Seminars in Thrombosis and Hemostasis 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Platelet Physiology
Semin Thromb Hemost DOI: 10.1055/s-0044-1786387Platelets are the smallest blood cells, numbering 150 to 350 × 109/L in healthy individuals. The ability of activated platelets to adhere to an injured vessel wall and form aggregates was first described in the 19th century. Besides their long-established roles in thrombosis and hemostasis, platelets are increasingly recognized as pivotal players in numerous other pathophysiological processes including inflammation and atherogenesis, antimicrobial host defense, and tumor growth and metastasis. Consequently, profound knowledge of platelet structure and function is becoming...
Source: Seminars in Thrombosis and Hemostasis - April 23, 2024 Category: Hematology Authors: Gremmel, Thomas Frelinger, Andrew L. Michelson, Alan D. Tags: Historical Paper Source Type: research
Reviewing the Rich History of Fibrin Clot Research with a Focus on Clinical Relevance
Semin Thromb Hemost DOI: 10.1055/s-0044-1785485Fibrin, described on a single-lens microscopy for the first time by Malpighi in 1666 and named by de Fourcroy, has been extensively studied by biochemists, biophysicists, and more recently by clinicians who recognized that fibrin is the major component of most thrombi. Elucidation of key reactions leading to fibrin clot formation in the 1950s and 1960s grew interest in the clinical relevance of altered fibrin characteristics. Implementation of scanning electron microscopy to image fibrin clots in 1947 and clot permeation studies in the 1970s to evaluate an average pore size en...
Source: Seminars in Thrombosis and Hemostasis - April 11, 2024 Category: Hematology Authors: Undas, Anetta Tags: Review Article Source Type: research
Machine Learning as a Diagnostic and Prognostic Tool for Predicting Thrombosis in Cancer Patients: A Systematic Review
This study was conducted per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Databases Medline, EMBASE, Cochrane, and ClinicalTrials.gov, were searched from inception to September 15, 2023, for studies evaluating the use of ML models for the prediction of thrombosis in cancer patients. Search terms “machine learning,” “artificial intelligence,” “thrombosis,” and “cancer” were used. Studies that examined adult cancer patients using any ML model were included. Two independent reviewers conducted study selection and data extraction. Three hundred citations were screened, of which...
Source: Seminars in Thrombosis and Hemostasis - April 11, 2024 Category: Hematology Authors: El-Sherbini, Adham H. Coroneos, Stefania Zidan, Ali Othman, Maha Tags: Review Article Source Type: research
Heterozygous ITGA2B Phe1024 Deletion Associated with Abnormal αIIbβ3 Function in a Patient with Congenital Thrombocytopenia
Semin Thromb Hemost DOI: 10.1055/s-0044-1785655 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 11, 2024 Category: Hematology Authors: Wang, Bin Tang, Ning Hou, Hongyan Chen, Junkun Wang, Xiong Li, Jiaoyuan Tags: Letter to the Editor Source Type: research
Heparin-induced Thrombocytopenia with Thrombosis in COVID-19 versus Vaccine-induced Immune Thrombocytopenia and Thrombosis in the United Kingdom
Semin Thromb Hemost DOI: 10.1055/s-0044-1785484 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 9, 2024 Category: Hematology Authors: Arachchillage, Deepa J. Rajakaruna, Indika Makris, Mike Laffan, Mike Tags: Letter to the Editor Source Type: research
Gene Therapy in Hemophilia A: Achievements, Challenges, and Perspectives
Semin Thromb Hemost DOI: 10.1055/s-0044-1785483Strides in advancements of care of persons with hemophilia include development of long-acting factor replacement therapies, novel substitution and hemostatic rebalancing agents, and most recently approved gene therapy. Several decades of preclinical and clinical trials have led to development of adeno-associated viral (AAV) vector-mediated gene transfer for endogenous production of factor VIII (FVIII) in hemophilia A (HA). Only one gene therapy product for HA (valoctocogene roxaparvovec) has been approved by regulatory authorities. Results of valoctocogene roxaparvovec trial s...
