Examining the impact of interventions in reducing self-reported engagement in distracted driving: A systematic review
Accid Anal Prev. 2024 May 3;202:107608. doi: 10.1016/j.aap.2024.107608. Online ahead of print.ABSTRACTDespite the implementation of legal countermeasures, distracted driving remains a prevalent concern for road safety. This systematic review (following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines) summarised the literature on the impact of interventions targeting attitudes/intentions towards, and self-reported engagement in, distracted driving. Studies were eligible for this review if they examined self-reported behaviour/attitudes/intentions pertaining to distracted driving at baseline...
Source: Accident; Analysis and Prevention. - May 4, 2024 Category: Accident Prevention Authors: M Nicolls V Truelove K B Stefanidis Source Type: research
Testosterone Replacement Therapy and Associated Rates of Trigger Finger, de Quervain Tenosynovitis, and Their Subsequent Management
CONCLUSIONS: TRT is associated with an increased likelihood of both trigger finger and de Quervain tenosynovitis, and an increased likelihood of requiring surgical release for both conditions.TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.PMID:38703145 | DOI:10.1016/j.jhsa.2024.01.018 (Source: Hand Surgery)
Source: Hand Surgery - May 4, 2024 Category: Surgery Authors: Patrick S Barhouse J Alex Albright Elliot Rebello Kenny Chang Matthew S Quinn Alan H Daniels Michel Arcand Joseph A Gil Source Type: research
Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model
CONCLUSIONS: GLS1 expression in CRC plays important roles in tumor progression. CB-839 has inhibitory effects on cancer proliferation and the tumor microenvironment.PMID:38703552 | DOI:10.1016/j.yexmp.2024.104896 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - May 4, 2024 Category: Pathology Authors: Ryo Miyamoto Hidehiko Takigawa Ryo Yuge Daisuke Shimizu Misa Ariyoshi Rina Otani Akiyoshi Tsuboi Hidenori Tanaka Ken Yamashita Yuichi Hiyama Yuji Urabe Akira Ishikawa Kazuhiro Sentani Shiro Oka Source Type: research
Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs
CONCLUSION: In comparison to bDMARDs, JAKi are associated with a slightly higher infection risk and a higher risk of herpes zoster specifically. In older patients, infection IRs are higher but similar infection risks for JAKi and bDMARDs are observed. No differences in infection risk between tofacitinib and baricitinib were found. Key Points • Compared to bDMARDs, JAKi are associated with a slightly higher infection risk for all ages • An increased risk of herpes zoster in patients who use JAK inhibitors was confirmed • No significant differences in infection incidence were found between tofacitinib and baricitinib.P...
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: M A A Opdam N den Broeder B J F van den Bemt K Mulder K M van de Wiel H van Ballegooijen R van Crevel A A den Broeder Source Type: research
An MCDM approach for Reverse vaccinology model to predict bacterial protective antigens
Vaccine. 2024 May 3:S0264-410X(24)00517-6. doi: 10.1016/j.vaccine.2024.04.078. Online ahead of print.ABSTRACTReverse vaccinology (RV) is a significant step in sensible vaccine design. In recent years, many machine learning (ML) methods have been used to improve RV prediction accuracy. However, there are still issues with prediction accuracy and programme accessibility in ML-based RV. This paper presents a supervised ML-based method to classify bacterial protective antigens (BPAgs) and identify the model(s) that consistently perform well for the training dataset. Six ML classifiers are used for testing with physiochemical f...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Pratik Angaitkar Rekh Ram Janghel Tirath Prasad Sahu Source Type: research
Acupuncture for poststroke coma: A systematic review and meta-analysis
CONCLUSIONS: The existing evidence suggests that acupuncture combined with conventional treatment may be an effective treatment for poststroke coma patients. In the meantime, more high-quality RCTs are needed to demonstrate these findings due to methodological weaknesses like randomization, blinding, heterogeneous interventions and long-term follow-up.PMID:38704101 | DOI:10.1016/j.ctim.2024.103046 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 4, 2024 Category: Complementary Medicine Authors: Yulun Wu Kun Zhao Wanshun Wen Keying Zhu Fei'ao Lu Yurou Kong Xiangming Ye Hui Wang Source Type: research
MPoMA protects against lung epithelial cell injury via p65 degradation
This study aimed to identify compounds from a library of compounds that prevent viral infection that could reduce and prevent lung epithelial cell damage. We investigated the cytotoxicity of the compounds, their activity in inhibiting viral spike protein binding to cells, and their activity in reducing IL-8 production in lung epithelial cells damaged by amodiaquine (AQ). We identified N-(4-(4-methoxyphenoxy)-3-methylphenyl)-N-methylacetamide (MPoMA) as a non-cytotoxic inhibitor against viral infection and AQ-induced cell damage. MPoMA inhibited the expression of IL-8, IL-6, IL-1β, and fibronectin induced by AQ and protect...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Soheun Lee Suh Jin Yoon Ji Hyun Oh Jae-Sang Ryu Yunjeong Park Eun Sook Hwang Source Type: research
Shared biomarkers and mechanisms in idiopathic pulmonary fibrosis and non-small cell lung cancer
CONCLUSIONS: We revealed dysregulated extracellular matrix through aberrant expression of the relevant genes, which provided further understanding for the common molecular mechanisms predisposing the occurrence of both IPF and NSCLC.PMID:38703565 | DOI:10.1016/j.intimp.2024.112162 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Xiaorui Ding Huarui Liu Qinghua Xu Tong Ji Ranxun Chen Zhengcheng Liu Jinghong Dai Source Type: research
