Population Pharmacokinetic Modeling and Exposure-Efficacy and Body Weight-Response Analyses for Tezepelumab in Patients With Severe, Uncontrolled Asthma
In conclusion, a fixed-dose regimen of tezepelumab 210 mg subcutaneously Q4W is appropriate for eligible adults and adolescents with severe, uncontrolled asthma.PMID:38632826 | DOI:10.1002/jcph.2433 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Yanan Zheng Lubna Abuqayyas Angelica Quartino Ye Guan Yuying Gao Lu Liu Åsa Hellqvist Gene Colice Alexander MacDonald Source Type: research
EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects Against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis.
Pemphigus is a severe blistering disease caused by autoantibodies primarily against the desmosomal cadherins desmoglein (DSG)1 and DSG3 which impair desmosome integrity. Especially for the acute phase, additional treatment options allowing to reduce corticosteroids would fulfill an unmet medical need. Here, we provide evidence that epidermal growth factor receptor (EGFR) inhibition by erlotinib ameliorates pemphigus vulgaris immunoglobulin G (PV-IgG) -induced acantholysis in intact human epidermis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Desalegn Tadesse Egu, Thomas Schmitt, Nancy Ernst, Ralf Joachim Ludwig, Michael Fuchs, Matthias Hiermaier, Sina Moztarzadeh, Carla Sebasti à Morỏn, Enno Schmidt, Vivien Beyersdorfer, Volker Spindler, Letyfee Sarah Steinert, Franziska Vielmuth, Anna Mag Tags: Original Article Source Type: research
Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
CONCLUSIONS: At our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI.PMID:38629258 | DOI:10.1002/cam4.7154 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi Susan N Chi Kee Kiat Yeo Allison F O'Neill David S Shulman Steven G DuBois Natalie B Collins Source Type: research
Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: Results from a randomised, double-blind, placebo-controlled, phase II/III clinical study in patients aged ≥13 years
CONCLUSIONS: Improvements in prurigo nodularis were greater following nemolizumab treatment, despite continuation of topical corticosteroids in both groups. (Funded by Maruho; jRCT number, 2011200017.).PMID:38629497 | DOI:10.1093/bjd/ljae131 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 17, 2024 Category: Dermatology Authors: Hiroo Yokozeki Hiroyuki Murota Takayo Matsumura Hiroshi Komazaki Nemolizumab-JP11 Study Group Source Type: research
Off ‐label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center
ConclusionsAt our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI. (Source: Cancer Medicine)
Source: Cancer Medicine - April 17, 2024 Category: Cancer & Oncology Authors: Ajami Gikandi,
Susan N. Chi,
Kee Kiat Yeo,
Allison F. O'Neill,
David S. Shulman,
Steven G. DuBois,
Natalie B. Collins Tags: RESEARCH ARTICLE Source Type: research
Defining predictors of responsiveness to advanced therapies in Crohns disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Introduction
Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients.
Current understanding of IBD pathogenesis implicates complex interactions between host genetics and the gut microbiome. Most cohorts s...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Wyatt, N. J., Watson, H., Anderson, C. A., Kennedy, N. A., Raine, T., Ahmad, T., Allerton, D., Bardgett, M., Clark, E., Clewes, D., Cotobal Martin, C., Doona, M., Doyle, J. A., Frith, K., Hancock, H. C., Hart, A. L., Hildreth, V., Irving, P. M., Iqbal, S. Tags: Open access, Gastroenterology and hepatology Source Type: research
The CORE syndrome: an overlap of severe asthma, obstructive sleep apnea, rhinosinusitis, and esophageal reflux
CONCLUSION: Whenever facing SA patients, non-responders to therapy, it is important to suspect the presence of CORE syndrome; in particular, the detection and subsequent treatment of OSA would seem to improve the outcome of such patients.PMID:38627338 | DOI:10.1007/s11325-024-03028-x (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Sleep Medicine Authors: Pasquale Tondo Anela Hoxhallari Donato Lacedonia Pietro Magaletti Roberto Sabato Maria Pia Foschino Barbaro Giulia Scioscia Source Type: research
Case Report: Mixed Airborne Contact Dermatitis-Chronic Actinic Dermatitis Pattern of Parthenium Dermatitis with Response to Tofacitinib Therapy
