EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects Against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis.

Pemphigus is a severe blistering disease caused by autoantibodies primarily against the desmosomal cadherins desmoglein (DSG)1 and DSG3 which impair desmosome integrity. Especially for the acute phase, additional treatment options allowing to reduce corticosteroids would fulfill an unmet medical need. Here, we provide evidence that epidermal growth factor receptor (EGFR) inhibition by erlotinib ameliorates pemphigus vulgaris immunoglobulin G (PV-IgG) -induced acantholysis in intact human epidermis.

Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Desalegn Tadesse Egu, Thomas Schmitt, Nancy Ernst, Ralf Joachim Ludwig, Michael Fuchs, Matthias Hiermaier, Sina Moztarzadeh, Carla Sebasti à Morỏn, Enno Schmidt, Vivien Beyersdorfer, Volker Spindler, Letyfee Sarah Steinert, Franziska Vielmuth, Anna Mag Tags: Original Article Source Type: research