorable outcome. These include markers of acute phase reaction (elevated C-reactive protein, erythrocyte sedimentation rate, white blood cell count, f...
Source: Seminars in Thrombosis and Hemostasis - September 1, 2020 Category: Hematology Authors: Christensen, Bianca Favaloro, Emmanuel J. Lippi, Giuseppe Van Cott, Elizabeth M. Tags: Review Article Source Type: research

Atypical Spontaneous Hematomas in a Patient with Severe Coronavirus Disease 2019 (COVID-19)
Semin Thromb Hemost DOI: 10.1055/s-0040-1715092 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 1, 2020 Category: Hematology Authors: Mattioli, Massimo Benfaremo, Devis Fustini, Elisa Gennarini, Silvia Tags: Letter to the Editor Source Type: research

Immune-Mediated Coagulopathy in COVID-19 Infection
Semin Thromb Hemost DOI: 10.1055/s-0040-1714272 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - September 1, 2020 Category: Hematology Authors: Vadasz, Zahava Brenner, Benjamin Toubi, Elias Tags: Commentary Source Type: research

The Spectrum of Disease Severity in Cirrhosis and Its Implications for Hemostasis
Semin Thromb Hemost DOI: 10.1055/s-0040-1715449Bleeding and thrombosis are both common complications that patients with advanced liver disease experience. While hemostatic pathways remain largely intact with cirrhosis, this balance can quickly shift in the direction of bleeding or clotting in an unpredictable manner. A growing body of literature is attempting to shed light on difficult scenarios that clinicians often face, ranging from predicting and mitigating bleeding risk in those who need invasive procedures to determining the best strategies to manage both bleeding and thrombotic complications when they occur. Studies...
Source: Seminars in Thrombosis and Hemostasis - August 19, 2020 Category: Hematology Authors: Stotts, Matthew J. Lisman, Ton Intagliata, Nicolas M. Tags: Review Article Source Type: research

New Insights into the Pathogenesis, Risk Factors, and Treatment of Portal Vein Thrombosis in Patients with Cirrhosis
Semin Thromb Hemost DOI: 10.1055/s-0040-1715473Portal vein thrombosis (PVT) is a frequent event in patients with cirrhosis regardless of etiology. Notwithstanding the commonality of the problem, the pathophysiology and risk factors for PVT in cirrhosis are largely unknown. The clinical impact of PVT in the natural history of cirrhosis is unclear, indications for PVT treatment are not well defined, and treatment recommendations are based on experts' opinion and consensus only. Therefore, this review aims to summarize current knowledge of mechanisms and risk factors for PVT development and assess the current evidence of PVT ...
Source: Seminars in Thrombosis and Hemostasis - August 19, 2020 Category: Hematology Authors: Nicoar ă-Farcău, Oana Soy, Guillem Magaz, Marta Baiges, Anna Turon, Fanny Garcia-Criado, Angeles Barrufet, Marta Burrel, Marta Hern ández-Gea, Virginia Garc ía-Pagán, Juan Carlos Tags: Review Article Source Type: research

Thrombin Generation and Cirrhosis: State of the Art and Perspectives
Semin Thromb Hemost DOI: 10.1055/s-0040-1715102Epidemiological and laboratory studies performed in the last decades have changed our understanding of coagulopathy in cirrhosis, from a condition at increased risk of hemorrhagic events to one at higher thrombotic risk. However, it is not clear whether the decrease in factors that promote (except factor [F] VIII) versus inhibit coagulation in patients with cirrhosis results in a rebalanced state or in a hypercoagulable phenotype. This issue can be partially addressed using thrombin generation assays (TGA), which unlike routine clotting tests (prothrombin time or activated par...
Source: Seminars in Thrombosis and Hemostasis - August 19, 2020 Category: Hematology Authors: Lebreton, Aur élien Sinegre, Thomas Lecompte, Thomas Talon, Laurie Abergel, Armand Lisman, Ton Tags: Review Article Source Type: research

