A Review of Design Considerations for Hemocompatibility within Microfluidic Systems
Semin Thromb Hemost 2020; 46: 622-636 DOI: 10.1055/s-0040-1710340The manipulation of blood within in vitro environments presents a persistent challenge, due to the highly reactive nature of blood, and its multifaceted response to material contact, changes in environmental conditions, and stimulation during handling. Microfluidic Lab-on-Chip systems offer the promise of robust point-of-care diagnostic tools and sophisticated research platforms. The capacity for precise control of environmental and experimental conditions afforded by microfluidic technologies presents unique opportunities that are particularly relevant to re...
Source: Seminars in Thrombosis and Hemostasis - June 30, 2020 Category: Hematology Authors: Szydzik, Crispin Brazilek, Rose J. Nesbitt, Warwick S. Tags: Review Article Source Type: research

Recent Advances in the Molecular Imaging of Atherosclerosis
Semin Thromb Hemost 2020; 46: 563-586 DOI: 10.1055/s-0039-1701019Atherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a vast number of factors, both environmental and pathophysiological. This wealth of factors has elicited much research into molecular imaging, with purely diagnostic purposes or with the hope of engineering an efficient theranostic tool. To these ...
Source: Seminars in Thrombosis and Hemostasis - June 30, 2020 Category: Hematology Authors: Larivi ère, Mélusine Bonnet, Samuel Lorenzato, Cyril Laroche-Traineau, Jeanny Otton ès, Florence Jacobin-Valat, Marie-Jos ée Clofent-Sanchez, Gis èle Tags: Review Article Source Type: research

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis
Semin Thromb Hemost 2020; 46: 553-562 DOI: 10.1055/s-0039-3400247Atherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will fir...
Source: Seminars in Thrombosis and Hemostasis - June 30, 2020 Category: Hematology Authors: Talev, Joshua Kanwar, Jagat Rakesh Tags: Review Article Source Type: research

Nanomedicine in Thrombosis and Hemostasis: The Future of Nanotechnology in Thrombosis and Hemostasis Research and Clinical Applications
Semin Thromb Hemost 2020; 46: 521-523 DOI: 10.1055/s-0040-1713680 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 30, 2020 Category: Hematology Authors: Hagemeyer, Christoph E. Lisman, Ton Kwaan, Hau C. Tags: Preface Source Type: research

Patients with Congenital Bleeding Disorders Appear to be Less Severely Affected by SARS-CoV-2: Is Inherited Hypocoagulability Overcoming Acquired Hypercoagulability of Coronavirus Disease 2019 (COVID-19)?
Semin Thromb Hemost DOI: 10.1055/s-0040-1713435 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 18, 2020 Category: Hematology Authors: Dorgalaleh, Akbar Dabbagh, Ali Tabibian, Shadi Baghaeipour, Mohammad Reza Jazebi, Mohammad Bahraini, Mehran Fazeli, Sahar Rad, Fariba Baghaeipour, Nazanin Tags: Letter to the Editor Source Type: research

Passive Immunity for Coronavirus Disease 2019: A Commentary on Therapeutic Aspects Including Convalescent Plasma
Semin Thromb Hemost DOI: 10.1055/s-0040-1712157In the ongoing pandemic of coronavirus disease 2019 (COVID-19), the novel virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is infecting a naïve population. The innate immunity of the infected patient is unable to mount an effective defense, resulting in a severe illness with substantial morbidity and mortality. As most treatment modalities including antivirals and anti-inflammatory agents are mostly ineffective, an immunological approach is needed. The mechanism of innate immunity to this viral illness is not fully understood. Passive immunity becomes an...
Source: Seminars in Thrombosis and Hemostasis - June 11, 2020 Category: Hematology Authors: Lindholm, Paul F. Ramsey, Glenn Kwaan, Hau C. Tags: Review Article Source Type: research

Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection
Semin Thromb Hemost DOI: 10.1055/s-0040-1712960 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 11, 2020 Category: Hematology Authors: de Maat, Steven de Mast, Quirijn Danser, A.H. Jan van de Veerdonk, Frank L. Maas, Coen Tags: Commentary Source Type: research

