Storage, security, and disposal.
Authors: Hutchison RW PMID: 31849024 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

"Blister packs" rather than "ashes to ashes, dust to dust" for medications.
"Blister packs" rather than "ashes to ashes, dust to dust" for medications. J Opioid Manag. 2019 Sep/Oct;15(5):355-356 Authors: Gupta D, Chakrabortty S PMID: 31849025 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Current practices in naloxone prescribing upon hospital discharge.
CONCLUSIONS: Providers agree with the Centers for Disease Control and Prevention recommendations to prescribe naloxone to high-risk patients. Certain barriers affect the rate of naloxone prescribing at discharge, including lack of time, patient education, provider training, and concern for increasing riskier behaviors. PMID: 31849026 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

A double blind randomized clinical trial of buprenorphine augmentation for treatment of psychotic symptoms in opioid addicted bipolar patients.
CONCLUSIONS: Buprenorphine did not add any efficacy to usual treatment of psychotic episodes of bipolar, although did not aggravate psychiatric symptoms. PMID: 31849027 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Increases in body mass index and cardiovascular risk factors during methadone maintenance treatment.
CONCLUSIONS: These data indicate that methadone maintenance treatment is associated with clinically meaningful weight gain and increases in cardiovascular risk factors. Given the importance of methadone maintenance for treatment of opioid use disorder, future research should examine additional predictors and potential mechanisms of weight gain among methadone patients and develop tailored interventions including nutritional knowledge and lifestyle recommendations. PMID: 31849028 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Opioid-induced constipation in mixed chronic pain patients: Prevalence and predictors analysis.
CONCLUSIONS: OIC was found in almost all evaluations of weak or strong opioidusers (97 percent); moderate to severe OIC was found in 72 percent of the evaluations. Cancer patients were associated with severe constipation. Macrogol was superior to other laxatives. In our experience, macrogol relieved constipation in those on the combination of oxycodone and naloxone and in those on fentanyl patches. Lactulose and glycerol suppositories were associated with severe constipation. PMID: 31849029 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Intraoperative opioid and non-opioid administration patterns and early postoperative pain: A single-center retrospective longitudinal study.
CONCLUSION: This study confirms that intraoperative opioid use has decreased over time with increased utilization of non-opioid analgesic adjuncts and a commensurate decrease in immediate postoperative pain. PMID: 31849030 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Birth outcomes with prescribed chronic and acute opioid exposure during pregnancy.
CONCLUSIONS: While a dose response of opioid exposure was not identified, these results add to existing evidence that opioid exposure during pregnancy is correlated with negative outcomes. Practitioners may better serve pregnant women and their fetuses by encouraging alternate pain relief treatments. PMID: 31849031 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Effects of naltrexone exposure observed in two phase three studies with ALO-02, an extended-release oxycodone surrounding sequestered naltrexone.
CONCLUSIONS: Naltrexone plasma concentrations were low, not correlated with COWS or BPI-sf scores, and considered clinically insignificant. PMID: 31849032 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Fentanyl analogue overdose: Key lessons in management in the synthetic opioid age.
Authors: Raheemullah A, Andruska N Abstract Fentanyl overdoses are growing at an alarming rate. Fentanyl is often mixed into heroin and counterfeit prescription opioid pills without the customer's knowledge and only detected upon laboratory analysis. This is problematic because fentanyl analogues like carfentanil are 10,000 times more potent than morphine and pose new challenges to opioid overdose management. A 62-year-old male with an overdose from a rare fentanyl analogue, acrylfentanyl, was given two doses of intranasal 2 mg naloxone with improvements in respiratory rate. In lieu of more naloxone, his trachea wa...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

