Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model

CONCLUSIONS: GLS1 expression in CRC plays important roles in tumor progression. CB-839 has inhibitory effects on cancer proliferation and the tumor microenvironment.PMID:38703552 | DOI:10.1016/j.yexmp.2024.104896

Source: Experimental and Molecular Pathology - May 4, 2024 Category: Pathology Authors: Ryo Miyamoto Hidehiko Takigawa Ryo Yuge Daisuke Shimizu Misa Ariyoshi Rina Otani Akiyoshi Tsuboi Hidenori Tanaka Ken Yamashita Yuichi Hiyama Yuji Urabe Akira Ishikawa Kazuhiro Sentani Shiro Oka Source Type: research