Patterns of recurrence and disease progression in patients with positive-margin olfactory neuroblastoma following primary resection
CONCLUSIONS: Approximately half of patients with positive-margin ONB may experience disease recurrence. Patients with an advanced disease stage (Kadish D) may have a higher likelihood of developing recurrence/progression. Furthermore, patients with tumor burden following resection (STR and Kadish D) may have worse OS. However, in positive-margin ONB with no gross disease following initial resection, the presence of disease recurrence does not significantly alter survival when receiving salvage therapy.PMID:38518294 | DOI:10.3171/2024.1.JNS23730 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Megan M J Bauman Jeffrey P Graves Travis J Haller Ryan A McMillan David M Routman Aditya Raghunathan Janalee K Stokken Michael J Link Eric J Moore Garret Choby Jamie J Van Gompel Source Type: research
A comprehensive review on the development of sporadic cerebral arteriovenous malformations: from Padget to next-generation sequencing
J Neurosurg. 2024 Mar 22:1-10. doi: 10.3171/2023.12.JNS232233. Online ahead of print.ABSTRACTCerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistr...
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Stephanie A Coffman Keyan Peterson Nicholas Contillo Kyle M Fargen Stacey Q Wolfe Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Long-term radiographic and endocrinological outcomes of stereotactic radiosurgery for recurrent or residual nonfunctioning pituitary adenomas
CONCLUSIONS: SRS affords favorable and durable tumor control for the vast majority of NFPAs. Post-SRS hypopituitarism occurs in a minority of patients, but this risk increases with time and warrants long-term follow-up.PMID:38518285 | DOI:10.3171/2024.1.JNS232285 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Ahmed Shaaban Chlo é Dumot Georgios Mantziaris Sam Dayawansa Selcuk Peker Yavuz Samanci Ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdel Karim Amr M N El-Shehaby Reem M Emad Eldin Ahmed Ragab Abdelsalam Roman Liscak Jaromir May Elad Mashiach Fern Source Type: research
Microsurgical anatomy of the olfactory filaments in the nasal mucosa
CONCLUSIONS: Compared with the EM, the OFs are significantly fewer in number and smaller in size in the NSM. The uppermost edge of the nasoseptal flap incision in the NSM might be safer to start below 12 mm from the cribriform plate for OF protection.PMID:38518287 | DOI:10.3171/2024.1.JNS23920 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Hasan Bar ış Ilgaz Kamran Urgun Ula ş Yener Melike Mut James K Liu Kaan Ya ğmurlu Source Type: research
Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group
CONCLUSIONS: Despite similar EORs, Black patients had worse clinical outcomes following meningioma resection, characterized by a higher prevalence of somatic hedgehog mutations, increased recurrence rates, and shorter PFS. Meanwhile, Hispanic patients had less aggressive meningiomas, a predisposition for TRAF7 mutations, and no difference in PFS. These findings could inform the care and treatment strategies for meningiomas, and they establish the foundation for future studies focusing on the genomic origins of these observed differences.PMID:38518289 | DOI:10.3171/2024.1.JNS231633 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Joanna K Tabor Alper Dincer Joseph O'Brien Haoyi Lei Shaurey Vetsa Sagar Vasandani Muhammad I Jalal Kanat Yalcin Saul F Morales-Valero Neelan Marianayagam Hasan Alanya Aladine A Elsamadicy Miguel A Millares Chavez Stephanie M Aguilera Ketu Mishra-Gorur De Source Type: research
Ventral amygdalofugal pathway as an integrated surgically important network: microsurgical anatomy and segmentation based on fiber dissection
CONCLUSIONS: This study supports the concept that interconnected forebrain, diencephalic, mesencephalic, and brainstem connections of the VAFP form an integrated surgically important network. The fiber dissection findings also provide the neuroanatomical basis for VAFP segmentation, which may help neurosurgeons better appreciate the complex microsurgical anatomy of the amygdalar connections. Amygdala-substantia innominata and amygdalotegmental connections are demonstrated for the first time and clarified within the structure of the VAFP.PMID:38518292 | DOI:10.3171/2024.1.JNS231541 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Buru ç Erkan Batu Herg ünsel Ozan Barut Tahsin Sayg ı Burak Kocak Abuzer G üngör Kaan Ya ğmurlu Necmettin Tanriover Source Type: research
Retraction. Immunohistochemical markers predicting recurrence following resection and radiotherapy in chordoma patients: insights from a multicenter study
J Neurosurg. 2024 Mar 22:1. doi: 10.3171/2024.2.JNS23862r. Online ahead of print.NO ABSTRACTPMID:38518293 | DOI:10.3171/2024.2.JNS23862r (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Carlos Pinheiro Neto Mohamad Bydon Source Type: research
Patterns of recurrence and disease progression in patients with positive-margin olfactory neuroblastoma following primary resection
CONCLUSIONS: Approximately half of patients with positive-margin ONB may experience disease recurrence. Patients with an advanced disease stage (Kadish D) may have a higher likelihood of developing recurrence/progression. Furthermore, patients with tumor burden following resection (STR and Kadish D) may have worse OS. However, in positive-margin ONB with no gross disease following initial resection, the presence of disease recurrence does not significantly alter survival when receiving salvage therapy.PMID:38518294 | DOI:10.3171/2024.1.JNS23730 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Megan M J Bauman Jeffrey P Graves Travis J Haller Ryan A McMillan David M Routman Aditya Raghunathan Janalee K Stokken Michael J Link Eric J Moore Garret Choby Jamie J Van Gompel Source Type: research
A comprehensive review on the development of sporadic cerebral arteriovenous malformations: from Padget to next-generation sequencing
J Neurosurg. 2024 Mar 22:1-10. doi: 10.3171/2023.12.JNS232233. Online ahead of print.ABSTRACTCerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistr...
