Seven new triterpenoids from the roots of Adenophora tetraphylla (Thub.) Fisch
Fitoterapia. 2024 Mar 14:105902. doi: 10.1016/j.fitote.2024.105902. Online ahead of print.ABSTRACTSeven new triterpenoids, named Adeterpenoids A-G (1-7) and eight known compounds (8-15), were isolated from 70% ethanol extract of the roots of Adenophora tetraphylla (Thub.) Fisch. The compounds from it were separated by column chromatography techniques such as silica gel, ODS, and preparative liquid chromatography. Their structures were clarified based on extensive spectral analysis (1D, 2D-NMR, HR-ESI-MS, IR, UV, and CD) and comparison with the literature. At the same time, all compounds were evaluated for their cytotoxic a...
Source: Fitoterapia - March 16, 2024 Category: Biochemistry Authors: Zhe-Yue Han Jia-Tong Wu Yu-Xuan Lin Yu Bi Anam Naseem Zhi-Chao Hao Juan Pan Wei Guan Hai-Xue Kuang Qing-Shan Chen Li-Li Zhang Yan Liu Bing-You Yang Source Type: research

Seven new triterpenoids from the roots of Adenophora tetraphylla (Thub.) Fisch
Fitoterapia. 2024 Mar 16;175:105902. doi: 10.1016/j.fitote.2024.105902. Online ahead of print.ABSTRACTSeven new triterpenoids, named Adeterpenoids A-G (1-7) and eight known compounds (8-15), were isolated from 70% ethanol extract of the roots of Adenophora tetraphylla (Thub.) Fisch. The compounds from it were separated by column chromatography techniques such as silica gel, ODS, and preparative liquid chromatography. Their structures were clarified based on extensive spectral analysis (1D, 2D-NMR, HR-ESI-MS, IR, UV, and CD) and comparison with the literature. At the same time, all compounds were evaluated for their cytotox...
Source: Fitoterapia - March 16, 2024 Category: Biochemistry Authors: Zhe-Yue Han Jia-Tong Wu Yu-Xuan Lin Yu Bi Anam Naseem Zhi-Chao Hao Juan Pan Wei Guan Hai-Xue Kuang Qing-Shan Chen Li-Li Zhang Yan Liu Bing-You Yang Source Type: research

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. Analysis of CRISPR/Cas9 loss-of-function gene deletion screens identified PIK3CA and MTOR as targetable molecular dependencies across patient derived models of DIPG, highlighting the therapeutic potential of the blood-brain barrier–penetrant PI3K/Akt/mTOR inhibitor, paxalisib. At the human-equivalent maximum tolerated dose, mice treated with paxalisib experienced systemic glucose feedback and increased insulin levels commensurate with patients ...
Source: Journal of Clinical Investigation - March 16, 2024 Category: Biomedical Science Authors: Ryan J. Duchatel, Evangeline R. Jackson, Sarah G. Parackal, Dylan Kiltschewskij, Izac J. Findlay, Abdul Mannan, Dilana E. Staudt, Bryce C. Thomas, Zacary P. Germon, Sandra Laternser, Padraic S. Kearney, M. Fairuz B. Jamaluddin, Alicia M. Douglas, Tyrone B Source Type: research

Just a spoonful of metformin helps the medicine go down
Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor with a need for novel therapies. So far, monotherapies have failed to prolong survival for these patients, and combinatorial strategies have often shown severe, dose-limiting toxicities. In this issue of the JCI, Duchatel, Jackson, and colleagues address this challenge by introducing a drug combination that mitigates side effects and overcomes resistance. After identifying the PI3K/mTOR pathway as a therapeutic vulnerability, they treated DIPG-bearing mice with paxalisib and saw responses but also observed hyperglycemia as a severe side effect. Combining ...
Source: Journal of Clinical Investigation - March 16, 2024 Category: Biomedical Science Authors: Theophilos Tzaridis, Robert J. Wechsler-Reya Source Type: research

Vasorin exocytosed from glioma cells facilitates angiogenesis via VEGFR2/AKT signaling pathway
In this study, we found that human vascular endothelial cells (hECs) co-cultured with VASN-overexpressing glioma cells exhibited accelerated migration ability and increased expression of VASN originated from glioma cells. VASN was found in exosomes secreted by glioma cells and could be taken up by hECs. hECs showed more edge filopodia and significantly upregulated expression of endothelial tip cell marker gene and protein levels after co-culture with VASN-overexpressing glioma cells. In clinical glioma tissue and orthotopic transplantation glioma tissue, the vascular density and the number of vascular endothelial cells wit...
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Ying Zhong Hui Kang Ziqing Ma Jiayu Li Zixi Qin Zixuan Zhang Peiwen Li Ying Zhong Lihui Wang Source Type: research

Cancers, Vol. 16, Pages 1161: Awake Craniotomy for Gliomas in the Non-Dominant Right Hemisphere: A Comprehensive Review
This article aims to comprehensively review the current literature on the benefits of awake craniotomy in gliomas of the non-dominant right hemisphere. A systematic review was conducted using the PubMed and ScienceDirect databases with keywords such as “right hemisphere”, “awake surgery”, “direct electrical brain stimulation and mapping”, and “glioma”. The search focused on anatomical and surgical aspects, including indications, tools, and techniques of awake surgery in right cerebral hemisphere gliomas. The lite...
Source: Cancers - March 15, 2024 Category: Cancer & Oncology Authors: Dilshod Muhammadvalievich Mamadaliev Ryuta Saito Kazuya Motomura Fumiharu Ohka Gianluca Scalia Giuseppe Emmanuele Umana Alfredo Conti Bipin Chaurasia Tags: Review Source Type: research

