Body fluid markers for multiple sclerosis and differential diagnosis from atypical demyelinating disorders
Expert Rev Mol Diagn. 2024 Mar 27:1-15. doi: 10.1080/14737159.2024.2334849. Online ahead of print.ABSTRACTINTRODUCTION: Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of the central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated in the current MS diagnostic criteria, could assist early MS diagnosis.AREAS COVERED: This review examines existing knowledge on a broad spectrum of body fluid markers in people with a first CNS demyelinating event, explores their potential to pr...
Source: Expert Review of Molecular Diagnostics - March 27, 2024 Category: Laboratory Medicine Authors: Angelika Bauer Harald Hegen Markus Reindl Source Type: research

Performance of noninvasive prenatal screening for fetal sex chromosome aneuploidies in a cohort of 116,862 pregnancies
CONCLUSIONS: NIPS screening for fetal SCAs has high sensitivity, specificity and NPV. The PPV of SCAs was moderate, but that of 45,X was lower than that of SCTs. Invasive prenatal diagnosis should be recommended for high-risk patients.PMID:38526221 | DOI:10.1080/14737159.2024.2333951 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - March 25, 2024 Category: Laboratory Medicine Authors: Yanfei Xu Jianbo Lou Yeqing Qian Pengzhen Jin Yangwen Qian Jiawei Hong Yuqing Xu Yixuan Yin Songjia Yi Minyue Dong Source Type: research

A state-of-the-art overview of candidate diagnostic biomarkers for Attention-deficit/hyperactivity disorder (ADHD)
Expert Rev Mol Diagn. 2024 Mar 26:1-13. doi: 10.1080/14737159.2024.2333277. Online ahead of print.ABSTRACTINTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and is highly heterogeneous in terms of symptom profile, associated cognitive deficits, comorbidities, and outcomes. Heterogeneity may also affect the ability to recognize and diagnose this condition. The diagnosis of ADHD is primarily clinical but there are increasing research efforts aiming at identifying biomarkers that can aid the diagnosis.AREAS COVERED: We first discuss the definition of biomarker...
Source: Expert Review of Molecular Diagnostics - March 20, 2024 Category: Laboratory Medicine Authors: Valeria Parlatini Alessio Bellato Alessandra Gabellone Lucia Margari Lucia Marzulli Emilia Matera Maria Giuseppina Petruzzelli Marco Solmi Christoph U Correll Samuele Cortese Source Type: research

A state-of-the-art overview of candidate diagnostic biomarkers for attention-Deficit/Hyperactivity disorder (ADHD)
Expert Rev Mol Diagn. 2024 Mar 20. doi: 10.1080/14737159.2024.2333277. Online ahead of print.ABSTRACTINTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and is highly heterogeneous in terms of symptom profile, associated cognitive deficits, comorbidities, and outcomes. Heterogeneity may also affect the ability to recognize and diagnose this condition. The diagnosis of ADHD is primarily clinical but there are increasing research efforts aiming at identifying biomarkers that can aid the diagnosis.AREAS COVERED: We first discuss the definition of biomarkers and...
Source: Expert Review of Molecular Diagnostics - March 20, 2024 Category: Laboratory Medicine Authors: Valeria Parlatini Alessio Bellato Alessandra Gabellone Lucia Margari Lucia Marzulli Emilia Matera Maria Giuseppina Petruzzelli Marco Solmi Christoph U Correll Samuele Cortese Source Type: research

PCR diagnostic platforms for non- < em > Aspergillus < /em > mold infections: ready for routine implementation in the clinic?
Expert Rev Mol Diagn. 2024 Mar 19:1-10. doi: 10.1080/14737159.2024.2326474. Online ahead of print.ABSTRACTINTRODUCTION: While Aspergillus spp. remain the predominant cause of invasive mold infections, non-Aspergillus molds, such as the Mucorales or Fusarium spp., account for an increasing proportion of cases. The diagnosis of non-Aspergillus invasive mold infections (NAIMI) is challenging because of the low sensitivity and delay of conventional microbiological tests. Therefore, there is a particular interest to develop molecular tools for their early detection in blood or other clinical samples.AREAS COVERED: This extensiv...
Source: Expert Review of Molecular Diagnostics - March 19, 2024 Category: Laboratory Medicine Authors: Frederic Lamoth Dimitrios P Kontoyiannis Source Type: research

Opportunities and challenges of point of care testing paradigms in the post-COVID era
Expert Rev Mol Diagn. 2024 Mar 19:1-3. doi: 10.1080/14737159.2024.2330774. Online ahead of print.NO ABSTRACTPMID:38501435 | DOI:10.1080/14737159.2024.2330774 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - March 19, 2024 Category: Laboratory Medicine Authors: Barbara Van Der Pol Source Type: research

An overview of point-of-care testing for infections in critically ill patients
Expert Rev Mol Diagn. 2024 Feb 27:1-8. doi: 10.1080/14737159.2024.2322146. Online ahead of print.ABSTRACTINTRODUCTION: Molecular diagnostic systems for point-of-care (POC) testing are nowadays routinely used and are part of many labs. Although often intended for bedside use outside of the microbiology lab, there is still room for expansion.AREAS COVERED: This review discusses the two techniques that are currently the most widespread, real-time polymerase-chain reaction (RT-PCR) and loop-mediated isothermal amplification (LAMP). An overview is provided of the various manufacturers and products as well as the evidence and cu...
Source: Expert Review of Molecular Diagnostics - February 28, 2024 Category: Laboratory Medicine Authors: Alena Moerman Jan J De Waele Jerina Boelens Source Type: research