Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
CONCLUSIONS: This overview summarises the evidence of nine SRs investigating the effect of postnatal corticosteroids in preterm infants at risk for BPD. Late initiated (≥ seven days after birth) systemic administration of dexamethasone is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD, based on a favourable balance between benefits and harms. Endotracheal instillation of corticosteroids (budesonide) with surfactant as a carrier is a promising intervention, based on the beneficial effect on desirable outcomes without (so far) negative side effects. Pending result...
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Moniek van de Loo Anton van Kaam Martin Offringa Lex W Doyle Chris Cooper Wes Onland Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 10, 2024 Category: Respiratory Medicine Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
Lateral Epicondylitis: Treatment Preferences from the Potential Patient Perspective
CONCLUSIONS: It is important to include patient preferences in treatment discussions of lateral epicondylitis. Survey respondents preferred formal physical therapy for initial treatment. A surprising majority of respondents were likely to consider a PRP injection. With prolonged symptoms, respondents were interested in discussions of surgical intervention and thus, it should continue to be offered to patients with recalcitrant symptoms.PMID:38596580 | PMC:PMC11000778 | DOI:10.1097/GOX.0000000000005706 (Source: Hand Surgery)
Source: Hand Surgery - April 10, 2024 Category: Surgery Authors: Harin B Parikh Mackinzie Stanley Cassie C Tseng David A Kulber Stuart H Kuschner Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
Drug-induced Steatohepatitis Caused by Long-term Use of Topical Steroids for Atopic Dermatitis: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3439-23. Online ahead of print.ABSTRACTAtopic dermatitis is common in children and often treated with topical corticosteroids (TCs). A boy in his late teens who had been using TCs for atopic dermatitis was diagnosed with liver damage during a health checkup. A medical examination revealed severe steatotic liver disease and elevated liver enzyme levels despite the absence of typical symptoms such as central obesity. After discontinuation of TCs, an improvement in liver enzyme levels was observed, leading to the diagnosis of drug-induced steatohepatitis. This case undersc...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Yuki Tamura Atsushi Naganuma Yuhei Suzuki Sanae Uehara Takashi Hosino Takeshi Hatanaka Nobuyuki Shibusawa Akihito Uehara Akira Ogawa Satoru Kakizaki Toshio Uraoka Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 10, 2024 Category: Intensive Care Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
Impact of concurrent medications on clinical outcomes of cancer patients treated with immune checkpoint inhibitors: analysis of Health Insurance Review and Assessment data
CONCLUSION: A high number of concurrent medications was associated with poor clinical outcomes.PMID:38600328 | PMC:PMC11006739 | DOI:10.1007/s00432-024-05728-z (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Soojung Hong Ju Hyun Lee Ja Yoon Heo Koung Jin Suh Se Hyun Kim Yu Jung Kim Jee Hyun Kim Source Type: research
Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
CONCLUSIONS: This overview summarises the evidence of nine SRs investigating the effect of postnatal corticosteroids in preterm infants at risk for BPD. Late initiated (≥ seven days after birth) systemic administration of dexamethasone is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD, based on a favourable balance between benefits and harms. Endotracheal instillation of corticosteroids (budesonide) with surfactant as a carrier is a promising intervention, based on the beneficial effect on desirable outcomes without (so far) negative side effects. Pending result...
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Moniek van de Loo Anton van Kaam Martin Offringa Lex W Doyle Chris Cooper Wes Onland Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 10, 2024 Category: Respiratory Medicine Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
Drug-induced Steatohepatitis Caused by Long-term Use of Topical Steroids for Atopic Dermatitis: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3439-23. Online ahead of print.ABSTRACTAtopic dermatitis is common in children and often treated with topical corticosteroids (TCs). A boy in his late teens who had been using TCs for atopic dermatitis was diagnosed with liver damage during a health checkup. A medical examination revealed severe steatotic liver disease and elevated liver enzyme levels despite the absence of typical symptoms such as central obesity. After discontinuation of TCs, an improvement in liver enzyme levels was observed, leading to the diagnosis of drug-induced steatohepatitis. This case undersc...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Yuki Tamura Atsushi Naganuma Yuhei Suzuki Sanae Uehara Takashi Hosino Takeshi Hatanaka Nobuyuki Shibusawa Akihito Uehara Akira Ogawa Satoru Kakizaki Toshio Uraoka Source Type: research
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma
CONCLUSIONS: The NMU/NMUR1 axis stimulates rapid effects on ILC2, and maybe an important early activator of these cells in eosinophilic inflammatory responses in asthma.PMID:38598774 | DOI:10.1164/rccm.202311-2164OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 10, 2024 Category: Intensive Care Authors: Xiaotian Ju Akimichi Nagashima Anna Dvorkin-Gheva Jennifer Wattie Karen Howie Christiane Whetstone Maral Ranjbar Ruth Cusack Reina Ditta Guillaume Par é Imran Satia Paul M O'Byrne Gail M Gauvreau Roma Sehmi Source Type: research
Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
CONCLUSIONS: This overview summarises the evidence of nine SRs investigating the effect of postnatal corticosteroids in preterm infants at risk for BPD. Late initiated (≥ seven days after birth) systemic administration of dexamethasone is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD, based on a favourable balance between benefits and harms. Endotracheal instillation of corticosteroids (budesonide) with surfactant as a carrier is a promising intervention, based on the beneficial effect on desirable outcomes without (so far) negative side effects. Pending result...
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Moniek van de Loo Anton van Kaam Martin Offringa Lex W Doyle Chris Cooper Wes Onland Source Type: research
Drug-induced Steatohepatitis Caused by Long-term Use of Topical Steroids for Atopic Dermatitis: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3439-23. Online ahead of print.ABSTRACTAtopic dermatitis is common in children and often treated with topical corticosteroids (TCs). A boy in his late teens who had been using TCs for atopic dermatitis was diagnosed with liver damage during a health checkup. A medical examination revealed severe steatotic liver disease and elevated liver enzyme levels despite the absence of typical symptoms such as central obesity. After discontinuation of TCs, an improvement in liver enzyme levels was observed, leading to the diagnosis of drug-induced steatohepatitis. This case undersc...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Yuki Tamura Atsushi Naganuma Yuhei Suzuki Sanae Uehara Takashi Hosino Takeshi Hatanaka Nobuyuki Shibusawa Akihito Uehara Akira Ogawa Satoru Kakizaki Toshio Uraoka Source Type: research
Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
CONCLUSIONS: This overview summarises the evidence of nine SRs investigating the effect of postnatal corticosteroids in preterm infants at risk for BPD. Late initiated (≥ seven days after birth) systemic administration of dexamethasone is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD, based on a favourable balance between benefits and harms. Endotracheal instillation of corticosteroids (budesonide) with surfactant as a carrier is a promising intervention, based on the beneficial effect on desirable outcomes without (so far) negative side effects. Pending result...
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Moniek van de Loo Anton van Kaam Martin Offringa Lex W Doyle Chris Cooper Wes Onland Source Type: research
Impact of concurrent medications on clinical outcomes of cancer patients treated with immune checkpoint inhibitors: analysis of Health Insurance Review and Assessment data
ConclusionA high number of concurrent medications was associated with poor clinical outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research