A multicomponent intervention to improve adherence to opioid prescribing and monitoring guidelines in primary care.
Authors: Huang KTL, Blazey-Martin D, Chandler D, Wurcel A, Gillis J, Tishler J Abstract OBJECTIVE: Guidelines for appropriate management of chronic opioid therapy are underutilized by primary care physicians (PCPs). The authors hypothesized that developing a multicomponent, team-based opioid management system with electronic health record (EHR) support would allow our clinicians to improve adherence to chronic opioid prescribing and monitoring guidelines. DESIGN: This was a retrospective pre-post study. SETTING: The authors performed this intervention at our large, urban, academic primary care practice. ...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Knowledge gaps and practice patterns of clinicians treating patients with opioid use disorder.
CONCLUSIONS: There are multiple educational intervention strategies that can support the clinicians; including reducing restrictions to access treatment for OUD, care coordination programs for patients to improve early access to treatment and education, and frequent chart audit and feedback programs to support clinician decision making and education. PMID: 31850507 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Opioid prescription patterns among patients with fibromyalgia.
Authors: Sarmento CVM, Maz M, Pfeifer T, Pessoa M, Liu W Abstract OBJECTIVES: To investigate opioid prescribing patterns among patients with fibromyalgia (FM) in terms of age, gender, race, type of opioids, and to examine changes in opioid prescription over the past 8 years compared to the US Food and Drug Administration (FDA)-approved FM medications. DESIGN: Retrospective review of data using the Healthcare Enterprise Repository for Ontological Narration database. The collected data were analyzed descriptively and a chi-square test for trend was used to analyze a possible linear relationship between the propor...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

What physicians need to implement safer opioid prescribing: A qualitative study.
DISCUSSION: These qualitative data document practical issues that should be considered in the development of implementation plans for safer opioid prescribing practices. Specifically, healthcare systems may need to provide opioid-relevant communication strategies and training, education on key topics such as naloxone prescribing, resources for referrals to appropriate nonpharmacologic treatments, and innovative IT solutions. Future research is needed to establish that such measures will be effective in producing better outcomes for patients on opioids for chronic pain. PMID: 31850509 [PubMed - in process] (Source: Jour...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Hedonic eating behaviors and food preferences associated with medication-assisted treatment for opioid use disorder.
Authors: McDonald E, Laurent J Abstract OBJECTIVE: To characterize hedonic eating behaviors such as sugar cravings, food preferences, and appetitive responsiveness for sweet and hyper-palatable foods, and to determine the prevalence of addictive like eating behaviors and food addiction (FA) in individuals receiving medication-assisted treatment (MAT) for opioid use disorder (OUD). DESIGN: Quasi-experimental. SETTING: Outpatient MAT center. PARTICIPANTS: Nonpregnant adult patients undergoing MAT (n = 116) receiving either buprenorphine/naloxone or methadone for at least 6 months. MAIN OUTCOME MEASURE...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Validation of the prescription drug monitoring program Web site.
CONCLUSIONS: The authors' results suggest that the PA PDMP and its many supplementary databases are accurate as it relates to monitoring opioid prescriptions. PMID: 31850511 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Patterns in opioid prescription in the United States by region and prescribers over a 4-year period.
Authors: Bigal LM, Bibeau K, Dumbar S Abstract BACKGROUND: As determinants of the opioid epidemic are several, describing patterns of opioid prescription over time is of importance. OBJECTIVE: To characterize the prescribing patterns of opioids per US region and physician specialty from 2012 to 2015. METHODS: Truven Health Analytics MarketScan® Databases were used to obtain data on opioid prescription rates per US region and physician specialty for the years 2012-2015. Opioids included in the study are tramadol, hydrocodone, codeine, oxycodone, oxymorphone, methadone, and fentanyl. RESULTS: Starting...
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Key characteristics and habits of the recreational opioid user.
CONCLUSIONS: Recreational opioid users have distinct drug-related behaviors and preferences. Monitoring current trends and examining these behaviors is an important component to understand the potential safety risks associated with recreational opioid use. PMID: 31850513 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - December 19, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Patient health literacy and the receipt of opioids in the emergency department.
CONCLUSIONS: A greater proportion of older adults receiving ED care for musculoskeletal pain with low health literacy receive and use opioids during and following an ED visit. PMID: 31637678 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Validity of the screener and opioid assessment for patients with pain-revised (SOAPP-R) in patients with cancer.
CONCLUSIONS: The SOAPP-R, in its current form, may have value in screening patients with cancer for substance abuse. Incorporation of the screening tool in palliative and oncology settings may help reduce opioid abuse in cancer patients. PMID: 31637679 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

