Discovery of a novel chemotype as DYRK1A inhibitors against Alzheimer's disease: Computational modeling and biological evaluation
Int J Biol Macromol. 2024 May 2:132024. doi: 10.1016/j.ijbiomac.2024.132024. Online ahead of print.ABSTRACTDual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) plays an essential role in Tau and Aβ pathology closely related to Alzheimer's disease (AD). Accumulative evidence has demonstrated DYRK1A inhibition is able to reduce the pathological features of AD. Nevertheless, there is no approved DYRK1A inhibitor for clinical use as anti-AD therapy. This is somewhat due to the lack of effective and safe chemotypes of DYRK1A inhibitors. To address this issue, we carried out in silico screening, in vitro assa...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Nianzhuang Qiu Chenliang Qian Tingting Guo Yaling Wang Hongwei Jin Mingli Yao Mei Li Tianyang Guo Yuli Lv Xinxin Si Song Wu Hao Wang Xuehui Zhang Jie Xia Source Type: research
CLIPPER 2.0: Peptide level annotation and data analysis for positional proteomics
Mol Cell Proteomics. 2024 May 2:100781. doi: 10.1016/j.mcpro.2024.100781. Online ahead of print.ABSTRACTPositional proteomics methodologies have transformed protease research, and have brought mass spectrometry (MS)-based degradomics studies to the forefront of protease characterization and system-wide interrogation of protease signaling. Considerable advancements in both sensitivity and throughput of liquid chromatography (LC)-MS/MS instrumentation enable the generation of enormous positional proteomics datasets of natural and protein termini and neo-termini of cleaved protease substrates. However, a concomitant progress ...
Source: Molecular and Cellular Proteomics : MCP - May 4, 2024 Category: Molecular Biology Authors: Konstantinos Kalogeropoulos Aleksander Moldt Haack Elizabeta Madzharova Antea Di Lorenzo Rawad Hanna Erwin M Schoof Ulrich Auf dem Keller Source Type: research
Application of machine learning for antibiotic resistance in water and wastewater: A systematic review
Chemosphere. 2024 May 2:142223. doi: 10.1016/j.chemosphere.2024.142223. Online ahead of print.ABSTRACTAntibiotic resistance (AR) is considered one of the greatest global threats in the current century, which can only be overcome if all interconnected areas of humans, animals and the environment are taken into account as part of the One Health concept proposed by the World Health Organization (WHO). Water and wastewater are among the most important environmental media of AR sources, where the phenomena are generally non-linear. Therefore, the aim of this study was to investigate the application of machine learning-based met...
Source: Chemosphere - May 4, 2024 Category: Chemistry Authors: Maryam Foroughi Afrooz Arzehgar Seyedeh Nahid Seyedhasani Azam Nadali Khaled Zoroufchi Benis Source Type: research
Role of autophagy-related genes in liver cancer prognosis
Genomics. 2024 May 2:110852. doi: 10.1016/j.ygeno.2024.110852. Online ahead of print.ABSTRACTAutophagy, a highly conserved process of protein and organelle degradation, has emerged as a critical regulator in various diseases, including cancer progression. In the context of liver cancer, the predictive value of autophagy-related genes remains ambiguous. Leveraging chip datasets from the TCGA and GTEx databases, we identified 23 differentially expressed autophagy-related genes in liver cancer. Notably, five key autophagy genes, PRKAA2, BIRC5, MAPT, IGF1, and SPNS1, were highlighted as potential prognostic markers, with MAPT ...
