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2022 Eberhard F. Mammen Award Announcements: Part II —Young Investigator Awards
Semin Thromb Hemost DOI: 10.1055/s-0043-57033 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 28, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Perioperative Monitoring with Rotational Thromboelastometry in a Severe Hemophilia A Patient Undergoing Elective Ankle Surgery
Semin Thromb Hemost DOI: 10.1055/s-0043-57009 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 19, 2023 Category: Hematology Authors: Simurda, Tomas Drotarova, Miroslava Skornova, Ingrid Dobrotova, Miroslava Brunclikova, Monika Necas, Libor Cibula, Zoltan Kubisz, Peter Stasko, Jan Tags: Letter to the Editor Source Type: research

Plasma Kallikrein as a Forgotten Clotting Factor
Semin Thromb Hemost DOI: 10.1055/s-0043-57034For decades, it was considered that plasma kallikrein's (PKa) sole function within the coagulation cascade is the activation of factor (F)XII. Until recently, the two key known activators of FIX within the coagulation cascade were activated FXI(a) and the tissue factor–FVII(a) complex. Simultaneously, and using independent experimental approaches, three groups identified a new branch of the coagulation cascade, whereby PKa can directly activate FIX. These key studies identified that (1) FIX or FIXa can bind with high affinity to either prekallikrein (PK) or PKa; (2) in human p...
Source: Seminars in Thrombosis and Hemostasis - April 18, 2023 Category: Hematology Authors: Kearney, Katherine J. Spronk, Henri M.H. Emsley, Jonas Key, Nigel S. Philippou, Helen Tags: Review Articlwe Source Type: research

The Pitfalls of Global Hemostasis Assays in Myeloproliferative Neoplasms and Future Challenges
Semin Thromb Hemost DOI: 10.1055/s-0043-57010Venous and arterial thromboembolism are major complications of myeloproliferative neoplasms (MPNs), comprising polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Global hemostasis assays, including thrombin generation assay (TGA), rotational thromboelastometry (ROTEM), and thromboelastography (TEG), have been proposed as biomarkers to assess the hypercoagulability and thrombotic risk stratification in MPNs. We performed a systematic literature review on the parameters of TGA, ROTEM, and TEG and their association with thrombotic events and tr...
Source: Seminars in Thrombosis and Hemostasis - April 17, 2023 Category: Hematology Authors: Tiu, Andrew Chiasakul, Thita Kessler, Craig M. Tags: Review Article Source Type: research

Targeting the Contact Pathway of Coagulation for the Prevention and Management of Medical Device-Associated Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0043-57011Hemorrhage remains a major complication of anticoagulants, with bleeding leading to serious and even life-threatening outcomes in rare settings. Currently available anticoagulants target either multiple coagulation factors or specifically coagulation factor (F) Xa or thrombin; however, inhibiting these pathways universally impairs hemostasis. Bleeding complications are especially salient in the medically complex population who benefit from medical devices. Extracorporeal devices—such as extracorporeal membrane oxygenation, hemodialysis, and cardiac bypass—require anticoagula...
Source: Seminars in Thrombosis and Hemostasis - April 12, 2023 Category: Hematology Authors: Goel, Abhishek Tathireddy, Harsha Wang, Si-Han Vu, Helen H. Puy, Cristina Hinds, Monica T. Zonies, David McCarty, Owen J.T. Shatzel, Joseph J. Tags: Review Article Source Type: research

Thrombotic Antiphospholipid Syndrome and Direct Oral Anticoagulants: Unmet Needs and Review of the Literature
Semin Thromb Hemost DOI: 10.1055/s-0043-1767728Patients with thrombotic antiphospholipid syndrome (APS) require long-term anticoagulation due to the high-thrombotic recurrence risk. Vitamin K antagonists (VKA) have been traditionally considered the standard of care in thrombotic APS. Nevertheless, the risk of recurrence persists with VKA. There are publications considering different intensities of anticoagulation with VKA; however, the standard-intensity anticoagulation (international normalized ratio between 2.0 and 3.0) is the most recommended. Furthermore, there is no consensus on the role of antiplatelet treatment in t...
Source: Seminars in Thrombosis and Hemostasis - March 30, 2023 Category: Hematology Authors: Marco-Rico, Ana Marco-Vera, Pascual Tags: Review Article Source Type: research

Pediatric Presentation of Antiphospholipid Syndrome: A Review of Recent Literature With Estimation of Local Prevalence
In conclusion, clinical manifestations of pediatric APS seem to be more severe and with a high prevalence of noncriteria manifestations. International efforts are needed to better characterize this condition and to develop new specific diagnostic criteria to avoid missed/delayed diagnosis in children with APS. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Radin, Massimo Cecchi, Irene Arbrile, Marta Montin, Davide Farinasso, Loredana Cioffi, Michele Foddai, Silvia Grazietta Barinotti, Alice Menegatti, Elisa Baldovino, Simone Sciascia, Savino Roccatello, Dario Tags: Review Article Source Type: research

