The intriguing role of IL33/ST2 axis signaling in oral diseases - A systematic review
CONCLUSIONS: Accumulating evidence demonstrates that the IL-33/ST2 axis is a fundamental pathogenetic mechanism of oral diseases of inflammatory, autoimmune, or neoplastic origin.PMID:38705460 | DOI:10.1016/j.advms.2024.04.007 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 5, 2024 Category: Biomedical Science Authors: Mala Kamboj R Keerthika Anjali Narwal Ambika Gupta Anju Devi Adarsh Kumar Gitika Sharma Source Type: research
Pediatric palliative epilepsy surgery: a report from the Pediatric Epilepsy Research Consortium (PERC) Surgery Database
Epilepsy is common, occurring in 0.5-1.5% of the pediatric US population, with drug-resistant epilepsy (DRE) occurring in nearly one-third of persons with epilepsy under 18 years of age.1,2,3,50 The International League Against Epilepsy (ILAE) defines DRE as “failure of adequate trials of two tolerated, appropriately chosen and used, antiepileptic drug schedules to achieve sustained seizure freedom”.4 After two anti-seizure medications (ASMs) have failed, the likelihood that an additional ASM will lead to seizure freedom is around 4-5%. (Source: Pediatric Neurology)
Source: Pediatric Neurology - May 5, 2024 Category: Neurology Authors: M. Jeno, B. Zimmerman, S. Shandley, L. Wong-Kisiel, R. Singh, N. McNamara, E. Fedak Romanowski, Z. Grinspan, K. Eschbach, A. Alexander, P. McGoldrick, S. Wolf, S. Nangia, J. Bolton, J. Olaya, D.W. Shrey, S. Karia, C. Karakas, P. Tatachar, A.P. Ostendorf, Tags: Research Paper Source Type: research
Extended Oral Antibiotics Continue to be Prescribed in Larger Quantities, but Are We Prescribing Them for the Right Reasons?
We are seeing an annual increase in the number of primary and revision arthroplasty procedures, necessitating efforts to avoid or manage post-operative complications. Despite these efforts, periprosthetic joint infection (PJI) is one such devastating complication following either primary or revision total hip (THA) or total knee arthroplasty (TKA) that is associated with a large clinical and financial burden. A recent database study identified infection as the most common etiology for revision TKA, followed by mechanical loosening. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - May 5, 2024 Category: Orthopaedics Authors: Sean B. Sequeira, Giles R. Scuderi, Michael A. Mont Tags: Editorial Source Type: research
Editorial Comment: "Critically Evaluating the Role for Postoperative Antibiotics in Patients Undergoing Urethroplasty with Buccal Mucosa Graft: A Claims Database Analysis" (#URL-D-23-02180R1)
In this publication, Galansky et al examined stricture recurrence and infectious complications in patients undergoing primary buccal mucosa graft urethroplasty, using a large claims-based database. The authors found that there was no difference in rates of endoscopic revisions or re-do urethroplasties at 5-years. They also found that there were no differences in urinary tract infections (UTIs) and surgical site infections (SSIs) at 31-90 days, and no differences in clostridium difficile infection within 30 days. (Source: Urology)
Source: Urology - May 5, 2024 Category: Urology & Nephrology Authors: Jeffery S. Lin, Lee C. Zhao Source Type: research
Viruses, Vol. 16, Pages 731: Rapid Detection and Quick Characterization of African Swine Fever Virus Using the VolTRAX Automated Library Preparation Platform
Bonto Faburay
African swine fever virus (ASFV) is the causative agent of a severe and highly contagious viral disease affecting domestic and wild swine. The current ASFV pandemic strain has a high mortality rate, severely impacting pig production and, for countries suffering outbreaks, preventing the export of their pig products for international trade. Early detection and diagnosis of ASFV is necessary to control new outbreaks before the disease spreads rapidly. One of the rate-limiting steps to identify ASFV by next-generation sequencing platforms is library preparation. Here, we investigated the capability of the...
Source: Viruses - May 5, 2024 Category: Virology Authors: Vivian O ’Donnell Jim L. Pierce Oleg Osipenko Lizhe Xu Amy Berninger Steven M. Lakin Roger W. Barrette Douglas P. Gladue Bonto Faburay Tags: Brief Report Source Type: research
Sensors, Vol. 24, Pages 2940: Smart Sensing Chairs for Sitting Posture Detection, Classification, and Monitoring: A Comprehensive Review
in Gibson
Incorrect sitting posture, characterized by asymmetrical or uneven positioning of the body, often leads to spinal misalignment and muscle tone imbalance. The prolonged maintenance of such postures can adversely impact well-being and contribute to the development of spinal deformities and musculoskeletal disorders. In response, smart sensing chairs equipped with cutting-edge sensor technologies have been introduced as a viable solution for the real-time detection, classification, and monitoring of sitting postures, aiming to mitigate the risk of musculoskeletal disorders and promote overall health. This compre...