Source: Genomics - May 4, 2024 Category: Genetics & Stem Cells Authors: Yuling Zhou Rong Shan Wangti Xie Qiang Zhou Qinghua Yin Yuqi Su Jia Xiao Pan Luo Xiang Yao Jianlong Fang Fang Wen Erdong Shen Jie Weng Source Type: research
Pangenome analyses of Clostridium butyricum provide insights into its genetic characteristics and industrial application
In conclusion, our research provides a desirable pan-genome database for the industrial production, food application, and genetic research of C. butyricum.PMID:38703968 | DOI:10.1016/j.ygeno.2024.110855 (Source: Genomics)
Source: Genomics - May 4, 2024 Category: Genetics & Stem Cells Authors: Yicheng Yang Yuan Shao Chenchen Pei Yangyang Liu Min Zhang Xi Zhu Jinshan Li Lifei Feng Guanghua Li Keke Li Yunxiang Liang Yingjun Li Source Type: research
Identification of LPCAT1 as a key biomarker for Crohn's disease based on bioinformatics and machine learnings and experimental verification
This study aims to explore the molecular mechanisms of EMT-related genes in Crohn's disease (CD) through bioinformatics methods and identify potential key biomarkers. In our research, we identified differentially expressed genes (DEGs) related to EMT based on the GSE52746 dataset and the gene set in the GeneCards database. Key genes were identified through Lasso-cox and Random Forest and validated using the external dataset GSE10616. Immune infiltration analysis showed that Lysophosphatidylcholine acyltransferase 1 (LPCAT1) was positively correlated with Neutrophils and Macrophages M1. The Gene Set Enrichment Analysis (GSE...
Source: Gene - May 4, 2024 Category: Genetics & Stem Cells Authors: Wei Chen Zeyan Xu Jingjing Jiang Hong Chen Ruihua Shi Source Type: research
Examining the impact of interventions in reducing self-reported engagement in distracted driving: A systematic review
Accid Anal Prev. 2024 May 3;202:107608. doi: 10.1016/j.aap.2024.107608. Online ahead of print.ABSTRACTDespite the implementation of legal countermeasures, distracted driving remains a prevalent concern for road safety. This systematic review (following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines) summarised the literature on the impact of interventions targeting attitudes/intentions towards, and self-reported engagement in, distracted driving. Studies were eligible for this review if they examined self-reported behaviour/attitudes/intentions pertaining to distracted driving at baseline...
Source: Accident; Analysis and Prevention. - May 4, 2024 Category: Accident Prevention Authors: M Nicolls V Truelove K B Stefanidis Source Type: research
Testosterone Replacement Therapy and Associated Rates of Trigger Finger, de Quervain Tenosynovitis, and Their Subsequent Management
CONCLUSIONS: TRT is associated with an increased likelihood of both trigger finger and de Quervain tenosynovitis, and an increased likelihood of requiring surgical release for both conditions.TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.PMID:38703145 | DOI:10.1016/j.jhsa.2024.01.018 (Source: Hand Surgery)
Source: Hand Surgery - May 4, 2024 Category: Surgery Authors: Patrick S Barhouse J Alex Albright Elliot Rebello Kenny Chang Matthew S Quinn Alan H Daniels Michel Arcand Joseph A Gil Source Type: research
Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model
CONCLUSIONS: GLS1 expression in CRC plays important roles in tumor progression. CB-839 has inhibitory effects on cancer proliferation and the tumor microenvironment.PMID:38703552 | DOI:10.1016/j.yexmp.2024.104896 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - May 4, 2024 Category: Pathology Authors: Ryo Miyamoto Hidehiko Takigawa Ryo Yuge Daisuke Shimizu Misa Ariyoshi Rina Otani Akiyoshi Tsuboi Hidenori Tanaka Ken Yamashita Yuichi Hiyama Yuji Urabe Akira Ishikawa Kazuhiro Sentani Shiro Oka Source Type: research
Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs
CONCLUSION: In comparison to bDMARDs, JAKi are associated with a slightly higher infection risk and a higher risk of herpes zoster specifically. In older patients, infection IRs are higher but similar infection risks for JAKi and bDMARDs are observed. No differences in infection risk between tofacitinib and baricitinib were found. Key Points • Compared to bDMARDs, JAKi are associated with a slightly higher infection risk for all ages • An increased risk of herpes zoster in patients who use JAK inhibitors was confirmed • No significant differences in infection incidence were found between tofacitinib and baricitinib.P...
