Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma
CONCLUSION: Our results indicated that PLSCR1 could facilitate proliferation, mobility, EMT and glycolysis, but repress apoptosis through activating IL-6/ JAK/STAT3 signaling in glioma. Therefore, PLSCR1 may function as a potential therapeutic target for glioma.PMID:38636689 | DOI:10.1016/j.abb.2024.110002 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - April 18, 2024 Category: Biochemistry Authors: ShiZhen Zhou Jun Xu YuFang Zhu Source Type: research
The RAS oncogene in brain tumors and the involvement of let-7 microRNA
Mol Biol Rep. 2024 Apr 18;51(1):531. doi: 10.1007/s11033-024-09439-z.ABSTRACTRAS oncogenes are master regulator genes in many cancers. In general, RAS-driven cancers have an oncogenic RAS mutation that promotes disease progression (colon, lung, pancreas). In contrast, brain tumors are not necessarily RAS-driven cancers because RAS mutations are rarely observed. In particular, glioblastomas (the most lethal brain tumor) do not appear to have dominant genetic mutations that are suitable for targeted therapy. Standard treatment for most brain tumors continues to focus on maximal surgical resection, radiotherapy and chemothera...
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Samantha Messina Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
Cancers, Vol. 16, Pages 1543: Predicting Isocitrate Dehydrogenase Status in Non-Contrast-Enhanced Adult-Type Astrocytic Tumors Using Diffusion Tensor Imaging and 11C-Methionine, 11C-Choline, and 18F-Fluorodeoxyglucose PET
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Tsuyoshi Izumo
We aimed to differentiate the isocitrate dehydrogenase (IDH) status among non-enhanced astrocytic tumors using preoperative MRI and PET. We analyzed 82 patients with non-contrast-enhanced, diffuse, supratentorial astrocytic tumors (IDH mutant [IDH-mut], 55 patients; IDH-wildtype [IDH-wt], 27 patients) who underwent MRI and PET between May 2012 and December 2022. We calculated the fractional anisotropy (FA) and mean diffusivity (MD) values using diffusion tensor imaging. We evaluated the tumor/normal brain uptake (T/N) ratios using 11C-methionine, 11C-choline, and 18F-fluorodeoxyglucose PET; extracte...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Shoji Yasuda Hirohito Yano Yuka Ikegame Soko Ikuta Takashi Maruyama Morio Kumagai Yoshihiro Muragaki Toru Iwama Jun Shinoda Tsuyoshi Izumo Tags: Article Source Type: research
Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma
ConclusionICEUS facilitates the identification of residual tumors. Age and ICEUS are prognostic factors for malignant glioma surgery, and use of ICEUS offers a better prognosis for patients with malignant glioma. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 18, 2024 Category: Research Source Type: research
Incidence rates of the most common canine tumors based on data from the Swiss Canine Cancer Registry (2008 to 2020)
In conclusion, the calculated IRs and IRRs revealed previously unknown predisposing factors, including novel breed-specific suscepti bilities. The results may have implications for cancer screening, diagnostic work-up, breeding management and oncologic and translational research. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Elena Sophie Dhein Source Type: research
Correction to: Metabolomic Profiles of Human Glioma Inform Patient Survival, by Scott et al. Antioxid Redox Signal 2023;39(13 –15):942–956; doi: 10.1089/ars.2022.0085
Antioxidants&Redox Signaling, Ahead of Print. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - April 18, 2024 Category: Research Source Type: research
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt –β-catenin pathway
Protein arginine methyltransferase 6 (PRMT6) plays a crucial role in various pathophysiological processes and diseases. Glioblastoma (GBM; WHO Grade 4 glioma) is the most common and lethal primary brain tumor ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 18, 2024 Category: Cancer & Oncology Authors: Peng Yu, Tutu Xu, Wenmeng Ma, Xiang Fang, Yue Bao, Chengran Xu, Jinhai Huang, Yongqing Sun and Guangyu Li Tags: Research Source Type: research
Identifying Diffuse Glioma Subtypes Based on Pathway Enrichment Evaluation
AbstractGliomas are highly heterogeneous in molecular, histology, and microenvironment. However, a classification of gliomas by integrating different tumor microenvironment (TME) components remains unexplored. Based on the enrichment scores of 17 pathways involved in immune, stromal, DNA repair, and nervous system signatures in diffuse gliomas, we performed consensus clustering to uncover novel subtypes of gliomas. Consistently in three glioma datasets (TCGA-glioma, CGGA325, and CGGA301), we identified three subtypes: Stromal-enriched (Str-G), Nerve-enriched (Ner-G), and mixed (Mix-G). Ner-G was charactered by low immune...
