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Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation
Semin Thromb Hemost DOI: 10.1055/s-0042-1758058Viscoelastic testing (VET) in liver transplantation (LT) has been used since its origin, in combination with standard laboratory testing (SLT). There are only a few, small, randomized controlled trials that demonstrated a reduction in transfusion rates using VET to guide coagulation management. Retrospective analyses contrasting VET to SLT have demonstrated mixed results, with a recent concern for overtreatment and the increase in postoperative thrombotic events. An oversight of many studies evaluating VET in LT is a single protocol that does not address the different phases o...
Source: Seminars in Thrombosis and Hemostasis - November 1, 2022 Category: Hematology Authors: Stewart, Erin Nydam, Trevor L. Hendrickse, Adrian Pomposelli, James J. Pomfret, Elizabeth A. Moore, Hunter B. Tags: Review Article Source Type: research

Frequency and Clinical Significance Anti-PS/PT Antibodies in Patients with Antiphospholipid Syndrome – Single Centre Observational Study in the United Kingdom
Semin Thromb Hemost DOI: 10.1055/s-0042-1757633 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - November 1, 2022 Category: Hematology Authors: Noble, Hithin Crossette-Thambiah, Christina Odho, Zain Karawitage, Nilanthi Logan, Karen Pericleous, Charis Laffan, Mike Arachchillage, Deepa J. Tags: Review Article Source Type: research

Fibrinolysis Shutdown and Hypofibrinolysis Are Not Synonymous Terms: The Clinical Significance of Differentiating Low Fibrinolytic States
Semin Thromb Hemost DOI: 10.1055/s-0042-1758057Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown. Hypofibrinolysis is a chronic state of lack of ability to generate an appropriate fibrinolytic response when anticipated. Fibrinolysis shutdown is the shutdown of fibrinolysis after systemic activation of the fibrinolytic system. There has been interchanging of these terms to describe critically ill patients in multiple settings. This is problematic in understanding the path...
Source: Seminars in Thrombosis and Hemostasis - November 1, 2022 Category: Hematology Authors: Moore, Hunter B. Tags: Review Article Source Type: research

Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method
Semin Thromb Hemost DOI: 10.1055/s-0042-1757896Compared with conventional coagulation tests and factor-specific assays, viscoelastic hemostatic assays (VHAs) can provide a more thorough evaluation of clot formation and lysis but have several limitations including clot deformation. In this proof-of-concept study, we test a noncontact technique, termed resonant acoustic rheometry (RAR), for measuring the kinetics of human plasma coagulation. Specifically, RAR utilizes a dual-mode ultrasound technique to induce and detect surface oscillation of blood samples without direct physical contact and measures the resonant frequency ...
Source: Seminars in Thrombosis and Hemostasis - November 1, 2022 Category: Hematology Authors: Li, Weiping Hobson, Eric C. Bunch, Connor M. Miller, Joseph B. Nehme, Jimmy Kwaan, Hau C. Walsh, Mark M. McCurdy, Michael T. Aversa, John G. Thomas, Anthony V. Zackariya, Nuha Thomas, Samuel J. Smith, Stephanie A. Cook, Bernard C. Boyd, Bryan Stegemann, J Tags: Review Article Source Type: research

The Role of Thromboelastography during the Management of Postpartum Hemorrhage: Background, Evidence, and Practical Application
Semin Thromb Hemost DOI: 10.1055/s-0042-1757895Postpartum hemorrhage (PPH) is a common cause of significant maternal morbidity and mortality that can be associated with coagulopathy, especially hypofibrinogenemia. There is interest in point-of-care viscoelastic hemostatic assays (POC-VHA) in PPH because prompt knowledge of coagulation status can aid diagnosis, identify cases of severe coagulopathy, and allow ongoing monitoring during rapid bleeding. The incidence of coagulopathy in most cases of PPH is low because of the procoagulant state of pregnancy, including raised fibrinogen levels of around 4 to 6 g/L. A Clauss fi...
Source: Seminars in Thrombosis and Hemostasis - November 1, 2022 Category: Hematology Authors: Collis, Rachel Bell, Sarah Tags: Review Article Source Type: research