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: M A A Opdam N den Broeder B J F van den Bemt K Mulder K M van de Wiel H van Ballegooijen R van Crevel A A den Broeder Source Type: research
MPoMA protects against lung epithelial cell injury via p65 degradation
This study aimed to identify compounds from a library of compounds that prevent viral infection that could reduce and prevent lung epithelial cell damage. We investigated the cytotoxicity of the compounds, their activity in inhibiting viral spike protein binding to cells, and their activity in reducing IL-8 production in lung epithelial cells damaged by amodiaquine (AQ). We identified N-(4-(4-methoxyphenoxy)-3-methylphenyl)-N-methylacetamide (MPoMA) as a non-cytotoxic inhibitor against viral infection and AQ-induced cell damage. MPoMA inhibited the expression of IL-8, IL-6, IL-1β, and fibronectin induced by AQ and protect...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Soheun Lee Suh Jin Yoon Ji Hyun Oh Jae-Sang Ryu Yunjeong Park Eun Sook Hwang Source Type: research
Residual Axillary Metastases in Node-Positive Breast Cancer Patients After Neoadjuvant Treatment: A Register-Based Study
CONCLUSIONS: Breast pCR or ITC only in TAD LNs can, with reasonable certainty, preclude more than three positive non-TAD LNs. Additionally, patients with only ITCs in the TAD LN had a low risk of having any non-TAD LN metastases after NACT. De-escalated axillary treatment may be considered in both subgroups.PMID:38704502 | DOI:10.1245/s10434-024-15354-1 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Frederikke Munck Maj-Britt Jensen Ilse Vejborg Maria K Gerlach Maja V Maraldo Niels T Kroman Tove H F Tvedskov Source Type: research
Detoxification and underlying mechanisms towards toxic alkaloids by Traditional Chinese Medicine processing: A comprehensive review
CONCLUSION: Through this exploration, we review toxic alkaloids and the mechanisms underlying their toxicity, discuss methods to reduce toxicity, and unravel the intricate mechanisms behind detoxification. These offers insights into the quality control of herbs containing toxic alkaloids, safe and rational use of alkaloid-rich TCMs in clinics, new strategies for drug discovery and development, and ultimately helping improve the quality of life for millions of people.PMID:38703661 | DOI:10.1016/j.phymed.2024.155623 (Source: Cancer Control)
Source: Cancer Control - May 4, 2024 Category: Cancer & Oncology Authors: Qiyuan Shan Wei Yu Qiongfang Xu Ruina Liu Shuye Ying Jie Dong Yini Bao Qiang Lyu Changcheng Shi Junjie Xia Jing Tang Haodan Kuang Kuilong Wang Gang Tian Gang Cao Source Type: research
Effects of antidepressant and antipsychotic medication on peripheral brain-derived neurotrophic factor concentration: Systematic review and meta-analysis
In conclusion, antidepressants and antipsychotics increase serum BDNF concentrations.PMID:38703562 | DOI:10.1016/j.psychres.2024.115946 (Source: Cancer Control)
Source: Cancer Control - May 4, 2024 Category: Cancer & Oncology Authors: Tassadit Merabtine Zeinab Tarhini Pierre-Marie Preux Niki Christou Jeremy Jost Source Type: research
The Association Between Adverse Cardiovascular Outcomes in Celiac Disease and the Role of Inflammation: Retrospective Analysis Using the National Inpatient Sample
Curr Probl Cardiol. 2024 May 2:102612. doi: 10.1016/j.cpcardiol.2024.102612. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-mediated disease with patients being prone to a proinflammatory state. With recent studies showing an association between adverse cardiovascular events in patients with CD, we aim to further elucidate this relationship. Furthermore, when risk-stratifying patients with cardiovascular disease (CVD), chronic inflammatory conditions such as CD are not included in these calculations. We conducted a retrospective analysis using the National Inpatient Sample database from 2016 to 2019 to inve...
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Rabab Elsadek Zeeshan Ismail Raghav Bassi Anuoluwa Oyetoran Yaseen Perbtani Tony Brar Suzanne Zentko Source Type: research