Thrombopoietin Receptor Agonists in Patients with Chronic Liver Disease
Semin Thromb Hemost DOI: 10.1055/s-0040-1715451Thrombocytopenia is one of the most common hematologic complications in cirrhosis. Despite limited data linking platelet count and bleeding risk in patients with cirrhosis, the use of platelets transfusions for invasive procedures has been a common practice. Recently, thrombopoietin (TPO) receptor agonists have been approved for use in patients with chronic liver disease (CLD) undergoing invasive procedures. The aim of this study was to review current literature on bleeding risk in patients with cirrhosis and the use of platelet transfusions and TPO receptor agonists in the co...
Source: Seminars in Thrombosis and Hemostasis - August 19, 2020 Category: Hematology Authors: Khemichian, Saro Terrault, Norah A. Tags: Review Article Source Type: research

Pharmacotherapy for Prevention and Management of Thrombosis in COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1714273 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - August 19, 2020 Category: Hematology Authors: Hashemi, Ashkan Madhavan, Mahesh V. Bikdeli, Behnood Tags: Commentary Source Type: research

Thrombosis and Hemostasis Issues in Cancer Patients with COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1714275 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - August 11, 2020 Category: Hematology Authors: Horowitz, Netanel A. Brenner, Benjamin Tags: Commentary Source Type: research

Incidence of Bleeding and Thrombosis in Patients with Liver Disease
Semin Thromb Hemost DOI: 10.1055/s-0040-1714205Historically, liver disease has been associated with a bleeding tendency. Global hemostatic assays have demonstrated that hemostasis is overall rebalanced, in both acute liver failure and chronic liver disease. It is now recognized that many bleeding events in chronic liver disease are mediated by portal hypertension rather than an underlying hemostatic defect. This is acknowledged in recent guidelines, which recommend against coagulation testing prior to low risk procedures in this patient group, with avoidance also of attempts at correction of prolonged coagulation times. Ov...
Source: Seminars in Thrombosis and Hemostasis - August 4, 2020 Category: Hematology Authors: Roberts, Lara N. Bernal, William Tags: Review Article Source Type: research

Shortcomings in Design and Analysis of Clinical Studies on Bleeding and Thrombosis in Patients with Cirrhosis
Semin Thromb Hemost DOI: 10.1055/s-0040-1714203Significant gains have been made in our understanding of bleeding and thrombosis in patients with liver disease in recent years, with concurrent exponential growth in the scientific literature published in this realm. Clinical studies of this population are challenging for multiple reasons including some hurdles unique to this population. Cirrhosis patients as a whole, especially those with decompensated cirrhosis, are a high-risk and heterogeneous population prone to serious adverse events. Outcomes of bleeding and thrombosis are relatively rare and lack standardized, validat...
Source: Seminars in Thrombosis and Hemostasis - August 4, 2020 Category: Hematology Authors: Northup, Patrick Davis, Jessica Tags: Review Article Source Type: research

Anticoagulant Management and Synthesis of Hemostatic Proteins during Machine Preservation of Livers for Transplantation
Semin Thromb Hemost DOI: 10.1055/s-0040-1715452Liver transplantation remains the only curative treatment for patients with end-stage liver disease. Despite a steadily increasing demand for suitable donor livers, the current pool of donor organs fails to meet this demand. To resolve this discrepancy, livers traditionally considered to be of suboptimal quality and function are increasingly utilized. These marginal livers, however, are less tolerant to the current standard cold preservation of donor organs. Therefore, alternative preservation methods have been sought and are progressively applied into clinical practice. Ex si...
Source: Seminars in Thrombosis and Hemostasis - August 4, 2020 Category: Hematology Authors: Karangwa, Shanice A. Lisman, Ton Porte, Robert J. Tags: Review Article Source Type: research