We report a patient with a chronic and extensive mixed ABCD-CAD pattern of parthenium dermatitis recalcitrant to conventional treatment, with rapid resolution after initiation of treatment with tofacitinib.PMID:38626752 | DOI:10.4269/ajtmh.23-0720 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 16, 2024 Category: Tropical Medicine Authors: Ananta Khurana Sheetal Yadav Kunal Chanana Kabir Sardana Aakash Vidholiya Source Type: research
Case Report: Mixed Airborne Contact Dermatitis-Chronic Actinic Dermatitis Pattern of Parthenium Dermatitis with Response to Tofacitinib Therapy
We report a patient with a chronic and extensive mixed ABCD-CAD pattern of parthenium dermatitis recalcitrant to conventional treatment, with rapid resolution after initiation of treatment with tofacitinib.PMID:38626752 | DOI:10.4269/ajtmh.23-0720 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 16, 2024 Category: Infectious Diseases Authors: Ananta Khurana Sheetal Yadav Kunal Chanana Kabir Sardana Aakash Vidholiya Source Type: research
Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study
ConclusionTCZ can treat active moderate-to-severe TED, showing high drug compliance and reasonable response to inflammation and extraocular motility abnormality. (Source: International Ophthalmology)
Source: International Ophthalmology - April 16, 2024 Category: Opthalmology Source Type: research
Peripheral ulcerative keratitis associated with tralokinumab therapy: a case report and review of IL-13 inhibitor-associated ocular surface disease
ConclusionThis case report documents ulcerative keratitis occurring in association with tralokinumab therapy for AD, which has previously been described with dupilumab but not tralokinumab. This report demonstrates the need for vigilant ocular surface monitoring for patients on tralokinumab and illustrates successful management and long-term control of adverse ocular events associated with this medication. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - April 16, 2024 Category: Opthalmology Source Type: research
The CORE syndrome: an overlap of severe asthma, obstructive sleep apnea, rhinosinusitis, and esophageal reflux
ConclusionWhenever facing SA patients, non-responders to therapy, it is important to suspect the presence of CORE syndrome; in particular, the detection and subsequent treatment of OSA would seem to improve the outcome of such patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Respiratory Medicine Source Type: research
A case of celiac plexus block causing iatrogenic Cushing's syndrome
Key Clinical MessageTreatment with corticosteroids can lead to iatrogenic Cushing's syndrome when used for longer intervals and in high doses. Less common administration routes may conceal the exposure, raising the possibility of misdiagnosis and mismanagement. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 15, 2024 Category: General Medicine Authors: Ana ‐Maria Chindris,
Sarika N. Rao,
Razvan M. Chirila,
Adrian G. Dumitrascu Tags: CASE REPORT Source Type: research
Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients (the Alantel study)
CONCLUSIONS: The higher efficacy of Alantel® compared to the control cream in reducing the incidence of RD in women with breast cancer has been demonstrated.PMID:38616815 | PMC:PMC11010796 | DOI:10.1016/j.conctc.2024.101288 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: E Villegas-Becerril C Jimenez-Garcia L A Perula-de Torres M Espinosa-Calvo C M Bueno-Serrano F Romero-Ruperto F Gines-Santiago M C Moreno-Manzanaro J J Mu ñoz-Gavilan G Montes-Redondo M A Quesada-Roman M C Linares-Ramirez J M Parras-Rejano N Mu ñoz-Alca Source Type: research
Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients (the Alantel study)
CONCLUSIONS: The higher efficacy of Alantel® compared to the control cream in reducing the incidence of RD in women with breast cancer has been demonstrated.PMID:38616815 | PMC:PMC11010796 | DOI:10.1016/j.conctc.2024.101288 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 15, 2024 Category: Cancer & Oncology Authors: E Villegas-Becerril C Jimenez-Garcia L A Perula-de Torres M Espinosa-Calvo C M Bueno-Serrano F Romero-Ruperto F Gines-Santiago M C Moreno-Manzanaro J J Mu ñoz-Gavilan G Montes-Redondo M A Quesada-Roman M C Linares-Ramirez J M Parras-Rejano N Mu ñoz-Alca Source Type: research