Source: Seminars in Thrombosis and Hemostasis - April 8, 2024 Category: Hematology Authors: Bala, Natasha S. Thornburg, Courtney D. Tags: Review Article Source Type: research
Celebrating 50 Years of Seminars in Thrombosis and Hemostasis —Part IV
Semin Thromb Hemost DOI: 10.1055/s-0044-1785652 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 8, 2024 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Preface Source Type: research
The Most Highly Downloaded Publications from Seminars in Thrombosis and Hemostasis: A Data Analysis 10 Years in the Making
Semin Thromb Hemost DOI: 10.1055/s-0044-1785654 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 8, 2024 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research
Platelet Physiology and Biochemistry: A Topic as Relevant as Ever
Semin Thromb Hemost DOI: 10.1055/s-0044-1785653 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 8, 2024 Category: Hematology Authors: Larsen, Julie B. Tags: Commentary Source Type: research
The Role of Myeloid Cells in Thromboinflammatory Disease
Semin Thromb Hemost DOI: 10.1055/s-0044-1782660Inflammation contributes to the development of thrombosis, but the mechanistic basis for this association remains poorly understood. Innate immune responses and coagulation pathways are activated in parallel following infection or injury, and represent an important host defense mechanism to limit pathogen spread in the bloodstream. However, dysregulated proinflammatory activity is implicated in the progression of venous thromboembolism and arterial thrombosis. In this review, we focus on the role of myeloid cells in propagating thromboinflammation in acute inflammatory conditi...
Source: Seminars in Thrombosis and Hemostasis - March 28, 2024 Category: Hematology Authors: Noone, David Preston, Roger J.S. Rehill, Aisling M. Tags: Review Article Source Type: research
Glanzmann Thrombasthenia 10 Years Later: Progress Made and Future Directions
Semin Thromb Hemost DOI: 10.1055/s-0044-1782519Glanzmann thrombasthenia (GT) is the most common inherited platelet disorder (IPD) with mucocutaneous bleeding and a failure of platelets to aggregate when stimulated. The molecular cause is insufficient or defective αIIbβ3, an integrin encoded by the ITGA2B and ITGB3 genes. On activation αIIbβ3 undergoes conformational changes and binds fibrinogen (Fg) and other proteins to join platelets in the aggregate. The application of next-generation sequencing (NGS) to patients with IPDs has accelerated genotyping for GT; progress accompanied by improved mutation curation. The eva...
Source: Seminars in Thrombosis and Hemostasis - March 18, 2024 Category: Hematology Authors: Nurden, Alan T. Nurden, Paquita Tags: Review Article Source Type: research
Prophylactic Treatment of Children with Hemophilia in Sweden
Semin Thromb Hemost DOI: 10.1055/s-0044-1782518Hemophilia A/B are caused by deficiency or lack of coagulation factors VIII (FVIII) or factor IX (FIX), respectively, in plasma. A person with hemophilia develops bleeding in the joints and muscles at an early age, which, if left untreated, leads to early arthropathy. Preventive treatment can be achieved by regular (prophylactic) administration of FVIII/FIX. In 1958, this was implemented on a small scale in Sweden with FVIII in patients with severe hemophilia A, and in those with hemophilia B in 1972 when FIX became available. However, there were problems with human immunodefi...
Source: Seminars in Thrombosis and Hemostasis - March 18, 2024 Category: Hematology Authors: Ljung, Rolf Tags: Review Article Source Type: research
Pearls and Pitfalls in the Measurement of Direct Oral Anticoagulants
Semin Thromb Hemost DOI: 10.1055/s-0044-1782196Due to their widespread use, testing for direct oral anticoagulants (DOACs) has become urgent in certain clinical situations. Screening based on widely available, rapid, and simple hemostasis assays such as prothrombin time, activated partial thromboplastin time, or even diluted Russel Viper venom time may provide sufficient evidence of “over-coagulation” and could be used “in small/peripheral/spoke laboratories” as an emergency strategy, but is not thought to be reliable for driving clinical decision making. Given their good correlation with plasma concentration, urin...
Source: Seminars in Thrombosis and Hemostasis - March 8, 2024 Category: Hematology Authors: Lippi, Giuseppe Favaloro, Emmanuel J. Tags: Review Article Source Type: research
Editorial Compilation XV
Semin Thromb Hemost DOI: 10.1055/s-0044-1782195 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 8, 2024 Category: Hematology Authors: Favaloro, Emmanuel J. Pasalic, Leonardo Lippi, Giuseppe Tags: Preface Source Type: research
2024 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost DOI: 10.1055/s-0044-1782197 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 8, 2024 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research
