Immunogenicity, Effectiveness, and Safety of COVID-19 Vaccines among Patients with Immune-Mediated Dermatological Diseases: A Systematic Review and Meta-analysis
In conclusion, immune-mediated dermatological diseases showed a reduced vaccine response in our meta-analysis, yet vaccination remained effective against COVID-19 infection and well tolerated.PMID:38698654 | DOI:10.2340/actadv.v104.40009 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 3, 2024 Category: Dermatology Authors: Sonphet Chirasuthat Yanisa Ratanapokasatit Kunlawat Thadanipon Kumutnart Chanprapaph Source Type: research
Which Drugs are More Effective in Preventing Familial Adenomatous Polyposis Progression Based on Network Meta-Analysis?
CONCLUSION: The most effective treatment for reducing the number of colorectal polyps is celecoxib 16 mg/kg/day. On the other hand, a daily dosage of 2 g EPA-FFA demonstrates the best results in terms of decreasing colorectal polyp diameter.PMID:38698755 | DOI:10.2174/0113816128289465240422074745 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 3, 2024 Category: Drugs & Pharmacology Authors: Pei Luo Wenjun Shi Xianshuo Cheng Jun Yang Gen Pei Jian Dong Source Type: research
PD-1/PD-L1 pathway: Current research in breast cancer
CONCLUSIONS: The combination of PD-1/PD-L1 is essential for many malignancies. According to the evidence presented, this combination presents both an opportunity and a challenge in cancer treatment. Since many solid cancers, especially BC, express high levels of PD-1/PD-L1, cancer treatment mainly involves targeted therapies.PMID:38701137 | DOI:10.3233/BD-249006 (Source: Breast Disease)
Source: Breast Disease - May 3, 2024 Category: Cancer & Oncology Authors: Salman Ardi Syamsu Muhammad Faruk Nilam Smaradania Elridho Sampepajung Agung Sindu Pranoto Febie Irsandy Iin Fadhilah Utami Tammasse Source Type: research
Effect of Nonpharmacological Methods on Pruritus in Patients with Liver Disease and Liver Cirrhosis: Systematic Review
CONCLUSIONS: Based on the findings, nonpharmacological methods have a positive effect on itching in individuals with liver disease and liver cirrhosis. It is recommended to conduct more studies with higher methodological quality, using larger sample groups, different interventions, randomization, and blinding methods, to examine the effectiveness of nonpharmacological methods in patients with liver disease and liver cirrhosis.PMID:38702165 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Yasemin Çayir Meral G ün Emine Kaplan Serin Source Type: research
The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review
CONCLUSIONS: Despite the promising results observed in the included studies, the overall evidence supporting the positive effects of polyphenols on periodontal and diabetes mellitus status, along with their anti-inflammatory properties, remains inadequate.PMID:38700145 | DOI:10.2340/aos.v83.40484 (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - May 3, 2024 Category: Dentistry Authors: Kornelija Rogalnikovaite Auste Antipoviene Asta Burbulyte Egle Aida Bendoraitiene Source Type: research
Beyond disclaimers: The need for a curation-based model of PubMed
Curr Med Res Opin. 2024 May 3:1-12. doi: 10.1080/03007995.2024.2350612. Online ahead of print.ABSTRACTAccording to its own description, the biomedical meta-database PubMed exists "with the aim of improving health-both globally and personally." Unfortunately, PubMed contains an increasing amount of low-quality research that may detract from this goal. Currently, PubMed warns its users and protects itself from such problems with a disclaimer stating that the presence of any article, book, or document in PubMed does not imply an endorsement of, or concurrence with, its contents by the NLM, the National Institutes of Health (N...
Source: Current Medical Research and Opinion - May 3, 2024 Category: Research Authors: Jaime A Teixeira da Silva Helmar Bornemann-Cimenti Timothy Daly Jens C T ürp Source Type: research
SMARCA4 alterations in non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSION: Our findings suggest that SMARCA4 mutation negatively affects NSCLC OS and PFS. The prognostic effects of SMARCA4-co-occurring mutations and the predictive role of SMARCA4 mutation status in immunotherapy require further exploration.PMID:38702192 | DOI:10.1136/jcp-2024-209394 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Durgesh Wankhede Sandeep Grover Paul Hofman Source Type: research
State-level policies and receipt of CDC-informed opioid thresholds among commercially insured new chronic opioid users
CONCLUSION: States with highly robust PDMPs and medical cannabis dispensaries had lower odds of receiving higher opioid thresholds, while cannabis decriminalization correlated with higher odds of receiving high opioid thresholds.PMID:38700395 | DOI:10.5055/jom.0824 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - May 3, 2024 Category: Addiction Authors: Martin J Calabrese Fadia T Shaya Francis Palumbo Mary Lynn McPherson Ester Villalonga-Olives Zafar Zafari Ryan Mutter Source Type: research
The first decade of the Danish Palliative Care Database: improvements and ongoing challenges in the quality and use of specialised palliative care
Acta Oncol. 2024 May 2;63:259-266. doi: 10.2340/1651-226X.2024.28515.ABSTRACTBACKGROUND: Danish Palliative Care Database comprises five quality indicators: (1) Contact with specialised palliative care (SPC) among referred patients, (2) Waiting time of less than 10 days, (3) Proportion of patients who died from (A) cancer or (B) non-cancer diseases, and had contact with SPC, (4) Proportion of patients completing the patient-reported outcome measure at baseline (EORTC QLQ-C15-PAL), and (5) Proportion of patients discussed at a multidisciplinary conference.PURPOSE: To investigate changes in the quality indicators from 2010 un...
