Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis
CONCLUSION: Our findings indicate that NASP may serve as a potential biomarker of GBM radioresistance and has important implications for improving clinical radiotherapy.PMID:38605477 | PMC:PMC11009454 | DOI:10.1111/cns.14709 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 12, 2024 Category: Neuroscience Authors: Yuning Qiu Dongling Pei Minkai Wang Qimeng Wang Wenchao Duan Li Wang Kehan Liu Yu Guo Lin Luo Zhixuan Guo Fangzhan Guan Zilong Wang Aoqi Xing Zhongyi Liu Zeyu Ma Guozhong Jiang Dongming Yan Xianzhi Liu Zhenyu Zhang Weiwei Wang Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Temozolomide-associated blepharoconjunctivitis: a case report
Temozolomide (TMZ) is an effective oral alkylating agent used in treating glioblastoma multiforme (GBM) and high-grade gliomas. It works by introducing methyl groups into DNA, inhibiting cell division. A case ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 12, 2024 Category: Opthalmology Authors: Tom Kornhauser and John D Pemberton Tags: Case Report Source Type: research
The safety and efficacy of dabrafenib and trametinib in patients with glioma: A systematic review and meta-analysis
ConclusionsDabrafenib and trametinib demonstrate promising anti-tumor efficacy in gliomas, particularly low-grade tumors, achieving durable disease stabilization in many patients. However, toxicity significantly limited tolerability. Additional research should further examine efficacy and refine safe administration protocols across glioma subtypes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
Identification and validation of anoikis-related genes to clarify the prognosis and immune mechanisms of patients with low-grade glioma
CONCLUSIONS: This study confirmed that TIMP1 promoted the malignant progression of LGG by inhibiting anoikis, providing insights into LGG pathogenesis and potential therapeutic targets.PMID:38603834 | DOI:10.1016/j.bbrc.2024.149894 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Ji Wang Yantin Liu Min Qian Wen Xu Jianfeng Chen Yuanguo Deng Ran Luo Jian Chen Wenxue Jia Longhu Liu Chunlei Tian Source Type: research
Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma
CONCLUSION: The ARID1A gene is a critical predictive biomarker for glioma. Mutations at the ARID1A locus alter the stability of the SWI/SNF complex, leading to changes in transcriptional regulation in glioma cells. This contributes to an increased malignant phenotype of GBM and plays a pivotal role in mediating chemoresistance.PMID:38600891 | DOI:10.1111/cns.14698 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 11, 2024 Category: Neuroscience Authors: Menglin Xiao Xiaoteng Cui Can Xu Lei Xin Jixing Zhao Shixue Yang Biao Hong Yanli Tan Jie Zhang Xiang Li Jie Li Chunsheng Kang Chuan Fang Source Type: research
Identification and validation of anoikis-related genes to clarify the prognosis and immune mechanisms of patients with low-grade glioma
CONCLUSIONS: This study confirmed that TIMP1 promoted the malignant progression of LGG by inhibiting anoikis, providing insights into LGG pathogenesis and potential therapeutic targets.PMID:38603834 | DOI:10.1016/j.bbrc.2024.149894 (Source: Cell Research)
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Ji Wang Yantin Liu Min Qian Wen Xu Jianfeng Chen Yuanguo Deng Ran Luo Jian Chen Wenxue Jia Longhu Liu Chunlei Tian Source Type: research
Glycolysis ‑related lncRNA may be associated with prognosis and immune activity in grade II‑III glioma
In conclusion, a large sample of human grade II-III glioma in The Cancer Genome Atlas database was used to construct a risk model using glycolysis-related lncRNAs to predict the prognosis of patients with grade II-III glioma.PMID:38601183 | PMC:PMC11005085 | DOI:10.3892/ol.2024.14371 (Source: Oncology Letters)
Source: Oncology Letters - April 11, 2024 Category: Cancer & Oncology Authors: Tao Yang Ruiguang Zhang Zhenfen Cui Bowen Zheng Xiaowei Zhu Xinyu Yang Qiang Huang Source Type: research
A role for RIO kinases in the crosshair of cancer research and therapy
Biochim Biophys Acta Rev Cancer. 2024 Apr 9:189100. doi: 10.1016/j.bbcan.2024.189100. Online ahead of print.ABSTRACTRIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3 are known for their role in the ribosomal biogenesis. Dysfunction of RIO kinases have been implicated in malignancies, including acute myeloid leukemia, glioma, breast, colorectal, lung and prostatic adenocarcinoma suggesting RIO kinases as potential targets in cancer. In vitro, in vivo and clinical studies have demonstrated that RIO kinases are overexpressed in various types of cancers suggesting important roles in tumorigenesi...
Source: Biochimica et Biophysica Acta - April 11, 2024 Category: Biochemistry Authors: Morteza Ghandadi Albert Dobi Sanjay V Malhotra Source Type: research
Identification and validation of anoikis-related genes to clarify the prognosis and immune mechanisms of patients with low-grade glioma
CONCLUSIONS: This study confirmed that TIMP1 promoted the malignant progression of LGG by inhibiting anoikis, providing insights into LGG pathogenesis and potential therapeutic targets.PMID:38603834 | DOI:10.1016/j.bbrc.2024.149894 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Ji Wang Yantin Liu Min Qian Wen Xu Jianfeng Chen Yuanguo Deng Ran Luo Jian Chen Wenxue Jia Longhu Liu Chunlei Tian Source Type: research
Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma
CONCLUSION: The ARID1A gene is a critical predictive biomarker for glioma. Mutations at the ARID1A locus alter the stability of the SWI/SNF complex, leading to changes in transcriptional regulation in glioma cells. This contributes to an increased malignant phenotype of GBM and plays a pivotal role in mediating chemoresistance.PMID:38600891 | PMC:PMC11007544 | DOI:10.1111/cns.14698 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 11, 2024 Category: Neuroscience Authors: Menglin Xiao Xiaoteng Cui Can Xu Lei Xin Jixing Zhao Shixue Yang Biao Hong Yanli Tan Jie Zhang Xiang Li Jie Li Chunsheng Kang Chuan Fang Source Type: research
Glycolysis ‑related lncRNA may be associated with prognosis and immune activity in grade II‑III glioma
In conclusion, a large sample of human grade II-III glioma in The Cancer Genome Atlas database was used to construct a risk model using glycolysis-related lncRNAs to predict the prognosis of patients with grade II-III glioma.PMID:38601183 | PMC:PMC11005085 | DOI:10.3892/ol.2024.14371 (Source: Oncology Letters)
Source: Oncology Letters - April 11, 2024 Category: Cancer & Oncology Authors: Tao Yang Ruiguang Zhang Zhenfen Cui Bowen Zheng Xiaowei Zhu Xinyu Yang Qiang Huang Source Type: research