Pathogen Reduction Technologies and Their Impact on Metabolic and Functional Properties of Treated Platelet Concentrates: A Systematic Review
Semin Thromb Hemost DOI: 10.1055/s-0042-1757897Pathogen reduction technologies (PRTs) such as Mirasol and Intercept were developed to eliminate transfusion-transmitted infections. The impact of PRTs on platelet function during the storage period, their effect on platelet storage lesions, and the optimal storage duration following PRTs have not been clearly defined. The aim of this study was to systematically review the existing literature and investigate the impact of PRTs on functional alterations of PRT-treated platelets during the storage period. The authors identified 68 studies suitable to be included in this review. ...
Source: Seminars in Thrombosis and Hemostasis - October 17, 2022 Category: Hematology Authors: Tsalas, Stavros Petrou, Eleni Tsantes, Andreas G. Sokou, Rozeta Loukopoulou, Electra Houhoula, Dimitra Mantzios, Petros G. Kriebardis, Anastasios G. Tsantes, Argirios E. Tags: Review Article Source Type: research

Hemostasis from Bench to Bedside: The History of Three Successful Stories of Translational Medicine
This article aims to review the history on the development of D-dimer, heparin, and coagulometers, which have been chosen as paradigmatic examples of diagnostic testing, drugs, and measuring devices, respectively. They should be considered among the most successful histories of translational medicine. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 17, 2022 Category: Hematology Authors: Tripodi, Armando Tags: Review Article Source Type: research

Predictors of Recurrent Venous Thromboembolism or Arterial Thrombotic Events during and after Anticoagulation for a First Venous Thromboembolism
Semin Thromb Hemost DOI: 10.1055/s-0042-1757899After first episodes of venous thromboembolism (VTE), patients are at increased risk of recurrent VTE and arterial thrombotic events (ATE) compared with the general population, two disorders that are influenced by anticoagulation. However, risk factors of these conditions occurring during and after anticoagulation are little described. Using cause-specific hazard regression models, we aimed to determine risk factors of the composite outcome recurrent VTE/ATE, and separately recurrent VTE or ATE, during and after anticoagulation in patients with first episodes of VTE from a pro...
Source: Seminars in Thrombosis and Hemostasis - October 17, 2022 Category: Hematology Authors: Noumegni, Steve Raoul Tromeur, C écile Hoffmann, Cl ément Mao, Raphael Le Moigne, Emmanuelle Le Moreuil, Claire de Mansourati, Vincent Nasr, Bahaa Gentric, Jean-Christophe Guegan, Marie Poulhazan, Elise Bressollette, Luc Lacut, Karine Didier, Romain Cou Tags: Review Article Source Type: research

Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0042-1757545Viscoelastic testing (VET), such as thromboelastography, can measure whole blood coagulation dynamics in real time and is used across a range of clinical settings, including cardiac surgery, liver transplant, and trauma. The use of modified thromboelastography with platelet function assessment (TEG(R) PlateletMapping(R) Assay) can provide an analysis of platelet contribution to hemostasis, including the contribution of the P2Y12 receptor and thromboxane pathway to platelet function. The TEG PlateletMapping Assay has shown high correlation with the current gold standard test of...
Source: Seminars in Thrombosis and Hemostasis - October 17, 2022 Category: Hematology Authors: Hartmann, Jan Curzen, Nick Tags: Review Article Source Type: research

COVID-19-Associated Pulmonary Embolism: Review of the Pathophysiology, Epidemiology, Prevention, Diagnosis, and Treatment
Semin Thromb Hemost DOI: 10.1055/s-0042-1757634COVID-19 is associated with endothelial activation in the setting of a potent inflammatory reaction and a hypercoagulable state. The end result of this thromboinflammatory state is an excess in thrombotic events, in particular venous thromboembolism. Pulmonary embolism (PE) has been of special interest in patients with COVID-19 given its association with respiratory deterioration, increased risk of intensive care unit admission, and prolonged hospital stay. The pathophysiology and clinical characteristics of COVID-19-associated PE may differ from the conventional non–COVID-1...
Source: Seminars in Thrombosis and Hemostasis - October 12, 2022 Category: Hematology Authors: Ortega-Paz, Luis Talasaz, Azita H. Sadeghipour, Parham Potpara, Tatjana S. Aronow, Herbert D. Jara-Palomares, Luis Sholzberg, Michelle Angiolillo, Dominick J. Lip, Gregory Y.H. Bikdeli, Behnood Tags: Review Article Source Type: research

