Hyaluronic Acid in Shoulder Tendinopathy
Conditions: Shoulder Tendinitis Interventions: Drug: Hyaluronic acid injection; Drug: Corticosteroid injection; Drug: Placebo injection Sponsors: Centre Hospitalier Departemental Vendee Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 22, 2024 Category: Research Source Type: clinical trials

Pragmatic Open - Label Randomized Clinical Trial of FF/UMEC/VI vs Non-ellipta Usual Care ICS-LABA for Adult Participants With Uncontrolled Asthma
Conditions: Asthma Interventions: Drug: Fluticasone furoate/umeclidinium bromide/vilanterol trifenatate; Drug: Inhaled corticosteroids/long-acting beta-2 agonists Sponsors: GlaxoSmithKline Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials

Tocilizumab in Corticosteroid-Resistant Graves' Orbitopathy (Thyroid Eye Disease)
Conditions: Orbitopathy, Graves; Thyroid Eye Disease; Ophthalmopathy Interventions: Drug: Tocilizumab Sponsors: Medical University of Warsaw Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials

A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation
Conditions: Kidney Transplantation Interventions: Biological: TCD601; Drug: Tacrolimus (TAC); Drug: Corticosteroids (CS); Drug: Mycophenolate Mofetil (MMF); Drug: ATG Sponsors: ITB-Med LLC Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials

The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries
DiscussionThis trial will evaluate the benefits and possible harms of ACS when used in women likely to have a late preterm birth. It will also evaluate a lower-dose ACS regimen based on literature from pharmacokinetic studies. The results of this trial will provide robust critical evidence on the safe and appropriate use of ACS in the late preterm period internationally.Trial registrationISRCTN11434567. Registered on 7 June 2021. (Source: Trials)
Source: Trials - April 12, 2024 Category: Research Source Type: clinical trials

Immediate Corticosteroid Therapy and Rituximab to Prevent Generalization in Ocular Myasthenia: a PROBE Multicenter Open-label Randomized Controlled Trial.
Conditions: Ocular Myasthenia Gravis Interventions: Drug: immediate treatment with corticosteroids; Drug: addition of rituximab if recurrence Sponsors: Fondation Ophtalmologique Adolphe de Rothschild Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 2, 2024 Category: Research Source Type: clinical trials

A Study of Lebrikizumab (LY3650150) in Adult Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
Conditions: Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Interventions: Drug: LY3650150; Drug: Placebo; Drug: Standard therapy for INCS Sponsors: Eli Lilly and Company Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2024 Category: Research Source Type: clinical trials

A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)
Conditions: Intranasal Corticosteroids Interventions: Drug: LY3650150; Drug: Administered SC Sponsors: Eli Lilly and Company Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2024 Category: Research Source Type: clinical trials

Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial
This article presents the statistical analysis plan to evaluate the outcomes of the ACCURE trial.Design and methodsThe ACCURE trial was designed as a multicentre, randomised controlled trial. UC patients with a new diagnosis or a disease relapse within the past 12  months, treated with 5-ASA, corticosteroids, or immunomodulators until complete clinical and endoscopic remission (defined as total Mayo score <  3 with endoscopic subscore of 0 or 1), were counselled for inclusion. Also, patients previously treated with biologicals who had a washout period of at least 3 months were considered for inclusion. Patients we...
Source: Trials - March 26, 2024 Category: Research Source Type: clinical trials

Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis
Conditions: Knee Osteoarthritis Interventions: Other: Ozone - oxygen Therapy; Other: Corticosteroid Sponsors: Sisli Hamidiye Etfal Training and Research Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials

A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
Conditions: Atopic Dermatitis Interventions: Drug: Tralokinumab + TCS; Drug: Placebo + TCS Sponsors: LEO Pharma Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials

Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis
Conditions: Uveitis Interventions: Drug: Adalimumab Biosimilars Injection; Drug: Corticosteroid; Drug: Immunosuppressive Agents Sponsors: Zhongshan Ophthalmic Center, Sun Yat-sen University; The Eye Hospital of Wenzhou Medical University; The First Affiliated Hospital of Soochow University; Shandong Eye Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials

Impact of Antenatal Steroids on Coagulation.
Conditions: Corticosteroids Adverse Reaction Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials

Various Strategies to Reduce Acute Post Hemorrhoidectomy Pain: A Comparative Study
Conditions: Acute Post Operative Pain Interventions: Drug: ketorolac and light marcaine; Drug: light marcaine; Drug: Corticosteroids injection; Drug: Diclofenac Sodium Gel Sponsors: Zagazig University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials

The efficacy and safety of deucravacitinib compared to methotrexate, in patients with vulvar lichen planus who have failed topical therapy with potent corticosteroids: a study protocol for a single-centre double-blinded randomised controlled trial
DiscussionHigh-quality evidence guiding the management of women with VLP is lacking. Once completed, this will be the first double-blinded RCT to compare systemic treatments in VLP. The results of this study will provide valuable, high-quality data to guide second-line therapy options for VLP that is recalcitrant to potent topical corticosteroids.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12623000682640. Registered on 26 June 2023. (Source: Trials)
Source: Trials - March 12, 2024 Category: Research Source Type: clinical trials