An Acute Pain Service experience initiating methadone for opioid use disorder in hospitalized patients with acute pain.
CONCLUSION: This pathway provides an example of an effective and safe response to address the opioid epidemic and pro-vide quality care to patients with OUD and pain. PMID: 31637680 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Measuring opioid dependence in chronic pain patients: A comparison between addiction clinic and pain clinic patient populations.
CONCLUSIONS: Some degree of dependence was present across both addiction and pain clinic groups, supporting the notion a state of dependence can be identified among chronic pain patients taking opioids long term. Aberrant behaviors were not common in the pain clinic sample, suggesting these patients are unlikely to meet Diagnostic and Statistical Manual of Mental Disorders-V criteria for Substance Use Disorder. However, opioid dependence carries significant risks for relapse, chronicity, morbidity and mortality, warranting specific medical management. Management of such risks should be considered routine care in chronic pa...
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

"We get tunnel vision": Emergency medical service providers' views on the opioid epidemic in Baltimore City.
CONCLUSIONS: EMS providers may be uniquely positioned to deliver substance use treatment messages to substance users. This could be a life- and cost-saving improvement to EMS in Baltimore City with incentivized training. More research is needed to inform opioid use preparedness in urban settings, which remain at the center of the opioid epidemic. PMID: 31637682 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Postoperative surgical trainee opioid prescribing practices (POST-OPP): A national survey.
CONCLUSION: In this survey, nearly two-thirds of surgical residents felt that they were inadequately trained in opioid pre-scribing. Our findings additionally suggest that improving education may result in increased resident comfort with man-aging surgical pain, potentially leading to more responsible opioid prescribing. Further work will facilitate residency pro-grams' development of educational curricula for opioid prescribing best practices. PMID: 31637683 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse.
CONCLUSION: Twenty-four percent of unselected adult SCD patients on opioids were identified as at-risk for opioid misuse using a quick survey. This may represent as much as 2.5-7 times the national misuse rate. This group of patients may benefit from additional diagnostic and therapeutic interventions to help understand and manage their opioid usage. PMID: 31637684 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Developing opioid prescribing recommendations in the postoperative orthopedic setting.
CONCLUSION: There is a need for more high quality research to be conducted to standardize postoperative opioid prescribing patterns and create best practice guidelines to guide clinicians. Orthopedic practices should consider creating institutional guidelines to reduce the amount of opioids prescribed. PMID: 31637685 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Mania induced by tramadol-venlafaxine combination.
Authors: Hefzi N, Grekin J, Ahmed A Abstract A 49-year-old male with major depressive disorder well-managed with venlafaxine [serotonin and norepinephrine reuptake inhibitor (SNRI)] and no history of manic episodes developed his first manic episode following use of tramadol. Tramadol-induced mania has been described with selective serotonin reuptake inhibitors but not SNRIs. In addition, mania is not listed as a potential clinical side effect-further illustrating this relative rarity. Due to tramadol's SNRI activity, there is definitive risk for mood lability in individuals managed with tramadol and other serotoner...
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Tapering off long-term methadone: A case study.
Authors: Zhou K, Frankish L, Wang GG Abstract Opioid tapering may be necessary for patients on long-term opioids. Here, the authors presented a patient who had uncontrolled chronic musculoskeletal pain while on chronic methadone. Upon methadone tapering, the patient had been taking methadone for longer than six years and had severe methadone-related adverse effects. Using multidisciplinary interventions of patient education and counseling, physical interventions, and nonopioid medications, patient's methadone was discontinued after longer than one year tapering with relatively good pain control. The tapering proces...
Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

