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Changes in Coagulation in Cancer Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Treatment (HIPEC) —A Systematic Review
In conclusion, a decrease in platelet count and subtle changes in secondary hemostasis were found following cytoreductive surgery with HIPEC. Data on the effect of cytoreductive surgery with HIPEC on fibrinolysis are sparse and this needs to be further investigated. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 24, 2023 Category: Hematology Authors: Lundbech, Mikkel Damsbo, Matilde Krag, Andreas Engel Hvas, Anne-Mette Tags: Review Article Source Type: research

The Role of the von Willebrand Factor Collagen-Binding Assay (VWF:CB) in the Diagnosis and Treatment of von Willebrand Disease (VWD) and Way Beyond: A Comprehensive 36-Year History
Semin Thromb Hemost DOI: 10.1055/s-0043-1763259The von Willebrand factor (VWF) collagen binding (VWF:CB) assay was first reported for use in von Willebrand diagnostics in 1986, by Brown and Bosak. Since then, the VWF:CB has continued to be used to help diagnose von Willebrand disease (VWD) (correctly) and also to help assign the correct subtype, as well as to assist in the monitoring of VWD therapy, especially desmopressin (DDAVP). However, it is important to recognize that the specific value of any VWF:CB is predicated on the use of an optimized VWF:CB, and that not all VWF:CB assays are so optimized. There are some good ...
Source: Seminars in Thrombosis and Hemostasis - February 20, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Review Article Source Type: research

Association between Severe Acute Respiratory Syndrome Coronavirus 2Infection (Coronavirus Disease 2019) and Lupus Anticoagulant-Hypoprothrombinemia Syndrome: A Case Report and Literature Assessment
Semin Thromb Hemost DOI: 10.1055/s-0043-1762577 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 20, 2023 Category: Hematology Authors: Monti, Marta Martini, Tiziano Pengo, Vittorio Poletti, Giovanni Pedrazzi, Paola Biasoli, Chiara Giovacchini, Maddalena Fasano, Tommaso Tags: Letter to the Editor Source Type: research

Assessment of Hemostatic Profile in Neonates with Intrauterine Growth Restriction: A Systematic Review of Literature
Semin Thromb Hemost DOI: 10.1055/s-0043-1762893Intrauterine growth restriction (IUGR) affects nearly 10 to 15% of pregnancies and is responsible for many short- and long-term adverse consequences, including hemostatic derangement. Both thrombotic and hemorrhagic events are described in the perinatal period in these neonates. The aim of this study was to systematically review the literature on the laboratory studies used to evaluate the hemostatic system of the IUGR small for gestational age neonate. We reviewed the current literature via PubMed and Scopus until September 2022. Following our inclusion/exclusion criteria, we...
Source: Seminars in Thrombosis and Hemostasis - February 17, 2023 Category: Hematology Authors: Karapati, Eleni Sokou, Rozeta Iliodromiti, Zoi Tsaousi, Marina Sulaj, Alma Tsantes, Andreas G. Petropoulou, Chrysa Pouliakis, Abraham Tsantes, Argirios E. Boutsikou, Theodora Iacovidou, Nicoletta Tags: Review Article Source Type: research

Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients
Semin Thromb Hemost DOI: 10.1055/s-0043-1762578 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 13, 2023 Category: Hematology Authors: Wang, Samuel Sherng Young Chee, Keefe Wong, Shiun Woei Tan, Guat Bee Ang, Hong Leung, Bernard PuiLam Tan, Chuen Wen Ramanathan, Kollengode Dalan, Rinkoo Cheung, Christine Lye, David Chien Young, Barnaby Edward Yap, Eng Soo Chia, Yew Woon Fan, Bingwen Euge Tags: Review Articvle Source Type: research

Editorial Compilation XIII
Semin Thromb Hemost DOI: 10.1055/s-0043-1762576 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - February 13, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Pasalic, Leonardo Lippi, Giuseppe Tags: Preface Source Type: research

Hemostasis in the Pregnant Woman, the Placenta, the Fetus, and the Newborn Infant
Semin Thromb Hemost DOI: 10.1055/s-0042-1760332The hemostasis system is composed of procoagulant, anticoagulant, and fibrinolytic proteins that interact with endothelial and blood cells and with each other in a complex system of checks and balances to maintain blood flow while preventing both hemorrhage and thrombosis. Pregnancy is a unique physiological state in which biological alterations predispose both mother and fetus to both bleeding and clotting. The placenta is a vascular interface for maternal and fetal blood exchange which predisposes the mother to hemorrhage. Maternal hemostasis presents a compensatory hypercoa...
Source: Seminars in Thrombosis and Hemostasis - February 7, 2023 Category: Hematology Authors: Warren, Beth Boulden Moyer, Genevieve C. Manco-Johnson, Marilyn J. Tags: Review Article Source Type: research

The History of Extracorporeal Membrane Oxygenation and the Development of Extracorporeal Membrane Oxygenation Anticoagulation
Semin Thromb Hemost DOI: 10.1055/s-0043-1761488Extracorporeal membrane oxygenation (ECMO) was first started for humans in early 1970s by Robert Bartlett. Since its inception, there have been numerous challenges with extracorporeal circulation, such as coagulation and platelet activation, followed by consumption of coagulation factors and platelets, and biocompatibility of tubing, pump, and oxygenator. Unfractionated heparin (heparin hereafter) has historically been the defacto anticoagulant until recently. Also, coagulation monitoring was mainly based on bedside activated clotting time and activated partial thromboplastin ...
Source: Seminars in Thrombosis and Hemostasis - February 7, 2023 Category: Hematology Authors: Bartlett, Robert Arachichilage, Deepa J. Chitlur, Meera Hui, Shiu-Ki Rocky Neunert, Cindy Doyle, Andrew Retter, Andrew Hunt, Beverley J Lim, Hoong Sern Saini, Arun Renn é, Thomas Kostousov, Vadim Teruya, Jun Tags: Review Article Source Type: research

