Maximum burn prevention practice vs conventional care after direct current cardioversion treatment: The BURN-PREVENTION trial
Development of cutaneous burns at the site of electrode placement is a known complication of the direct current cardioversion for atrial arrhythmias. Whereas local cooling has been shown to mitigate burns,1 the effectiveness of weaker corticosteroids, such as betamethasone, has been less promising.2 This BURN-PREVENTION trial, a single-center, prospective, randomized, investigator-initiated superiority trial, aimed to evaluate the efficacy of combining local cold application with clobetasol, a potent corticosteroid ointment, in preventing skin burns after cardioversion. (Source: Heart Rhythm)
Source: Heart Rhythm - April 8, 2024 Category: Cardiology Authors: Reina Tonegawa-Kuji, Kenichiro Yamagata, Koshiro Kanaoka, Akinori Wakamiya, Yuko Y. Inoue, Koji Miyamoto, Yoshihiro Miyamoto, Eiji Kiyohara, Kengo Kusano Tags: Research Letter Source Type: research
Frequency and economic burden of exacerbations in inhaled corticosteroid/long-acting beta-agonist-treated patients with asthma: a retrospective US claims study
This study assessed the frequency and economic burden of moderate exacerbations in patients receiving ICS/LABA. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 7, 2024 Category: Respiratory Medicine Authors: Mei Sheng Duh, Melissa H. Roberts, Kieran J. Rothnie, Wendy Y. Cheng, Philippe Thompson-Leduc, Shiyuan Zhang, Alexandrosz Czira, David Slade, Alexandra Greatsinger, Adina Zhang, Douglas Mapel Source Type: research
Hormonal effects on glucose and ketone metabolism in a perfused liver of an elasmobranch, the North Pacific spiny dogfish, Squalus suckleyi
Gen Comp Endocrinol. 2024 Apr 4;352:114514. doi: 10.1016/j.ygcen.2024.114514. Online ahead of print.ABSTRACTHormonal influence on hepatic function is a critical aspect of whole-body energy balance in vertebrates. Catecholamines and corticosteroids both influence hepatic energy balance via metabolite mobilization through glycogenolysis and gluconeogenesis. Elasmobranchs have a metabolic organization that appears to prioritize the mobilization of hepatic lipid as ketone bodies (e.g. 3-hydroxybutyrate [3-HB]), which adds complexity in determining the hormonal impact on hepatic energy balance in this taxon. Here, a liver perfu...
Source: General and Comparative Endocrinology - April 6, 2024 Category: Endocrinology Authors: Alexandra N Schoen Alyssa M Weinrauch Ian A Bouyoucos Jason R Treberg W Gary Anderson Source Type: research
Equivalence of Single and Standard Doses of Antenatal Corticosteroids for Late Preterm Neonatal Outcomes: Insights from a Secondary Analysis
The recent paradigm shift of treating individuals at risk of late preterm birth with antenatal corticosteroids warrants an assessment of the effect of single dosage. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 6, 2024 Category: OBGYN Authors: Yossi BART, Suneet P. CHAUHAN, Michal FISHEL BARTAL, Sean BLACKWELL, Baha M. SIBAI Tags: Original Research: Obstetrics Source Type: research
Treatment of resistant Paecilomyces lilacinus keratitis with topical voriconazole and oral itraconazole: a rare case report from Somalia
CONCLUSION: For the treatment of Paecilomyces lilacinus keratitis that is unresponsive to conventional antifungal medications, voriconazole may be helpful. Early organism detection and the appropriate therapy are necessary for the management of keratitis.PMID:38576982 | PMC:PMC10990336 | DOI:10.1097/MS9.0000000000001925 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Hassan Muhumed Mohamed Ibrahim Ali Hassan Aisha Abdirahman Yussuf Yahye Abshir Nor Abdirisak Abdikarin Ahmed Abdullahi Ali Roble Source Type: research
Unveiling the complexity of right middle lobe syndrome: a case series highlighting the association with asthma
CONCLUSION: These cases exhibited obstructive MLS with and without asthma. Accurate diagnosis is challenging, requiring imaging techniques. MLS has clinical implications, particularly in asthma patients. Future studies should focus on understanding the aetiology of non-obstructive MLS.PMID:38576953 | PMC:PMC10990357 | DOI:10.1097/MS9.0000000000001848 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Eman Shhada Ali Alakbar Nahle Hussein Hamdar Alaa Jlailati Ali Jawad Zeinab Nahle Sawssan Ali Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Hand Surgery)
