Letter to the Editor. Preoperative DVT screening in neurooncology: is it cost-effective to perform duplex sonography in all patients?
PMID: 31299648 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Sardana H, Kaura M, Kedia S Tags: J Neurosurg Source Type: research

Utilization of 3D imaging reconstructions and assessment of symptom-free survival after microvascular decompression of the facial nerve in hemifacial spasm.
Abstract OBJECTIVE: Hemifacial spasm (HFS), largely caused by neurovascular compression (NVC) of the facial nerve, is a rare condition characterized by paroxysmal, unilateral, involuntary contraction of facial muscles. It has long been suggested that these symptoms are due to compression at the transition zone of the facial nerve. The aim of this study was to examine symptom-free survival and long-term quality of life (QOL) in HFS patients who underwent microvascular decompression (MVD). A secondary aim was to examine the benefit of utilizing fused MRI and MRA post hoc 3D reconstructions to better characterize com...
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Teton ZE, Blatt D, Holste K, Raslan AM, Burchiel KJ Tags: J Neurosurg Source Type: research

Acute kidney injury after aneurysmal subarachnoid hemorrhage and its effect on patient outcome: an exploratory analysis.
Abstract OBJECTIVE: Acute kidney injury (AKI) is associated with death in critically ill patients, but this complication has not been well characterized after aneurysmal subarachnoid hemorrhage (aSAH). The purpose of this study was to determine the incidence of AKI after aSAH and to identify risk factors for renal dysfunction. Secondary objectives were to examine what effect AKI has on patient mortality and functional outcome at 12 weeks post-aSAH. METHODS: The authors performed a post hoc analysis of the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CON...
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Eagles ME, Powell MF, Ayling OGS, Tso MK, Macdonald RL Tags: J Neurosurg Source Type: research

Impact of cochlear modiolus dose on hearing preservation following stereotactic radiosurgery for non-vestibular schwannoma neoplasms of the lateral skull base: a cohort study.
CONCLUSIONS: The modiolus dose threshold of 5 Gy does not predict hearing loss in patients with non-VS tumors undergoing SRS, suggesting that dosimetric parameters derived from VS may not be applicable to this population. Differential rates of hearing loss appear to vary by pathology, with paragangliomas and petroclival meningiomas demonstrating decreased risk of hearing loss compared to CPA meningiomas that may directly compress the cochlear nerve similarly to VS. PMID: 31299651 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Carlstrom LP, Jacob JT, Graffeo CS, Perry A, Oldenburg MS, Foote RL, Pollock BE, Driscoll CL, Carlson ML, Link MJ Tags: J Neurosurg Source Type: research

Gamma Knife radiosurgery for the treatment of Nelson's syndrome: a multicenter, international study.
CONCLUSIONS: GKRS affords a high rate of pituitary adenoma control and improvement in ACTH level for the majority of Nelson's syndrome patients. Hypopituitarism is the most common adverse effect from GKRS in Nelson's syndrome patients and warrants longitudinal follow-up for detection and endocrine replacement. PMID: 31299652 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Cordeiro D, Xu Z, Li CE, Iorio-Morin C, Mathieu D, Sisterson ND, Kano H, Attuati L, Picozzi P, Sheehan KA, Lee CC, Liscak R, Jezkova J, Lunsford LD, Sheehan J Tags: J Neurosurg Source Type: research

Retromastoid-transmuscular identification and harvest of the occipital artery during retrosigmoid craniotomy.
CONCLUSIONS: This transmuscular technique for identification of the OA is a reliable method and may facilitate exposure and protection of the OA during a retrosigmoid approach. This technique may obviate the need for larger incisions when planning a bypass to nearby arteries in the posterior circulation via a retrosigmoid craniotomy. Additionally, the small skin incision can be enlarged when a different craniotomy and/or bypass is planned or when a greater length of the OA is needed to be harvested. PMID: 31299653 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Tayebi Meybodi A, Lawton MT, Moreira LB, Zhao X, Lang MJ, Nakaji P, Preul MC Tags: J Neurosurg Source Type: research