Correction to: Prognostic factors analysis of diffuse midline glioma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research

Cerebrospinal Fluid Liquid Biopsies in the Evaluation of Adult Gliomas
AbstractPurpose of ReviewThis review aims to discuss recent research regarding the biomolecules explored in liquid biopsies and their potential clinical uses for adult-type diffuse gliomas.Recent FindingsEvaluation of tumor biomolecules via cerebrospinal fluid (CSF) is an emerging technology in neuro-oncology. Studies to date have already identified various circulating tumor DNA, extracellular vesicle, micro-messenger RNA and protein biomarkers of interest. These biomarkers show potential to assist in multiple avenues of central nervous system (CNS) tumor evaluation, including tumor differentiation and diagnosis, treatment...
Source: Current Oncology Reports - March 15, 2024 Category: Cancer & Oncology Source Type: research

Integrating and optimizing tonabersat in standard glioblastoma therapy: A preclinical study
In conclusion, this preclinical investigation highlights tonabersat’s potenti al as an effective adjuvant treatment for GB, and its established safety profile from clinical trials in migraine treatment presents a promising foundation for further exploration. (Source: PLoS One)
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: Velislava Zoteva Source Type: research

Theory and application of TTFields in newly diagnosed glioblastoma
CONCLUSION: This review summarizes mechanisms of TTFields in the treatment of ndGBM, and describes the current clinical application of TTFields in ndGBM. Through the understanding of its principle and application status, we believe that TTFields still has the potential to further prolong the survival of ndGBM patients. Thus,research is still needed to explore new ways to combine TTFields with other therapies and optimize the use of TTFields to realize its full potential in ndGBM patients.PMID:38481068 | DOI:10.1111/cns.14563 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 14, 2024 Category: Neuroscience Authors: Ao Yu Juan Zeng Jinhui Yu Shuo Cao Ailin Li Source Type: research

Comprehensive analysis of the effects of the cuprotosis-associated gene < em > SLC31A1 < /em > on patient prognosis and tumor microenvironment in human cancer
CONCLUSIONS: SLC31A1 may be a potential target related to cancer energy metabolism and may have prognostic value.PMID:38482443 | PMC:PMC10928633 | DOI:10.21037/tcr-23-1308 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Guiqian Zhang Ning Wang Shixun Ma Pengxian Tao Hui Cai Source Type: research

Longitudinal impact of intracerebral low-grade glioma disease on health-related quality of life
CONCLUSIONS: Low-grade glioma disease has a significant impact on HRQOL and treatment might contribute to further deterioration. New-onset neurological deficits and ongoing epileptic seizures are predictors of limitations in quality of life. Since the results are based on a small cohort with limited follow-up time, the generalizability of these statements is limited and further studies are required.PMID:38483435 | DOI:10.23736/S0390-5616.23.06107-6 (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - March 14, 2024 Category: Neurosurgery Authors: Laur èl Rauschenbach Pauline Bartsch Alejandro N Santos Anna Michel Hanah H Gull Pikria Ketelauri Marvin Darkwah Oppong B örge Schmidt Celia Dobersalske Tobias Blau Yahya Ahmadipour Ramazan Jabbarli Karsten H Wrede Ulrich Sure Philipp Dammann Source Type: research

Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research

Brain tumor surgery in adults.
Magy Onkol. 2024 Mar 14;68(1):13-25. Epub 2023 Nov 12.ABSTRACTDespite the advanced medical and radiation therapy, the role of surgical resection of brain neoplasms still remains indisputable. The maximal safe resection of benign brain tumors may result in complete recovery of the patient. Surgery of malignant tumors can resolve mass effect, improve the neurological condition of the patient providing the possibility for further complex oncotherapy based on molecular level histopathology results. The advances in technical and multidisciplinary environment of brain tumor surgery facilitate more radical and safer resection res...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: Gy örgy Attila Bagó Gerg ő Dávid Nagy Source Type: research

Antitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects
Mol Neurobiol. 2024 Mar 14. doi: 10.1007/s12035-024-04086-8. Online ahead of print.ABSTRACTThe aim of this study was to investigate the antiglioma effect of Cecropia pachystachya Trécul (CEC) leaves extract against C6 and U87 glioblastoma (GB) cells and in a rat preclinical GB model. The CEC extract reduced in vitro cell viability and biomass. In vivo, the extract decreased the tumor volume approximately 62%, without inducing systemic toxicity. The deficit in locomotion and memory and an anxiolytic-like behaviors induced in the GB model were minimized by CEC. The extract decreased the levels of reactive oxygen species, ni...
Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Nat ália Pontes Bona Nathalia Stark Pedra Luiza Spohr Francieli da Silva Dos Santos Juliane Torchelsen Saraiva Fabiano Barbosa Carvalho Marilda da Cruz Fernandes Ana Sofia Fernandes Nuno Saraiva Marta Filipa Martins Rejane Giacomelli Tavares Roselia Mari Source Type: research