In Memorial: Professor Gavril Pasternak.
Authors: Sloan PA PMID: 31343710 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Letter to the Editor.
Authors: Aytuluk HG PMID: 31343711 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Decline in primary care providers' prescribing of Schedule II opioids following the implementation of federal and state guidelines.
CONCLUSIONS: This study reports the benefit of incorporating federal and state regulations and institutional evidence-based guidelines into primary care practice to decrease the number of Schedule II opioids prescribed. Further preventive measures include selecting alternative treatments to opioids and reducing the rates of opioid nonmedical use and overdose while maintaining access to prescription opioids when indicated. PMID: 31343712 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Opioid e-prescribing trends at discharge in a large pediatric health system.
Authors: Horvat CM, Martin B, Wu L, Fabio A, Empey PE, Hagos F, Bigelow S, Kantawala S, Au AK, Kochanek PM, Clark RSB Abstract OBJECTIVE: Legitimate opioid prescriptions have been identified as a risk factor for opioid misuse in pediatric patients. In 2014, Pennsylvania legislation expanded a prescription drug monitoring program (PDMP) to curb inappropriate controlled substance prescriptions. The authors' objective was to describe recent opioid prescribing trends at a large, pediatric health system situated in a region with one of the highest opioid-related death rates in the United States and examine the impact of...
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Perceptions of opioid misuse and chronic pain: A qualitative assessment of Rhode Island commercial fishing captains.
CONCLUSIONS: Rhode Island commercial fishing captains perceived opioid misuse among crewmembers, work-related chronic pain, and inadequate healthcare access as barriers to sustainability of their industry. PMID: 31343714 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Discussions between patients with chronic pain and their primary care provider about opioids and pain relief during routine clinic encounters.
CONCLUSIONS: Much of the treatment of chronic pain, as a result of opioid prescriptions, revolves around negotiations about whether to use opioids or not. Patient education is required to disseminate realistic expectations regarding pain relief and risks of long-term opioid use. This may reduce patients' focus on pain severity and difficult conversations and increase shared decision making. PMID: 31343715 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Understanding transdermal buprenorphine and a practical guide to its use for chronic cancer and non-cancer pain management.
This article presents an overview of TDB and also provides practical recommendations for its use as part of a multifaceted strategy in chronic cancer and non-cancer pain. PMID: 31343716 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Low-dose versus high-dose methadone for the management of neonatal abstinence syndrome.
Authors: Miller JL, Ernst K, Neely SB, Stephens K, Barker P, Skrepnek GH, Johnson PN Abstract OBJECTIVES: The primary objective was to compare median time to symptom relief (time from methadone initiation until two consecutive modified Finnegan [neonatal abstinence syndrome, NAS] scores 0.275 mg/kg/day) methadone. Secondary objectives included assessment of factors associated with symptom relief. DESIGN: Retrospective cross-sectional study. SETTING: Ninety-nine bed neonatal intensive care unit within a tertiary-care academic hospital. PARTICIPANTS: Seventy-two neonates who received methadone for NAS ove...
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Postlaparotomy pain management: Comparison of patient-controlled analgesia pump alone, with subcutaneous bupivacaine infusion, or with injection of liposomal bupivacaine suspension.
CONCLUSIONS: Laparotomy patients treated with liposomal bupivacaine as part of a multimodal regimen consumed less opioids, had lower pain scores, and had fewer ORAEs. The role of liposomal bupivacaine in the postoperative care of laparotomy patients merits further study. PMID: 31343718 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Letter to the Editor.
Authors: Gupta D, Chakrabortty S PMID: 31343719 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Primary care physicians' perspectives on Veterans who obtain prescription opioids from multiple healthcare systems.
CONCLUSIONS: PCPs within the VA have varying perceptions of patients obtaining opioid medications from multiple healthcare systems, with pain complaints and opioid misuse as the primary themes. This knowledge about PCPs' perceptions can be incorporated into interventions to better manage pain and prescription opioid use by VA patients. PMID: 31343720 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Addressing the opioid crisis: An assessment of clinicians' training experience, practices, and attitudes within a large healthcare organization.
Authors: Kirane H, Drits E, Ahn S, Kapoor S, Morgenstern J, Conigliaro J, Enden J Abstract OBJECTIVE: To assess provider practices and attitudes toward addiction care and pain management within a large healthcare system, as well as to determine the impact of prior training and perceived effectiveness of organizational implementation strategies. DESIGN: A cross-sectional study. SETTING: Large healthcare organization comprising 21 hospitals. PARTICIPANTS: Three hundred and thirteen healthcare providers within a large healthcare organization. MAIN OUTCOME MEASURES: Training, practices, and attitudes to...
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