Temporal disconnection between pain relief and trigeminal nerve microstructural changes after Gamma Knife radiosurgery for trigeminal neuralgia.
Abstract OBJECTIVE: Gamma Knife radiosurgery (GKRS) is a noninvasive surgical treatment option for patients with medically refractive classic trigeminal neuralgia (TN). The long-term microstructural consequences of radiosurgery and their association with pain relief remain unclear. To better understand this topic, the authors used diffusion tensor imaging (DTI) to characterize the effects of GKRS on trigeminal nerve microstructure over multiple posttreatment time points. METHODS: Ninety-two sets of 3-T anatomical and diffusion-weighted MR images from 55 patients with TN treated by GKRS were divided within 6-,...
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Shih-Ping Hung P, Tohyama S, Zhang JY, Hodaie M Tags: J Neurosurg Source Type: research

A phase II randomized controlled trial of tiopronin for aneurysmal subarachnoid hemorrhage.
CONCLUSIONS: The power of this study was affected by missing data. Therefore, the authors could not establish or refute an effect of tiopronin on CSF 3-AP levels. Additional observational studies investigating the role of 3-AP as a biomarker for DCI may be warranted prior to its use as a molecular target in future clinical trials.Clinical trial registration no.: NCT01095731 (ClinicalTrials.gov). PMID: 31299655 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Ironside N, Christophe B, Bruce S, Carpenter AM, Robison T, Yoh N, Cremers S, Landry D, Frey HP, Chen CJ, Hoh BL, Kim LJ, Claassen J, Connolly ES Tags: J Neurosurg Source Type: research

Infuse-as-you-go convective delivery to enhance coverage of elongated brain targets: technical note.
Abstract OBJECTIVE: To develop and assess a convective delivery technique that enhances the effectiveness of drug delivery to nonspherical brain nuclei, the authors developed an occipital "infuse-as-you-go" approach to the putamen and compared it to the currently used transfrontal approach. METHODS: Eleven nonhuman primates received a bilateral putamen injection of adeno-associated virus with 2 mM gadolinium-DTPA by real-time MR-guided convective perfusion via either a transfrontal (n = 5) or occipital infuse-as-you-go (n = 6) approach. RESULTS: MRI provided contemporaneous assessment and monit...
Source: Journal of Neurosurgery - July 12, 2019 Category: Neurosurgery Authors: Sudhakar V, Naidoo J, Samaranch L, Bringas JR, Lonser RR, Fiandaca MS, Bankiewicz KS Tags: J Neurosurg Source Type: research

Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience.
Abstract OBJECTIVE: The authors report their experience in treating patients suffering from medication-resistant essential tremor (ET) with MR-guided focused ultrasound (MRgFUS) thalamotomy over a 5-year period. METHODS: Forty-four ET patients treated with unilateral MRgFUS ventral intermediate nucleus (VIM) thalamotomy were assessed using the Clinical Rating Scale for Tremor (CRST) score and the Quality of Life in Essential Tremor Questionnaire (QUEST) over a 5-year span. RESULTS: Tremor was significantly improved immediately following MRgFUS in all patients and ceased completely in 24 patients. CRST sc...
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Sinai A, Nassar M, Eran A, Constantinescu M, Zaaroor M, Sprecher E, Schlesinger I Tags: J Neurosurg Source Type: research

Letter to the Editor. Doing more with less and the barebones neurosurgical setup.
PMID: 31277065 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Yagnick NS, Deora H, Tripathi M, Batish A, Mohindra S Tags: J Neurosurg Source Type: research

