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Editorial Compilation XI
Semin Thromb Hemost 2022; 48: 127-131 DOI: 10.1055/s-0041-1740151 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 28, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

Cerebral Venous Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0042-1742738Cerebral venous thrombosis (CVT) is a rare form of stroke that often affects younger age groups, especially reproductive age group females. CVT is a potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. Headache is the most common presenting symptom. However, a wide range of symptoms can be present and the symptom onset can be acute, subacute, or chronic. Neuroimaging is mandatory in cases where CVT is suspected. Both magnetic resonance venography and computed tomography venography can ...
Source: Seminars in Thrombosis and Hemostasis - February 15, 2022 Category: Hematology Authors: Aamodt, Anne Hege Skatt ør, Thor Håkon Tags: Review Article Source Type: research

The Benefits of Heparin Use in COVID-19: Pleiotropic Antiviral Activity beyond Anticoagulant and Anti-Inflammatory Properties
Semin Thromb Hemost DOI: 10.1055/s-0042-1742740 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 14, 2022 Category: Hematology Authors: Lippi, Giuseppe Henry, Brandon M. Favaloro, Emmanuel J. Tags: Commentary Source Type: research

Response to “Parathyroid Adenoma in a Young Girl with Type 3 von Willebrand Disease”
Semin Thromb Hemost DOI: 10.1055/s-0042-1742436 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 9, 2022 Category: Hematology Authors: Franchini, Massimo Tags: Letter to the Editor Source Type: research

Trousseau's Syndrome in 19th Century Qing Dynasty Paintings of Breast Tumors: Early Insights into Cancer and Thrombosis Risk
Semin Thromb Hemost DOI: 10.1055/s-0042-1742437 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 9, 2022 Category: Hematology Authors: Fan, Bingwen Eugene Tags: Letter to the Editor Source Type: research

Effects of Inflammation on Hemostasis in Acutely Ill Patients with Liver Disease
Semin Thromb Hemost DOI: 10.1055/s-0042-1742438Patients with liver diseases are in a rebalanced state of hemostasis, due to simultaneous decline in pro- and anticoagulant factors. This balance seems to remain even in the sickest patients, but is less stable and might destabilize when patients develop disease complications. Patients with acute decompensation of cirrhosis, acute-on-chronic liver failure, or acute liver failure often develop complications associated with changes in the hemostatic system, such as systemic inflammation. Systemic inflammation causes hemostatic alterations by adhesion and aggregation of platelets...
Source: Seminars in Thrombosis and Hemostasis - February 8, 2022 Category: Hematology Authors: Driever, Ellen G. Lisman, Ton Tags: Review Article Source Type: research

Parathyroid Adenoma in a Young Girl with Type 3 von Willebrand Disease: Comment on “Cancers in Patients with von Willebrand Disease”
Semin Thromb Hemost DOI: 10.1055/s-0042-1742435 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 2, 2022 Category: Hematology Authors: Da şdemir, Sevgi Kaya, Z ühre Tags: Letter to the Editor Source Type: research

Maintaining Hemostasis and Preventing Thrombosis in Coronavirus Disease 2019 (COVID-19) —Part III
Semin Thromb Hemost 2022; 48: 003-007 DOI: 10.1055/s-0041-1736169 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 1, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research

Welcome to Seminars in Thrombosis & Hemostasis 2022
Semin Thromb Hemost 2022; 48: 001-002 DOI: 10.1055/s-0041-1736167 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 1, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Mutations Accounting for Congenital Fibrinogen Disorders: An Update
Semin Thromb Hemost DOI: 10.1055/s-0041-1742170Fibrinogen is a complex protein that plays a key role in the blood clotting process. It is a hexamer composed of two copies of three distinct chains: Aα, Bβ, and γ encoded by three genes, FGA, FGB, and FGG, clustered on the long arm of chromosome 4. Congenital fibrinogen disorders (CFDs) are divided into qualitative deficiencies (dysfibrinogenemia, hypodysfibrinogenemia) in which the mutant fibrinogen molecule is present in the circulation and quantitative deficiencies (afibrinogenemia, hypofibrinogenemia) with no mutant molecule present in the bloodstream. Phenotypic manif...
Source: Seminars in Thrombosis and Hemostasis - January 24, 2022 Category: Hematology Authors: Richard, Maxime Celeny, David Neerman-Arbez, Marguerite Tags: Review Article Source Type: research