Source: Interdisciplinary Sciences, Computational Life Sciences - April 18, 2024 Category: Bioinformatics Source Type: research
Cortical incisions and transcortical approaches for intra-axial and intraventricular lesions: A scoping review
CONCLUSION: Transcortical approaches are crucial techniques for managing a wide range of intracranial lesions, with the transcortical-transtemporal approach being the most common. According to the current literature, the selective choice of cortical incision and surgical corridor based on the lesion's pathology and anatomic-functional location correlates with acceptable functional outcomes.PMID:38628541 | PMC:PMC11021096 | DOI:10.25259/SNI_58_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Samer S Hoz Mustafa Ismail Paolo Palmisciano Younus M Al-Khazaali Saleh A Saleh Ahmed Muthana Jonathan A Forbes Charles J Prestigiacomo Mario Zuccarello Norberto Andaluz Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
Relationship between chemokine/chemokine receptor and glioma prognosis and outcomes: Systematic review and meta-analysis
CONCLUSION: The findings of this study showed a robust association between elevated levels of CXCR4, CXCL12, CCL2, CXCL8, CXCL10 and CXCR7 with a higher risk of glioma. Furthermore, the WHO grading system was validated by the strong correlation shown between higher expression of CXCR4, CXCL12, CCL2, and CCL18 and WHO high-grade gliomas (grades 3-4). Furthermore, the results of the meta-analysis suggested that CXCR4 might be a helpful biomarker for predicting the worse prognosis of glioma patients.PMID:38631221 | DOI:10.1016/j.intimp.2024.112047 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Shaobo Yang Minjie Luo Shun Yang Min Yuan Hu Zeng Jun Xia Nianhua Wang Source Type: research
Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
CONCLUSIONS: At our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI.PMID:38629258 | DOI:10.1002/cam4.7154 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi Susan N Chi Kee Kiat Yeo Allison F O'Neill David S Shulman Steven G DuBois Natalie B Collins Source Type: research
Transient Receptor Potential Vanilloid-1 (TRPV1) Channels act as Suppressors of the Growth of Glioma
Brain Res Bull. 2024 Apr 15:110950. doi: 10.1016/j.brainresbull.2024.110950. Online ahead of print.ABSTRACTThe aim of this study was to investigate the expression and function of the transient receptor potential vanilloid 1 (TRPV1) in glioma. We found that the expression of TRPV1 mRNA and protein were upregulated in glioma compared with normal brain by qPCR and western blot analysis. In order to investigate the function of TRPV1 in glioma, short hairpin RNA (shRNA) and the inhibitor of TRPV1 were used. In vitro, the activation of TRPV1 induced cell apoptosis with decreased migration capability and inhibited proliferation, ...
Source: Brain Research Bulletin - April 17, 2024 Category: Neurology Authors: Jingjing Cheng Mengliu Zeng Biwen Peng Ping Li ShiYu Zhao Source Type: research
Transient Receptor Potential Vanilloid-1 (TRPV1) Channels act as Suppressors of the Growth of Glioma
Brain Res Bull. 2024 Apr 15:110950. doi: 10.1016/j.brainresbull.2024.110950. Online ahead of print.ABSTRACTThe aim of this study was to investigate the expression and function of the transient receptor potential vanilloid 1 (TRPV1) in glioma. We found that the expression of TRPV1 mRNA and protein were upregulated in glioma compared with normal brain by qPCR and western blot analysis. In order to investigate the function of TRPV1 in glioma, short hairpin RNA (shRNA) and the inhibitor of TRPV1 were used. In vitro, the activation of TRPV1 induced cell apoptosis with decreased migration capability and inhibited proliferation, ...
Source: Brain Research - April 17, 2024 Category: Neurology Authors: Jingjing Cheng Mengliu Zeng Biwen Peng Ping Li ShiYu Zhao Source Type: research