Editorial Compilation VIII
Semin Thromb Hemost 2020; 46: 393-397 DOI: 10.1055/s-0040-1709476 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 11, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

2020 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost 2020; 46: 383-392 DOI: 10.1055/s-0040-1712971 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 11, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Coronavirus Disease 2019 Coagulopathy: Disseminated Intravascular Coagulation and Thrombotic Microangiopathy —Either, Neither, or Both
Semin Thromb Hemost DOI: 10.1055/s-0040-1712156 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 8, 2020 Category: Hematology Authors: Levi, Marcel Thachil, Jecko Tags: Commentary Source Type: research

Challenges in the Production of Convalescent Hyperimmune Plasma in the Age of COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1713433 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 8, 2020 Category: Hematology Authors: Franchini, Massimo Del Fante, Claudia Klersy, Catherine Glingani, Claudia Percivalle, Elena Baldanti, Fausto Perotti, Cesare Tags: Commentary Source Type: research

Bleeding and Bleeding Risk in COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0040-1713434 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 8, 2020 Category: Hematology Authors: Dorgalaleh, Akbar Tags: Commentary Source Type: research

Confronting COVID-19: Issues in Hemophilia and Congenital Bleeding Disorders
Semin Thromb Hemost DOI: 10.1055/s-0040-1712961 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 8, 2020 Category: Hematology Authors: Coppola, Antonio Tagliaferri, Annarita Rivolta, Gianna Franca Quintavalle, Gabriele Franchini, Massimo Tags: Commentary Source Type: research

Erratum: Thromboelastometry Variables in Neonates with Perinatal Hypoxia
Semin Thromb Hemost DOI: 10.1055/s-0040-1713395 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 3, 2020 Category: Hematology Authors: Konstantinidi, Aikaterini Sokou, Rozeta Tsantes, Andreas G. Parastatidou, Stavroula Bonovas, Stefanos Kouskouni, Evaggelia Gounaris, Antonios K. Tsantes, Argyrios E. Iacovidou, Nicoletta Tags: Erratum Source Type: research

Thromboelastometry Variables in Neonates with Perinatal Hypoxia
Semin Thromb Hemost DOI: 10.1055/s-0040-1709473Perinatal hypoxia is associated with an increased risk of coagulation disorders by enhancing the consumption of platelets and some clotting factors due to the associated severe hypoxemia, acidemia, and compromised oxygen and blood supply to the neonatal liver and bone marrow. Thromboelastometry (TEM), which estimates the dynamics of blood coagulation, may represent an attractive tool for studying the coagulation status of these neonates. We aimed at assessing the hemostatic profile of neonates with perinatal hypoxia using the standard extrinsically activated TEM (ex-TEM) assay...
Source: Seminars in Thrombosis and Hemostasis - May 21, 2020 Category: Hematology Authors: Konstantinidi, Aikaterini Sokou, Rozeta Tsantes, Andreas G. Parastatidou, Stavroula Bonovas, Stefanos Kouskouni, Evaggelia Gounaris, Antonios K. Tsantes, Argyrios E. Lacovidou, Nicoletta Tags: Review Article Source Type: research

The Central Role of Acute Phase Proteins in Rheumatoid Arthritis: Involvement in Disease Autoimmunity, Inflammatory Responses, and the Heightened Risk of Cardiovascular Disease
Semin Thromb Hemost DOI: 10.1055/s-0040-1709475Rheumatoid arthritis (RA) is an autoimmune disease of complex etiopathogenic origin and traditionally characterized by chronic synovitis and articular erosions. Furthermore, there is strong evidence that infectious agents, including those that become dormant within the host, play a major role in much of the etiology of RA and its hallmark of inflammation. A combination of genetic predisposition, environmental exposure, and presence of infectious agents may therefore lead to a loss of immune tolerance to citrullinated proteins, which present as self-antigens to the human immune...
Source: Seminars in Thrombosis and Hemostasis - May 21, 2020 Category: Hematology Authors: Bezuidenhout, Johannes A. Pretorius, Etheresia Tags: Review Article Source Type: research