Endoscopic endonasal anterior clinoidectomy: surgical anatomy, technique nuance, and case series.
Abstract Advances in endoscopic technique allow for resection of the anterior clinoid process (ACP) via an endoscopic endonasal approach. The authors discuss the endoscopic endonasal anterior clinoidectomy (EEAC) and demonstrate the relevant surgical anatomy and technical nuances. The approach was simulated in 6 cadaveric heads. From a technical point of view, the lateral optic carotid recess was used as the landmark in the proposed technique. The superomedial, superolateral, and inferior vertices of this recess are the main operative points. The EEAC approach was achieved by disconnecting the ACP tip from the bas...
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Xiao L, Xie S, Tang B, Hu J, Hong T Tags: J Neurosurg Source Type: research

Impact of temperature decline from the previous day as a trigger of spontaneous subarachnoid hemorrhage: case-crossover study of prefectural stroke database.
Abstract OBJECTIVE: Several environmental factors have been reported to correlate with incidence of spontaneous subarachnoid hemorrhage (SAH). However, because of different patient selection and study designs among these studies, meteorological factors that trigger the incidence of SAH in a short hazard period remain unknown. Among meteorological factors, daily temperature changes may disrupt and violate homeostasis and predispose to cerebrovascular circulatory disturbances and strokes. The authors aimed to investigate whether a decline in the temperature from the highest of the previous day to the lowest of the e...
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Fukuda H, Ninomiya H, Ueba Y, Ohta T, Kaneko T, Kadota T, Hamada F, Fukui N, Nonaka M, Watari Y, Nishimoto S, Fukuda M, Hayashi S, Izumidani T, Nishimura H, Moriki A, Lo B, Ueba T Tags: J Neurosurg Source Type: research

Antithrombotic agents and traumatic brain injury in the elderly population: hemorrhage patterns and outcomes.
oux J Abstract OBJECTIVE: Among the elderly, use of antithrombotics (ATs), antiplatelets (APs; aspirin, clopidogrel), and/or anticoagulants (ACs; warfarin, direct oral ACs [DOACs; dabigatran, rivaroxaban, apixaban]) to prevent thromboembolic events must be carefully weighed against the risk of intracranial hemorrhage (ICH) with trauma. The goal of this study was to assess the risk of sustaining a traumatic brain injury (TBI), ICH, and poorer outcomes in relation to AT use among all patients 65 years or older presenting to a single institution with head trauma. METHODS: Data were collected from all head trauma...
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Scotti P, Séguin C, Lo BWY, de Guise E, Troquet JM, Marcoux J Tags: J Neurosurg Source Type: research

A 360 ° electronic device for recording high-resolution intraoperative electrocorticography of the brain during awake craniotomy.
CONCLUSIONS: The circular grid is a safe, feasible tool that grants direct access to the cortical surgical surface for tissue resection while simultaneously monitoring electrical activity. Application of the circular grid to different brain pathologies may improve intraoperative epileptogenic detection accuracy and functional outcomes, while decreasing postoperative complications. PMID: 31277069 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: ReFaey K, Chaichana KL, Feyissa AM, Vivas-Buitrago T, Brinkmann BH, Middlebrooks EH, McKay JH, Lankford DJ, Tripathi S, Bojaxhi E, Roth GE, Tatum WO, Quiñones-Hinojosa A Tags: J Neurosurg Source Type: research

Classification of the variations of the palmar recurrent branch of the median nerve with special emphasis on angulation.
CONCLUSIONS: Close attention should be paid to the potential anatomical variabilities when performing nerve surgeries. For the palmar recurrent branch, the more medial the origin and the greater the angle it makes with the median nerve, the more dangerous it is. This classification is helpful in unifying the language and comparing results. PMID: 31277070 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Hanna A Tags: J Neurosurg Source Type: research

