Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol
AbstractPurposeTo describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure.MethodsBased on record linkage between the seventh wave of the Troms ø Study and the Norwegian Prescription Database, medication adherence was calculated as the proportion of days covered (PDC) for persistent prevalent users in the period of 365 days before the attendance date. Multivariable linear regression models...
Source: European Journal of Clinical Pharmacology - January 21, 2022 Category: Drugs & Pharmacology Source Type: research

The impact of omega-3 polyunsaturated fatty acids on primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials
This study is a systematic review and meta-analysis in which the electronic databases of PubMed, Scopus, Web of Science, ProQuest, Google Scholar, and SID were searched. In this regard, randomized controlled trials (RCTs) conducted to investigate the effect of n-3 PUFAs on primary dysmenorrhea were included. The quality of the studies was assessed using the Cochrane Collaboration ’s Risk of Bias Tool. Meta-analysis was performed based on the random-effects model using CMA software version 2.ResultsThe results of the meta-analysis showed that n-3 PUFAs reduce the severity of primary dysmenorrhea in women (SMD =...
Source: European Journal of Clinical Pharmacology - January 21, 2022 Category: Drugs & Pharmacology Source Type: research

Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib
ConclusionPBPK model-based predictions highlighted potential clinically significant interactions between goldenseal extract and bosutinib, but not imatinib. Dose adjustment may need to be considered if co-administration is desirable. These findings should be confirmed with optimally designed controlled drug interaction studies. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 20, 2022 Category: Drugs & Pharmacology Source Type: research

Evaluation of two European risk models for predicting medication harm in an Australian patient cohort
ConclusionNeither model demonstrated sufficient discrimination to warrant further evaluation in our local setting. This is likely a result of variations between the development and the validation cohorts, and the change in healthcare systems over time, and highlights the need for an up-to-date and context-specific risk prediction model. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 18, 2022 Category: Drugs & Pharmacology Source Type: research

Selective serotonin reuptake inhibitor use and the risk of hepatocellular carcinoma: a systematic review and dose –response analysis of cohort studies with one million participants
ConclusionsThe results of this review show that SSRI use was associated with a 34% lower risk of HCC, which tend to be dose dependent. Further prospective studies are warranted to confirm these observations across the spectrum of chronic liver disease and hepatitis infection. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 18, 2022 Category: Drugs & Pharmacology Source Type: research

Severe CNS depression with duloxetine, ciprofloxacin and CYP2D6 deficiency —role and recognition of drug-drug-gene interactions
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research

European association for clinical pharmacology and therapeutics young clinical pharmacologists working group: a cornerstone for the brighter future of clinical pharmacology
AbstractThe European Association for Clinical Pharmacology and Therapeutics (EACPT) is a leading society in Europe serving the European and global Clinical Pharmacology and Therapeutics community. Its specific aims include promotion of the utilisation and divulgation of the utility of clinical pharmacology services in health care delivery. EACPT currently has four active working groups (WGs): Education, Regulatory affairs, Clinical research and Young Clinical Pharmacologists (YCP WG). EACPT YCP WG was established in 2015 with the idea of improving education, research, training and networking/mobility opportunities for YCPs...
Source: European Journal of Clinical Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research

Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review
ConclusionsAlthough LNG-IUS, dienogest and GnRH analogues have better evidence for effectiveness in adenomyosis, the need of the hour is to thoroughly evaluate other novel molecules for adenomyosis using well-designed randomized controlled trials. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research

Effect of GLP-1R rs2254336 and rs3765467 polymorphisms on gastrointestinal adverse reactions in type 2 diabetes patients treated with liraglutide
ConclusionOur results suggest that female sex, the T allele atGLP-1R rs2254336 and the A allele atGLP-1R rs3765467 could be predictors of GIARs with liraglutide in T2DM patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Source Type: research