Effect of Multiple Freeze –Thaw Cycles on Coagulation Testing
Semin Thromb Hemost DOI: 10.1055/s-0040-1709474 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 21, 2020 Category: Hematology Authors: Gosselin, Robert C. Honeychurch, Kaitlyn Kang, Hyun Ji Dwyre, Denis M. Tags: Letter to the Editor Source Type: research

SARS-2 Coronavirus –Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism?
Semin Thromb Hemost DOI: 10.1055/s-0040-1712155 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 12, 2020 Category: Hematology Authors: Thachil, Jecko Srivastava, Alok Tags: Commentary Source Type: research

Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism
Semin Thromb Hemost DOI: 10.1055/s-0040-1710337 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 11, 2020 Category: Hematology Authors: Schulman, Sam Tags: Commentary Source Type: research

Coronavirus Disease 2019: The Role of the Fibrinolytic System from Transmission to Organ Injury and Sequelae
Semin Thromb Hemost DOI: 10.1055/s-0040-1709996 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 9, 2020 Category: Hematology Authors: Kwaan, Hau C. Tags: Commentary Source Type: research

Platelets in Coronavirus Disease 2019
Semin Thromb Hemost DOI: 10.1055/s-0040-1710006 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 30, 2020 Category: Hematology Authors: Larsen, Julie Brogaard Pasalic, Leonardo Hvas, Anne-Mette Tags: Commentary Source Type: research

Acquired Platelet Dysfunction —Laboratory and Clinical Implications
Semin Thromb Hemost 2020; 46: 235-237 DOI: 10.1055/s-0040-1708826 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 21, 2020 Category: Hematology Authors: Hvas, Anne-Mette Larsen, Julie B. Pasalic, Leonardo Tags: Preface Source Type: research

A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection
Semin Thromb Hemost DOI: 10.1055/s-0040-1708827Thrombocytopenia is commonly associated with sepsis and infections, which in turn are characterized by a profound immune reaction to the invading pathogen. Platelets are one of the cellular entities that exert considerable immune, antibacterial, and antiviral actions, and are therefore active participants in the host response. Platelets are sensitive to surrounding inflammatory stimuli and contribute to the immune response by multiple mechanisms, including endowing the endothelium with a proinflammatory phenotype, enhancing and amplifying leukocyte recruitment and inflammation...
Source: Seminars in Thrombosis and Hemostasis - April 12, 2020 Category: Hematology Authors: Page, Martin J. Pretorius, Etheresia Tags: Review Article Source Type: research

Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring
Semin Thromb Hemost DOI: 10.1055/s-0040-1709498 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 12, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Commentary Source Type: research

Platelets in Advanced Chronic Kidney Disease: Two Sides of the Coin
Semin Thromb Hemost DOI: 10.1055/s-0040-1708841Rates of thrombosis and bleeding episodes are both increased in patients with advanced chronic kidney disease (CKD). The pathogenic mechanisms of thrombosis in these patients include platelet activation, increased formation of platelet-leukocyte conjugates, and platelet-derived microparticles, as well as effects of uremic toxins on platelets. On the other side of the coin, platelet hyporeactivity mediated by uremic toxins and anemia contributes to the increased bleeding risk in advanced CKD. Platelets also contribute to the inflammatory environment, thus increasing the risk of...
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Lutz, Prof. Dr. med. Jens Jurk, PD Dr. rer. nat. Kerstin Tags: Review Article Source Type: research

Thrombocytopenia in Pregnancy: Approach to Diagnosis and Management
Semin Thromb Hemost DOI: 10.1055/s-0040-1708842The impact of thrombocytopenia varies widely depending on the underlying pathophysiology driving it. The biggest challenge in managing thrombocytopenia in pregnancy is accurately identifying the responsible pathophysiology—a task made difficult given the tremendous overlap in clinical and laboratory abnormalities associated with different thrombocytopenia processes. The most common etiologies of thrombocytopenia in pregnancy range from physiology deemed benign to those that are life-threatening to the mother and fetus. Even in cases in which the responsible etiology is d...
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Fogerty, Annemarie E. Tags: Review Article Source Type: research

