Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Real-World Treatment Patterns and Healthcare Resource Use for Ulcerative Colitis and Crohn ’s Disease in Italy
ConclusionThis analysis, carried-out in an Italian clinical setting, may help to optimise therapy for patients with UC and CD and provide relevant clinical practice data to inform decision-makers. (Source: Advances in Therapy)
Source: Advances in Therapy - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Use of inhaled corticosteroids and the risk of hospitalisation for pneumonia in children with asthma: a nationwide cohort study
Conclusions
In this nationwide cohort study, we found no evidence of an association between ICS use and the risk of hospitalisation for pneumonia among children with asthma, as compared with no use. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Sielinou Kamgang, K.-H., Rhedin, S. A., Almqvist, C., Wintzell, V. Tags: Open access, Thorax Asthma Source Type: research
Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care
Conclusions
Females had increased symptoms and were more likely to be obese despite higher FEV1% predicted and lower type 2 biomarkers with consistent and clinically important differences across both datasets. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Loewenthal, L., Busby, J., McDowell, R., Brown, T., Burhan, H., Chaudhuri, R., Dennison, P., Dodd, J. W., Doe, S., Faruqi, S., Gore, R., Idris, E., Jackson, D. J., Patel, M., Pantin, T., Pavord, I., Pfeffer, P. E., Price, D. B., Rupani, H., Siddiqui, S., Tags: Thorax Asthma Source Type: research
Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection
ConclusionsIn this large prospective study in the US primary and urgent care setting, antibiotics had no measurable impact on the severity or duration of cough due to acute LRTI. Patients had unrealistic expectations regarding the duration of LRTI and the effect of antibiotics which should be the target of antibiotic stewardship efforts. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults
This study addresses this gap by investigating associations between steroid hormones (cortisol, cortisone, and testosterone) and paracetamol concentrations measured in human hair, indexing a timeframe of approximately three months. The data came from a large community sample of young adults (N = 1002). Hair data were assayed using liquid chromatography-tandem mass spectrometry. Multiple regression models tested associations between paracetamol and steroid hormones, while adjusting for a wide range of potential confounders, such as sex, stressful live events, psychoactive substance use, hair colour, and body mass index. Alm...
Source: Archives of Toxicology - April 14, 2024 Category: Toxicology Authors: Lydia Johnson-Ferguson Lilly Shanahan Michelle Loher Laura Bechtiger Tina M Binz Markus Baumgartner Denis Ribeaud Manuel Eisner Boris B Quednow Source Type: research
Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults
This study addresses this gap by investigating associations between steroid hormones (cortisol, cortisone, and testosterone) and paracetamol concentrations measured in human hair, indexing a timeframe of approximately three months. The data came from a large community sample of young adults (N = 1002). Hair data were assayed using liquid chromatography-tandem mass spectrometry. Multiple regression models tested associations between paracetamol and steroid hormones, while adjusting for a wide range of potential confounders, such as sex, stressful live events, psychoactive substance use, hair colour, and body mass index. Alm...
Source: Archives of Toxicology - April 14, 2024 Category: Toxicology Authors: Lydia Johnson-Ferguson Lilly Shanahan Michelle Loher Laura Bechtiger Tina M Binz Markus Baumgartner Denis Ribeaud Manuel Eisner Boris B Quednow Source Type: research
Advancements in De Quervain Tenosynovitis Management: A Comprehensive Network Meta-Analysis
CONCLUSIONS: Corticosteroid injection with a short duration of immobilization remains the primary and effective treatment for De Quervain tenosynovitis. Extracorporeal shockwave therapy can be considered a secondary option. Alternative treatment modalities, such as isolated therapeutic injection, should be approached with caution because they did not show substantial benefits over placebo.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic I.PMID:38613563 | DOI:10.1016/j.jhsa.2024.03.003 (Source: Hand Surgery)
Source: Hand Surgery - April 13, 2024 Category: Surgery Authors: Han Hong Chong Akhilesh Pradhan Mohit Dhingra William Liong Melinda Y T Hau Rohi Shah Source Type: research
Advancements in De Quervain Tenosynovitis Management: A Comprehensive Network Meta-Analysis
CONCLUSIONS: Corticosteroid injection with a short duration of immobilization remains the primary and effective treatment for De Quervain tenosynovitis. Extracorporeal shockwave therapy can be considered a secondary option. Alternative treatment modalities, such as isolated therapeutic injection, should be approached with caution because they did not show substantial benefits over placebo.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic I.PMID:38613563 | DOI:10.1016/j.jhsa.2024.03.003 (Source: Hand Surgery)
Source: Hand Surgery - April 13, 2024 Category: Surgery Authors: Han Hong Chong Akhilesh Pradhan Mohit Dhingra William Liong Melinda Y T Hau Rohi Shah Source Type: research
Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis
ConclusionThe results of this analysis demonstrate that, in combination with TCS, tralokinumab and dupilumab have similar efficacy in the treatment of moderate-to-severe AD at 32 weeks of therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 13, 2024 Category: Dermatology Source Type: research
Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review
Front Immunol. 2024 Mar 28;15:1380372. doi: 10.3389/fimmu.2024.1380372. eCollection 2024.ABSTRACTJuvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppr...
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: Camilla Bertoni Alessandra Mazzocchi Ludovica Leone Carlo Agostoni Giovanni Filocamo Source Type: research
Antitubercular drug-induced lichen planus: A case study with a mini literature review
CONCLUSION: Lichenoid drug eruptions are characterized by type IV hypersensitivity reactions, and rechallenge is required to ensure safer treatment since the risk of disseminated and multi-drug-resistant tuberculosis increases with the cessation of antitubercular therapy.PMID:38605770 | PMC:PMC11006073 | DOI:10.4103/jfmpc.jfmpc_499_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Sanjana C Shanmukhappa Winny John Vineeta Kevalramani Srivatsa Lokeshwaran Shireen Furtado Mahesh Nosenoor Source Type: research
Idiopathic intracranial hypertension as the initial presenting manifestation of systemic lupus erythematosus in a child
We report a 12-year-old girl presented with chronic holocranial headache and occasional episodes of projectile vomiting for the last 6 months and then developed blurring of vision for the last month. She fulfilled the criteria for IIH. Subsequent evaluation revealed a diagnosis of SLE. The occurrence of IIH in SLE is not coincidental and is reported in 1%-5.4% of patients with SLE. Though corticosteroids have not been widely used in IIH, underlying SLE warranted administering corticosteroids with subsequent complete resolution of IIH. Pediatricians, neurologists, intensivists, and ophthalmologists should consider SLE as a ...
Source: Lupus - April 12, 2024 Category: Rheumatology Authors: Murugan Sudhakar Anu P Kocheril Anish S George George I Vettiyil Anitha Jasper Sathish Kumar Source Type: research
