Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers : Section A of Disease Markers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205720. Online ahead of print.ABSTRACTOur research investigated the effects of hsa-miR-134-5p on glioma progression, focusing on its interaction with the BDNF/ERK signaling pathway. U251 and U87 cell lines were analyzed post-transfection with hsa-miR-134-5p mimics and inhibitors, confirming the miRNA's binding to BDNF using dual luciferase assays. Q-PCR was employed to measure expression changes, revealing that hsa-miR-134-5p markedly inhibited glioma cell proliferation, migration, and invasion, as evidenced by CCK8, monoclonal formation, and Transwell assays. Scratch t...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zeshang Guo Pingxv An Xinyu Hong Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers : Section A of Disease Markers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway
In conclusion, interference with PGBD5 could inhibit the malignant progression of glioma through the PPAR pathway, suggesting that PGBD5 may be a potential molecular target of glioma.PMID:38577941 | DOI:10.3892/ijo.2024.5643 (Source: International Journal of Oncology)
Source: International Journal of Oncology - April 5, 2024 Category: Cancer & Oncology Authors: Pengren Luo Jinhong Yang Lipeng Jian Jigen Dong Shi Yin Chao Luo Shuai Zhou Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment
In this study, we systematically assessed the prognostic value of CRG-located DNA-methylation for lower-grade glioma (LGG). Clinical and molecular data were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We employed Cox hazard regression to examine the associations between CRG-located DNA-methylation and OS, leading to the development of a prognostic signature. Kaplan-Meier survival and time-dependent receiver operating characteristic (ROC) analyses were utilized to gauge the accuracy of the signature. Gene Set Enrichment Analysis (GSEA) was applied to uncover potential biological ...
Source: Cancer Biomarkers : Section A of Disease Markers - April 5, 2024 Category: Cancer & Oncology Authors: Liucun Zhu Fa Yuan Xue Wang Rui Zhu Wenna Guo Source Type: research
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - April 5, 2024 Category: Cancer & Oncology Authors: Ayush PantBrandon Hwa-Lin BergsneiderSiddhartha SrivastavaTimothy KimAanchal JainSadhana BomPavan ShahNivedha KannapadiKisha PatelJohn ChoiKwang Bog ChoRohit VermaCaren Yu-Ju WuHenry BremBetty TylerDrew M. PardollChristina JacksonMichael Lima Department o Source Type: research
Prognostic utility and characteristics of MIB-1 labeling index as a proliferative activity marker in childhood low-grade glioma: a retrospective observational study
ConclusionThese data confirm a correlation of MIB-1 LI and radiologically detectable TGV in PLGG for the first time. Compared with preoperative TGV, a crucially decreasing correlation of MIB-1 LI and TGV after surgery may result in limited prognostic capability of MIB-1 LI in PLGG. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 5, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis
(Source: Klinische Neuroradiologie)
Source: Klinische Neuroradiologie - April 5, 2024 Category: Radiology Source Type: research
Quantifying H & amp;E staining results, grading and predicting IDH mutation status of gliomas using hybrid multi-dimensional MRI
DiscussionHM-MRI can aid in non-invasive diagnosis of gliomas. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - April 5, 2024 Category: Materials Science Source Type: research
PSMA2 promotes glioma proliferation and migration via EMT
CONCLUSION: Our study provides evidence supporting the role of PSMA2 as a regulatory factor in EMT and suggests its potential as a prognostic biomarker for glioma progression.PMID:38574629 | DOI:10.1016/j.prp.2024.155278 (Source: Cell Research)
Source: Cell Research - April 4, 2024 Category: Cytology Authors: Yujun Zhang Zijin Xiang Le Chen Xingyan Deng Huaizheng Liu Xiangdong Peng Source Type: research
GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression
CONCLUSION: These findings unveil the intricate interplay between TAMs and tumor cells mediated by lactate and HMGB1, driving tumor progression in glioma. GPR65, selectively highly expressed on TAMs in glioma, sensed lactate stimulation and fostered HMGB1 secretion via the cAMP/PKA/CREB signaling pathway. Blocking this feedback loop presents a promising therapeutic strategy for GBM.PMID:38576043 | DOI:10.1186/s13046-024-03025-8 (Source: Cell Research)
Source: Cell Research - April 4, 2024 Category: Cytology Authors: Chaolong Yan Zijiang Yang Pin Chen Yuyang Yeh Chongjing Sun Tao Xie Wei Huang Xiaobiao Zhang Source Type: research