Thrombocytopenia in Surgery and Neuraxial Anesthesia
Semin Thromb Hemost DOI: 10.1055/s-0040-1702918This is a review of the evidence for the use of different platelet count thresholds prior to invasive procedures and surgery. This review will focus on three procedures that are common in patients with thrombocytopenia—central venous catheter insertion, liver biopsy, and lumbar punctures and epidural catheters—as well as highlighting the lack of evidence for more major surgery. Tunneled or untunneled central venous catheters are low-risk procedures and can be safely performed without any intervention when the platelet count is 20 × 109/L or abov...
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Estcourt, Lise J. Tags: Review Article Source Type: research

Immune-Mediated Thrombotic Thrombocytopenic Purpura: A Narrative Review of Diagnosis and Treatment in Adults
Semin Thromb Hemost DOI: 10.1055/s-0040-1708541Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially lethal disease characterized by fragmentary hemolysis, moderate-to-severe thrombocytopenia, end-organ dysfunction, and severely reduced ADAMTS13 levels (
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Blennerhassett, Richard Curnow, Jennifer Pasalic, Leonardo Tags: Review Article Source Type: research

Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation
Semin Thromb Hemost DOI: 10.1055/s-0040-1708542Extracorporeal membrane oxygenation (ECMO) is a form of life support used to treat neonates, children, and adults with cardiorespiratory failure refractory to conventional therapy. This therapy requires the use of anticoagulation to prevent clotting in the extracorporeal circuit, but anticoagulation also increases the risk of bleeding on ECMO. Both bleeding and thrombosis remain significant complications on ECMO and balancing these risks is challenging. Acquired platelet dysfunction is common during ECMO and quantitative and qualitative platelet dysfunction contributes to blee...
Source: Seminars in Thrombosis and Hemostasis - March 31, 2020 Category: Hematology Authors: Cashen, Katherine Meert, Kathleen Dalton, Heidi J. Tags: Review Article Source Type: research

Whole Blood for Civilian Urban Trauma Resuscitation: Historical, Present, and Future Considerations
Semin Thromb Hemost 2020; 46: 221-234 DOI: 10.1055/s-0040-1702174Whole blood (WB) has been used for more than a century for far-forward combat resuscitation. Following the Iraq/Afghanistan combat, maritime, and austere environment use of WB for the resuscitation of severely hemorrhaging patients, there has been an increasing use of WB for the civilian urban resuscitation environment population. The impetus for this was not just improved outcomes in far-forward hospitals, which had different populations and different needs than the civilian urban population, but also an application of the lessons suggested by recent 1:1:1 p...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Walsh, Mark Fries, Dietmar Moore, Ernest Moore, Hunter Thomas, Scott Kwaan, Hau C. Marsee, Mathew K. Grisoli, Anne McCauley, Ross Vande Lune, Stefani Chitta, Swetha Vyakaranam, Sudhir Waxman, Dan McCurdy, Michael T. Zimmer, Donald Patel, Bhavesh Thachil, Tags: Review Article Source Type: research

Temporal Changes in Fibrinolysis following Injury
Semin Thromb Hemost 2020; 46: 189-198 DOI: 10.1055/s-0039-1701016Trauma patients present to the emergency department with a spectrum of fibrinolytic activity. This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the degree of hemorrhagic shock and the amount of tissue injury the individual sustains. The fibrinolytic activity of the trauma patient at presentation to the hospital has prognostic and therapeutic implications. Those patients with high fibrinolytic activity (hyperfibrinolysis) are at risk of mortality from hemorrhage, whereas those patients with low fibrinolytic activity (s...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Moore, Hunter B. Moore, Ernest E. Tags: Review Article Source Type: research

