Cancers, Vol. 16, Pages 1579: High-Grade Glioma Recurrence Is Delayed in Hispanic Patients despite Severe Social Vulnerability: A Retrospective Cohort Study
Agarwal
High-grade gliomas (HGGs; WHO grade III or IV) are the most common and lethal brain malignancy. Patients of Hispanic ethnicity are diagnosed with HGGs earlier than non-Hispanic patients, but they exhibit improved HGG survival following diagnosis. Either environmental or biological factors could explain this survival benefit. We aimed to determine if post-diagnosis advantages would still be present in Hispanic patients with high social vulnerability, an environmental condition predisposing patients to poor oncologic outcomes. HGG outcomes were retrospectively assessed in a cohort of 22 Hispanic patients and 33 n...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Joshua A. Reynolds Isabella L. Pecorari Alexander Ledet Vijay Agarwal Tags: Article Source Type: research
A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome
AbstractCopper is a vital micronutrient involved in many biological processes and is an essential component of tumour cell growth and migration. Copper influences tumour growth through a process called cuproplasia, defined as abnormal copper-dependent cell-growth and proliferation. Copper-chelation therapy targeting this process has demonstrated efficacy in several clinical trials against cancer. While the molecular pathways associated with cuproplasia are partially known, genetic heterogeneity across different cancer types has limited the understanding of how cuproplasia impacts patient survival. Utilising RNA-sequencing ...
Source: Human Genetics - April 20, 2024 Category: Genetics & Stem Cells Source Type: research
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
CONCLUSIONS: Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.PMID:38639105 | DOI:10.1161/CIRCRESAHA.123.323736 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Xuran Chu Vahid Kheirollahi Arun Lingampally Prakash Chelladurai Chanil Valasarajan Ana Ivonne Vazquez-Armendariz Stefan Hadzic Ali Khadim Oleg Pak Stefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena Moiseenko Monika Heiner Simone Kraut Le Source Type: research
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis
CONCLUSION: The prognostic risk model can effectively classify patients with glioblastoma into high-risk and low-risk groups in terms of overall survival rate, which may help select high-risk patients with glioblastoma for more intensive treatment.PMID:38639614 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Jieying Wen Haojie Zheng Xi Yuan Cuilan Huang Xiaogang Yang Zhiying Lin Guanglong Huang Source Type: research
Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner
Transl Oncol. 2024 Apr 18;45:101956. doi: 10.1016/j.tranon.2024.101956. Online ahead of print.ABSTRACTTumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells. Here we asked if concomitant treatment of TTFields with other agents that interfere with GBM ciliogenesis further suppress GBM cell proliferation in vitro. Aurora kinase A (AURKA) promotes both cilia disassembly and GBM growth. Inhibitors of AURKA, such as Alisertib, inhibit cilia disassembly and increase ciliar...
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Jia Tian Julianne C Mallinger Ping Shi Dahao Ling Loic P Deleyrolle Min Lin Habibeh Khoshbouei Matthew R Sarkisian Source Type: research
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis
CONCLUSION: The prognostic risk model can effectively classify patients with glioblastoma into high-risk and low-risk groups in terms of overall survival rate, which may help select high-risk patients with glioblastoma for more intensive treatment.PMID:38639614 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Jieying Wen Haojie Zheng Xi Yuan Cuilan Huang Xiaogang Yang Zhiying Lin Guanglong Huang Source Type: research
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
CONCLUSIONS: Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.PMID:38639105 | DOI:10.1161/CIRCRESAHA.123.323736 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Xuran Chu Vahid Kheirollahi Arun Lingampally Prakash Chelladurai Chanil Valasarajan Ana Ivonne Vazquez-Armendariz Stefan Hadzic Ali Khadim Oleg Pak Stefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena Moiseenko Monika Heiner Simone Kraut Le Source Type: research
Opportunities to Improve Palliative Care Delivery in High-Grade Glioma
1. Identify unique palliative care needs in high-grade glioma, distinct from those in systemic cancer.2. Identify opportunities to improve palliative care delivery for patients with high-grade glioma. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Rita Crooms, Jeannys F. Nnemnbeng, Jennie Taylor, Ksenia Gorbenko, Nathan Goldstein, Barbara G. Vickrey Source Type: research
GSE172387 Loss of retinoic acid signaling drives immune escape in IDH mutant gliomas
Contributors : Anthony R Cillo ; Aparna Rao ; Xiaoran Zhang ; Tullia C Bruno ; Dario A Vignali ; Nduka AmankulorSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusGliomas are immunologically cold tumors that can be broken into several categories based on either RNA expression profiles or methylation profiles, with isocitrate dehydrogenase (IDH) mutations defining a major segregration between types. IDH mutant gliomas often exhibit defects in the retinoic acid pathway. We treated mice harboring IDH mutant gliomas with all-trans retinoic acid, and found that this treatment cause...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells & mdash;Features for New Therapy Design
Cancers, Vol. 16, Pages 1557: Glioma Stem Cells—Features for New Therapy Design
Cancers doi: 10.3390/cancers16081557
Authors:
Nives Pećina-Šlaus
Reno Hrašćan
On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cell...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Nives Pe ćina-Šlaus Reno Hra šćan Tags: Review Source Type: research
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
ConclusionA risk stratification algorithm based on significant prognostic factors allowed a personalized early prognosis estimation at the time of GBM diagnosis, that can contribute to a more personalized patient counseling. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1576: Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients
In conclusion, FUS-BBBO-enhanced liquid biopsy using stable cavitation shows diagnostic potential for primary brain tumors. Further research is imperative before integrating FUS-BBBO for liquid biopsy enhancement into clinical practice. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Akke Bakker Anna E. Ixkes Hema Venugopal Mario G. Ries Nathalie S. M. Lak Filip Y. F. L. de Vos Dannis G. van Vuurden Tom J. Snijders Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1574: The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience
io Melcarne
Diego Garbossa
Given the importance of maximizing resection for prognosis in patients with HGG and the potential risks associated with ventricle opening, this study aimed to assess the actual increase in post-surgical complications related to lateral ventricle opening and its influence on OS and PFS. A retrospective study was conducted on newly diagnosed HGG, dividing the patients into two groups according to whether the lateral ventricle was opened (69 patients) or not opened (311 patients). PFS, OS, subependymal dissemination, distant parenchymal recurrences, the development of hydrocephalus and CSF lea...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Fabio Cofano Andrea Bianconi Raffaele De Marco Elena Consoli Pietro Zeppa Francesco Bruno Alessia Pellerino Flavio Panico Luca Francesco Salvati Francesca Rizzo Alberto Morello Roberta Rud à Giovanni Morana Antonio Melcarne Diego Garbossa Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1566: Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated
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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference ...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Guido Frosina Tags: Review Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