Extent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis.
Abstract OBJECTIVE: Intracranial epidermoid tumors are slow-growing, histologically benign tumors of epithelial cellular origin that can be symptomatic because of their size and mass effect. Neurosurgical resection, while the treatment of choice, can be quite challenging due to locations where these lesions commonly occur and their association with critical neurovascular structures. As such, subtotal resection (STR) rather than gross-total resection (GTR) can often be performed, rendering residual and recurrent tumor potentially problematic. The authors present a case of a 28-year-old man who underwent STR followe...
Source: Journal of Neurosurgery - July 5, 2019 Category: Neurosurgery Authors: Shear BM, Jin L, Zhang Y, David WB, Fomchenko EI, Erson-Omay EZ, Huttner A, Fulbright RK, Moliterno J Tags: J Neurosurg Source Type: research

Cavernous angiomas: deconstructing a neurosurgical disease.
Abstract Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and cerebral cavernous malformation (CCM) (National Library of Medicine Medical Subject heading unique ID D006392). In its sporadic form, CA occurs as a solitary hemorrhagic vascular lesion or as clustered lesions associated with a developmental venous anomaly. In its autosomal dominant familial form (Online Mendelian Inheritance in Man #116860), CA is caused by a heterozygous germline loss-of-function mutation in one of three genes-CCM1/KRIT1, CCM2/Malcavernin, and CCM3/PDCD10-causing multifocal lesions throughout the brain and spin...
Source: Journal of Neurosurgery - July 1, 2019 Category: Neurosurgery Authors: Awad IA, Polster SP Tags: J Neurosurg Source Type: research

2019 AANS Annual Scientific Meeting.
, 2019 PMID: 31261135 [PubMed - in process] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 1, 2019 Category: Neurosurgery Authors: San Diego, CA • April 13–17, 2019 Tags: J Neurosurg Source Type: research

Letter to the Editor. Establishing the role of prophylactic antiepileptic drugs in glioma and meningioma surgery.
PMID: 31252387 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Jenkinson MD, Ali A, Islim AI, Helmy A, Grant R Tags: J Neurosurg Source Type: research

Letter to the Editor. Biomarker for delayed cerebral ischemia after aSAH.
PMID: 31252388 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Yu Z, Zheng J, Guo R, You C, Li H, Ma L Tags: J Neurosurg Source Type: research

Erratum. Intermittent CSF drainage and rapid EVD weaning approach after subarachnoid hemorrhage: association with fewer VP shunts and shorter length of stay.
PMID: 31252389 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Shasby G Tags: J Neurosurg Source Type: research

Letter to the Editor. Are disproportionate subarachnoid spaces and stroke history predictors of external lumbar drainage outcome in iNPH?
PMID: 31252390 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Gallina P, Lastrucci G, Caini S, Porfirio B Tags: J Neurosurg Source Type: research

Clinical outcome after decompression of intraneural peroneal ganglion cyst and its morphologic correlation to postoperative nerve ultrasound.
CONCLUSIONS: The results of this study demonstrate significant recovery from preoperative weakness after decompression of intraneural ganglion cysts of the CPN. A favorable clinical outcome was highly correlated with an intraneural hypoechogenic ring-shaped structure on the medial side of the CPN identified during a follow-up postoperative ultrasound scan. These study results indicate the potential benefit of ultrasound scanning as a prognostic tool following decompression procedures for intraneural ganglion cysts of the CPN. PMID: 31252391 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Knoll A, Pal'a A, Pedro MT, Bäzner U, Schneider M, König RW, Wirtz CR, Friedrich S, Pauly M, Antoniadis G Tags: J Neurosurg Source Type: research

Development and evaluation of a patient-specific surgical simulator for endoscopic colloid cyst resection.
CONCLUSIONS: A patient-specific synthetic surgical simulator for training residents and fellows in endoscopic colloid cyst resection was successfully developed. The simulator's anatomy, instrument handling, and procedural content were found to be realistic. The simulator may serve as a valuable educational tool to learn the critical steps of endoscopic colloid cyst resection, develop a detailed understanding of intraventricular anatomy, and gain proficiency with bimanual neuroendoscopic techniques. PMID: 31252392 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Bodani VP, Breimer GE, Haji FA, Looi T, Drake JM Tags: J Neurosurg Source Type: research

