The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
A 78-year-old woman with diffuse white matter infiltration and predominant involvement of bilateral temporo-parieto-occipital regions
J Cell Mol Med. 2024 Apr;28(8):e18245. doi: 10.1111/jcmm.18245.ABSTRACTDiffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (H3/IDH-wt-pHGG) is a newly defined entity amongst brain tumours, primarily reported in children. It is a rare, ill-defined type of tumour and the only method to diagnose it is DNA methylation profiling. The case we report here carries new knowledge about this tumour which may, in fact, occur in elderly patients, be devoid of evocative genomic abnormalities reported in children and harbour a misleading mutation.PMID:38613356 | PMC:PMC11015387 | DOI:10.1111/jcmm.18245 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Charlotte Paoli Anne Mc Leer Julien Boyer Lydiane Mondot B érengère Dadone-Montaudié Catherine Godfraind Fanny Burel-Vandenbos Source Type: research
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis
This study aimed to develop a reliable molecular stratification based on these key components of TME. The TCGA data set (training cohort) and two independent cohorts from CGGA database (validation cohort) were enrolled in this study. First, the enrichment score of 277 TME-related signalling pathways was calculated by gene set variation analysis (GSVA). Then, consensus clustering identified four stable and reproducible subtypes (AFM, CSS, HIS and GLU) based on TME-related signalling pathways, which were characterized by differences in hypoxia and immune responses, metabolism status, somatic alterations and clinical outcomes...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Ruoyu Huang Bo Han Ying Zhang Jingchen Yang Kuanyu Wang Xing Liu Zhiliang Wang Source Type: research
Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification
CONCLUSIONS: In conclusion, our study identifies LATPM4A as a promising biomarker for prognosis and immune characteristics in glioma.PMID:38613802 | DOI:10.18632/aging.205736 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Yongqi Ding Yike Jiang Hong Zeng Minqin Zhou Xuanrui Zhou Zichuan Yu Jingying Pan Xitong Geng Yanting Zhu Hao Zheng Shuhan Huang Yiyang Gong Huabin Huang Chengfeng Xiong Da Huang Source Type: research
Prognostic value of brain perfusion by MRI in the initial study of high grade gliomas
CONCLUSIONS: It has become evident that the tumour perfusion via MRI scan has a prognostic value in the initial analysis of HGG. The average survival period of patients with rCBV less than or equal to 3.0 is significantly higher than those patients whose values are higher, which allows to be more precise with the prognosis of each patient.PMID:38614528 | DOI:10.1016/j.rxeng.2022.12.010 (Source: Radiologia)
Source: Radiologia - April 13, 2024 Category: Radiology Authors: F Fern ández-Valverde M P Bautista-B árcena E Rold án-Romero J Solivera-Vela F Bravo-Rodr íguez M J Ramos-G ómez Source Type: research
Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification
CONCLUSIONS: In conclusion, our study identifies LATPM4A as a promising biomarker for prognosis and immune characteristics in glioma.PMID:38613802 | DOI:10.18632/aging.205736 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Yongqi Ding Yike Jiang Hong Zeng Minqin Zhou Xuanrui Zhou Zichuan Yu Jingying Pan Xitong Geng Yanting Zhu Hao Zheng Shuhan Huang Yiyang Gong Huabin Huang Chengfeng Xiong Da Huang Source Type: research
Prognostic value of brain perfusion by MRI in the initial study of high grade gliomas
CONCLUSIONS: It has become evident that the tumour perfusion via MRI scan has a prognostic value in the initial analysis of HGG. The average survival period of patients with rCBV less than or equal to 3.0 is significantly higher than those patients whose values are higher, which allows to be more precise with the prognosis of each patient.PMID:38614528 | DOI:10.1016/j.rxeng.2022.12.010 (Source: Radiologia)
Source: Radiologia - April 13, 2024 Category: Radiology Authors: F Fern ández-Valverde M P Bautista-B árcena E Rold án-Romero J Solivera-Vela F Bravo-Rodr íguez M J Ramos-G ómez Source Type: research
The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
A 78-year-old woman with diffuse white matter infiltration and predominant involvement of bilateral temporo-parieto-occipital regions
J Cell Mol Med. 2024 Apr;28(8):e18245. doi: 10.1111/jcmm.18245.ABSTRACTDiffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (H3/IDH-wt-pHGG) is a newly defined entity amongst brain tumours, primarily reported in children. It is a rare, ill-defined type of tumour and the only method to diagnose it is DNA methylation profiling. The case we report here carries new knowledge about this tumour which may, in fact, occur in elderly patients, be devoid of evocative genomic abnormalities reported in children and harbour a misleading mutation.PMID:38613356 | PMC:PMC11015387 | DOI:10.1111/jcmm.18245 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Charlotte Paoli Anne Mc Leer Julien Boyer Lydiane Mondot B érengère Dadone-Montaudié Catherine Godfraind Fanny Burel-Vandenbos Source Type: research
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis
This study aimed to develop a reliable molecular stratification based on these key components of TME. The TCGA data set (training cohort) and two independent cohorts from CGGA database (validation cohort) were enrolled in this study. First, the enrichment score of 277 TME-related signalling pathways was calculated by gene set variation analysis (GSVA). Then, consensus clustering identified four stable and reproducible subtypes (AFM, CSS, HIS and GLU) based on TME-related signalling pathways, which were characterized by differences in hypoxia and immune responses, metabolism status, somatic alterations and clinical outcomes...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Ruoyu Huang Bo Han Ying Zhang Jingchen Yang Kuanyu Wang Xing Liu Zhiliang Wang Source Type: research
Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate
Cell Death & Disease, Published online: 13 April 2024; doi:10.1038/s41419-024-06653-2Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate (Source: Cell death and disease)
Source: Cell death and disease - April 13, 2024 Category: Internal Medicine Authors: Francesco Marrocco Elisabetta Falvo Luciana Mosca Giada Tisci Alessandro Arcovito Alice Reccagni Cristina Limatola Roberta Bernardini Pierpaolo Ceci Giuseppina D ’Alessandro Gianni Colotti Source Type: research
Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study
ConclusionsThe application of IONM could improve long-term neurological function, which is closely related to prognosis and can be used as an independent prognostic factor. IONM is practical and widely available for predicting postoperative functional deficits in patients with eloquent area glioma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 13, 2024 Category: Cancer & Oncology Source Type: research
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis
CONCLUSION: Our findings indicate that NASP may serve as a potential biomarker of GBM radioresistance and has important implications for improving clinical radiotherapy.PMID:38605477 | DOI:10.1111/cns.14709 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 12, 2024 Category: Neuroscience Authors: Yuning Qiu Dongling Pei Minkai Wang Qimeng Wang Wenchao Duan Li Wang Kehan Liu Yu Guo Lin Luo Zhixuan Guo Fangzhan Guan Zilong Wang Aoqi Xing Zhongyi Liu Zeyu Ma Guozhong Jiang Dongming Yan Xianzhi Liu Zhenyu Zhang Weiwei Wang Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