Source: Sensors - May 5, 2024 Category: Biotechnology Authors: David Faith Odesola Janusz Kulon Shiny Verghese Adam Partlow Colin Gibson Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1781: Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis
This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-based pathway activation scoring method was employed to investigate the expression patterns of these signatures in the mRNA expression profiles of ovarian cancer cohorts. Compared to other subtype tumors, the results of this study show that the Hippo signaling pathway signatures are dysregulated prominently in serous subtype-specific ovarian carcinogenesis. A receiver oper...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Karthik Balakrishnan Yuanhong Chen Jixin Dong Tags: Article Source Type: research
Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model
CONCLUSIONS: GLS1 expression in CRC plays important roles in tumor progression. CB-839 has inhibitory effects on cancer proliferation and the tumor microenvironment.PMID:38703552 | DOI:10.1016/j.yexmp.2024.104896 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - May 4, 2024 Category: Pathology Authors: Ryo Miyamoto Hidehiko Takigawa Ryo Yuge Daisuke Shimizu Misa Ariyoshi Rina Otani Akiyoshi Tsuboi Hidenori Tanaka Ken Yamashita Yuichi Hiyama Yuji Urabe Akira Ishikawa Kazuhiro Sentani Shiro Oka Source Type: research
Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs
CONCLUSION: In comparison to bDMARDs, JAKi are associated with a slightly higher infection risk and a higher risk of herpes zoster specifically. In older patients, infection IRs are higher but similar infection risks for JAKi and bDMARDs are observed. No differences in infection risk between tofacitinib and baricitinib were found. Key Points • Compared to bDMARDs, JAKi are associated with a slightly higher infection risk for all ages • An increased risk of herpes zoster in patients who use JAK inhibitors was confirmed • No significant differences in infection incidence were found between tofacitinib and baricitinib.P...
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: M A A Opdam N den Broeder B J F van den Bemt K Mulder K M van de Wiel H van Ballegooijen R van Crevel A A den Broeder Source Type: research
An MCDM approach for Reverse vaccinology model to predict bacterial protective antigens
Vaccine. 2024 May 3:S0264-410X(24)00517-6. doi: 10.1016/j.vaccine.2024.04.078. Online ahead of print.ABSTRACTReverse vaccinology (RV) is a significant step in sensible vaccine design. In recent years, many machine learning (ML) methods have been used to improve RV prediction accuracy. However, there are still issues with prediction accuracy and programme accessibility in ML-based RV. This paper presents a supervised ML-based method to classify bacterial protective antigens (BPAgs) and identify the model(s) that consistently perform well for the training dataset. Six ML classifiers are used for testing with physiochemical f...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Pratik Angaitkar Rekh Ram Janghel Tirath Prasad Sahu Source Type: research
Acupuncture for poststroke coma: A systematic review and meta-analysis
CONCLUSIONS: The existing evidence suggests that acupuncture combined with conventional treatment may be an effective treatment for poststroke coma patients. In the meantime, more high-quality RCTs are needed to demonstrate these findings due to methodological weaknesses like randomization, blinding, heterogeneous interventions and long-term follow-up.PMID:38704101 | DOI:10.1016/j.ctim.2024.103046 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 4, 2024 Category: Complementary Medicine Authors: Yulun Wu Kun Zhao Wanshun Wen Keying Zhu Fei'ao Lu Yurou Kong Xiangming Ye Hui Wang Source Type: research
MPoMA protects against lung epithelial cell injury via p65 degradation
This study aimed to identify compounds from a library of compounds that prevent viral infection that could reduce and prevent lung epithelial cell damage. We investigated the cytotoxicity of the compounds, their activity in inhibiting viral spike protein binding to cells, and their activity in reducing IL-8 production in lung epithelial cells damaged by amodiaquine (AQ). We identified N-(4-(4-methoxyphenoxy)-3-methylphenyl)-N-methylacetamide (MPoMA) as a non-cytotoxic inhibitor against viral infection and AQ-induced cell damage. MPoMA inhibited the expression of IL-8, IL-6, IL-1β, and fibronectin induced by AQ and protect...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Soheun Lee Suh Jin Yoon Ji Hyun Oh Jae-Sang Ryu Yunjeong Park Eun Sook Hwang Source Type: research
Shared biomarkers and mechanisms in idiopathic pulmonary fibrosis and non-small cell lung cancer
CONCLUSIONS: We revealed dysregulated extracellular matrix through aberrant expression of the relevant genes, which provided further understanding for the common molecular mechanisms predisposing the occurrence of both IPF and NSCLC.PMID:38703565 | DOI:10.1016/j.intimp.2024.112162 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Xiaorui Ding Huarui Liu Qinghua Xu Tong Ji Ranxun Chen Zhengcheng Liu Jinghong Dai Source Type: research
The Association Between Adverse Cardiovascular Outcomes in Celiac Disease and the Role of Inflammation: Retrospective Analysis Using the National Inpatient Sample
Curr Probl Cardiol. 2024 May 2:102612. doi: 10.1016/j.cpcardiol.2024.102612. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease with patients being prone to a proinflammatory state. With recent studies showing an association between adverse cardiovascular events in patients with CD, we aim to further elucidate this relationship. Furthermore, when risk-stratifying patients with cardiovascular disease (CVD), chronic inflammatory conditions such as CD are not included in these calculations. We conducted a retrospective analysis using the National Inpatient Sample database from 2016 to 2019 to inve...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Rabab Elsadek Zeeshan Ismail Raghav Bassi Anuoluwa Oyetoran Yaseen Perbtani Tony Brar Suzanne Zentko Source Type: research
Residual Axillary Metastases in Node-Positive Breast Cancer Patients After Neoadjuvant Treatment: A Register-Based Study
CONCLUSIONS: Breast pCR or ITC only in TAD LNs can, with reasonable certainty, preclude more than three positive non-TAD LNs. Additionally, patients with only ITCs in the TAD LN had a low risk of having any non-TAD LN metastases after NACT. De-escalated axillary treatment may be considered in both subgroups.PMID:38704502 | DOI:10.1245/s10434-024-15354-1 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Frederikke Munck Maj-Britt Jensen Ilse Vejborg Maria K Gerlach Maja V Maraldo Niels T Kroman Tove H F Tvedskov Source Type: research
