Antiphospholipid Syndrome in Patients with Venous Thromboembolism
Semin Thromb Hemost DOI: 10.1055/s-0042-1749590Unprovoked (or provoked by mild risk factors) venous thromboembolism (VTE) in young patients, VTE in uncommon sites, or cases of unexplained VTE recurrence may be positive for antiphospholipid antibodies (aPL) and thus may be diagnosed with antiphospholipid syndrome (APS). The evaluation of aPL is standardized using immunological tests for anticardiolipin and anti-β2-glycoprotein I. The determination of functional antibodies (lupus anticoagulant) is less standardized, especially in patients on anticoagulant treatment. Patients positive for all the three tests are at high risk...
Source: Seminars in Thrombosis and Hemostasis - June 21, 2022 Category: Hematology Authors: Pengo, Vittorio Denas, Gentian Tags: Review Article Source Type: research

Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Response to Comment
Semin Thromb Hemost DOI: 10.1055/s-0042-1744280 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 21, 2022 Category: Hematology Authors: Benvenuto, Domenico Carnevale, Sergio Giovanetti, Marta Ciccozzi, Massimo Broccolo, Francesco Tags: Letter to the Editor Source Type: research

2022 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost DOI: 10.1055/s-0042-1748192 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 14, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Solid Phase Assays for Antiphospholipid Antibodies
Semin Thromb Hemost DOI: 10.1055/s-0042-1744364The diagnosis of antiphospholipid syndrome (APS) relies on the detection of circulating antiphospholipid antibodies (aPL). Currently, lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are the laboratory criteria if persistently present over time. As aCL and aβ2GPI are two out of the three laboratory criteria, the detection of aPL by solid phase assays is an essential step in the diagnosis of APS. Advancement has been made to resolve some of the methodological challenges of aCL and aβ2GPI assays by providing guideline...
Source: Seminars in Thrombosis and Hemostasis - June 8, 2022 Category: Hematology Authors: Devreese, Katrien M.J. Tags: Review Article Source Type: research

Testing for Lupus Anticoagulants
This article reviews current practices and challenges in the laboratory detection of LA. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - June 1, 2022 Category: Hematology Authors: Moore, Gary W. Tags: Review Article Source Type: research

Tranexamic Acid and Its Potential Anti-Inflammatory Effect: A Systematic Review
In conclusion, an anti-inflammatory effect of TXA was consistently found among orthopaedic patients only. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - May 30, 2022 Category: Hematology Authors: Okholm, S øren Hauge Krog, Jan Hvas, Anne-Mette Tags: Review Article Source Type: research

To Anticoagulate or Not to Anticoagulate in COVID-19: Lessons after 2 Years
Semin Thromb Hemost DOI: 10.1055/s-0042-1744302A hypercoagulable state associated with coronavirus disease 2019 (COVID-19) has been well documented and is believed to be strongly supported by a proinflammatory state. The hypercoagulable state in turn results in increased incidence of arterial and venous thromboembolism (VTE) seen in hospitalized COVID-19 when compared with hospitalized non-COVID-19 patient cohorts. Moreover, patients with arterial or VTE and COVID-19 have higher mortality compared with COVID-19 patients without arterial or VTE. Prevention of arterial or VTE thus remains an essential question in the managem...
Source: Seminars in Thrombosis and Hemostasis - April 25, 2022 Category: Hematology Authors: Rizk, John G. Gupta, Aashish Lazo, Jose G. Sardar, Partha Henry, Brandon Michael Lavie, Carl J. Effron, Mark B. Tags: Review Article Source Type: research

Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Comment
Semin Thromb Hemost DOI: 10.1055/s-0042-1744279 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 21, 2022 Category: Hematology Authors: Mungmunpuntipantip, Rujittika Wiwanitkit, Viroj Tags: Letter to the Editor Source Type: research

