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Developmental or Procedural Vena Cava Interruption and Venous Thromboembolism: A Review
This study aimed to review the various etiologies of developmental or procedural vena cava interruption and their impact on venous thromboembolism. A systematic search was performed in PubMed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines per each clinical question. For management questions with no high-quality evidence and no mutual agreements between authors, Delphi methods were used. IVC agenesis is the most common form of congenital vena cava interruption, is associated with an increased risk of DVT, and should be suspected in young patients with unexpected extensive...
Source: Seminars in Thrombosis and Hemostasis - January 4, 2024 Category: Hematology Authors: Bikdeli, Behnood Sadeghipour, Parham Lou, Junyang Bejjani, Antoine Khairani, Candrika D. Rashedi, Sina Lookstein, Robert Lansky, Alexandra Vedantham, Suresh Sobieszczyk, Piotr Mena-Hurtado, Carlos Aghayev, Ayaz Henke, Peter Mehdipoor, Ghazaleh Tufano, Ant Tags: Review Article Source Type: research

Blood Rheology and Hemodynamics
Semin Thromb Hemost DOI: 10.1055/s-0043-1777802 Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the most highly cited paper ever published in STH. The original abstract follows.Blood is a two-phase suspension of formed elements (i.e., red blood cells [RBCs], white blood cells [WBCs], platelets) suspended in an aqueous solution of organic molecules, proteins, and salts called plasma. The apparent viscosity of blood depends on the existing shear forces (i.e., blood behaves as a ...
Source: Seminars in Thrombosis and Hemostasis - December 20, 2023 Category: Hematology Authors: Baskurt, Oguz K. Meiselman, Herbert J. Tags: Historical Paper Source Type: research

From Field Study to Clinical Practice, a Personal Historical Experience Using the PFA-100 Analyzer for Platelet Function Testing
Semin Thromb Hemost DOI: 10.1055/s-0043-1777795 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - December 20, 2023 Category: Hematology Authors: Gosselin, Robert C. Tags: Commentary Source Type: research

PFA-100 System: A New Method for Assessment of Platelet Dysfunction
Semin Thromb Hemost DOI: 10.1055/s-0043-1777306This is a celebratory reprint of a historical paper published in STH in 1998. The original Abstract follows.The PFA-100 system is a platelet function analyzer designed to measure platelet-related primary hemostasis. The instrument uses two disposable cartridges: a collagen/epinephrine (CEPI) and a collagen/ADP (CADP) cartridge. Previous experience has shown that CEPI cartridges detect qualitative platelet defects, including acetylsalicylic acid (ASA)-induced abnormalities, while CADP cartridges detect only thrombocytopathies and not ASA use. In this seven-center trial, 206 hea...
Source: Seminars in Thrombosis and Hemostasis - December 13, 2023 Category: Hematology Authors: Mammen, Eberhard F. Comp, Philip C. Gosselin, Robert Greenberg, Charles Hoots, W. Keith Kessler, Craig M. Larkin, Edward C. Liles, Darla Nugent, Diane J. Tags: Historical Paper Source Type: research

A Critical Reappraisal of the Bleeding Time
Semin Thromb Hemost DOI: 10.1055/s-0043-1777307 Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the second most highly cited paper ever published in STH. The manuscript published without an abstract, and essentially represented a State of the Art Review on the bleeding time, a relatively invasive procedure that required an incision on the skin or earlobe of a patient, and timing how long it took for the incision to stop bleeding. The bleeding time test was first described in 1...
Source: Seminars in Thrombosis and Hemostasis - December 12, 2023 Category: Hematology Authors: Rodgers, R. P. Channing Levin, Jack Tags: Historical Paper Source Type: research

Description of an In Vitro Platelet Function Analyzer —PFA-100™
Semin Thromb Hemost DOI: 10.1055/s-0043-1777308This manuscript represents a republication of a manuscript originally published in STH in 1995. This republication is to help celebrate 50 years of publishing for STH. The original abstract follows.A new in vitro system for the detection of platelet dysfunction, PFA-100®, has been developed. It provides a quantitative measure of platelet function in anticoagulated whole blood. The system comprises a microprocessor-controlled instrument and a disposable test cartridge containing a biologically active membrane. The instrument aspirates a blood sample under constant vacuum from ...
Source: Seminars in Thrombosis and Hemostasis - December 12, 2023 Category: Hematology Authors: Kundu, Sourav K. Heilmann, Eric J. Sio, Reynaldo Garcia, Carmen Davidson, Rosa M. Ostgaard, Roy A. Tags: Historical Paper Source Type: research

Platelets: Physiology and Biochemistry
This article gives an overview of the activation processes involved in primary and secondary hemostasis, for example, platelet adhesion, platelet secretion, platelet aggregation, microvesicle formation, and clot retraction/stabilization. In addition, activated platelets are predominantly involved in cross-talk to other blood and vascular cells. Stimulated “sticky” platelets enable recruitment of leukocytes at sites of vascular injury under high shear conditions. Platelet-derived microparticles as well as soluble adhesion molecules, sP-selectin and sCD40L, shed from the surface of activated platelets, are capable of act...
Source: Seminars in Thrombosis and Hemostasis - December 12, 2023 Category: Hematology Authors: Jurk, Kerstin Kehrel, Beate E. Tags: Historical Paper Source Type: research