How Do Laboratories Perform von Willebrand Disease Diagnostics and Classification of von Willebrand Disease Patients? Results from External Quality Data and an International Survey
Conclusions Diagnosis of VWD is heterogeneous in diagnostic approach, guidelines, and cutoff values within large ranges of VWF results between laboratories. Harmonization of approaches and increased accuracy of VWF measurements may help to establish a correct diagnosis. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 12, 2022 Category: Hematology Authors: Hollestelle, Martine J. Meijers, Joost C. M. Meijer, Piet Tags: Review Article Source Type: research

Analysis of College of American Pathologists von Willebrand Factor Proficiency Testing Program
Semin Thromb Hemost 2022; 48: 690-699 DOI: 10.1055/s-0042-1758161Von Willebrand factor (VWF) level and/or function is altered in von Willebrand disease (VWD), the most common heritable bleeding disorder worldwide. Laboratory assessment of VWF is continually evolving. Historically, the primary method for the assessment of VWF platelet-binding activity was the ristocetin cofactor assay (VWF:RCo). Contemporary alternative measures of VWF platelet-binding activity include VWF:GPIbR (recombinant; using ristocetin), VWF:GPIbM (recombinant; gain-of-function mutant), and monoclonal antibody. Recently, the American Society of Hemat...
Source: Seminars in Thrombosis and Hemostasis - October 12, 2022 Category: Hematology Authors: Salazar, Eric Long, Thomas A. Smock, Kristi Johnson Wool, Geoffrey D. Rollins-Raval, Marian Chen, Dong Harris, Neil Selwyn Chan, Clarence W. Olson, John D. Pham, Huy P. Ritter, Jacob Unold, David VanSandt, Amanda Matzke Goodwin IV, Andrew Jackson Tags: Review Article Source Type: research

Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance
Semin Thromb Hemost 2022; 48: 680-689 DOI: 10.1055/s-0042-1758162Activated protein C (APC) resistance (APCR) is considered a risk factor of venous thromboembolism (VTE). The most common genetic disorder conferring APCR is a factor (F) V Leiden mutation, but many other factors are also implicated, such as other F5 mutations (e.g., FV Hong-Kong and FV Cambridge), protein S deficiency, elevated factor VIII, exogenous hormone use, pregnancy and postpartum, depending on how APCR is defined. Considering the large population affected, the detection of this phenotype is crucial. Two types of tests are currently available: clotting...
Source: Seminars in Thrombosis and Hemostasis - October 12, 2022 Category: Hematology Authors: Morimont, Laure Donis, Nathalie Bouvy, C éline Mullier, Fran çois Dogn é, Jean-Michel Douxfils, Jonathan Tags: Review Article Source Type: research

New Seminars in Thrombosis and Hemostasis (STH) 2021 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics
Semin Thromb Hemost 2022; 48: 634-642 DOI: 10.1055/s-0042-1756172 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - October 12, 2022 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Editorial Source Type: research

Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials
This study aimed to determine whether the use of thromboelastography in adult patients with cirrhosis decreases blood product use and impacts adverse events or mortality compared with standard practice. A registered (PROSPERO CRD42020192458) systematic review and meta-analysis was conducted for randomized controlled trials (RCTs) comparing thromboelastography-guided hemostatic management versus standard practice (control). Co-primary outcomes were the number of transfused platelet units and fresh frozen plasma (FFP) units. Secondary outcomes were mortality, adverse events, utilization of individual blood products, blood lo...
Source: Seminars in Thrombosis and Hemostasis - October 10, 2022 Category: Hematology Authors: Hartmann, Jan Dias, Joao D. Pivalizza, Evan G. Garcia-Tsao, Guadalupe Tags: Review Article Source Type: research