A historical cohort of temporal lobe surgery for medically refractory epilepsy: a systematic review and meta-analysis to guide future nonrandomized controlled trial studies.
Abstract OBJECTIVE: Recent trials for temporal lobe epilepsy (TLE) highlight the challenges of investigating surgical outcomes using randomized controlled trials (RCTs). Although several reviews have examined seizure-freedom outcomes from existing data, there is a need for an overall seizure-freedom rate estimated from level I data as investigators consider other methods besides RCTs to study outcomes related to new surgical interventions. METHODS: The authors performed a systematic review and meta-analysis of the 3 RCTs of TLE in adults and report an overall surgical seizure-freedom rate (Engel class I) comp...
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Lee AT, Burke JF, Chunduru P, Molinaro AM, Knowlton R, Chang EF Tags: J Neurosurg Source Type: research

Results of 1940 embolizations for dural arteriovenous fistulas: Japanese Registry of Neuroendovascular Therapy (JR-NET3).
CONCLUSIONS: Complication rates of dAVF embolization in Japan were acceptable. For better results, the risk factors identified in this study should be considered in treatment decisions. PMID: 31252394 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Hiramatsu M, Sugiu K, Hishikawa T, Nishihiro S, Kidani N, Takahashi Y, Murai S, Date I, Kuwayama N, Satow T, Iihara K, Sakai N Tags: J Neurosurg Source Type: research

Sealing of superior semicircular canal dehiscence is associated with improved balance outcomes postoperatively versus plugging of the canal in middle fossa craniotomy repairs: a case series.
CONCLUSIONS: The authors found that superior semicircular canal dehiscence patients who undergo sealing without plugging have improved balance outcomes but show more tinnitus postoperatively than patients who undergo plugging. PMID: 31252395 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 28, 2019 Category: Neurosurgery Authors: Wung V, Romiyo P, Ng E, Duong C, Nguyen T, Seo D, Yang I, Gopen Q Tags: J Neurosurg Source Type: research

Letter to the Editor. Predictors for radiation toxicity and tumor control.
PMID: 31226685 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Paddick I, Dimitriadis A Tags: J Neurosurg Source Type: research

Letter to the Editor. The role of annexin A7 in SAH.
PMID: 31226686 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Chen Y, Zhou L Tags: J Neurosurg Source Type: research

Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma.
Abstract OBJECTIVE: Glioblastoma (GBM) carries a high economic burden for patients and caregivers, much of which is associated with initial surgery. The authors investigated the impact of insurance status on the inpatient hospital costs of surgery for patients with GBM. METHODS: The authors conducted a retrospective review of patients with GBM (2010-2015) undergoing their first resection at the University of California, San Francisco, and corresponding inpatient hospital costs. RESULTS: Of 227 patients with GBM (median age 62 years, 37.9% females), 31 (13.7%) had Medicaid, 94 (41.4%) had Medicare, and 10...
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK Tags: J Neurosurg Source Type: research

Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects.
CONCLUSIONS: PIM is a rare but important differential diagnosis for osteosclerotic lesions of the skull, especially in women. Tumor-induced, cellular-mediated bone resorption and formation may play a central role in the underlying pathogenesis. PMID: 31226688 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Butscheidt S, Ernst M, Rolvien T, Hubert J, Zustin J, Amling M, Martens T Tags: J Neurosurg Source Type: research

Endoscopic transorbital and endonasal approach for trigeminal schwannomas: a retrospective multicenter analysis (KOSEN-005).
CONCLUSIONS: ETOA provides adequate access and resectability for trigeminal schwannomas limited in the middle fossa or dumbbell-shaped tumors located in the middle and posterior fossae, as does EEA for extracranial tumors. Tumors predominantly involving the posterior fossa still remain a challenge in endoscopic surgery. PMID: 31226689 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Park HH, Hong SD, Kim YH, Hong CK, Woo KI, Yun IS, Kong DS Tags: J Neurosurg Source Type: research