Neurocoagulation from a Mechanistic Point of View in the Central Nervous System
Semin Thromb Hemost DOI: 10.1055/s-0041-1741569Coagulation mechanisms are critical for maintaining homeostasis in the central nervous system (CNS). Thrombin, an important player of the coagulation cascade, activates protease activator receptors (PARs), members of the G-protein coupled receptor family. PAR1 is located on neurons and glia. Following thrombin activation, PAR1 signals through the extracellular signal-regulated kinase pathway, causing alterations in neuronal glutamate release and astrocytic morphological changes. Similarly, the anticoagulation factor activated protein C (aPC) can cleave PAR1, following interact...
Source: Seminars in Thrombosis and Hemostasis - January 20, 2022 Category: Hematology Authors: Shavit-Stein, Efrat Berkowitz, Shani Gofrit, Shany Guly Altman, Keren Weinberg, Nitai Maggio, Nicola Tags: Review Article Source Type: research

Gastrointestinal Bleeding in Congenital Bleeding Disorders
Semin Thromb Hemost DOI: 10.1055/s-0041-1741571Gastrointestinal bleeding (GIB) is serious, intractable, and potentially life-threatening condition. There is considerable heterogeneity in GIB phenotypes among congenital bleeding disorders (CBDs), making GIB difficult to manage. Although GIB is rarely encountered in CBDs, its severity in some patients makes the need for a comprehensive and precise assessment of underlying factors and management approaches imperative. Initial evaluation of GIB begins with assessment of hematological status; GIB should be ruled out in patients with chronic anemia, and in presentations that inc...
Source: Seminars in Thrombosis and Hemostasis - January 12, 2022 Category: Hematology Authors: Samii, Amir Norouzi, Mahshaad Ahmadi, Abbas Dorgalaleh, Akbar Tags: Review Article Source Type: research

Interaction between Antiphospholipid Antibodies and Protein C Anticoagulant Pathway: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0041-1742083Thrombotic antiphospholipid syndrome (APS) is a condition in which thrombosis in venous, arterial, and/or small vessels is ascribed to the presence of antiphospholipid antibodies (aPL). Among the various proposed pathogenic theories to explain thrombotic APS, those involving the interaction between aPL and the protein C system have gained much consensus. Indeed, robust data show an acquired activated protein C resistance (APC-R) in these patients. The role of aPL in this impairment is clear, but the mechanism of action is uncertain, as the type of aPL and to what extent aPL ar...
Source: Seminars in Thrombosis and Hemostasis - January 12, 2022 Category: Hematology Authors: Pengo, Vittorio Tags: Review Article Source Type: research

What We Know (and Do not Know) Regarding the Pathogenesis of Pulmonary Thrombosis in COVID-19
Semin Thromb Hemost DOI: 10.1055/s-0041-1742091The clinical course of coronavirus disease 2019 (COVID-19) is often complicated by the onset of venous thrombosis and thromboembolism (VTE), encompassing also pulmonary thrombosis. Recent statistics attests that the cumulative frequency of VTE can be as high as 30% in COVID-19 hospitalized patients, increasing to nearly 40 to 70% (depending on systematic screening) in those with severe illness, mechanical ventilation, or intensive care unit admission. The risk of venous thrombosis seems mostly limited to the active phase of disease, and is directly associated with some genetic...
Source: Seminars in Thrombosis and Hemostasis - January 12, 2022 Category: Hematology Authors: Lippi, Giuseppe Favaloro, Emmanuel J. Tags: Review Article Source Type: research

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review
In conclusion, no clear evidence indicates that PAI-1 polymorphisms are associated with placenta-mediated pregnancy complications, and the possible association between high PAI-1 plasma levels and preeclampsia needs further investigations. Thus, investigation of PAI-1 genotypes and PAI-1 plasma levels does not currently seem to have a place in daily clinical practice managing placenta-mediated pregnancy complications. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 12, 2022 Category: Hematology Authors: Agersnap, Ida Nissen, Peter H. Hvas, Anne-Mette Tags: Review Article Source Type: research