Source: Hand Surgery - April 5, 2024 Category: Surgery Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
Severe Visual Impairment Following CAR T-Cell Therapy in Two Individuals with Malignant Optic Nerve Infiltration
We report two patients who displayed evidence of localized ocular inflammation after CAR T-cell infusion. To manage the resulting severe visual impairment, systemic corticosteroids were administered to both patients. This treatment led to a reduction in local inflammation and restored vision in one of the patients.PMID:38579172 | DOI:10.1080/09273948.2024.2333393 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 5, 2024 Category: Allergy & Immunology Authors: Pierre-Maurice Herr Victor Brantl Siegfried Georg Priglinger Paul Foerster Stephan Thurau Source Type: research
Enteric Fever-Associated Hemophagocytic Lymphohistiocytosis: A Systematic Review of Clinical Characteristics and Outcomes
Am J Trop Med Hyg. 2024 Apr 2:tpmd230787. doi: 10.4269/ajtmh.23-0787. Online ahead of print.ABSTRACTEnteric fever is a major contributor to rising health care costs in developing countries. Associated disease-related complications and drug resistance further compound this problem. Hemophagocytic lymphohistiocytosis (HLH) is an uncommon complication of enteric fever with high morbidity and mortality. This systematic review aimed to evaluate the clinical characteristics and treatment outcomes in enteric fever-associated HLH syndrome. We searched major electronic databases (PubMed, Google Scholar, and Scopus) to identify the ...
Source: The American Journal of Tropical Medicine and Hygiene - April 5, 2024 Category: Tropical Medicine Authors: Durga Shankar Meena Akhilesh Kumar Deepak Kumar Gopal Krishana Bohra Abhishek Purohit Source Type: research
Asthma management, focused on the use of oral corticosteroids: the opinions of Italian asthmatic patients
CONCLUSIONS: The survey results confirmed many problems related to mild-moderate and severe asthma management in Italy and highlighted the overuse of OCS rather than more effective and safe treatments, which had strong negative effects on HRQoL.PMID:38578082 | DOI:10.1080/02770903.2024.2338863 (Source: Journal of Asthma)
Source: Journal of Asthma - April 5, 2024 Category: Respiratory Medicine Authors: Manuela Latorre Angela Rizzi Pierluigi Paggiaro Ilaria Baiardini Diego Bagnasco Stefano DelGiacco Carlo Lombardi Vincenzo Patella Eleonora Nucera Roberta Parente Giovanni Paoletti Laura Pini Erminia Ridolo Gianenrico Senna Francesco Blasi Giorgio Walter C Source Type: research
Immunoglobulin G4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant
CONCLUSION: Heterozygosity for gain-of-function IKZF1 variants underlies autoimmunity/inflammatory diseases, IgG4-RD and B-cell malignancies, the onset of which may occur in adulthood. Clinical and immunological data are similar to those for patients with unexplained IgG4-RD. Patients may therefore benefit from treatments inhibiting pathways displaying IKAROS-mediated overactivity.PMID:38579942 | DOI:10.1016/j.jaci.2024.03.018 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - April 5, 2024 Category: Cancer & Oncology Authors: Blanca Garc ía-Solís Mar ía Tapia-Torres Ana Garc ía-Soidán Elisa Hern ández-Brito Mar ía Teresa Martínez-Saavedra Jos é M Lorenzo Salazar Sonia Garc ía-Hernández Ana Van Den Rym Karan Mayani Mayani Jos é Vicente Govantes-Rodríguez Adrian Ger Source Type: research
Treatment of resistant Paecilomyces lilacinus keratitis with topical voriconazole and oral itraconazole: a rare case report from Somalia
CONCLUSION: For the treatment of Paecilomyces lilacinus keratitis that is unresponsive to conventional antifungal medications, voriconazole may be helpful. Early organism detection and the appropriate therapy are necessary for the management of keratitis.PMID:38576982 | PMC:PMC10990336 | DOI:10.1097/MS9.0000000000001925 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Hassan Muhumed Mohamed Ibrahim Ali Hassan Aisha Abdirahman Yussuf Yahye Abshir Nor Abdirisak Abdikarin Ahmed Abdullahi Ali Roble Source Type: research
