Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study
ConclusionsThe application of IONM could improve long-term neurological function, which is closely related to prognosis and can be used as an independent prognostic factor. IONM is practical and widely available for predicting postoperative functional deficits in patients with eloquent area glioma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 13, 2024 Category: Cancer & Oncology Source Type: research
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis
CONCLUSION: Our findings indicate that NASP may serve as a potential biomarker of GBM radioresistance and has important implications for improving clinical radiotherapy.PMID:38605477 | DOI:10.1111/cns.14709 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 12, 2024 Category: Neuroscience Authors: Yuning Qiu Dongling Pei Minkai Wang Qimeng Wang Wenchao Duan Li Wang Kehan Liu Yu Guo Lin Luo Zhixuan Guo Fangzhan Guan Zilong Wang Aoqi Xing Zhongyi Liu Zeyu Ma Guozhong Jiang Dongming Yan Xianzhi Liu Zhenyu Zhang Weiwei Wang Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Linagliptin decreased the tumor progression on glioblastoma model
CONCLUSION: Inhibition of DPP-4 by linagliptin showed the antitumor effect on GBM cells and the murine GBM model. The antitumor effects of linagliptin is suggested to be based on the changes in the expression of several proteins related to cell cycle and cell adhesion via the regulation of phosphorylated NF-kB. This study suggested that DPP-4 inhibitors could be a new therapeutic strategy for GBM.PMID:38608433 | DOI:10.1016/j.bbrc.2024.149897 (Source: Cell Research)
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Shohei Tsuji Urara Kudo Ryo Hatakeyama Kenji Shoda Shinsuke Nakamura Masamitsu Shimazawa Source Type: research
Linagliptin decreased the tumor progression on glioblastoma model
CONCLUSION: Inhibition of DPP-4 by linagliptin showed the antitumor effect on GBM cells and the murine GBM model. The antitumor effects of linagliptin is suggested to be based on the changes in the expression of several proteins related to cell cycle and cell adhesion via the regulation of phosphorylated NF-kB. This study suggested that DPP-4 inhibitors could be a new therapeutic strategy for GBM.PMID:38608433 | DOI:10.1016/j.bbrc.2024.149897 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 12, 2024 Category: Biochemistry Authors: Shohei Tsuji Urara Kudo Ryo Hatakeyama Kenji Shoda Shinsuke Nakamura Masamitsu Shimazawa Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis
CONCLUSION: Our findings indicate that NASP may serve as a potential biomarker of GBM radioresistance and has important implications for improving clinical radiotherapy.PMID:38605477 | PMC:PMC11009454 | DOI:10.1111/cns.14709 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 12, 2024 Category: Neuroscience Authors: Yuning Qiu Dongling Pei Minkai Wang Qimeng Wang Wenchao Duan Li Wang Kehan Liu Yu Guo Lin Luo Zhixuan Guo Fangzhan Guan Zilong Wang Aoqi Xing Zhongyi Liu Zeyu Ma Guozhong Jiang Dongming Yan Xianzhi Liu Zhenyu Zhang Weiwei Wang Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Association of disruption of the right posterior arcuate fasciculus with spatial neglect
CONCLUSIONS: These findings suggest that parietotemporal networks mediated by the right psAF may play a critical role in visuospatial attention. This analysis may help to disentangle the organization of the visuospatial attention networks, predict deficits in patients with glioma, and optimize surgical planning.PMID:38608308 | DOI:10.3171/2024.1.JNS232142 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Mia Andreoli Mauricio Medina-Pizarro Melissa-Ann Mackie Matthew C Tate Source Type: research
Use of circulating tumor cells and microemboli to predict diagnosis and prognosis in diffuse glioma
CONCLUSIONS: The authors revealed a correlation between CTCs and clinical characteristics and demonstrated that CTCs and CTMs are independent predictors for the diagnosis and prognosis of diffuse glioma. Their CTC- and CTM-based survival models can enable clinicians to evaluate patients' response to surgery as well as their outcomes.PMID:38608304 | DOI:10.3171/2024.1.JNS232020 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Yangzhi Qi Yang Xu Tengfeng Yan Wei Xiong Xinyi Zhu Qian Sun Gang Deng Fanen Yuan Liguo Ye Ping Hu Baohui Liu Shenqi Zhang Shuhang Deng Yan He Gao Wu Qingsong Ye Qianxue Chen Source Type: research
Temozolomide-associated blepharoconjunctivitis: a case report
Temozolomide (TMZ) is an effective oral alkylating agent used in treating glioblastoma multiforme (GBM) and high-grade gliomas. It works by introducing methyl groups into DNA, inhibiting cell division. A case ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 12, 2024 Category: Opthalmology Authors: Tom Kornhauser and John D Pemberton Tags: Case Report Source Type: research
The safety and efficacy of dabrafenib and trametinib in patients with glioma: A systematic review and meta-analysis
ConclusionsDabrafenib and trametinib demonstrate promising anti-tumor efficacy in gliomas, particularly low-grade tumors, achieving durable disease stabilization in many patients. However, toxicity significantly limited tolerability. Additional research should further examine efficacy and refine safe administration protocols across glioma subtypes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
