Minimally invasive keyhole approach for supramaximal frontal glioma resections: technical note
CONCLUSIONS: Keyhole approaches enabled successful SMR of frontal gliomas without added risks. Robust anatomical knowledge and meticulous surgical technique are paramount for obtaining successful resections.PMID:38564815 | DOI:10.3171/2023.7.JNS231363 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 2, 2024 Category: Neurosurgery Authors: Mart ín A Merenzon Mynor J Mendez Valdez Jay Chandar Victor M Lu Francisco Marco Del Pont Alexis A Morell Daniel G Eichberg Lekhaj Daggubati Carolina G Benjamin Ashish H Shah Michael E Ivan Ricardo J Komotar Source Type: research
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy
AbstractOligodendroglioma, IDH-mutant and 1p/19q-codeleted is known for their relative chemosensitivity and indolent clinical course among diffuse gliomas of adult type. Based on the data from phase 3 clinical trials, the standard of post-surgical care for those tumors is considered to be initial chemoradiotherapy regardless of histopathological grade, particularly with PCV. However, partly due to its renewed definition in late years, prognostic factors in patients with those tumors are not well established. Moreover, the survival rate declines over 15 years, with only a 37% OS rate at 20 years for grade 3 tumors, even ...
Source: Brain Tumor Pathology - April 2, 2024 Category: Neurology Source Type: research
End-to-End Multi-task Learning Architecture for Brain Tumor Analysis with Uncertainty Estimation in MRI Images
AbstractBrain tumors are a threat to life for every other human being, be it adults or children. Gliomas are one of the deadliest brain tumors with an extremely difficult diagnosis. The reason is their complex and heterogenous structure which gives rise to subjective as well as objective errors. Their manual segmentation is a laborious task due to their complex structure and irregular appearance. To cater to all these issues, a lot of research has been done and is going on to develop AI-based solutions that can help doctors and radiologists in the effective diagnosis of gliomas with the least subjective and objective error...
Source: Journal of Digital Imaging - April 2, 2024 Category: Radiology Source Type: research
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
ConclusionsOur data provide novel insights into the phenotypic adaptation of the heterogeneous TME instructed by GBM tumors. We show the key role of microglial phenotypic states in supporting GBM tumor growth and response to treatment. Our data place PDOXs as relevant models to assess the functionality of the TME and changes in the GBM ecosystem upon treatment.Graphical Abstract (Source: Genome Medicine)
Source: Genome Medicine - April 2, 2024 Category: Genetics & Stem Cells Source Type: research
Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes
GBM, also known as glioblastoma multiforme, is the most prevalent and lethal type of brain cancer. The cell proliferation, invasion, angiogenesis, and treatment of gliomas are significantly influenced by oxida... (Source: Cancer Cell International)
Source: Cancer Cell International - April 2, 2024 Category: Cancer & Oncology Authors: Kan Wang, Yifei Xiao, Ruipeng Zheng and Yu Cheng Tags: Research Source Type: research