A longitudinal analysis of temporal and spatial incidence of neonatal abstinence syndrome in Ontario: 2003-2016.
CONCLUSIONS: The incidence of NAS has dramatically increased across Ontario in the last decade. Actions should be taken to combat the continued increase in NAS rates, especially in health regions with disproportionately high incidence of NAS. PMID: 31343722 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Attitudes and self-reported practices of orthopedic providers regarding prescription opioid use.
CONCLUSIONS: Our findings support a need for targeted education to mitigate the role of orthopedic postoperative prescribing practices on the current opioid abuse epidemic. PMID: 31343723 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Race and ethnicity: Not factors in the prescribing of hydrocodone and codeine-containing products in two pediatric emergency departments.
CONCLUSIONS: Pediatric patients of all races and ethnicities received fewer HCP prescriptions after the 2014 DEA rescheduling of HCPs. However, Caucasian patients were prescribed HCPs and CCPs for abdominal pain more frequently than African American patients. There were no significant differences in the number of prescriptions of HCPs and CCPs by provider race. PMID: 31343724 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Pre-existing opioid use disorder and postoperative outcomes after appendectomy or cholecystectomy: A multi-state analysis, 2007-2014.
CONCLUSIONS: The authors found higher unadjusted rates and adjusted ORs of in-patient mortality, hospital readmission, and postoperative complications in patients with opioid use disorder undergoing common abdominal surgeries. The authors' study shows that opioid use disorder is a risk factor for poorer postoperative outcomes in this surgical patient population. PMID: 31343725 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Opioid overdose history and awareness of naloxone in patients seeking outpatient detoxification.
CONCLUSIONS: Results indicate more than half of participants presenting for outpatient detoxification from opioids have had an OD or witnessed an OD. More than half of the participants were willing to accept OEND. This study provides evidence that patients starting their recovery are willing to accept naloxone. PMID: 31343726 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

A case report of sweating caused by hydromorphone.
Authors: Bode LE Abstract Thermoregulatory control of shivering and sweating is a complex process that can be affected by centrally acting medications. Opioids, in particular fentanyl and methadone, have been associated with sweating, but it remains a relatively rare occurrence in clinical practice. Under-recognition of this medication side-effect may lead to patient discomfort as well as a potentially unnecessary work-up to determine the etiology of the sweating. Here, we discuss severe sweating caused by hydromorphone that resolved upon the medication's discontinuation. PMID: 31343727 [PubMed - in process] (S...
Source: Journal of Opioid Management - July 27, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West Virginia.
Conclusions: For the purposes of testing WV individuals via genetic means for predisposition to OUD, at least four single nucleotide polymorphisms in three genes are likely to have utility in predicting susceptibility. Additional studies with larger populations will need to be conducted to confirm these results before use in a clinical setting. PMID: 31057342 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - May 8, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Age differences in the association of nonmedical prescription opioid use and suicidality.
CONCLUSIONS: Among younger and older age groups, there is a higher prevalence and associated odds of suicidality for those who report any misuse within the 12-month period. PMID: 30855717 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 13, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Opioid utilization patterns among patients with cancer and non-cancer pain.
CONCLUSIONS: Opioid use was consistent between patients with cancer pain and non-cancer pain, including clinically comparable total daily opioid doses and consistent rates of dose escalations and chronic utilization. Opioid medications are an important element of cancer and non-cancer pain management; thus, access to appropriate therapies, use patterns, and risk assessment and management are important for both patient populations. PMID: 30855718 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 13, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research

Exploratory study examining associations between prescription opioid dose and delay discounting in patients with chronic pain.
CONCLUSIONS: Contrary to study expectations, higher opioid dose was associated with less DD. These findings call for prospective research to further elucidate the relationships between DD and other measures of impulsivity and prescription opioid doses. PMID: 30855719 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 13, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research