Drug –Drug Interactions in the Treatment of Cancer-Associated Venous Thromboembolism with Direct Oral Anticoagulants
Semin Thromb Hemost DOI: 10.1055/s-0043-1762596Venous thromboembolism (VTE) is a frequent complication of cancer, and management of cancer-associated thrombosis (CAT) is challenging due to increased risks of bleeding and recurrent VTE. Recent trials have shown an acceptable efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of CAT compared to low-molecular weight heparin. Although DOACs provide an effective and convenient treatment option in CAT, the need to assess the risk of drug–drug interactions (DDI) with antineoplastic therapies poses a barrier to their use in clinical practice. With the aim...
Source: Seminars in Thrombosis and Hemostasis - February 2, 2023 Category: Hematology Authors: Hellfritzsch, Maja Henriksen, Jakob N ørgaard Holt, Marianne Ingerslev Grove, Erik Lerkevang Tags: Review Article Source Type: research

Prognostic Impact of the International Society on Thrombosis and Hemostasis Disseminated Intravascular Coagulation Score in Sepsis: A Systematic Review
Semin Thromb Hemost DOI: 10.1055/s-0043-1761216The International Society on Thrombosis and Haemostasis (ISTH) diagnostic criteria for disseminated intravascular coagulation (DIC) are widely used for DIC diagnosis. However, the prognostic value of the score may vary between different patient populations and settings. This systematic review investigated the association between the ISTH DIC score and mortality in sepsis patients. A literature search was conducted in PubMed and Embase. Inclusion criteria were studies including adult and pediatric patients hospitalized with sepsis, using any sepsis definition, and investigating...
Source: Seminars in Thrombosis and Hemostasis - February 2, 2023 Category: Hematology Authors: Frank, Christian Sandberg Larsen, Julie Brogaard Tags: Review Article Source Type: research

Evolution of Hemostasis Testing: A Personal Reflection Covering over 40 Years of History*
Semin Thromb Hemost DOI: 10.1055/s-0043-1761487There is no certainty in change, other than change is certain. As Seminars in Thrombosis and Hemostasis celebrates 50 years of publication, I felt it appropriate to reflect on my own 40-year plus scientific career. My career in the thrombosis and hemostasis field did not start until 1987, but the subsequent 35 years reflected a period of significant change in associated disease diagnostics. I started in the Westmead Hospital “coagulation laboratory” when staff were still performing manual clotting tests, using stopwatches, pipettes, test tubes, and a water bath, which we t...
Source: Seminars in Thrombosis and Hemostasis - February 2, 2023 Category: Hematology Authors: Favaloro, Emmanuel J. Tags: Review Article Source Type: research

Mechanisms of Thrombosis in Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia
Semin Thromb Hemost DOI: 10.1055/s-0043-1761269Heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic thrombocytopenia (VITT) are rare, iatrogenic immune-mediated conditions with high rates of thrombosis-related morbidity and mortality. HIT is a long-recognized reaction to the administration of the common parenterally administered anticoagulant heparin (or its derivatives), while VITT is a new, distinct syndrome occurring in response to adenovirus-based vaccines against coronavirus disease 2019 and potentially other types of vaccines. A feature of both HIT and VITT is paradoxical thrombosis despite a ...
Source: Seminars in Thrombosis and Hemostasis - January 27, 2023 Category: Hematology Authors: Selvadurai, Maria V. Favaloro, Emmanuel J. Chen, Vivien M. Tags: Review Article Source Type: research

The History of Factor XIII Deficiency
Semin Thromb Hemost DOI: 10.1055/s-0043-1761217Despite the early discovery of factor XIII (FXIII) in 1944, the diagnosis of FXIII deficiency was not made until 1960, after all the other coagulation factor deficiencies, most likely due to the normality of routine coagulation testing in FXIII deficiency. Although the first case was detected by the clot solubility test and this test has long since been used to detect FXIII deficiency, the test is no longer recommended by experts. Over the past 60 years, knowledge about FXIII deficiency has expanded considerably, between 1992, when the first variant was identified, and 2022, 1...
Source: Seminars in Thrombosis and Hemostasis - January 27, 2023 Category: Hematology Authors: Dorgalaleh, Akbar Tags: Review Article Source Type: research

Has “D-Dimeritis” Worsened during the Coronavirus Disease 2019 Pandemic?
Semin Thromb Hemost DOI: 10.1055/s-0043-1761464 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - January 24, 2023 Category: Hematology Authors: Lippi, Giuseppe Perilli, Valeria Tags: Letter to the Editor Source Type: research

Evolution of Antiphospholipid Syndrome
Semin Thromb Hemost DOI: 10.1055/s-0042-1760333Antiphospholipid syndrome (APS) is an autoimmune prothrombotic disease characterized by thrombosis and/or pregnancy complications caused by antiphospholipid antibodies (aPL). The history of APS can be traced back to observations made during screening programs for syphilis conducted in the mid-20th century, with identification of patients with the so-called biological false-positive serological reactions for syphilis. Initial observation linking aPL with recurrent miscarriages was first reported more than 40 years ago. Since then, our understanding of the pathogenesis and manag...
Source: Seminars in Thrombosis and Hemostasis - January 16, 2023 Category: Hematology Authors: Arachchillage, Deepa J. Pericleous, Charis Tags: Review Article Source Type: research