In-hospital mortality and length of hospital stay with craniotomy versus craniectomy for acute subdural hemorrhage: a multicenter, propensity score-matched analysis.
Abstract OBJECTIVE: The optimal surgical treatment for acute subdural hemorrhage (ASDH) remains controversial. The purpose of this study was to compare outcomes in patients who underwent craniotomy with those in patients who underwent decompressive craniectomy for the treatment of ASDH. METHODS: Using the Japan Trauma Data Bank, a nationwide trauma registry, the authors identified patients aged ≥ 18 years with ASDH who underwent surgical evacuation after blunt head trauma between 2004 and 2015. Logistic regression analysis was used to estimate a propensity score to predict decompressive craniectomy use. Th...
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Shibahashi K, Sugiyama K, Tomio J, Hoda H, Morita A Tags: J Neurosurg Source Type: research

BIO alleviates inflammation through inhibition of GSK-3 β in a rat model of intracerebral hemorrhage.
CONCLUSIONS: BIO posttreatment inhibited microglia activation, prevented inflammation and hippocampal cell death, and ameliorated functional and morphological outcomes in a rat ICH model through inactivation of GSK-3β. PMID: 31226691 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Zhao S, Liu Z, Yu Z, Wu X, Li R, Tang X Tags: J Neurosurg Source Type: research

Epidermal growth factor receptor mutations: association with favorable local tumor control following Gamma Knife radiosurgery in patients with non-small cell lung cancer and brain metastases.
This study included 264 patients (1069 BMs) who underwent GKRS treatment and for whom EGFR mutation status, demographics, performance status, and tumor characteristics were available. Radiological images were obtained at 3 months after GKRS and at 3-month intervals thereafter. Kaplan-Meier plots and Cox regression analysis were used to correlate EGFR mutation status and other clinical features with tumor control and overall survival. RESULTS: The tumor control rates and overall 12-month survival rates were 87.8% and 65.5%, respectively. Tumor control rates in the EGFR mutant group versus the EGFR wild-type group were ...
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Lee CC, Hsu SPC, Lin CJ, Wu HM, Chen YW, Luo YH, Chiang CL, Hu YS, Chung WY, Shiau CY, Guo WY, Hung-Chi Pan D, Yang HC Tags: J Neurosurg Source Type: research

Neural network-based identification of patients at high risk for intraoperative cerebrospinal fluid leaks in endoscopic pituitary surgery.
CONCLUSIONS: The authors trained and internally validated a robust deep neural network-based prediction model that identifies patients at high risk for intraoperative CSF. Machine learning algorithms may predict outcomes and adverse events that were previously nearly unpredictable, thus enabling safer and improved patient care and better patient counseling. PMID: 31226693 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 21, 2019 Category: Neurosurgery Authors: Staartjes VE, Zattra CM, Akeret K, Maldaner N, Muscas G, Bas van Niftrik CH, Fierstra J, Regli L, Serra C Tags: J Neurosurg Source Type: research

Development and validation of the Skills Assessment in Microsurgery for Brain Aneurysms (SAMBA) instrument for predicting proficiency in aneurysm surgery.
ino G Abstract OBJECTIVE: Surgical performance evaluation was first described with the OSATS (Objective Structured Assessment of Technical Skills) and modified for aneurysm microsurgery simulation with the OSAACS (Objective Structured Assessment of Aneurysm Clipping Skills). These methods rely on the subjective opinions of evaluators, however, and there is a lack of objective evaluation for proficiency in the microsurgical treatment of brain aneurysms. The authors present a new instrument, the Skill Assessment in Microsurgery for Brain Aneurysms (SAMBA) scale, which can be used similarly in a simulation model and ...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Ribeiro de Oliveira MM, Ramos TM, Ferrarez CE, Machado CJ, Vieira Costa PH, Alvarenga DL, Soares CK, Mainart LM, Aguilar-Salinas P, Gusmão S, Sauvageau E, Hanel RA, Lanzino G Tags: J Neurosurg Source Type: research