Hemostasis and Neuroscience —Hemostasis and Fibrinolysis Involved in Brain Pathology and Brain Disorders
Semin Thromb Hemost 2022; 48: 274-276 DOI: 10.1055/s-0042-1742737 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 12, 2022 Category: Hematology Authors: Hvas, Christine Lodberg Kwaan, Hau C. Hvas, Anne-Mette Tags: Preface Source Type: research

2021 Eberhard F. Mammen Award Announcements: Part II —Young Investigator Awards
Semin Thromb Hemost 2022; 48: 265-273 DOI: 10.1055/s-0042-1743175 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 12, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Aspirin use Reduces Platelet Hyperreactivity and Degranulation in COVID-19 Patients
Semin Thromb Hemost DOI: 10.1055/s-0042-1744281 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 7, 2022 Category: Hematology Authors: Zaid, Younes Lahlimi, Qamar Khalki, Loubna Zaid, Nabil Oudghiri, Mounia Cheikh, Amine Naya, Abdallah Merhi, Yahye Guessous, Fadila Tags: Letter to the Editor Source Type: research

Flow Cytometric Assessment of Changes in Platelet Reactivity after Acute Coronary Syndrome: A Systematic Review
Semin Thromb Hemost DOI: 10.1055/s-0042-1742742Increased platelet activity is an important predictor for recurrent cardiovascular events in patients with acute coronary syndromes (ACS). Flow cytometry is an advanced method for evaluation of platelet activity. We aimed to summarize the current literature on dynamic changes in platelet activity analyzed by flow cytometry in patients with ACS. Employing the guidelines of Preferred Report Items for Systematic Reviews and Meta-Analyses (PRISMA), we searched PubMed and Embase on October 26, 2021, and identified studies measuring platelet activity with flow cytometry in ACS patie...
Source: Seminars in Thrombosis and Hemostasis - February 28, 2022 Category: Hematology Authors: Pedersen, Oliver Buchhave Pasalic, Leonardo Nissen, Peter H. Grove, Erik Lerkevang Kristensen, Steen Dalby Hvas, Anne-Mette Tags: Review Article Source Type: research

Utilization of the Caprini Score for Risk Stratification of the Arthroplasty Patient in the Prevention of Postoperative Venous Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0042-1742739Venous thromboembolism (VTE) is a serious and predictable complication following arthroplasty. It has been recognized that a strategy utilizing individualized anticoagulation choices based on patient risk stratification results in improved patient outcomes. A 2013 version of the Caprini Risk Score has previously been validated for use in total joint arthroplasty. A Caprini score of 10 or greater assesses the patient as “high risk” while 9 or less is considered “low risk.” Patients scored as “low risk” for postoperative VTE receive enteric coated aspirin 81 mg twi...
Source: Seminars in Thrombosis and Hemostasis - February 28, 2022 Category: Hematology Authors: Krauss, Eugene S. Segal, Ayal Dengler, Nancy Cronin, MaryAnne Pettigrew, Janelle Simonson, Barry G. Tags: Review Article Source Type: research

Systemic Antiangiogenic Therapies for Bleeding in Hereditary Hemorrhagic Telangiectasia: A Practical, Evidence-Based Guide for Clinicians
Semin Thromb Hemost DOI: 10.1055/s-0042-1743467Management of bleeding in hereditary hemorrhagic telangiectasia (HHT), the second most common hereditary bleeding disorder in the world, is currently undergoing a paradigm shift. Disease-modifying antiangiogenic therapies capable of achieving durable hemostasis via inducing telangiectasia regression have emerged as a highly effective and safe modality to treat epistaxis and gastrointestinal bleeding in HHT. While evidence to date is incomplete and additional studies are ongoing, patients presently in need are being treated with antiangiogenic agents off-label. Intravenous beva...
Source: Seminars in Thrombosis and Hemostasis - February 28, 2022 Category: Hematology Authors: Al-Samkari, Hanny Tags: Review Article Source Type: research

Editorial Compilation XI
Semin Thromb Hemost 2022; 48: 127-131 DOI: 10.1055/s-0041-1740151 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 28, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Lippi, Giuseppe Tags: Preface Source Type: research