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Ketorolac Injections for Musculoskeletal Conditions: A Narrative Review
Clin Med Res. 2024 Mar;22(1):19-27. doi: 10.3121/cmr.2024.1847.ABSTRACTMusculoskeletal conditions of the upper and lower extremities are commonly treated with corticosteroid injections. Ketorolac, a parenteral nonsteroidal anti-inflammatory drug, represents an alternative injectant for common shoulder, hip, and knee conditions. A review of the current literature was conducted on the efficacy of ketorolac injection in musculoskeletal diseases. Several studies support the use and efficacy of ketorolac injection in subacromial bursitis, adhesive capsulitis, and hip and knee osteoarthritis. Given the systemic effects of glucoc...
Source: Clinical Medicine and Research - April 12, 2024 Category: General Medicine Authors: John Kiel Andres I Applewhite Tais G O Bertasi Raphael A O Bertasi LaRae L Seemann Lorena M C Costa Haytham Helmi George G A Pujalte Source Type: research

Efficacy of dupilumab as an alternative to corticosteroids in the treatment of exacerbations of allergic bronchopulmonary aspergillosis
The pathogenesis of ABPA involves not only eosinophils but also plasma cells that produce IgE, which is responsible for type I allergic mechanisms. Dupilumab may be an effective alternative to corticosteroids because it inhibits T cell to plasma cell differentiation by blocking IL4. Key messageThe pathogenesis of allergic bronchopulmonary aspergillosis involves not only eosinophils but also plasma cells that produce immunoglobulin E. Dupilumab may be an effective alternative to corticosteroids because it inhibits T cell to plasma cell differentiation by blocking IL4. (Source: Respirology Case Reports)
Source: Respirology Case Reports - April 12, 2024 Category: Respiratory Medicine Authors: Masamitsu Hamakawa, Tadashi Ishida Tags: CLINICAL IMAGE Source Type: research

GSE263557 Distinctive Transcriptional and Microbial Signature in Cutaneous Acute Graft-vs-Host-Disease
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkin acute graft-vs-host disease (aGVHD) is often the first manifestation of GVHD, yet very few preclinical and clinical studies have focused on this target organ, leaving a critical information gap in the pathophysiology of GVHD. We hypothesized that analysis of host gene expression and microbiome profiling could yield novel insights into the molecular and immunologic mechanisms underlying skin GVHD. Our objectives were to determine the differential host gene expression and microbiome profile of human skin aGVHD samples compared to norm...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Dual Drug Therapy Versus Single Drug Therapy in Prevention of Pinna Keloid Recurrence
AbstractKeloids are fibroproliferative disorders caused due to injury to skin. The recurrence rate has been found to be as high as 100% even after surgical excision. The high recurrence rate has led to the need for various adjuvant therapies as a single approach alone has not been found to be efficient in preventing recurrence. This attributes to the need for a multimodal approach. Steroids are found to be useful in preventing recurrence. To evaluate the efficacy of the combination of hyaluronidase with corticosteroid injection compared to corticosteroid injection alone in the prevention of recurrence of keloid after surgi...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research

The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries
Preterm birth complications are the leading cause of newborn and under-5 mortality. Over 85% of all preterm births occur in the late preterm period, i.e. between 34 and (Source: Trials)
Source: Trials - April 12, 2024 Category: General Medicine Tags: Study protocol Source Type: research

COVID-19 and pregnancy: A European study on pre- and post-infection medication use
ConclusionOur findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

Oral corticosteroid prescribing practice for chronic rhinosinusitis with nasal polyps among otorhinolaryngologists in Scotland: a nationwide survey
J Laryngol Otol. 2024 Apr 11:1-18. doi: 10.1017/S0022215124000446. Online ahead of print.NO ABSTRACTPMID:38602175 | DOI:10.1017/S0022215124000446 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 11, 2024 Category: ENT & OMF Authors: Rasads Misirovs Gary Hoey Brian Lipworth Richard Green Source Type: research

Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization
In conclusion, we demonstrated that celastrol assisted in mitigating various parameters of obese asthma by regulating the balance of M1/M2 AMs polarization.PMID:38604543 | DOI:10.1016/j.ejphar.2024.176560 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yafeng Liang Sijia Shen Xiaoxiao Ye Weixi Zhang Xixi Lin Source Type: research

Impact of concurrent medications on clinical outcomes of cancer patients treated with immune checkpoint inhibitors: analysis of Health Insurance Review and Assessment data
CONCLUSION: A high number of concurrent medications was associated with poor clinical outcomes.PMID:38600328 | DOI:10.1007/s00432-024-05728-z (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Soojung Hong Ju Hyun Lee Ja Yoon Heo Koung Jin Suh Se Hyun Kim Yu Jung Kim Jee Hyun Kim Source Type: research