Source: Acta Oncologica - May 3, 2024 Category: Cancer & Oncology Authors: Mathilde Adsersen Maiken Bang Hansen Mette Asbjoern Neergaard Per Sj øgren Mai-Britt Guldin Mogens Groenvold Source Type: research
Association of ADP ‑ribosylation factor family genes with prognosis and immune infiltration of breast cancer
Oncol Lett. 2024 Apr 23;27(6):280. doi: 10.3892/ol.2024.14413. eCollection 2024 Jun.ABSTRACTBreast cancer (BC) is the most common type of cancer found in women. ADP-ribosylation factors (ARFs) are a group of small proteins that bind to GTP and are involved in controlling different cellular functions. The function and evolution of multiple ARFs in BC have remained to be fully elucidated, despite existing studies on this protein family in Homo sapiens and other species. In the present study, a systematic analysis of ARF expression levels in BC tissues compared to normal breast tissues was performed using data from The Cancer...
Source: Oncology Letters - May 3, 2024 Category: Cancer & Oncology Authors: Lixian Yang Shiyu Zhang Lei Zheng Fanting Kong Pengpeng Pu Xiaowei Li Lining Jia Source Type: research
Smoking may increase the usage of antidepressant: evidence from genomic perspective analysis
This study uses the two-sample Mendelian randomization (TSMR) method to explore the causal relationships between smoking initiation (SMKI), never smoking (NSMK), past tobacco smoking (PTSMK), and the usage of antidepressants (ATD). Single-nucleotide polymorphisms (SNPs) with genome-wide significance (P < 5E-08) related to SMKI, NSMK, and PTSMK were selected from the genome-wide association study (GWAS) database as instrumental variables (IVs). The main method, inverse variance weighted (IVW), was utilized to investigate the causal relationship. The results demonstrated a positive causal relationship between SMKI and ATD...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 3, 2024 Category: Psychiatry Authors: Yucai Qu Zhiqiang Du Yuan Shen Qin Zhou Zhenhe Zhou Ying Jiang Haohao Zhu Source Type: research
Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer
CONCLUSIONS: The study developed a UPR-related gene classifier and risk signature for predicting survival in stomach cancer, identifying IGFBP1 as a key factor promoting the disease's malignancy and a potential therapeutic target. IGFBP1's role in enhancing cancer cell adaptation to endoplasmic reticulum stress suggests its importance in stomach cancer prognosis and treatment.PMID:38700505 | DOI:10.18632/aging.205784 (Source: Aging)
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Wenhao Ouyang Yajing Liu Hong Huang Yujing Tan Zhenjun Huang Xueyuan Jia Yunfang Yu Herui Yao Source Type: research
Left ventricular systolic dysfunction predicts clinical prognosis in patients with acute ischemic stroke after intravenous thrombolysis
CONCLUSIONS: Our finding indicated that AIS patients with LVSD after IVT had poorer outcomes, suggesting the need to monitor and optimize LVEF in stroke management.PMID:38700495 | DOI:10.18632/aging.205786 (Source: Aging)
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chi Zhang Jun-Cang Wu Zheng Tan Xiao-Lu He Fei Li Long Wang Yu Wang Source Type: research
Dereplication tools for Rhizophora mangle extracts from different mangrove areas and their potential against Staphylococcus aureus
This study aimed to investigate the chemical profile of Rhizophora mangle leaves from fringe, basin, and transition mangrove zones and their bactericidal/bacteriostatic potential against S. aureus. R. mangle leaves were collected monthly in 2018 from litterfall in three different zones of the mangrove of Guaratiba State Reserve: fringe, basin, and transition. Extracts were prepared from the material collected in October and December for LC-HRMS/MS analysis, and dereplication was performed using a molecular library search and the classical molecular networking GNPS platform. The minimum inhibitory concentrations (MICs) of t...
Source: Chemistry and Biodiversity - May 3, 2024 Category: Biochemistry Authors: Amanda Let ícia da Silva Pontes Carla Monteiro Leal Manuela Pereira Lucas Gabriela Caama ño Muiño da Silva Jo ão Vitor Braga Alves Peixoto Juliana Barbosa Succar Vinicius Ribeiro Flores Ida Carolina Neves Direito Antonio Jorge Ribeiro da Silva Filipe Source Type: research
Terrorist attacks against healthcare facilities involving hostages
This study shows that terrorist attacks against healthcare facilities that involve -hostage-taking have increased in frequency over the past 10 years and have global reach. Systems may still be underprepared for this potentially increasing phenomenon and require preparedness plans with education and simulated practice in place. Healthcare facilities should consider mitigation strategies such as preparedness drills and additional education.PMID:38698512 | DOI:10.5055/ajdm.0478 (Source: American Journal of Disaster Medicine)
Source: American Journal of Disaster Medicine - May 3, 2024 Category: International Medicine & Public Health Authors: Reed Macy Greg Jasani Reem Alfalasi Garrett Cavaliere Benjamin J Lawner Source Type: research