Laboratory Evaluation of Antithrombin, Protein C, and Protein S
This article will describe the major pre-analytical, analytical, and post-analytical issues associated with the various types of assays and discuss evidence-based algorithms for analyzing AT, PC, and PS in plasma. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Marlar, Richard A. Tags: Review Article Source Type: research

Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa
Semin Thromb Hemost DOI: 10.1055/s-0043-1764469Coagulation factor XI (FXI) has increasingly been shown to play an integral role in several physiologic and pathological processes. FXI is among several zymogens within the blood coagulation cascade that are activated by proteolytic cleavage, with FXI converting to the active serine protease form (FXIa). The evolutionary origins of FXI trace back to duplication of the gene that transcribes plasma prekallikrein, a key factor in the plasma kallikrein–kinin system, before further genetic divergence led to FXI playing a unique role in blood coagulation. While FXIa is canonically...
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Lira, Andr é L. Kohs, Tia C.L. Moellmer, Samantha A. Shatzel, Joseph J. McCarty, Owen J.T. Puy, Cristina Tags: Review Article Source Type: research

Novel Insights into Heterozygous Factor XIII Deficiency
Semin Thromb Hemost DOI: 10.1055/s-0043-1764471The prevalence and clinical significance of heterozygous factor XIII (FXIII) deficiency has long been debated, with controversial reports emerging since 1988. In the absence of large epidemiologic studies, but based on a few studies, a prevalence of 1 per 1,000 to 5,000 is estimated. In southeastern Iran, a hotspot area for the disorder, a study of more than 3,500 individuals found an incidence of 3.5%. Between 1988 and 2023, a total of 308 individuals were found with heterozygous FXIII deficiency, of which molecular, laboratory, and clinical presentations were available for 2...
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Dorgalaleh, Akbar Tags: Review Article Source Type: research

The Post –Venous Thromboembolism Functional Status Scale: From Call to Action to Application in Research, Extension to COVID-19 Patients, and Its Use in Clinical Practice
Semin Thromb Hemost DOI: 10.1055/s-0043-1764467A broad spectrum of long-term sequelae may be present in venous thromboembolism (VTE) survivors, affecting their quality of life and functioning. To monitor recovery and improve the prognosis of patients with persistent functional limitations, the development of a new outcome measure that could better capture the consequences of VTE was an unmet need. Starting as a call to action, the Post-VTE Functional Status (PVFS) scale was developed to meet this need. The PVFS scale is an easy-to-use clinical tool to measure and quantify functional outcomes after VTE by focusing on key as...
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: de Jong, Cindy M. M. Boon, Gudula J.A.M. Le, Y. N. Jenny Barco, Stefano Siegerink, Bob Klok, Frederikus A. Tags: Review Article Source Type: research

A Brief History of Hemostasis and Thrombosis at the Mayo Clinic
Semin Thromb Hemost DOI: 10.1055/s-0043-1764470Coagulation is a crucial biological mechanism in human bodies to prevent blood loss. Abnormal coagulation can cause bleeding diathesis or thrombosis, common pathologic conditions in our clinical practice. Many individuals and organizations have dedicated their efforts in the past decades to understanding the biological and pathological mechanisms of coagulation and developing laboratory testing tools and treatment options to help patients with bleeding or thrombotic conditions. Since 1926, the Mayo Clinic coagulation group has made significant contributions to the clinical and...
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Chen, Dong Pruthi, Rajiv Tags: Review Article Source Type: research

2023 Eberhard F. Mammen Award Announcements: Part I —Most Popular Articles
Semin Thromb Hemost DOI: 10.1055/s-0043-1766093 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 20, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Platelet Parameters as Biomarkers for Thrombosis Risk in Cancer: A Systematic Review and Meta-analysis
In conclusion, platelet count is associated with CAT across different cancer types and settings. Platelet function or activation marker analysis may be valuable in assisting thrombosis risk assessment in cancer patients but is sparsely investigated so far. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 15, 2023 Category: Hematology Authors: Malte, Anne Lind H øjbjerg, Johanne Andersen Larsen, Julie Brogaard Tags: Review Article Source Type: research

Contraceptives and Thrombosis: An Intertwined Revolutionary Road
In conclusion, the OCs road has been long and difficult but has led to a great and unthinkable scientific and social enrichment since the 1960s. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - March 13, 2023 Category: Hematology Authors: Barcellona, Doris Marongiu, Francesco Grandone, Elvira Tags: Review Article Source Type: research