Modeling the return to consciousness after severe traumatic brain injury at a large academic level 1 trauma center.
Abstract OBJECTIVE: Severe traumatic brain injury (sTBI) carries significant morbidity and mortality. It remains difficult to counsel families on functional prognosis and plan research initiatives aimed at treating traumatic coma. In order to better address these problems, the authors set out to develop statistical models using retrospective data to identify admission characteristics that correlate with time until the return of consciousness, defined as the time to follow commands (TFC). These results were then used to create a TFC score, allowing for rapid identification of patients with predicted prolonged TFC. ...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Winans NJ, Liang JJ, Ashcroft B, Doyle S, Fry A, Fiore SM, Mofakham S, Mikell CB Tags: J Neurosurg Source Type: research

Long-term outcome in orbital meningiomas: progression-free survival after targeted resection combined with early or postponed postoperative radiotherapy.
CONCLUSIONS: These results indicate that receiving PORT early after targeted partial resection might help to postpone tumor recurrence and the need for additional treatment, while preserving or even improving visual outcome. PMID: 31200373 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Terpolilli NA, Ueberschaer M, Niyazi M, Hintschich C, Egensperger R, Muacevic A, Thon N, Tonn JC, Schichor C Tags: J Neurosurg Source Type: research

Clinical features and operative technique of transinfundibular craniopharyngioma.
CONCLUSIONS: TC is a special subtype of suprasellar craniopharyngioma, which is remarkably different from NC. Identification of this type of tumor preoperatively is essential for the planning of appropriate surgical approach and degree of excision. PMID: 31200374 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Tang B, Xie S, Huang G, Wang Z, Yang L, Yang X, Xu S, Zeng E, Hong T Tags: J Neurosurg Source Type: research

Percival S. Bailey: eminent scholar of neurosciences who revealed the workings of the hypothalamus through clinicopathological research on craniopharyngiomas.
This article aims to credit Bailey for his pioneering definition of craniopharyngiomas as tumors with a true intrahypothalamic position. PMID: 31200375 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Prieto R, Pascual JM Tags: J Neurosurg Source Type: research

Wide-neck aneurysms: systematic review of the neurosurgical literature with a focus on definition and clinical implications.
Abstract OBJECTIVE: Wide-necked aneurysms (WNAs) are a variably defined subset of cerebral aneurysms that require more advanced endovascular and microsurgical techniques than those required for narrow-necked aneurysms. The neurosurgical literature includes many definitions of WNAs, and a systematic review has not been performed to identify the most commonly used or optimal definition. The purpose of this systematic review was to highlight the most commonly used definition of WNAs. METHODS: The authors searched PubMed for the years 1998-2017, using the terms "wide neck aneurysm" and "broad neck ...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Hendricks BK, Yoon JS, Yaeger K, Kellner CP, Mocco J, De Leacy RA, Ducruet AF, Lawton MT, Mascitelli JR Tags: J Neurosurg Source Type: research

Significance of degree of neurovascular compression in surgery for trigeminal neuralgia.
Abstract OBJECTIVE: The aim of this study was to identify preoperative imaging predictors of surgical success in patients with classic trigeminal neuralgia (cTN) undergoing microvascular decompression (MVD) via retrospective multivariate regression analysis. METHODS: All included patients met criteria for cTN and underwent preoperative MRI prior to MVD. MR images were blindly graded regarding the presence and severity (i.e., mild or severe) of neurovascular compression (NVC). All patients were contacted by telephone to determine their postoperative pain status. RESULTS: A total of 79 patients were includ...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Hughes MA, Jani RH, Fakhran S, Chang YF, Branstetter BF, Thirumala PD, Sekula RF Tags: J Neurosurg Source Type: research