Blood Markers of Portal Hypertension Are Associated with Blood Loss and Transfusion Requirements during Orthotopic Liver Transplantation
Semin Thromb Hemost DOI: 10.1055/s-0040-1714202There is increasing evidence that portal hypertension plays a major role in bleeding risk during orthotopic liver transplantation (OLT). We investigated the association between preoperative blood levels of von Willebrand factor (VWF) and soluble CD163 (sCD163), which are established markers of portal hypertension, and blood loss and transfusion requirements during OLT. We measured levels of VWF and sCD163 in preoperative serum samples of 168 adult patients undergoing a primary OLT between 1998 and 2012. Preoperative levels of VWF and sCD163 correlated with the model of end-sta...
Source: Seminars in Thrombosis and Hemostasis - August 4, 2020 Category: Hematology Authors: Arshad, Freeha Lisman, Ton Porte, Robert J. Tags: Review Article Source Type: research

Reversal Agents for the Direct Factor Xa Inhibitors: Biochemical Mechanisms of Current and Newly Emerging Therapies
Semin Thromb Hemost DOI: 10.1055/s-0040-1709134The direct oral anticoagulants targeting coagulation factor Xa or thrombin are widely used as alternatives to vitamin K antagonists in the management of venous thromboembolism and nonvalvular atrial fibrillation. In case of bleeding or emergency surgery, reversal agents are helpful to counteract the anticoagulant therapy and restore hemostasis. While idarucizumab has been established as an antidote for the direct thrombin inhibitor dabigatran, reversal strategies for the direct factor Xa inhibitors have been a focal point in clinical care over the past years. In the absence of...
Source: Seminars in Thrombosis and Hemostasis - July 19, 2020 Category: Hematology Authors: Schreuder, Mark Reitsma, Pieter H. Bos, Mettine H. A. Tags: Review Article Source Type: research

Disturbances of Hemostasis with Vestibulo-Atactic Complications of Chronic Cerebral Ischemia
Semin Thromb Hemost DOI: 10.1055/s-0040-1709133 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - July 19, 2020 Category: Hematology Authors: Udut, Vladimir Vasilyevich Udut, Elena Vladimirovna Kingma, Herman Demkin, Vladimir Petrovich Kotlovskaya, Larisa Yurjevna Tags: Letter to the Editor Source Type: research

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems
Semin Thromb Hemost 2020; 46: 622-636 DOI: 10.1055/s-0040-1710340The manipulation of blood within in vitro environments presents a persistent challenge, due to the highly reactive nature of blood, and its multifaceted response to material contact, changes in environmental conditions, and stimulation during handling. Microfluidic Lab-on-Chip systems offer the promise of robust point-of-care diagnostic tools and sophisticated research platforms. The capacity for precise control of environmental and experimental conditions afforded by microfluidic technologies presents unique opportunities that are particularly relevant to re...
Source: Seminars in Thrombosis and Hemostasis - June 29, 2020 Category: Hematology Authors: Szydzik, Crispin Brazilek, Rose J. Nesbitt, Warwick S. Tags: Review Article Source Type: research

Recent Advances in the Molecular Imaging of Atherosclerosis
Semin Thromb Hemost 2020; 46: 563-586 DOI: 10.1055/s-0039-1701019Atherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a vast number of factors, both environmental and pathophysiological. This wealth of factors has elicited much research into molecular imaging, with purely diagnostic purposes or with the hope of engineering an efficient theranostic tool. To these ...
Source: Seminars in Thrombosis and Hemostasis - June 29, 2020 Category: Hematology Authors: Larivi ère, Mélusine Bonnet, Samuel Lorenzato, Cyril Laroche-Traineau, Jeanny Otton ès, Florence Jacobin-Valat, Marie-Jos ée Clofent-Sanchez, Gis èle Tags: Review Article Source Type: research

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis
Semin Thromb Hemost 2020; 46: 553-562 DOI: 10.1055/s-0039-3400247Atherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will fir...
Source: Seminars in Thrombosis and Hemostasis - June 29, 2020 Category: Hematology Authors: Talev, Joshua Kanwar, Jagat Rakesh Tags: Review Article Source Type: research

Nanomedicine in Thrombosis and Hemostasis: The Future of Nanotechnology in Thrombosis and Hemostasis Research and Clinical Applications
Semin Thromb Hemost 2020; 46: 521-523 DOI: 10.1055/s-0040-1713680 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 29, 2020 Category: Hematology Authors: Hagemeyer, Christoph E. Lisman, Ton Kwaan, Hau C. Tags: Preface Source Type: research

