Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
Awake brain mapping by direct cortical stimulation; technical note to get higher resection rate and low morbidity in low-grade glioma patients
CONCLUSION: Functional realignment in shifted brain and edema can be seen while doing cortical and subcortical stimulation. Most of the stimulation from low to high for language mapping may vary from patient to patient. For safe removal of low-grade glioma a steep learning curve is needed to find out the negative areas, though the authors emphasize positive mapping of areas to secure the maximum eloquence.PMID:38576956 | PMC:PMC10990364 | DOI:10.1097/MS9.0000000000001837 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Robert Ahmed Khan Md Moshiur Rahman Md Ziauddin Muhtamim Chowdhury Mahbub Hasan Source Type: research
Quantifying H & amp;E staining results, grading and predicting IDH mutation status of gliomas using hybrid multi-dimensional MRI
DISCUSSION: HM-MRI can aid in non-invasive diagnosis of gliomas.PMID:38578520 | DOI:10.1007/s10334-024-01154-x (Source: Magma)
Source: Magma - April 5, 2024 Category: Radiology Authors: Wenbo Sun Dan Xu Huan Li Sirui Li Qingjia Bao Xiaopeng Song Daniel Topgaard Haibo Xu Source Type: research
Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study
CONCLUSION: These data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG.PMID:38580878 | DOI:10.1007/s00432-024-05701-w (Source: Clin Med Res)
Source: Clin Med Res - April 5, 2024 Category: Research Authors: David Gorodezki Julian Zipfel Andrea Bevot Thomas N ägele Martin Ebinger Martin U Schuhmann Jens Schittenhelm Source Type: research
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205720. Online ahead of print.ABSTRACTOur research investigated the effects of hsa-miR-134-5p on glioma progression, focusing on its interaction with the BDNF/ERK signaling pathway. U251 and U87 cell lines were analyzed post-transfection with hsa-miR-134-5p mimics and inhibitors, confirming the miRNA's binding to BDNF using dual luciferase assays. Q-PCR was employed to measure expression changes, revealing that hsa-miR-134-5p markedly inhibited glioma cell proliferation, migration, and invasion, as evidenced by CCK8, monoclonal formation, and Transwell assays. Scratch t...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zeshang Guo Pingxv An Xinyu Hong Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
NCAPD3 is a prognostic biomarker and is correlated with immune infiltrates in glioma
Histol Histopathol. 2024 Mar 20:18736. doi: 10.14670/HH-18-736. Online ahead of print.ABSTRACTNon-SMC Condensin II Complex Subunit D3 (NCAPD3) has been linked with the genesis and progression of multiple human cancers. Nevertheless, the scientific value and molecular process of NCAPD3 in glioma remain unclear. We explored the level of NCAPD3 expression in pan-cancer by multiple online databases. And we focused on the level and prognostic value of NCAPD3 expression in glioma by immunohistochemistry (IHC) and survival analysis. Meanwhile, we verified the relationship between NCAPD3, biological function and immune infiltratio...
Source: Histology and Histopathology - April 5, 2024 Category: Cytology Authors: Linzhuo Qu Huiying Che Jingyu Zhao Xin Lu Zijun Ren Yu Wu Qian Liu Hongjian Guan Source Type: research
CLO24-076: Prolonged Anesthesia as a Risk Factor for Extended Length of Stay Following Craniotomy for Primary Glioma
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-076. doi: 10.6004/jnccn.2023.7182.NO ABSTRACTPMID:38580270 | DOI:10.6004/jnccn.2023.7182 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Samantha Schimmel Jonah Gordon Adam Alayli Gavin Lockard Anshruta Dhanashekar Vishnu V Iyer Bassel El Sayed Samuel Bauserman Nasrin Aldawoodi Allan Escher Rahul Mhaskar Nam D Tran Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers : Section A of Disease Markers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
Awake brain mapping by direct cortical stimulation; technical note to get higher resection rate and low morbidity in low-grade glioma patients
CONCLUSION: Functional realignment in shifted brain and edema can be seen while doing cortical and subcortical stimulation. Most of the stimulation from low to high for language mapping may vary from patient to patient. For safe removal of low-grade glioma a steep learning curve is needed to find out the negative areas, though the authors emphasize positive mapping of areas to secure the maximum eloquence.PMID:38576956 | PMC:PMC10990364 | DOI:10.1097/MS9.0000000000001837 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Robert Ahmed Khan Md Moshiur Rahman Md Ziauddin Muhtamim Chowdhury Mahbub Hasan Source Type: research
Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study
CONCLUSION: These data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG.PMID:38580878 | PMC:PMC10997709 | DOI:10.1007/s00432-024-05701-w (Source: Clin Med Res)
Source: Clin Med Res - April 5, 2024 Category: Research Authors: David Gorodezki Julian Zipfel Andrea Bevot Thomas N ägele Martin Ebinger Martin U Schuhmann Jens Schittenhelm Source Type: research
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205720. Online ahead of print.ABSTRACTOur research investigated the effects of hsa-miR-134-5p on glioma progression, focusing on its interaction with the BDNF/ERK signaling pathway. U251 and U87 cell lines were analyzed post-transfection with hsa-miR-134-5p mimics and inhibitors, confirming the miRNA's binding to BDNF using dual luciferase assays. Q-PCR was employed to measure expression changes, revealing that hsa-miR-134-5p markedly inhibited glioma cell proliferation, migration, and invasion, as evidenced by CCK8, monoclonal formation, and Transwell assays. Scratch t...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zeshang Guo Pingxv An Xinyu Hong Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
NCAPD3 is a prognostic biomarker and is correlated with immune infiltrates in glioma
Histol Histopathol. 2024 Mar 20:18736. doi: 10.14670/HH-18-736. Online ahead of print.ABSTRACTNon-SMC Condensin II Complex Subunit D3 (NCAPD3) has been linked with the genesis and progression of multiple human cancers. Nevertheless, the scientific value and molecular process of NCAPD3 in glioma remain unclear. We explored the level of NCAPD3 expression in pan-cancer by multiple online databases. And we focused on the level and prognostic value of NCAPD3 expression in glioma by immunohistochemistry (IHC) and survival analysis. Meanwhile, we verified the relationship between NCAPD3, biological function and immune infiltratio...
Source: Histology and Histopathology - April 5, 2024 Category: Cytology Authors: Linzhuo Qu Huiying Che Jingyu Zhao Xin Lu Zijun Ren Yu Wu Qian Liu Hongjian Guan Source Type: research
