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The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System
Semin Thromb Hemost DOI: 10.1055/s-0043-1776875Thrombin, a pleiotropic enzyme involved in coagulation, plays a crucial role in both procoagulant and anticoagulant pathways. Thrombin converts fibrinogen into fibrin, initiates platelet activation, and promotes clot formation. Thrombin also activates anticoagulant pathways, indirectly inhibiting factors involved in coagulation. Tissue factor triggers thrombin generation, and the overexpression of thrombin in various cancers suggests that it is involved in tumor growth, angiogenesis, and metastasis. Increased thrombin generation has been observed in cancer patients, especially...
Source: Seminars in Thrombosis and Hemostasis - November 20, 2023 Category: Hematology Authors: Aleksandrowicz, Karolina Hempel, Dominika Polity ńska, Barbara Wojtukiewicz, Anna M. Honn, Kenneth V. Tang, Dean G. Wojtukiewicz, Marek Z. Tags: Review Article Source Type: research

Recommendations on the use of COVID-19 Convalescent Plasma to Treat Immunocompromised Patients
Semin Thromb Hemost DOI: 10.1055/s-0043-1776876 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - November 20, 2023 Category: Hematology Authors: Franchini, Massimo Casadevall, Arturo Senefeld, Jonathon W. Joyner, Michael J. Sullivan, David J. Focosi, Daniele Tags: Letter to the Editor Source Type: research

International Council for Standardization in Haematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls
Semin Thromb Hemost DOI: 10.1055/s-0043-1776405The clinical laboratory uses commercial products with limited shelf life or certain expiry dates requiring frequent lot changes. Prior to implementation for clinical use, laboratories should determine the performance of the new reagent lot to ensure that there is no significant shift in reagent performance or reporting of patient data. This guideline has been written on behalf of the International Council for Standardization in Haematology (ICSH) to provide the framework and provisional guidance for clinical laboratories for evaluating and verifying the performance of new lot ...
Source: Seminars in Thrombosis and Hemostasis - November 15, 2023 Category: Hematology Authors: Gosselin, Robert C. Castellone, Donna Dorgalaleh, Akbar Hickey, Kieron Lippi, Giuseppe Moffat, Karen O'Toole, Rebecca Rigano, Joe Tags: Review Article Source Type: research

Variable Performance of Lupus Anticoagulant Testing: The Australasian/Asia-Pacific Experience
Semin Thromb Hemost DOI: 10.1055/s-0043-1776406Lupus anticoagulant (LA) is one of three tests identified as laboratory criteria for definite antiphospholipid syndrome (APS). The other two tests are anticardiolipin antibody (aCL) and anti-β2-glycoprotein I (aβ2GPI) antibody. The presence of LA is assessed using clot-based tests, while the presence of aCL and aβ2GPI is assessed by immunological assays. Since no test can be considered 100% sensitive or specific for LA, current guidelines recommend using two different clot-based assays reflecting different principles, with the dilute Russell viper venom time (dRVVT) and act...
Source: Seminars in Thrombosis and Hemostasis - November 15, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Dean, Elysse Arunachalam, Sandya Tags: Review Article Source Type: research

The Bleeding Time Test in 2024: A Glorious Past and Current Challenges
Semin Thromb Hemost DOI: 10.1055/s-0043-1776877 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - November 15, 2023 Category: Hematology Authors: Undas, Anetta Tags: Commentary Source Type: research

Description of an In Vitro Platelet Function Analyzer (PFA-100/PFA-200) 30 Years in the Making
Semin Thromb Hemost DOI: 10.1055/s-0043-1776325 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 30, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Commentary Source Type: research

Erratum: Laboratory Diagnosis of Activated Protein C Resistance and Factor V Leiden
Semin Thromb Hemost DOI: 10.1055/s-0043-1776324 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 25, 2023 Category: Hematology Authors: Bahraini, Mehran Fazeli, Alieh Dorgalaleh, Akbar Tags: Erratum Source Type: research

Classification Criteria for the Antiphospholipid Syndrome: Not the Same as Diagnostic Criteria for Antiphospholipid Syndrome
Semin Thromb Hemost DOI: 10.1055/s-0043-1776318 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 20, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Pasalic, Leonardo Lippi, Giuseppe Tags: Commentary Source Type: research

In Search of the Perfect Thrombosis and Bleeding-Associated Cancer Scale
In this report, we analyze the current literature and identify new risk factors for venous thrombosis and bleeding which are not included in routinely used risk scores. While some existing cancer scales partially capture the risk of thrombosis and bleeding, there is a need for more specific and accurate scales tailored to these complications. The development of such scales could improve risk stratification, aid in treatment selection, and enhance patient care. Therefore, further research and development of novel cancer scales focused on thrombosis and bleeding are warranted to optimize patient management and outcomes. [......
Source: Seminars in Thrombosis and Hemostasis - October 18, 2023 Category: Hematology Authors: Wojtukiewicz, Marek Z. Tesarova, Petra Karetov á, Debora Windyga, Jerzy Tags: Review Article Source Type: research