The Association Between Adverse Cardiovascular Outcomes in Celiac Disease and the Role of Inflammation: Retrospective Analysis Using the National Inpatient Sample
Curr Probl Cardiol. 2024 May 2:102612. doi: 10.1016/j.cpcardiol.2024.102612. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease with patients being prone to a proinflammatory state. With recent studies showing an association between adverse cardiovascular events in patients with CD, we aim to further elucidate this relationship. Furthermore, when risk-stratifying patients with cardiovascular disease (CVD), chronic inflammatory conditions such as CD are not included in these calculations. We conducted a retrospective analysis using the National Inpatient Sample database from 2016 to 2019 to inve...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Rabab Elsadek Zeeshan Ismail Raghav Bassi Anuoluwa Oyetoran Yaseen Perbtani Tony Brar Suzanne Zentko Source Type: research
Residual Axillary Metastases in Node-Positive Breast Cancer Patients After Neoadjuvant Treatment: A Register-Based Study
CONCLUSIONS: Breast pCR or ITC only in TAD LNs can, with reasonable certainty, preclude more than three positive non-TAD LNs. Additionally, patients with only ITCs in the TAD LN had a low risk of having any non-TAD LN metastases after NACT. De-escalated axillary treatment may be considered in both subgroups.PMID:38704502 | DOI:10.1245/s10434-024-15354-1 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Frederikke Munck Maj-Britt Jensen Ilse Vejborg Maria K Gerlach Maja V Maraldo Niels T Kroman Tove H F Tvedskov Source Type: research
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
This study aims to evaluate the efficacy of different material scaffold-mediated cell transplantation in treating SCI in rats. According to PRISMA's principle, Embase, PubMed, Web of Science, and Cochrane databases were searched, and relevant literature was referenced. Only original research on cell transplantation plus natural or synthetic scaffolds in SCI rats was included. Direct and indirect evidence for improving hind limb motor function was pooled through meta-analysis. A subgroup analysis of some factors that may affect the therapeutic effect was conducted to understand the results fully. In total, 25 studies met th...
Source: Cellular and Molecular Neurobiology - May 4, 2024 Category: Cytology Authors: Zhihua Wang Jun Li Tianqi Xu Boyu Guo Zhiping Xie Meihua Li Source Type: research
Maternal and neonatal outcomes in pregnant women with multiple sclerosis disease: A systematic review and meta-analysis
CONCLUSION: Pregnant women with MS have a greater chance of adverse pregnancy results than pregnant women without MS. Consequently, pregnant women with MS should create detailed before and after pregnancy plans, in consultation with their doctors, spouses, families, and friends, regarding the necessary care and supplements. Future studies applying a prospective cohort design that control for potential confounders are needed to further validate the findings.PMID:38703425 | DOI:10.1016/j.midw.2024.104004 (Source: Midwifery)
Source: Midwifery - May 4, 2024 Category: Midwifery Authors: Shoboo Rahmati Zahra Galavi Batoul Kavyani Homa Arshadi Jaason Geerts Hamid Sharifi Source Type: research
Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses
Comput Biol Chem. 2024 Apr 30;110:108089. doi: 10.1016/j.compbiolchem.2024.108089. Online ahead of print.ABSTRACTPsoriasis (Ps), a chronic inflammatory disease affecting approximately 2 % of the global population, has been associated with an increased risk of liver cancer in observational studies. However, their causal relationships as well as underlying shared molecular mechanisms between Ps and liver cancer remain unclear. Using bidirectional Mendelian randomization analysis, we revealed that a genetic predisposition to liver cancer increased the risk of Ps in European and East Asian populations but not the other way aro...
Source: Computational Biology and Chemistry - May 4, 2024 Category: Bioinformatics Authors: Maoxin Ran Ou Sha Kin Yip Tam Source Type: research
Compound heterozygous ABCA12 variants identified in a Chinese patient with congenital ichthyosiform erythroderma: Advancing genotype-phenotype correlations and literature review
CONCLUSIONS: The compound heterozygous ABCA12 variants caused the CIE phenotype observed in the patient. The spectrum of ABCA12 pathogenic variants were broaden. Genotype-phenotype correlation analysis provided detailed evidence which can be used in future prenatal diagnosis and can inform the need for genetic counselling for patients with ABCA12-related ARCIs.PMID:38702946 | DOI:10.1002/mgg3.2431 (Source: Molecular Medicine)
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Jia-Wei Liu Kexin Guo Rui Zhang Rongrong Wang Dong-Lai Ma Xue Zhang Source Type: research
Application of machine learning for antibiotic resistance in water and wastewater: A systematic review
Chemosphere. 2024 May 2:142223. doi: 10.1016/j.chemosphere.2024.142223. Online ahead of print.ABSTRACTAntibiotic resistance (AR) is considered one of the greatest global threats in the current century, which can only be overcome if all interconnected areas of humans, animals and the environment are taken into account as part of the One Health concept proposed by the World Health Organization (WHO). Water and wastewater are among the most important environmental media of AR sources, where the phenomena are generally non-linear. Therefore, the aim of this study was to investigate the application of machine learning-based met...
Source: Chemosphere - May 4, 2024 Category: Chemistry Authors: Maryam Foroughi Afrooz Arzehgar Seyedeh Nahid Seyedhasani Azam Nadali Khaled Zoroufchi Benis Source Type: research
