Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study
Conclusions This is the first discovery of omics biomarkers that predict improvement to a biologic for asthma. Their prospective validation and development for clinical use is justified.PMID:38635834 | DOI:10.1164/rccm.202310-1730OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Ratko Djukanovi ć Paul Brinkman Johan Kolmert Cristina Gomez James Schofield Joost Brandsma Andy Shapanis Paul J S Skipp Anthony Postle Craig Wheelock Sven-Erik Dahlen Peter J Sterk Thomas Brown David J Jackson Adel Mansur Ian Pavord Mitesh Patel Christo Source Type: research
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease
Expert Rev Mol Diagn. 2024 Apr 18. doi: 10.1080/14737159.2024.2344777. Online ahead of print.ABSTRACTINTRODUCTION: Chronic obstructive pulmonary disease (COPD) accounts for 545 million people living with chronic respiratory disorders and is the third leading cause of morbidity and mortality around the world. COPD is a progressive disease, characterized by episodes of acute worsening of symptoms such as cough, dyspnea, and sputum production.AREAS COVERED: Airway inflammation is a prominent feature of COPD. Chronic airway inflammation results in airway structural remodeling and emphysema. Persistent airway inflammation is a ...
Source: Expert Review of Molecular Diagnostics - April 18, 2024 Category: Laboratory Medicine Authors: Dina Yehia Clarus Leung Don D Sin Source Type: research
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. Online ahead of print.ABSTRACTPatients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth charac...
Source: Hamostaseologie - April 18, 2024 Category: Hematology Authors: Christina C Rolling Malte Mohme Carsten Bokemeyer Manfred Westphal Sabine Riethdorf Katrin Lamszus Klaus Pantel Felix Klingler Florian Langer Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. Online ahead of print.ABSTRACTPatients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth charac...
Source: Hamostaseologie - April 18, 2024 Category: Hematology Authors: Christina C Rolling Malte Mohme Carsten Bokemeyer Manfred Westphal Sabine Riethdorf Katrin Lamszus Klaus Pantel Felix Klingler Florian Langer Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. Online ahead of print.ABSTRACTPatients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth charac...
Source: Hamostaseologie - April 18, 2024 Category: Hematology Authors: Christina C Rolling Malte Mohme Carsten Bokemeyer Manfred Westphal Sabine Riethdorf Katrin Lamszus Klaus Pantel Felix Klingler Florian Langer Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. Online ahead of print.ABSTRACTPatients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth charac...
Source: Hamostaseologie - April 18, 2024 Category: Hematology Authors: Christina C Rolling Malte Mohme Carsten Bokemeyer Manfred Westphal Sabine Riethdorf Katrin Lamszus Klaus Pantel Felix Klingler Florian Langer Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. Online ahead of print.ABSTRACTPatients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth charac...
Source: Hamostaseologie - April 18, 2024 Category: Hematology Authors: Christina C Rolling Malte Mohme Carsten Bokemeyer Manfred Westphal Sabine Riethdorf Katrin Lamszus Klaus Pantel Felix Klingler Florian Langer Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects Against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis.
Pemphigus is a severe blistering disease caused by autoantibodies primarily against the desmosomal cadherins desmoglein (DSG)1 and DSG3 which impair desmosome integrity. Especially for the acute phase, additional treatment options allowing to reduce corticosteroids would fulfill an unmet medical need. Here, we provide evidence that epidermal growth factor receptor (EGFR) inhibition by erlotinib ameliorates pemphigus vulgaris immunoglobulin G (PV-IgG) -induced acantholysis in intact human epidermis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Desalegn Tadesse Egu, Thomas Schmitt, Nancy Ernst, Ralf Joachim Ludwig, Michael Fuchs, Matthias Hiermaier, Sina Moztarzadeh, Carla Sebasti à Morỏn, Enno Schmidt, Vivien Beyersdorfer, Volker Spindler, Letyfee Sarah Steinert, Franziska Vielmuth, Anna Mag Tags: Original Article Source Type: research
Comparison of Old and New Systemic Treatments for Moderate to Severe Atopic Dermatitis
AbstractPurpose of ReviewHistorically, systemic treatments for atopic dermatitis (AD) primarily consisted of immunosuppressive agents such as corticosteroids and Disease Modifying Antirheumatic Drugs (DMARDS), which provided symptomatic relief but often had long-term adverse effects. Newer treatments have shown significant efficacy with less side effects in clinical trials. This review discusses and compares conventional and newer systemic treatments for AD.Recent FindingsNewer medications for AD including dupilumab, tralokinumab, lebrikizumab, and oral JAK inhibitors have been shown to be safe and efficacious. High dose c...
Source: Current Allergy and Asthma Reports - April 18, 2024 Category: Allergy & Immunology Source Type: research
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia
Conclusion: This report summarizes the clinical significance of macrolide-resistant and refractory MP pneumonia and discusses the efficacy and safety of alternative drugs, with a stepwise approach to the management of MP pneumonia recommended from the viewpoint of clinical practice.What is Known:•Although MP pneumonia is usually a benign self-limited infection with response macrolides as first line therapy,severe life-threatening cases may develop if additional treatment strategies are not effectively implemented.•Macrolide-resistant and refractory MP pneumonia are two conditions that may complicate the clinical cour...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
