An efficient LC-QTOF-mass spectrometry method for monitoring nal-trexone compliance in urine of opioid-dependent subjects
J Opioid Manag. 2024 Jan-Feb;20(1):5-9. doi: 10.5055/jom.0841.ABSTRACTNaltrexone (NTX) is an orally effective opiate antagonist used in maintenance treatment for opiate dependence. Its utility is limited by the patient's noncompliance. The study aimed to develop an efficient method for the detection of NTX in urine by LC-QTOF-mass spectrometry (MS) and its application to NTX compliance in opioid-dependent subjects. Sample preparation included a dilution step and direct injection to LC-QTOF-MS. Chromatographic separation was achieved with a C-18 column using a mixture of mobile phase 0.1 percent formic acid in water and 0.1...
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Raka Jain Piyali Mandal Sachin Rana Source Type: research
Cancer pain patients do not successfully handle opioids
CONCLUSIONS: Despite being aware of opioid's danger, patients' attitudes evidenced a poor safety responsibility. We believe that this might be due to the high percentage of disinformation and the influence of psychological symptoms on patients' decision-making.PMID:38533711 | DOI:10.5055/jom.0849 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Liel Kosev Ofir Morag Michelle Levitan Itay Goor-Aryeh Source Type: research
Monitoring buprenorphine in patients on medication-assisted treatment
CONCLUSION: Urine and oral fluid drug testing can be used to monitor adherence in this population.PMID:38533712 | DOI:10.5055/jom.0844 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Amadeo Pesce Katie Bollman Kevin Krock Agnes Cua Keith Tran Richard Thomas Source Type: research
Opioid stewardship program implementation in rural and critical access hospitals in Arizona
CONCLUSIONS: Some OSP elements were in place in nearly every Arizona CAH, while others were present in only a quarter or a third of hospitals. To improve, more attention is needed to define and standardize OSPs. Equal priority should be given to preventing unnecessary opioid initiation and treating opioid misuse or OUD, as well as quality control strategies that provide an opportunity for continuous improvement.PMID:38533713 | DOI:10.5055/jom.0842 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Benjamin R Brady Bianca SantaMaria Kathryn Tucker Ortiz Y Pino Bridget S Murphy Source Type: research
Short-term healthcare resource utilization associated with receipt of CDC-informed opioid thresholds among commercially insured new chronic opioid users
CONCLUSIONS: There was no difference in odds of an all-cause or opioid-related ACE associated with the thresholds. Early-intervention programs and policies exploring reduction of MME/day among NCOUs may not result in short-term reduction in all-cause or opioid-related ACEs. Further assessment of potential long-term reduction in ACEs among this cohort may be insightful.PMID:38533714 | DOI:10.5055/jom.0848 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Martin J Calabrese Fadia T Shaya Francis Palumbo Mary Lynn McPherson Ester Villalonga-Olives Zafar Zafari Ryan Mutter Source Type: research
Chronic opioid pain treatment converted to buprenorphine: A case series using a 3-step low-dose incremental dosing guideline
We report a 30-case series from the Pain Management Center at the Massachusetts General Hospital where we have applied a guideline to convert chronic treatment for pain from full agonist opioids (FAO) to buprenorphine (BUP). Of the patients, 24 (80 percent) elected to continue BUP over FAO. Five conversions were stopped for side effects (fatigue) and/or lack of sufficient pain reduction. One patient elected not to participate on the day that the conversion was to begin. There were no major adverse events. We conclude that conversion to BUP should be considered as an alternative to treat patients on chronic opioids for pain...
