Medical image foundation models in assisting diagnosis of brain tumors: a pilot study
ConclusionsFoundation models obtained from self-supervised learning have demonstrated encouraging potential for scalability and interpretability in downstream brain tumor-related tasks and hold promise for extension to neurological diseases with diffusely distributed lesions.Clinical relevance statementThe application of our proposed method to the prediction of key molecular status in gliomas is expected to improve treatment planning and patient outcomes. Additionally, the foundation model we developed could serve as a cornerstone for advancing AI applications in the diagnosis of brain-related diseases. (Source: European Radiology)
Source: European Radiology - April 16, 2024 Category: Radiology Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells
AbstractGlioblastoma (GBM) is the highest grade of glioma for which no effective therapy is currently available. Despite extensive research in diagnosis and therapy, there has been no significant improvement in GBM outcomes, with a median overall survival continuing at a dismal 15 –18 months. In recent times, glioblastoma stem cells (GSCs) have been identified as crucial drivers of treatment resistance and tumor recurrence, and GBM therapies targeting GSCs are expected to improve patient outcomes. We used a multistep in silico screening strategy to identify repurposed cand idate drugs against selected therapeutic molecu...
Source: Molecular Neurobiology - April 15, 2024 Category: Neurology Source Type: research
Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy
In conclusion, we showed that ATP1A3 is a highly promising treatment target in GBM and the risk score is an independent prognostic factor for cancer and can be used to help guide the prediction of survival time in patients with GBM.PMID:38615384 | DOI:10.1016/j.intimp.2024.112045 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Yu-Long Lan Shuang Zou Bing Qin Xiangdong Zhu Source Type: research
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma
Int Immunopharmacol. 2024 Apr 13;133:112074. doi: 10.1016/j.intimp.2024.112074. Online ahead of print.ABSTRACTThe tumor microenvironment plays a vital role in glioblastoma growth and invasion. PD-1 and PD-L1 modulate the immunity in the brain tumor microenvironment. However, the underlying mechanisms remain unclear. In the present study, in vivo and in vitro experiments were conducted to reveal the effects of PD-1/PD-L1 on the crosstalk between microglia and glioma. Results showed that glioma cells secreted PD-L1 to the peritumoral areas, particularly microglia containing highly expressed PD-1. In the early stages of gliom...
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Xi-Peng Wang Wei Guo Ye-Fan Chen Chen Hong Juan Ji Xi-Yue Zhang Yin-Feng Dong Xiu-Lan Sun Source Type: research
Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy
In conclusion, we showed that ATP1A3 is a highly promising treatment target in GBM and the risk score is an independent prognostic factor for cancer and can be used to help guide the prediction of survival time in patients with GBM.PMID:38615384 | DOI:10.1016/j.intimp.2024.112045 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Yu-Long Lan Shuang Zou Bing Qin Xiangdong Zhu Source Type: research
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma
Int Immunopharmacol. 2024 Apr 13;133:112074. doi: 10.1016/j.intimp.2024.112074. Online ahead of print.ABSTRACTThe tumor microenvironment plays a vital role in glioblastoma growth and invasion. PD-1 and PD-L1 modulate the immunity in the brain tumor microenvironment. However, the underlying mechanisms remain unclear. In the present study, in vivo and in vitro experiments were conducted to reveal the effects of PD-1/PD-L1 on the crosstalk between microglia and glioma. Results showed that glioma cells secreted PD-L1 to the peritumoral areas, particularly microglia containing highly expressed PD-1. In the early stages of gliom...
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Xi-Peng Wang Wei Guo Ye-Fan Chen Chen Hong Juan Ji Xi-Yue Zhang Yin-Feng Dong Xiu-Lan Sun Source Type: research
GSE99979 Recognition of a pediatric glioblastoma-associated histone mutation by chromatin reader ZMYND8 promotes tumorigenesis
Contributors : Rui Guo ; Yang ShiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone H3 point mutations have recently been identified in pediatric brain cancers, including missense mutations on histone H3 at positions 27 (lysine to methionine; K27M) and 34 (glycine to arginine, G34R), respectively. H3K27M mutations are associated with a majority of pediatric Diffuse Intrinsic Pontine Pediatric Glioma (DIPG) cases, while H3.3G34R is found in pediatric glioblastoma (GBM) arising in the cerebral cortex1,2. While the mechanisms of H3K27M-driven tumorigenesis are beginn...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
Prognostic value of brain perfusion by MRI in the initial study of high grade gliomas
CONCLUSIONS: It has become evident that the tumour perfusion via MRI scan has a prognostic value in the initial analysis of HGG. The average survival period of patients with rCBV less than or equal to 3.0 is significantly higher than those patients whose values are higher, which allows to be more precise with the prognosis of each patient.PMID:38614528 | DOI:10.1016/j.rxeng.2022.12.010 (Source: Radiologia)
Source: Radiologia - April 13, 2024 Category: Radiology Authors: F Fern ández-Valverde M P Bautista-B árcena E Rold án-Romero J Solivera-Vela F Bravo-Rodr íguez M J Ramos-G ómez Source Type: research
The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
A 78-year-old woman with diffuse white matter infiltration and predominant involvement of bilateral temporo-parieto-occipital regions
J Cell Mol Med. 2024 Apr;28(8):e18245. doi: 10.1111/jcmm.18245.ABSTRACTDiffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (H3/IDH-wt-pHGG) is a newly defined entity amongst brain tumours, primarily reported in children. It is a rare, ill-defined type of tumour and the only method to diagnose it is DNA methylation profiling. The case we report here carries new knowledge about this tumour which may, in fact, occur in elderly patients, be devoid of evocative genomic abnormalities reported in children and harbour a misleading mutation.PMID:38613356 | PMC:PMC11015387 | DOI:10.1111/jcmm.18245 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Charlotte Paoli Anne Mc Leer Julien Boyer Lydiane Mondot B érengère Dadone-Montaudié Catherine Godfraind Fanny Burel-Vandenbos Source Type: research
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis
This study aimed to develop a reliable molecular stratification based on these key components of TME. The TCGA data set (training cohort) and two independent cohorts from CGGA database (validation cohort) were enrolled in this study. First, the enrichment score of 277 TME-related signalling pathways was calculated by gene set variation analysis (GSVA). Then, consensus clustering identified four stable and reproducible subtypes (AFM, CSS, HIS and GLU) based on TME-related signalling pathways, which were characterized by differences in hypoxia and immune responses, metabolism status, somatic alterations and clinical outcomes...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Ruoyu Huang Bo Han Ying Zhang Jingchen Yang Kuanyu Wang Xing Liu Zhiliang Wang Source Type: research
Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification
CONCLUSIONS: In conclusion, our study identifies LATPM4A as a promising biomarker for prognosis and immune characteristics in glioma.PMID:38613802 | DOI:10.18632/aging.205736 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Yongqi Ding Yike Jiang Hong Zeng Minqin Zhou Xuanrui Zhou Zichuan Yu Jingying Pan Xitong Geng Yanting Zhu Hao Zheng Shuhan Huang Yiyang Gong Huabin Huang Chengfeng Xiong Da Huang Source Type: research