Cellular Components Contributing to the Development of Venous Thrombosis in Patients with Pancreatic Cancer
Semin Thromb Hemost DOI: 10.1055/s-0043-1777304Pancreatic ductal adenocarcinoma (PDAC) is an aggressive type of cancer and has a poor prognosis. Patients with PDAC are at high risk of developing thromboembolic events, which is a leading cause of morbidity and mortality following cancer progression. Plasma-derived coagulation is the most studied process in cancer-associated thrombosis. Other blood components, such as platelets, red blood cells, and white blood cells, have been gaining less attention. This narrative review addresses the literature on the role of cellular components in the development of venous thromboembolis...
Source: Seminars in Thrombosis and Hemostasis - December 4, 2023 Category: Hematology Authors: Willems, Ruth Anne Laura Biesmans, Charlotte Campello, Elena Simioni, Paolo de Laat, Bas de Vos-Geelen, Judith Roest, Mark ten Cate, Hugo Tags: Review Article Source Type: research

Dosing, Monitoring, Blood Product Utilization, and Thromboembolic Complications of Four-Factor Prothrombin Complex Concentrate as Part of an Institutional Protocol in Pediatric Cardiac Surgery: A Retrospective Cohort Study
The objective of this study was to describe dosing, monitoring, blood product utilization, and thromboembolic complications of administering four-factor PCC (4F-PCC) in pediatric cardiac surgery. We performed a retrospective review of patients aged <18 years undergoing cardiac surgery from June 2020 to May 2022 (inclusive) who received 4F-PCC. Outcomes of interest included 4F-PCC dosing (units/kg) and number of doses administered, chest tube output, blood product administration, donor exposure, length of stay, and thromboembolic events. Eighty-six patients met eligibility criteria. The median (range) age and weight were...
Source: Seminars in Thrombosis and Hemostasis - December 4, 2023 Category: Hematology Authors: Kiskaddon, Amy L. Goldenberg, Neil A. Fierstein, Jamie L. Miller, Alexandra Quintessenza, James A. Kartha, Vyas M. Tags: Review Article Source Type: research

Coronary Thrombosis with Distal Embolization in a Young Patient after Orthopaedic Surgery: An Informative Case Report
Semin Thromb Hemost DOI: 10.1055/s-0043-1777302 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - December 4, 2023 Category: Hematology Authors: Pengo, Vittorio Bracco, Alessia Denas, Gentian Iliceto, Sabino Tags: Letter to the Editor (Correspondence) Source Type: research

Insights into Cancer-Associated Thrombosis from Leukemia ( “Leucocythemia”) from the 19th Century: The Untimely Death of the Scottish Slater John Menteith
Semin Thromb Hemost DOI: 10.1055/s-0043-1777303 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - December 4, 2023 Category: Hematology Authors: Fan, Bingwen Eugene Tags: Letter to the Editor Source Type: research

Disseminated Intravascular Coagulation in Anaphylaxis
In conclusion, DIC can complicate anaphylaxis and is expected to contribute to poor microvascular perfusion after anaphylaxis. Particularly, elderly patients with known cardiovascular disease and patients who develop thrombotic events are susceptible to lethal outcomes. As a rare and largely uncharacterized disease entity, further research is needed to investigate the link between DIC and anaphylaxis and to potentially identify better treatment strategies. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full...
Source: Seminars in Thrombosis and Hemostasis - November 29, 2023 Category: Hematology Authors: Gelbenegger, Georg Buchtele, Nina Schoergenhofer, Christian Grafeneder, J ürgen Schwameis, Michael Schellongowski, Peter Denk, Wolfgang Jilma, Bernd Tags: Review Article Source Type: research

Bleeding Scoring Systems in Neonates: A Systematic Review
Semin Thromb Hemost DOI: 10.1055/s-0043-1777070We conducted a systematic review aiming to summarize the data on the current hemorrhage prediction models and evaluate their potential for generalized application in the neonatal population. The electronic databases PubMed and Scopus were searched, up to September 20, 2023, for studies that focused on development and/or validation of a prediction model for bleeding risk in neonates, and described the process of model building. Nineteen studies fulfilled the inclusion criteria for the present review. Eighteen bleeding risk prediction models in the neonatal population were ident...
Source: Seminars in Thrombosis and Hemostasis - November 28, 2023 Category: Hematology Authors: Sokou, Rozeta Parastatidou, Stavroula Konstantinidi, Aikaterini Tsantes, Andreas G. Iacovidou, Nicoletta Piovani, Daniele Bonovas, Stefanos Tsantes, Argirios E. Tags: Review Article Source Type: research

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases
Semin Thromb Hemost DOI: 10.1055/s-0043-1777071Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune dise...
Source: Seminars in Thrombosis and Hemostasis - November 28, 2023 Category: Hematology Authors: P éč, Martin Jozef Jurica, Jakub P éčová, Monika Benko, Jakub Sokol, Juraj Bolek, Tom áš Samec, Marek Hurtov á, Tatiana Galajda, Peter Samo š, Matej Mok áň, Marián Tags: Review Article Source Type: research

The Molecular Structure of Fibrinogen
Semin Thromb Hemost DOI: 10.1055/s-0043-1776311 Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the first full paper ever published in STH. The manuscript published without an abstract, and essentially covered in considerable detail the molecular structure of fibrinogen, as was known at that time. Fittingly, it covers some historical perspectives, the physicochemical properties and structure of fibrinogen across several species of animals (including humans) and its transformat...
Source: Seminars in Thrombosis and Hemostasis - November 24, 2023 Category: Hematology Authors: Murano, Genesio Tags: Review Article Source Type: research