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Gregory Acampora Yi Zhang Source Type: research
Role of opioid use in gastrointestinal obstruction and perforation: A retrospective review
CONCLUSION: Pain killers should always be prescribed with caution and for a short duration. Alternative options for pain relief should be made available, and doctors should be trained. Drug abusers tend to have a gastrointestinal complication at an early age, which means they are prone to further complications and recurrence if the problem is not addressed on time.PMID:38533716 | DOI:10.5055/jom.0850 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Divya Bishnoi Priyanka Sharma Anant Kumar Rathi Source Type: research
Examining the relationship between head trauma and opioid use disorder: A systematic review
CONCLUSION: Findings indicate that therapists and clinicians must consider a risk profile for persons with TBI and follow an integrated care approach to account for mental health, prior substance misuse, presenting somatic symptoms, and current medication regimen during evaluation.PMID:38533717 | DOI:10.5055/jom.0846 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Ali Abid Maria Paracha Iva Çepele Awais Paracha Joseph Rueve Akbar Fidahussain Humza Rehman McKimmon Engelhardt Noor Alyasiry Zohair Siddiqui Satvik Vasireddy Bishal Kadariya Nikith Rao Rohan Das Wilson Rodriguez Dixie Meyer Source Type: research
Patient genetic heterogeneities acting as indicators of post-operative pain and opioid requirement in orthopedic surgery: A systematic review
CONCLUSION: There have been genetic association studies performed on the patient heterogeneity and its relationship on patient pain levels, but more data need to be collected to understand the clinical utility of stratifying patients based on genomic sequence.PMID:38533718 | DOI:10.5055/jom.0809 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Ahmad Hasan Adam Pearl Mohammad Daher Khaled J Saleh Source Type: research
Tianeptine as an opiate replacement in a patient on methadone treatment: A case report
J Opioid Manag. 2024 Jan-Feb;20(1):87-91. doi: 10.5055/jom.0851.ABSTRACTTianeptine, an antidepressant and full µ-opioid receptor agonist, has increased in popularity and has been used as an over-the-counter supplement over the past decade. Due to its well-documented euphoric effects, there exists elevated risk for potential abuse. Buprenorphine-naloxone has been successfully utilized to treat opioid use disorder (OUD) in patients concurrently using tianeptine, limiting withdrawal symptoms and abstinence. However, there is limited evidence on the management of tianeptine use disorder, specifically methadone or naltrexone. ...
Source: Journal of Opioid Management - March 27, 2024 Category: Addiction Authors: Vivek Velagapudi Jordan Calabrese Roopa Sethi Source Type: research
Surgical prescription opioid trajectories among state Medicaid enrollees
CONCLUSIONS: Findings support the importance of surgeons setting realistic patient expectations for post-surgical opioid use, as well as the importance of coordination of post-surgical care among patients failing to fully taper off opioids within 1-3 months of surgery.PMID:38189189 | DOI:10.5055/jom.0832 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - January 8, 2024 Category: Addiction Authors: Jenna L McCauley Ralph C Ward David J Taber William T Basco Mulugeta Gebregziabher Charles Reitman William P Moran Robert A Cina Mark A Lockett Sarah J Ball Source Type: research
Opioid prescription patterns in a children's hospital from 2012 to 2016
CONCLUSION: Data show that there is a decrease in overall opioid prescriptions among pediatric patients, which may be secondary to new Food and Drug Administration regulations and increased awareness of morbidity associated with opioid use. Not surprisingly, increased hospital stay and increase in age lead to more analgesic prescriptions. Further investigation is needed to determine the differences within opioid prescription patterns.PMID:38189190 | DOI:10.5055/jom.0833 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - January 8, 2024 Category: Addiction Authors: Nicole Titze Rishi Bhargava Ara Jamasbi Montalvo Gawon Shin Campbell Belisle Haley Soheil Saadat Bharath Chakravarthy Source Type: research
Patients with glenohumeral arthritis are more likely to be prescribed opioids in the emergency department or urgent care setting
CONCLUSION: Despite evidence against routine opioid use for osteoarthritis, one-third of patients with a primary diagnosis of glenohumeral osteoarthritis received an opioid prescription. Of those who received a prescription, over one-third had a risk factor for opioid misuse. An electronic clinic decision support tool influenced the prescription in less than 10 percent of encounters.PMID:38189191 | DOI:10.5055/jom.0834 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - January 8, 2024 Category: Addiction Authors: Jacob Gorbaty Meghan K Wally Susan Odum Ziqing Yu Nady Hamid Joseph R Hsu Michael Beuhler Michael Bosse Michael Gibbs Christopher Griggs Steven Jarrett Madhav Karunakar Laurence Kempton Daniel Leas Kevin Phelps Tamar Roomian Michael Runyon Animita Saha St Source Type: research
Opioid use disorder and motivational interviewing: Training physician assistants for the epidemic
CONCLUSIONS: An educational intervention using MI for PA students was found to be valuable, and students who completed the intervention had greater knowledge about using MI with OUD patients than those who did not complete the training. The size of the effect was small, and more research on the curriculum is necessary prior to widespread adoption.PMID:38189192 | DOI:10.5055/jom.0835 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - January 8, 2024 Category: Addiction Authors: Brian B Peacock Catherine N Shull Carol A Hildebrandt Gayle B Bodner Kristin J Lindaman Chris Gillette Source Type: research
Provider attitudes and current practice regarding the prescription of opioid-containing pain medication for vaginal delivery
CONCLUSIONS: Practice patterns for opioid prescription vary by provider type as well as by delivery characteristics. Further study is necessary to delineate the optimal care while minimizing unnecessary opioid prescriptions.PMID:38189193 | DOI:10.5055/jom.0836 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - January 8, 2024 Category: Addiction Authors: Sarah Atkinson Anna R Whelan Abigail Litwiller Source Type: research
