Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion
ConclusionOur review provides evidence for the impact of AHR ligands on adrenocortical function and indicates further avenues of research to better clarify its effects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2024 Category: Endocrinology Source Type: research
The use of late preterm antenatal corticosteroids in women with gestational diabetes : a puzzle worth solving
To investigate the association between late preterm antenatal corticosteroid treatment and outcome in late preterm neonates born to mothers with gestational diabetes mellitus, (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 18, 2024 Category: OBGYN Authors: Sadullah Özkan, Murat Levent Dereli, Dilara Kurt, Ahmet Kurt, Sadun Sucu, Fahri Burçin Fıratlıgil, Fatih İşleyen, Şevki Çelen and Yaprak Engin Üstün Tags: Research Source Type: research
Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
CONCLUSIONS: At our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI.PMID:38629258 | DOI:10.1002/cam4.7154 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi Susan N Chi Kee Kiat Yeo Allison F O'Neill David S Shulman Steven G DuBois Natalie B Collins Source Type: research
Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: Results from a randomised, double-blind, placebo-controlled, phase II/III clinical study in patients aged ≥13 years
CONCLUSIONS: Improvements in prurigo nodularis were greater following nemolizumab treatment, despite continuation of topical corticosteroids in both groups. (Funded by Maruho; jRCT number, 2011200017.).PMID:38629497 | DOI:10.1093/bjd/ljae131 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 17, 2024 Category: Dermatology Authors: Hiroo Yokozeki Hiroyuki Murota Takayo Matsumura Hiroshi Komazaki Nemolizumab-JP11 Study Group Source Type: research
Autopsy case of meningoencephalitis induced by nivolumab and ipilimumab in a patient being treated for non-small cell lung cancer
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3457-24. Online ahead of print.ABSTRACTA 75-year-old woman with stage IVB (cT2bN3M1b) lung adenocarcinoma was administered nivolumab, ipilimumab, carboplatin, and paclitaxel. Fourteen days after receiving chemotherapy, she experienced an impaired consciousness and a cerebrospinal fluid analysis revealed high protein levels and pleocytosis. She was diagnosed with nivolumab- and ipilimumab-induced encephalitis and was treated with corticosteroids which were tapered to 10 mg/day, with no symptom recurrence. She died 18 weeks after the initial presentation, as the cancer w...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Keisuke Shiraha Hiromi Watanabe Keiichi Fujiwara Mayu Goda Tomoyoshi Inoue Miho Fujiwara Suzuka Matsuoka Yuki Takigawa Sho Mitsumune Kenichiro Kudo Akiko Sato Ken Sato Yoko Shinno Takuo Shibayama Source Type: research
Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: Results from a randomised, double-blind, placebo-controlled, phase II/III clinical study in patients aged ≥13 years
CONCLUSIONS: Improvements in prurigo nodularis were greater following nemolizumab treatment, despite continuation of topical corticosteroids in both groups. (Funded by Maruho; jRCT number, 2011200017.).PMID:38629497 | DOI:10.1093/bjd/ljae131 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 17, 2024 Category: Dermatology Authors: Hiroo Yokozeki Hiroyuki Murota Takayo Matsumura Hiroshi Komazaki Nemolizumab-JP11 Study Group Source Type: research
Surgical management of a case of non-resolving bullous retinal detachment due to probable Vogt-Koyanagi-Harada syndrome
Eur J Ophthalmol. 2024 Apr 17:11206721241247582. doi: 10.1177/11206721241247582. Online ahead of print.ABSTRACTA 45-year-old male with Vogt-Koyanagi-Harada (VKH) syndrome presented with vision loss in his right eye after discontinuing treatment during the COVID-19 pandemic. He was found to have bullous retinal detachment (RD) in the right eye and was started on subcutaneous adalimumab with oral corticosteroid following three doses of pulse corticosteroid. But when RD did not resolve after 4 months of treatment and ultrasound B scan showed bullous RD with retino-retinal adhesion, he was planned for surgical intervention. Du...