Elevation of alkaline phosphatase and long-term drug therapy for cystic fibrosis
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative analysis of PIM criteria and drug labels in the elderly
ConclusionThere are certain differences between PIM criteria and PIM criteria, labels and labels, and PIM criteria and labels, which will affect the use of drugs in the elderly. Therefore, the unity between the criteria and labels should be strengthened to provide more instructive guidance for the elderly, so as to jointly realize rational drug use in the elderly. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Loss of function polymorphisms in SLCO1B1 (c.521T & gt;C, rs4149056) and ABCG2 (c.421C & gt;A, rs2231142) genes are associated with adverse events of rosuvastatin: a case –control study
ConclusionLoss of function polymorphisms inSLCO1B1 c.521T>C andABCG2 c.421C>A genes are associated with the presence of rosuvastatin related myotoxicity and/or hepatotoxicity. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Investigation of the risk factors of vomiting during linezolid therapy: a retrospective observational study
ConclusionsThis study is the first to successfully identify risk factors for LZD-induced vomiting. Careful monitoring of patients with these risk factors may lead to safer and sustainable LZD administration. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Drug-related deaths among inpatients: a meta-analysis
ConclusionDrug-related problems are an important cause of mortality. The variability in its estimation could be explained by admission wards. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Bevacizumab and aflibercept in second-line metastatic colorectal cancer: 12  years of experience
ConclusionAlthough no statistically significant differences have been found in TT or PFS, it would be more advisable to use BFIR scheme due to its better results in OS and toxicity profile. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study
ConclusionsCBC may have preferential absorption over CBD and THC when administered together.Trial Registration: Australian New Zealand Clinical Trials Registry #ACTRN12619001450101, registered 18 October 2019. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Drug utilisation in neonatal units in England and Wales: a national cohort study
AbstractPurposeTo describe drug utilisation patterns in neonatal units.MethodsRetrospective observational cohort study using data held in the National Neonatal Research Database (NNRD) for neonatal units in England and Wales including infants born at 23 to 44  weeks’ gestational age (GA) from 01 January 2010 to 31 December 2017.ResultsThe cohort included 17,501 (3%) extremely preterm infants; 40,607 (7%) very preterm infants; 193,536 (31%) moderate-to-late preterm infants; and 371,606 (59%) term infants. The number of unique drugs received by an infant (median (IQR)) increased with decreasing GA: 17 (11 –2...
Source: European Journal of Clinical Pharmacology - January 13, 2022 Category: Drugs & Pharmacology Source Type: research

Investigation of the risk factors of vomiting during linezolid therapy: a retrospective observational study
ConclusionsThis study is the first to successfully identify risk factors for LZD-induced vomiting. Careful monitoring of patients with these risk factors may lead to safer and sustainable LZD administration. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 11, 2022 Category: Drugs & Pharmacology Source Type: research

A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients
ConclusionsThe large variability in PK/PD profiles can be partially explained by the genetic variants in an extent different from other population, which confirmed the necessity to conduct such a study in the specific Chinese patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 11, 2022 Category: Drugs & Pharmacology Source Type: research

Immune-mediated necrotizing myopathy with pembrolizumab: a specific neuromuscular entity
ConclusionThe diagnosis of IMNM does not always take into account recent criteria for the diagnosis of this pathology. This study highlights the existence of a signal, as well as the need for collaboration between oncologists and neurologists for these neurological pathologies. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 6, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative analysis of PIM criteria and drug labels in the elderly
ConclusionThere are certain differences between PIM criteria and PIM criteria, labels and labels, and PIM criteria and labels, which will affect the use of drugs in the elderly. Therefore, the unity between the criteria and labels should be strengthened to provide more instructive guidance for the elderly, so as to jointly realize rational drug use in the elderly. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 4, 2022 Category: Drugs & Pharmacology Source Type: research

Low- vs high-dose ARNI effects on clinical status, exercise performance and cardiac function in real-life HFrEF patients
AbstractPurposeOnly a few studies are available on dose-related effects of sacubitril/valsartan (angiotensin receptor neprilysin inhibition (ARNI)) in real-life patients with heart failure and reduced ejection fraction (HFrEF). We sought to investigate clinical and functional effects in real-life HFrEF  patients receiving ARNI at a different cumulative dose.MethodsThis was an observational study in consecutive outpatients admitted for HFrEF from October 2017 to June 2019. The PARADIGM criteria were needed for enrolment. ARNI was uptitrated according to blood pressure, drug tolerability, renal function and kaliemia. At...
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