Influence of Tranexamic Acid on Inflammatory Signaling in Trauma
Semin Thromb Hemost 2020; 46: 183-188 DOI: 10.1055/s-0040-1702169Plasmin generation in trauma patients has wide-ranging effects, from breakdown of clots to remodeling the extracellular matrix. An evolving recognition of plasmin as a critical effector molecule in various inflammatory signals and pathways has rendered the study of plasmin(ogen) and its regulation by upstream activators and downstream targets and inhibitors key to understanding the inflammatory responses to trauma. Tranexamic acid, a widely available lysine analogue medication on the World Health Organization's list of essential medicines, has rapidly become ...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Barrett, Christopher D. Kong, Yi Wen Yaffe, Michael B. Tags: Review Article Source Type: research

Changes in Coagulation following Brain Injury
Semin Thromb Hemost 2020; 46: 155-166 DOI: 10.1055/s-0040-1702178Traumatic brain injury (TBI) is a worldwide public health concern due to increasing mortality, affecting around 10 million patients per year. A wide variety of clinical presentations are a function of the magnitude of injury and the anatomical perturbation of the brain parenchyma, supporting structures, and cerebral vasculature, with subsequent alteration of the blood–brain barrier. These disturbances correspond with the evolution of intracerebral hemorrhage and clinical outcomes. The associated hemostatic alterations associated with TBI are caused by t...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Maegele, Marc Aversa, John Marsee, Mathew K. McCauley, Ross Chitta, Swetha Hanuma Vyakaranam, Sudhir Walsh, Mark Tags: Review Article Source Type: research

Trauma-Induced Coagulopathy in Children
Semin Thromb Hemost 2020; 46: 147-154 DOI: 10.1055/s-0040-1702203Trauma-induced coagulopathy (TIC) is well documented in injured children. However, many important features of pediatric hemostasis are still in development in early childhood and may impact TIC. Certain pediatric subgroups are at a higher risk. Traumatic brain injury, which occurs with a higher rate in children, and physical child abuse are known risk factors for TIC that deserve special consideration. Resuscitation of a pediatric trauma patient follows many of the same goals as in the injured adult trauma, although some key aspects of pediatric resuscitation...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Lucisano, Amelia C. Leeper, Christine M. Gaines, Barbara A. Tags: Review Article Source Type: research

Diagnosis and Treatment of Trauma-Induced Coagulopathy by Viscoelastography
This article explores the application of viscoelastic tests (VETs) in trauma-induced coagulopathy and trauma resuscitation. We describe the advantages of VETs over conventional coagulation tests in the trauma setting and refer to previous disciplines in which VET use has reduced blood product utilization, guided prohemostatic agents, and improved clinical outcomes such as the mortality of critically bleeding patients. We describe different VETs and provide guidance for blood component therapy and prohemostatic therapy based on specific VET parameters. Because the two most commonly used VET systems, rotational thromboelasto...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Hartmann, Jan Walsh, Mark Grisoli, Anne Thomas, Anthony V. Shariff, Faisal McCauley, Ross Vande Lune, Stefani Zackariya, Nuha Patel, Shivani Farrell, Michael S. Sixta, Sherry March, Robert Evans, Edward Tracy, Rebecca Campello, Elena Sc ărlătescu, Ecate Tags: Review Article Source Type: research

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy
Semin Thromb Hemost 2020; 46: 125-133 DOI: 10.1055/s-0039-1701017Trauma induces a change in nearly every observable aspect of hemostasis, generally tipping the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical early stages. Two particularly important aspects of TIC are platelets and fibrinogen, which are the primary determinants of clot formation and hemostasis. Their loss and dysfunction represent important transition points between coagulopathy phenotypes, highlighting their mechanistic roles in TIC as well as unveiling new potential avenues toward important diagnostic and therapeutic interven...
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: John, Alexander E. White, Nathan J. Tags: Review Article Source Type: research

The Complexity of Trauma-Induced Coagulopathy
Semin Thromb Hemost 2020; 46: 114-115 DOI: 10.1055/s-0040-1702202 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Moore, Hunter B. Walsh, Mark Kwaan, Hau C. Medcalf, Robert L. Tags: Preface Source Type: research