Platelet Contributions to the (Pre)metastatic Tumor Microenvironment
Semin Thromb Hemost DOI: 10.1055/s-0043-1776005Alongside their conventional roles in thrombosis and hemostasis, platelets have long been associated with nonhemostatic pathologies, including tumor cell metastasis. Numerous mechanistic studies have since demonstrated that the direct binding of platelets to intravascular tumor cells promotes key hallmarks of metastasis, including survival in circulation and tumor cell arrest at secondary sites. However, platelets also interact with nonmalignant cells that make up the stromal and immune compartments within both primary and metastatic tumors. This review will first provide a br...
Source: Seminars in Thrombosis and Hemostasis - October 13, 2023 Category: Hematology Authors: Roweth, Harvey G. Tags: Review Article Source Type: research

Trends (2020 –2022) toward Reduced Prevalence of Postcoronavirus Disease Syndrome and Improved Quality of Life for Hospitalized Coronavirus Disease 2019 Patients with Severe Infection and Venous Thromboembolism
Semin Thromb Hemost DOI: 10.1055/s-0043-1776004The coronavirus disease 2019 (COVID-19) pandemic seems to be at its end. During the first outbreak, alfa was the dominant variant, and in the two following years, delta was the dominant variant. Questions remain about the prevalence and severity of post-COVID syndrome (PCS). We compared the medium-term outcomes of a selected group of patients considered at high risk for PCS: hospitalized patients with severe COVID-19 infection who presented clinical evidence of the acute onset of venous thromboembolism. Weighted Cox regression was used to estimate the adjusted hazard ratios fo...
Source: Seminars in Thrombosis and Hemostasis - October 13, 2023 Category: Hematology Authors: Bozzani, Antonio Arici, Vittorio Tavazzi, Guido Ragni, Franco Mojoli, Francesco Cavallini, Elena Vugt, Floris van Cutti, Sara Figini, Silvia Venturi, Alessandro Sterpetti, Antonio V. Arbustini, Eloisa Tags: Review Article Source Type: research

The Diagnostic Role of Lung Ultrasound and Contrast-Enhanced Ultrasound in Pulmonary Embolism
Semin Thromb Hemost DOI: 10.1055/s-0043-1776006The diagnosis of pulmonary embolism (PE) relies essentially on a probabilistic approach that requires careful clinical assessments, targeted laboratory tests, and the use of appropriate imaging tools. Nowadays, the diagnostic gold standard is computed tomographic pulmonary angiography. Lung ultrasound (LUS) can play a role in the diagnosis of PE mainly by allowing the visualization of peripheral lung infarctions. Hypoechoic, pleural-based parenchymal consolidation is the most typical and common finding of pulmonary infarction. More than 85% of infarct lesions are wedge-shaped,...
Source: Seminars in Thrombosis and Hemostasis - October 13, 2023 Category: Hematology Authors: Boccatonda, Andrea Andreetto, Lorenzo Vicari, Susanna Campello, Elena Simioni, Paolo Ageno, Walter Tags: Review Article Source Type: research

Optimizing and Extending the Risk-Adapted Management of Acute Pulmonary Embolism beyond the Acute Phase: Progress in Pulmonary Embolism Research
Semin Thromb Hemost DOI: 10.1055/s-0043-1775978 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 13, 2023 Category: Hematology Authors: Barco, Stefano Klok, Frederikus A. Bikdeli, Behnood Tags: Preface Source Type: research

Thrombin Generation Markers as Predictors of Cancer-Associated Venous Thromboembolism: A Systematic Review
In conclusion, markers of thrombin generation were found to be elevated in cancer patients with VTE, and particularly, F1.2 was found to be a promising predictor of cancer-associated VTE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 9, 2023 Category: Hematology Authors: Gyldenholm, Tua Hvas, Anne-Mette Christensen, Thomas Decker Larsen, Julie Brogaard Tags: Review Article Source Type: research

Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke
Semin Thromb Hemost DOI: 10.1055/s-0043-1775858Existing effective treatments for ischemic stroke restore blood supply to the ischemic region using thrombolysis or mechanical removal of clot. However, it is increasingly recognized that successful removal of occlusive thrombus from the large artery—recanalization, may not always be accompanied by successful restoration of blood flow to the downstream tissues—reperfusion. Ultimately, brain tissue survival depends on cerebral perfusion, and a functioning microcirculation. Because capillary diameter is often equal to or smaller than an erythrocyte, microcirculation is large...
Source: Seminars in Thrombosis and Hemostasis - October 9, 2023 Category: Hematology Authors: Gyawali, Prajwal Lillicrap, Thomas P. Esperon, Carlos G. Bhattarai, Aseem Bivard, Andrew Spratt, Neil Tags: Review Article Source Type: research