Patients with Congenital Bleeding Disorders Appear to be Less Severely Affected by SARS-CoV-2: Is Inherited Hypocoagulability Overcoming Acquired Hypercoagulability of Coronavirus Disease 2019 (COVID-19)?
Semin Thromb Hemost DOI: 10.1055/s-0040-1713435 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 17, 2020 Category: Hematology Authors: Dorgalaleh, Akbar Dabbagh, Ali Tabibian, Shadi Baghaeipour, Mohammad Reza Jazebi, Mohammad Bahraini, Mehran Fazeli, Sahar Rad, Fariba Baghaeipour, Nazanin Tags: Letter to the Editor Source Type: research

Passive Immunity for Coronavirus Disease 2019: A Commentary on Therapeutic Aspects Including Convalescent Plasma
Semin Thromb Hemost DOI: 10.1055/s-0040-1712157In the ongoing pandemic of coronavirus disease 2019 (COVID-19), the novel virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is infecting a naïve population. The innate immunity of the infected patient is unable to mount an effective defense, resulting in a severe illness with substantial morbidity and mortality. As most treatment modalities including antivirals and anti-inflammatory agents are mostly ineffective, an immunological approach is needed. The mechanism of innate immunity to this viral illness is not fully understood. Passive immunity becomes an...
Source: Seminars in Thrombosis and Hemostasis - June 10, 2020 Category: Hematology Authors: Lindholm, Paul F. Ramsey, Glenn Kwaan, Hau C. Tags: Review Article Source Type: research

Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection
Semin Thromb Hemost DOI: 10.1055/s-0040-1712960 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 10, 2020 Category: Hematology Authors: de Maat, Steven de Mast, Quirijn Danser, A.H. Jan van de Veerdonk, Frank L. Maas, Coen Tags: Commentary Source Type: research

Editorial Compilation VIII
Semin Thromb Hemost 2020; 46: 393-397 DOI: 10.1055/s-0040-1709476 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 10, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

2020 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost 2020; 46: 383-392 DOI: 10.1055/s-0040-1712971 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 10, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Coronavirus Disease 2019 Coagulopathy: Disseminated Intravascular Coagulation and Thrombotic Microangiopathy —Either, Neither, or Both
Semin Thromb Hemost DOI: 10.1055/s-0040-1712156 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 7, 2020 Category: Hematology Authors: Levi, Marcel Thachil, Jecko Tags: Commentary Source Type: research

Challenges in the Production of Convalescent Hyperimmune Plasma in the Age of COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1713433 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 7, 2020 Category: Hematology Authors: Franchini, Massimo Del Fante, Claudia Klersy, Catherine Glingani, Claudia Percivalle, Elena Baldanti, Fausto Perotti, Cesare Tags: Commentary Source Type: research

Bleeding and Bleeding Risk in COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1713434 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 7, 2020 Category: Hematology Authors: Dorgalaleh, Akbar Tags: Commentary Source Type: research

Confronting COVID-19: Issues in Hemophilia and Congenital Bleeding Disorders
Semin Thromb Hemost DOI: 10.1055/s-0040-1712961 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 7, 2020 Category: Hematology Authors: Coppola, Antonio Tagliaferri, Annarita Rivolta, Gianna Franca Quintavalle, Gabriele Franchini, Massimo Tags: Commentary Source Type: research

Erratum: Thromboelastometry Variables in Neonates with Perinatal Hypoxia
Semin Thromb Hemost DOI: 10.1055/s-0040-1713395 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 2, 2020 Category: Hematology Authors: Konstantinidi, Aikaterini Sokou, Rozeta Tsantes, Andreas G. Parastatidou, Stavroula Bonovas, Stefanos Kouskouni, Evaggelia Gounaris, Antonios K. Tsantes, Argyrios E. Iacovidou, Nicoletta Tags: Erratum Source Type: research