GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
CONCLUSIONS: Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.PMID:38639105 | DOI:10.1161/CIRCRESAHA.123.323736 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Xuran Chu Vahid Kheirollahi Arun Lingampally Prakash Chelladurai Chanil Valasarajan Ana Ivonne Vazquez-Armendariz Stefan Hadzic Ali Khadim Oleg Pak Stefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena Moiseenko Monika Heiner Simone Kraut Le Source Type: research
Opportunities to Improve Palliative Care Delivery in High-Grade Glioma
1. Identify unique palliative care needs in high-grade glioma, distinct from those in systemic cancer.2. Identify opportunities to improve palliative care delivery for patients with high-grade glioma. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Rita Crooms, Jeannys F. Nnemnbeng, Jennie Taylor, Ksenia Gorbenko, Nathan Goldstein, Barbara G. Vickrey Source Type: research
GSE172387 Loss of retinoic acid signaling drives immune escape in IDH mutant gliomas
Contributors : Anthony R Cillo ; Aparna Rao ; Xiaoran Zhang ; Tullia C Bruno ; Dario A Vignali ; Nduka AmankulorSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusGliomas are immunologically cold tumors that can be broken into several categories based on either RNA expression profiles or methylation profiles, with isocitrate dehydrogenase (IDH) mutations defining a major segregration between types. IDH mutant gliomas often exhibit defects in the retinoic acid pathway. We treated mice harboring IDH mutant gliomas with all-trans retinoic acid, and found that this treatment cause...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells & mdash;Features for New Therapy Design
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells—Features for New Therapy Design
Cancers doi: 10.3390/cancers16081557
Authors:
Nives Pećina-Šlaus
Reno Hrašćan
On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cell...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Nives Pe ćina-Šlaus Reno Hra šćan Tags: Review Source Type: research
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
ConclusionA risk stratification algorithm based on significant prognostic factors allowed a personalized early prognosis estimation at the time of GBM diagnosis, that can contribute to a more personalized patient counseling. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1576: Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients
In conclusion, FUS-BBBO-enhanced liquid biopsy using stable cavitation shows diagnostic potential for primary brain tumors. Further research is imperative before integrating FUS-BBBO for liquid biopsy enhancement into clinical practice. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Akke Bakker Anna E. Ixkes Hema Venugopal Mario G. Ries Nathalie S. M. Lak Filip Y. F. L. de Vos Dannis G. van Vuurden Tom J. Snijders Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1574: The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience
io Melcarne
Diego Garbossa
Given the importance of maximizing resection for prognosis in patients with HGG and the potential risks associated with ventricle opening, this study aimed to assess the actual increase in post-surgical complications related to lateral ventricle opening and its influence on OS and PFS. A retrospective study was conducted on newly diagnosed HGG, dividing the patients into two groups according to whether the lateral ventricle was opened (69 patients) or not opened (311 patients). PFS, OS, subependymal dissemination, distant parenchymal recurrences, the development of hydrocephalus and CSF lea...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Fabio Cofano Andrea Bianconi Raffaele De Marco Elena Consoli Pietro Zeppa Francesco Bruno Alessia Pellerino Flavio Panico Luca Francesco Salvati Francesca Rizzo Alberto Morello Roberta Rud à Giovanni Morana Antonio Melcarne Diego Garbossa Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1566: Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated
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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference ...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Guido Frosina Tags: Review Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt- β-catenin pathway
CONCLUSIONS: Our results demonstrate the PRMT6-YTHDF2-Wnt-β-Catenin axis promotes GBM migration, invasion, and EMT in vitro and in vivo, potentially serving as a therapeutic target for GBM.PMID:38637831 | DOI:10.1186/s13046-024-03038-3 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Peng Yu Tutu Xu Wenmeng Ma Xiang Fang Yue Bao Chengran Xu Jinhai Huang Yongqing Sun Guangyu Li Source Type: research
Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma
CONCLUSION: Our results indicated that PLSCR1 could facilitate proliferation, mobility, EMT and glycolysis, but repress apoptosis through activating IL-6/ JAK/STAT3 signaling in glioma. Therefore, PLSCR1 may function as a potential therapeutic target for glioma.PMID:38636689 | DOI:10.1016/j.abb.2024.110002 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - April 18, 2024 Category: Biochemistry Authors: ShiZhen Zhou Jun Xu YuFang Zhu Source Type: research
The RAS oncogene in brain tumors and the involvement of let-7 microRNA
Mol Biol Rep. 2024 Apr 18;51(1):531. doi: 10.1007/s11033-024-09439-z.ABSTRACTRAS oncogenes are master regulator genes in many cancers. In general, RAS-driven cancers have an oncogenic RAS mutation that promotes disease progression (colon, lung, pancreas). In contrast, brain tumors are not necessarily RAS-driven cancers because RAS mutations are rarely observed. In particular, glioblastomas (the most lethal brain tumor) do not appear to have dominant genetic mutations that are suitable for targeted therapy. Standard treatment for most brain tumors continues to focus on maximal surgical resection, radiotherapy and chemothera...
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Samantha Messina Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
Cancers, Vol. 16, Pages 1543: Predicting Isocitrate Dehydrogenase Status in Non-Contrast-Enhanced Adult-Type Astrocytic Tumors Using Diffusion Tensor Imaging and 11C-Methionine, 11C-Choline, and 18F-Fluorodeoxyglucose PET
da
Tsuyoshi Izumo
We aimed to differentiate the isocitrate dehydrogenase (IDH) status among non-enhanced astrocytic tumors using preoperative MRI and PET. We analyzed 82 patients with non-contrast-enhanced, diffuse, supratentorial astrocytic tumors (IDH mutant [IDH-mut], 55 patients; IDH-wildtype [IDH-wt], 27 patients) who underwent MRI and PET between May 2012 and December 2022. We calculated the fractional anisotropy (FA) and mean diffusivity (MD) values using diffusion tensor imaging. We evaluated the tumor/normal brain uptake (T/N) ratios using 11C-methionine, 11C-choline, and 18F-fluorodeoxyglucose PET; extracte...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Shoji Yasuda Hirohito Yano Yuka Ikegame Soko Ikuta Takashi Maruyama Morio Kumagai Yoshihiro Muragaki Toru Iwama Jun Shinoda Tsuyoshi Izumo Tags: Article Source Type: research
Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma
ConclusionICEUS facilitates the identification of residual tumors. Age and ICEUS are prognostic factors for malignant glioma surgery, and use of ICEUS offers a better prognosis for patients with malignant glioma. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 18, 2024 Category: Research Source Type: research