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Stephanie A Coffman Keyan Peterson Nicholas Contillo Kyle M Fargen Stacey Q Wolfe Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Long-term radiographic and endocrinological outcomes of stereotactic radiosurgery for recurrent or residual nonfunctioning pituitary adenomas
CONCLUSIONS: SRS affords favorable and durable tumor control for the vast majority of NFPAs. Post-SRS hypopituitarism occurs in a minority of patients, but this risk increases with time and warrants long-term follow-up.PMID:38518285 | DOI:10.3171/2024.1.JNS232285 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Ahmed Shaaban Chlo é Dumot Georgios Mantziaris Sam Dayawansa Selcuk Peker Yavuz Samanci Ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdel Karim Amr M N El-Shehaby Reem M Emad Eldin Ahmed Ragab Abdelsalam Roman Liscak Jaromir May Elad Mashiach Fern Source Type: research
Microsurgical anatomy of the olfactory filaments in the nasal mucosa
CONCLUSIONS: Compared with the EM, the OFs are significantly fewer in number and smaller in size in the NSM. The uppermost edge of the nasoseptal flap incision in the NSM might be safer to start below 12 mm from the cribriform plate for OF protection.PMID:38518287 | DOI:10.3171/2024.1.JNS23920 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Hasan Bar ış Ilgaz Kamran Urgun Ula ş Yener Melike Mut James K Liu Kaan Ya ğmurlu Source Type: research
Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group
CONCLUSIONS: Despite similar EORs, Black patients had worse clinical outcomes following meningioma resection, characterized by a higher prevalence of somatic hedgehog mutations, increased recurrence rates, and shorter PFS. Meanwhile, Hispanic patients had less aggressive meningiomas, a predisposition for TRAF7 mutations, and no difference in PFS. These findings could inform the care and treatment strategies for meningiomas, and they establish the foundation for future studies focusing on the genomic origins of these observed differences.PMID:38518289 | DOI:10.3171/2024.1.JNS231633 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Joanna K Tabor Alper Dincer Joseph O'Brien Haoyi Lei Shaurey Vetsa Sagar Vasandani Muhammad I Jalal Kanat Yalcin Saul F Morales-Valero Neelan Marianayagam Hasan Alanya Aladine A Elsamadicy Miguel A Millares Chavez Stephanie M Aguilera Ketu Mishra-Gorur De Source Type: research
Ventral amygdalofugal pathway as an integrated surgically important network: microsurgical anatomy and segmentation based on fiber dissection
CONCLUSIONS: This study supports the concept that interconnected forebrain, diencephalic, mesencephalic, and brainstem connections of the VAFP form an integrated surgically important network. The fiber dissection findings also provide the neuroanatomical basis for VAFP segmentation, which may help neurosurgeons better appreciate the complex microsurgical anatomy of the amygdalar connections. Amygdala-substantia innominata and amygdalotegmental connections are demonstrated for the first time and clarified within the structure of the VAFP.PMID:38518292 | DOI:10.3171/2024.1.JNS231541 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Buru ç Erkan Batu Herg ünsel Ozan Barut Tahsin Sayg ı Burak Kocak Abuzer G üngör Kaan Ya ğmurlu Necmettin Tanriover Source Type: research