The impact of PIPs on mortality and readmissions in older adults: a retrospective cohort study
ConclusionThe number of drugs at discharge and having any STOPP criteria significantly increased the risk of hospital admission in this cohort. PIP, only according to some specific STOPP-2 criteria involving digoxin, neuroleptics and SSRIs, might associate with a statistically non-significantly higher risk on mortality. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Improving medication adherence and effective prescribing through a patient-centered prescription model in patients with multimorbidity
This study aimed to assess the impact of the patient-centered prescription (PCP) model in medication adherence and effective prescribing in patients with multimorbidity.MethodsUncontrolled before –after study in an intermediate care facility in a mixed urban–rural district. Inpatients aged ≥ 65 years with multimorbidity exposed to polypharmacy before hospital admission were consecutively enrolled. Every patient’s treatment plan was analyzed through the PCP model, which includes interventions aimed at improving medication adherence. The primary endpoint was the change in the proportio...
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study
ConclusionIntravenous lidocaine may be an alternative treatment method for patients with migraine attack headaches in the emergency department. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel
ConclusionThe study findings proved a negative impact of pantoprazole use on Ca2+ and Mg2+ levels, which can impact TRPM7-mediated bone remodelling which serves to be a possible mechanism for osteoporosis upon pantoprazole use.Graphical abstract (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

European NSTEMI guidelines —return of clopidogrel?
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Correction to: Population pharmacokinetics ‑pharmacodynamics of fondaparinux in dialysis‑dependent chronic kidney disease patients undergoing chronic renal replacement therapy
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Man vs. machine: comparison of pharmacogenetic expert counselling with a clinical medication support system in a study with 200 genotyped patients
ConclusionWith the computerized version of this approach, it became possible to score all combinations of all alternative drugs from each class of drugs administered ( “personalized medication landscape “) and to identify critical patients even before problems are reported (“medication alert”). Careful comparison of manual and score-based results shows that the incomplete manual consideration of genetic specialties and pharmacokinetic conflicts is responsi ble for most of the (minor) deviations between the two approaches. The meaning of the reduction of working time for experts by about 2 orders of ...
Source: European Journal of Clinical Pharmacology - December 27, 2021 Category: Drugs & Pharmacology Source Type: research

Prevalence, contributory factors and severity of medication errors associated with direct-acting oral anticoagulants in adult patients: a systematic review and meta-analysis
ConclusionsDespite their favourable safety profile, DOAC medication errors are common. There is a need to promote multidisciplinary working, guideline-adherence, training, and education of healthcare professionals, and the use of theory-based and technology-facilitated interventions to minimise errors and maximise the benefits of DOACs usage in all settings.ProtocolA protocol developed as per PRISMA-P guideline is registered under PROSPERO ID  = CRD42019122996 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research

Who gets prescriptions for proton pump inhibitors and why? A drug-utilization study with claims data in Bavaria, Germany, 2010 –2018
ConclusionsThe utilization of prescribed PPIs has decreased since 2016. However, a large proportion of new PPI-users had no documentation of a potential indication, and the sums of DDDs prescribed often seemed not to comply with guidelines. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 8, 2021 Category: Drugs & Pharmacology Source Type: research

Updated network meta-analysis assessing the relative efficacy of 13 GLP-1 RA and SGLT2 inhibitor interventions on cardiorenal and mortality outcomes in type 2 diabetes
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 3, 2021 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder
ConclusionsA qualified PPK model of VPA was developed in Chinese patients with bipolar disorder. This model could be used as a suitable tool for the personalization of VPA dosing for bipolar patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 2, 2021 Category: Drugs & Pharmacology Source Type: research