Surgical treatment of meningiomas located in the rolandic area: the role of navigated transcranial magnetic stimulation for preoperative planning, surgical strategy, and prediction of arachnoidal cleavage and motor outcome.
CONCLUSIONS: nTMS-based motor mapping is a useful tool for presurgical assessment of rolandic meningiomas, especially when a clear cleavage plane with M1 is not present. Moreover, the RMT can indicate the presence or absence of an intraoperative cleavage plane and predict the motor outcome, thereby helping to identify high-risk patients before surgery. PMID: 31200378 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Raffa G, Picht T, Scibilia A, Rösler J, Rein J, Conti A, Ricciardo G, Cardali SM, Vajkoczy P, Germanò A Tags: J Neurosurg Source Type: research

Spatial distribution and hemispheric asymmetry of electrically evoked experiential phenomena in the human brain.
CONCLUSIONS: These findings suggest that complex visual hallucinations arise from wider spread in the right compared to the left hemisphere, possibly mirroring the asymmetry in the white matter organization of the two hemispheres. These results offer some insights into lateralized differences in functional organization and connectivity that may be important for functional mapping and planning of surgical resections in patients with epilepsy. PMID: 31200379 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Andelman-Gur MM, Gazit T, Andelman F, Kipervasser S, Kramer U, Neufeld MY, Fried I, Fahoum F Tags: J Neurosurg Source Type: research

Evidence for a conditioning effect of inhalational anesthetics on angiographic vasospasm after aneurysmal subarachnoid hemorrhage.
Abstract OBJECTIVE: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is characterized by large-artery vasospasm, distal autoregulatory dysfunction, cortical spreading depression, and microvessel thrombi. Large-artery vasospasm has been identified as an independent predictor of poor outcome in numerous studies. Recently, several animal studies have identified a strong protective role for inhalational anesthetics against secondary brain injury after SAH including DCI-a phenomenon referred to as anesthetic conditioning. The aim of the present study was to assess the potential role of inh...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Athiraman U, Aum D, Vellimana AK, Osbun JW, Dhar R, Tempelhoff R, Zipfel GJ Tags: J Neurosurg Source Type: research

Prolactinomas and nonfunctioning adenomas: preoperative diagnosis of tumor type using serum prolactin and tumor size.
CONCLUSIONS: Prolactinoma volume has a significant impact on serum prolactin level, whereas NFA volume does not. This finding indicates that the amount of prolactin-producing tissue is a more important factor regarding serum prolactin level than absolute adenoma volume. Hence, volume should be a determining factor to distinguish between prolactinoma and NFA prior to surgery. Current serum prolactin threshold level guidelines are suboptimal and cannot be generalized across all adenoma volumes. PMID: 31200381 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Burke WT, Penn DL, Castlen JP, Donoho DA, Repetti CS, Iuliano S, Barkhoudarian G, Laws ER Tags: J Neurosurg Source Type: research

Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke.
CONCLUSIONS: The authors' results show that surgical smoke from various brain tumors has distinct DMS profiles and the DMS analyzer connected to a special sampling system can differentiate between tumorous and nontumorous tissue and also between different tumor types ex vivo. PMID: 31200382 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Haapala I, Karjalainen M, Kontunen A, Vehkaoja A, Nordfors K, Haapasalo H, Haapasalo J, Oksala N, Roine A Tags: J Neurosurg Source Type: research

Scrubbing technique and surgical site infections: an analysis of 14,200 neurosurgical cases.
CONCLUSIONS: There is no evidence to suggest that perioperative infection is associated with personal scrubbing or gloving preference in neurosurgical procedures. PMID: 31200383 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Kashkoush A, Agarwal N, Ayres A, Novak V, Chang YF, Friedlander RM Tags: J Neurosurg Source Type: research