2019 Eberhard F. Mammen Award Announcements: Part II —Young Investigator Awards
Semin Thromb Hemost 2020; 46: 105-113 DOI: 10.1055/s-0040-1702201 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 11, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Fibrinolysis and the Immune Response in Trauma
Semin Thromb Hemost DOI: 10.1055/s-0040-1702170It has long been known that the fibrinolytic system becomes activated following trauma. At first glance, this is not at all surprising and would appear to be in response to coagulation and the apparent need to remove blood clots and restore blood flow. However, in a bleeding patient, the opposite is what is actually needed. Therefore, one may ask why the fibrinolytic system gets activated in the first place or is there another purpose? Or is it that the waxing and waning of hemostasis in such severely injured patients creates a “moving target” such that the fibrino...
Source: Seminars in Thrombosis and Hemostasis - February 18, 2020 Category: Hematology Authors: Medcalf, Robert L. Keragala, Charithani B. Draxler, Dominik F. Tags: Review Article Source Type: research

Traumatic-Induced Coagulopathy as a Systems Failure: A New Window into Hemostasis
Semin Thromb Hemost DOI: 10.1055/s-0039-1701018Traumatic-induced coagulopathy (TIC) is often associated with significant bleeding, transfusion requirements, inflammation, morbidity, and mortality. This review considers TIC as a systems failure, not as a single-event manifestation of trauma. After briefly reviewing the meaning of TIC and the bewildering array of fibrinolysis phenotypes, we will discuss the role of platelets and fibrinogen in coagulopathy. Next, we will review the different TIC hypotheses and drill down to a single mechanistic domain comprising (1) thrombin's differential binding to thrombomodulin, (2) the e...
Source: Seminars in Thrombosis and Hemostasis - February 18, 2020 Category: Hematology Authors: Dobson, Geoffrey P. Morris, Jodie L. Davenport, Lisa M. Letson, Hayley L. Tags: Review Article Source Type: research

Perioperative Thrombosis and Hemostasis
Semin Thromb Hemost 2020; 46: 006-007 DOI: 10.1055/s-0039-1701015 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 4, 2020 Category: Hematology Authors: Hunt, Beverley J. Levy, Jerrold H. Tags: Preface Source Type: research

Welcome to Seminars in Thrombosis and Hemostasis 2020 —New (2018) Impact Factor and Most Highly Cited Papers
Semin Thromb Hemost 2020; 46: 001-005 DOI: 10.1055/s-0039-1701014 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 4, 2020 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Genetic Background of von Willebrand Disease: History, Current State, and Future Perspectives
Semin Thromb Hemost DOI: 10.1055/s-0039-3402430Sequencing of the gene encoding for von Willebrand factor (VWF) has brought new insight into the physiology of VWF as well as its pathophysiology in the context of von Willebrand disease (VWD). Molecular testing in VWD patients has shown high variability in the overall genetic background of this condition. Almost 600 mutations and many disease-causing mechanisms have been described in the 35 years since the VWF gene was identified. Genetic testing in VWD patients is now available in many centers as a part of the VWD diagnostic algorithm. Molecular mechanisms leading to types 2...
Source: Seminars in Thrombosis and Hemostasis - December 30, 2019 Category: Hematology Authors: Zolkova, Jana Sokol, Juraj Simurda, Tomas Vadelova, Lubica Snahnicanova, Zuzana Loderer, Dusan Dobrotova, Miroslava Ivankova, Jela Skornova, Ingrid Lasabova, Zora Kubisz, Peter Stasko, Jan Tags: Review Article Source Type: research

Extracellular Mitochondria in Traumatic Brain Injury Induced Coagulopathy
Semin Thromb Hemost DOI: 10.1055/s-0039-3402427Traumatic brain injury (TBI) induced coagulopathy remains a significant clinical challenge, with unmet needs for standardizing diagnosis and optimizing treatments. TBI-induced coagulopathy is closely associated with poor outcomes in affected patients. Recent studies have demonstrated that TBI induces coagulopathy, which is mechanistically distinct from the deficient and dilutional coagulopathy found in patients with injuries to the body/limbs and hemorrhagic shock. Multiple causal and disseminating factors have been identified to cause TBI-induced coagulopathy. Among these are...
Source: Seminars in Thrombosis and Hemostasis - December 30, 2019 Category: Hematology Authors: Zhao, Zilong Zhou, Yuan Li, Min Zhang, Jianning Dong, Jing-Fei Tags: Review Article Source Type: research