Self-report instruments for assessing adherence to warfarin therapy: a systematic review
ConclusionsThis review highlighted a gap in knowledge regarding the scarcity of validated instruments to assess adherence to warfarin therapy. Limitations were found in instruments that comprised the assessment of the isolated use of medication and the lack of analysis of other relevant therapeutic aspects. Future studies are needed to develop and validate more comprehensive instruments in an attempt to assess adherence to warfarin therapy.PROSPERORegistration number CRD42019128324 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Serum concentrations of antidepressants, antipsychotics, and antiepileptics over the bariatric surgery procedure
ConclusionsSerum concentrations of psychotropic/antiepileptic drugs vary after bariatric surgery and can be hard to predict in individual patients, suggesting that therapeutic drug monitoring is of value. Conversely, effects of the pre-surgery, low-calorie diet appear generalizable, with decreased concentrations of highly lipophilic drugs and increased concentrations of highly hydrophilic drugs. Interaction effects (surgery/dose/concentration) were not evident but cannot be excluded. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study
ConclusionsSacubitril/valsartan improves systolic function in HFrEF, mainly due to reverse left ventricular remodelling. Improvement in EF after 6  months of treatment could help prevent ICD implantation in nearly one out of four patients, with important clinical and economic implications. However, the risk of sudden cardiac death in this recovered HFrEF population has not been thoroughly studied, and the present data should be interpreted on ly as hypothesis-generating. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Evaluation of drug-drug interactions of pemigatinib in healthy participants
ConclusionCoadministration with itraconazole or rifampin resulted in a clinically significant change in pemigatinib exposure. Therefore, coadministration of strong CYP3A inducers with pemigatinib should be avoided, and the dose of pemigatinib should be reduced if coadministration with strong CYP3A inhibitors cannot be avoided. The effect of PPIs/H2 antagonists on pemigatinib exposure was modest, and pemigatinib can be administered without regard to coadministration of PPIs/H2 antagonists. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis
ConclusionsAspirin 50  mg twice daily, 75 mg once daily, and aspirin 50 mg once daily produce antiplatelet effects that are similar to aspirin 100 mg once daily. Aspirin given less often than once daily and indobufen 100 mg twice daily do not suppress platelets as effectively as aspirin 100 mg once daily. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

External evaluation of published population pharmacokinetic models of polymyxin B
ConclusionNot all published models were satisfactory in prediction- and simulation-based diagnostics; however, Bayesian forecasting improved the predictability considerably with priors, which can be applied to guide polymyxin B dosing recommendations and adjustments for clinicians. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Successful deprescribing of proton pump inhibitors with a patient-centered process: the DESPIBP Project
ConclusionThere is a high inappropriate indication for PPIs in patients admitted to the gastroenterology department. The application of a patient-centered deprescribing algorithm is a safe and effective strategy to reduce their inappropriate consumption in the medium term. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Comparative study evaluating antihistamine versus leukotriene receptor antagonist as adjuvant therapy for rheumatoid arthritis
AbstractPurposeInvestigating the efficacy and safety of rupatadine (RUP) versus montelukast (MON) as adjuvant therapy for patients with rheumatoid arthritis (RA).MethodsFrom December 2018 to December 2019, 75 patients with active RA were enrolled in this randomized double-blind placebo-controlled study. The patients were randomized into three groups (n  = 25 in each group); methotrexate (MTX) group which received MTX 15–25 mg/week plus placebo tablet once daily; MTX/RUP group which received MTX plus RUP 10 mg once daily; and MTX/MON group which received MTX plus MON 10 mg once daily. The ...
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetics and exposure –response relationship of trastuzumab and bevacizumab in early-stage breast cancer
AbstractAimsTo describe the sources of interindividual variability of bevacizumab and trastuzumab pharmacokinetics in early-stage breast cancer, and to study the relationship between exposure and both early clinical response and specific adverse events.Patients and methodsPatients (n = 86) received 6 cycles of docetaxel + trastuzumab. Early tumour response was assessed by determination of the maximum standard uptake value (SUVmax) variation ( ΔSUVmax) after 1 cycle using [18F]-fluorodeoxyglucose (FDG) PET. Early poor responders ( ΔSUVmax 
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources
We present a set of considerations to make researchers aware of the potentials and pitfalls of these methods that may aid in minimizing biases in research using these methods. Additionally, we highlight that, to date, there is no one-size-fits-all solution. Thus, the choice of method should be ba sed on their area of applicability combined with a careful mapping to the research scenario under investigation. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research