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Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a Potential Basis for Autoimmune Responses in Vaccinated and Naturally Infected Patients?
Semin Thromb Hemost DOI: 10.1055/s-0041-1742092 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 12, 2022 Category: Hematology Authors: Carnevale, Sergio Giovanetti, Marta Benvenuto, Domenico Ciccozzi, Massimo Broccolo, Francesco Tags: Letter to the Editor Source Type: research

Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study
In conclusion, VOE in moderate-to-severe TBI patients was relatively uncommon, and did not affect 12-month GOS. This suggests that the potential benefit of treating bleeding progression might outweigh the risks of VOE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 6, 2022 Category: Hematology Authors: Fletcher-Sandersj öö, Alexander Tatter, Charles Tjerkaski, Jonathan Bartek Jr, Jiri Svensson, Mikael Thelin, Eric Peter Bellander, Bo-Michael Tags: Review Article Source Type: research

Risk and Management of Intracerebral Hemorrhage in Patients with Bleeding Disorders
Semin Thromb Hemost DOI: 10.1055/s-0041-1740566Intracerebral hemorrhage (ICH) is the most dreaded complication, and the main cause of death, in patients with congenital bleeding disorders. ICH can occur in all congenital bleeding disorders, ranging from mild, like some platelet function disorders, to severe disorders such as hemophilia A, which can cause catastrophic hemorrhage. While extremely rare in mild bleeding disorders, ICH is common in severe coagulation factor (F) XIII deficiency. ICH can be spontaneous or trauma-related. Spontaneous ICH occurs more often in adults, while trauma-related ICH is more prevalent in ch...
Source: Seminars in Thrombosis and Hemostasis - January 6, 2022 Category: Hematology Authors: Dorgalaleh, Akbar Farshi, Yadolah Haeri, Kamand Ghanbari, Omid Baradarian Ahmadi, Abbas Tags: Review Article Source Type: research

Role of Circulating Microparticles in Type 2 Diabetes Mellitus: Implications for Pathological Clotting
Semin Thromb Hemost DOI: 10.1055/s-0041-1740150Type 2 diabetes mellitus (T2DM) is a multifactorial chronic metabolic disease characterized by chronic hyperglycemia due to insulin resistance and a deficiency in insulin secretion. The global diabetes pandemic relates primarily to T2DM, which is the most prevalent form of diabetes, accounting for over 90% of all cases. Chronic low-grade inflammation, triggered by numerous risk factors, and the chronic activation of the immune system are prominent features of T2DM. Here we highlight the role of blood cells (platelets, and red and white blood cells) and vascular endothelial cel...
Source: Seminars in Thrombosis and Hemostasis - December 27, 2021 Category: Hematology Authors: Maphumulo, Siphosethu Cassandra Pretorius, Etheresia Tags: Review Article Source Type: research

Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease
Semin Thromb Hemost DOI: 10.1055/s-0041-1740265Tissue plasminogen activator's (tPA) fibrinolytic function in the vasculature is well-established. This specific role for tPA in the vasculature, however, contrasts with its pleiotropic activities in the central nervous system. Numerous physiological and pathological functions have been attributed to tPA in the central nervous system, including neurite outgrowth and regeneration; synaptic and spine plasticity; neurovascular coupling; neurodegeneration; microglial activation; and blood–brain barrier permeability. In addition, multiple substrates, both plasminogen-dependent an...
Source: Seminars in Thrombosis and Hemostasis - December 23, 2021 Category: Hematology Authors: Stevenson, Tamara K. Moore, Shannon J. Murphy, Geoffrey G. Lawrence, Daniel A. Tags: Review Article Source Type: research