Managing Preoperative Hemostasis in Patients with Inherited and Acquired Bleeding Disorders
This article gives an overview of the bleeding risks involved and therapeutic options to overcome them. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - December 30, 2019 Category: Hematology Authors: Mensah, Patrick Kyei Pavord, Sue Tags: Review Article Source Type: research

The Role of Platelets in Cancer-Related Bleeding Risk: A Systematic Review
This study provides a systematic review of the available literature on associations between platelet count and/or function and bleeding in adult cancer patients. The review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. PubMed, Embase, and Web of Science were searched up to August 2019. The National Heart, Lung, and Blood Institute's tools were used for quality assessment. In total, 52 studies investigated associations between bleeding and platelet count (n = 40) or function (n = 12) in patients with hematological malignancy ...
Source: Seminars in Thrombosis and Hemostasis - December 30, 2019 Category: Hematology Authors: Larsen, Julie Brogaard Hojbjerg, Johanne Andersen Hvas, Anne-Mette Tags: Review Article Source Type: research

The Evolution of Blood Transfusion in the Trauma Patient: Whole Blood Has Come Full Circle
Semin Thromb Hemost DOI: 10.1055/s-0039-3402426Whole blood transfusion in the United States dates back to the Civil War, and it was widely used in all major conflicts since World War I. To understand our current civilian transfusion practices and to anticipate future changes in trauma resuscitation, it is important to understand the series of decisions that led trauma surgeons away from whole blood resuscitation and toward component therapy. In this review, we examine the historical basis for blood transfusion in trauma and examine the recent literature and future directions pertaining to blood product resuscitation in hem...
Source: Seminars in Thrombosis and Hemostasis - December 30, 2019 Category: Hematology Authors: Black, Jonathan A. Pierce, Virginia S. Kerby, Jeffrey D. Holcomb, John B. Tags: Review Article Source Type: research

Direct Oral Anticoagulants for Disseminated Intravascular Coagulation: An Alliterative Wordplay or Potentially Valuable Therapeutic Interventions?
Semin Thromb Hemost DOI: 10.1055/s-0039-3402478Disseminated intravascular coagulation (DIC) is a relatively rare but life-threatening condition, the outcome of which depends largely on timely and accurate therapeutic management. Inhibiting the activation of blood coagulation is an effective option for limiting the burden of diffuse intravascular thrombosis for attenuating consumption of clotting factors and platelets and ultimately preventing massive bleeding. Direct oral anticoagulants (DOACs) are a relatively new generation of drugs that specifically inhibit activated factors II (thrombin) and X, thus providing effective...
Source: Seminars in Thrombosis and Hemostasis - December 26, 2019 Category: Hematology Authors: Lippi, Giuseppe Langer, Florian Favaloro, Emmanuel J. Tags: Review Article Source Type: research

The Central Role of Fibrinolytic Response in Trauma-Induced Coagulopathy: A Hematologist's Perspective
Semin Thromb Hemost DOI: 10.1055/s-0039-3402428Severe trauma is the leading cause of death globally. Though improved resuscitation, particularly early initiation, has reduced the 24-hour mortality rate, the overall morbidity and 30-day mortality remain high mostly due to massive hemorrhage and head injury in the early stages and sepsis and multiorgan failure later on. With recent clinical trials of antifibrinolytic treatment with tranexamic acid, and with the observations that fibrinolytic activity varies widely among the injured patients, the role of the fibrinolytic system in trauma has become a major focus of investigat...
Source: Seminars in Thrombosis and Hemostasis - December 26, 2019 Category: Hematology Authors: Kwaan, Hau C. Tags: Review Article Source Type: research

Comment on: Inherited Thrombophilia and Pregnancy Complications: Should We Test?
Semin Thromb Hemost DOI: 10.1055/s-0039-3402479 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - December 26, 2019 Category: Hematology Authors: Sokol, Juraj Kubisz, Peter Stasko, Jan Tags: Letter to the Editor Source Type: research