Source: European Journal of Ophthalmology - April 17, 2024 Category: Opthalmology Authors: Parthopratim Dutta Majumder Mauli Shah Parveen Sen Source Type: research
Autopsy case of meningoencephalitis induced by nivolumab and ipilimumab in a patient being treated for non-small cell lung cancer
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3457-24. Online ahead of print.ABSTRACTA 75-year-old woman with stage IVB (cT2bN3M1b) lung adenocarcinoma was administered nivolumab, ipilimumab, carboplatin, and paclitaxel. Fourteen days after receiving chemotherapy, she experienced an impaired consciousness and a cerebrospinal fluid analysis revealed high protein levels and pleocytosis. She was diagnosed with nivolumab- and ipilimumab-induced encephalitis and was treated with corticosteroids which were tapered to 10 mg/day, with no symptom recurrence. She died 18 weeks after the initial presentation, as the cancer w...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Keisuke Shiraha Hiromi Watanabe Keiichi Fujiwara Mayu Goda Tomoyoshi Inoue Miho Fujiwara Suzuka Matsuoka Yuki Takigawa Sho Mitsumune Kenichiro Kudo Akiko Sato Ken Sato Yoko Shinno Takuo Shibayama Source Type: research
Off ‐label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
ConclusionsAt our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI. (Source: Cancer Medicine)
Source: Cancer Medicine - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi,
Susan N. Chi,
Kee Kiat Yeo,
Allison F. O'Neill,
David S. Shulman,
Steven G. DuBois,
Natalie B. Collins Tags: RESEARCH ARTICLE Source Type: research
Defining predictors of responsiveness to advanced therapies in Crohns disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Introduction
Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients.
Current understanding of IBD pathogenesis implicates complex interactions between host genetics and the gut microbiome. Most cohorts s...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Wyatt, N. J., Watson, H., Anderson, C. A., Kennedy, N. A., Raine, T., Ahmad, T., Allerton, D., Bardgett, M., Clark, E., Clewes, D., Cotobal Martin, C., Doona, M., Doyle, J. A., Frith, K., Hancock, H. C., Hart, A. L., Hildreth, V., Irving, P. M., Iqbal, S. Tags: Open access, Gastroenterology and hepatology Source Type: research
The CORE syndrome: an overlap of severe asthma, obstructive sleep apnea, rhinosinusitis, and esophageal reflux
CONCLUSION: Whenever facing SA patients, non-responders to therapy, it is important to suspect the presence of CORE syndrome; in particular, the detection and subsequent treatment of OSA would seem to improve the outcome of such patients.PMID:38627338 | DOI:10.1007/s11325-024-03028-x (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Sleep Medicine Authors: Pasquale Tondo Anela Hoxhallari Donato Lacedonia Pietro Magaletti Roberto Sabato Maria Pia Foschino Barbaro Giulia Scioscia Source Type: research
Case Report: Mixed Airborne Contact Dermatitis-Chronic Actinic Dermatitis Pattern of Parthenium Dermatitis with Response to Tofacitinib Therapy
We report a patient with a chronic and extensive mixed ABCD-CAD pattern of parthenium dermatitis recalcitrant to conventional treatment, with rapid resolution after initiation of treatment with tofacitinib.PMID:38626752 | DOI:10.4269/ajtmh.23-0720 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Ananta Khurana Sheetal Yadav Kunal Chanana Kabir Sardana Aakash Vidholiya Source Type: research
Case Report: Mixed Airborne Contact Dermatitis-Chronic Actinic Dermatitis Pattern of Parthenium Dermatitis with Response to Tofacitinib Therapy
We report a patient with a chronic and extensive mixed ABCD-CAD pattern of parthenium dermatitis recalcitrant to conventional treatment, with rapid resolution after initiation of treatment with tofacitinib.PMID:38626752 | DOI:10.4269/ajtmh.23-0720 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Ananta Khurana Sheetal Yadav Kunal Chanana Kabir Sardana Aakash Vidholiya Source Type: research
The CORE syndrome: an overlap of severe asthma, obstructive sleep apnea, rhinosinusitis, and esophageal reflux
CONCLUSION: Whenever facing SA patients, non-responders to therapy, it is important to suspect the presence of CORE syndrome; in particular, the detection and subsequent treatment of OSA would seem to improve the outcome of such patients.PMID:38627338 | DOI:10.1007/s11325-024-03028-x (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Sleep Medicine Authors: Pasquale Tondo Anela Hoxhallari Donato Lacedonia Pietro Magaletti Roberto Sabato Maria Pia Foschino Barbaro Giulia Scioscia Source Type: research
