Implementation and management outcomes of pharmacogenetic CYP2C19 testing for clopidogrel therapy in clinical practice
ConclusionPGx-guided clopidogrel therapy can identify patients with an elevated risk of ischemic events and offer evidence-based alternative treatments. Successful implementation in clinical practice requires a personalized interdisciplinary service that evaluates indications and additional risk factors, provides specific recommendations, and proactively follows their implementation. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 26, 2020 Category: Drugs & Pharmacology Source Type: research

Reply to the letter to the Editor “Prediction of lopinavir/ritonavir effectiveness in COVID-19 patients: a recall of basic pharmacology concepts”
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 26, 2020 Category: Drugs & Pharmacology Source Type: research

Prediction of lopinavir/ritonavir effectiveness in COVID-19 patients: a recall of basic pharmacology concepts
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 25, 2020 Category: Drugs & Pharmacology Source Type: research

Authors ’ reply to letters to the editor “model-based simulation to support the extended dosing regimens of atezolizumab”
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 25, 2020 Category: Drugs & Pharmacology Source Type: research

Arrhythmias related to antipsychotics and antidepressants: an analysis of the summaries of product characteristics of original products approved in Germany
AbstractPurposeMost psychiatric drugs, such as antidepressants (AD) and antipsychotics (AP), may cause cardiac adverse events (CAE). We used summaries of product characteristics (SmPC) for assessing the likelihood of AD and AP to cause CAE.MethodsWe identified all original medicinal products (OMP) of AD and AP approved in Germany. We searched for their SmPCs using the online services of PharmaNet.Bund, Gelbe liste ®, Rote Liste®, Fachinfo-Service®, and via manufacturer contact. We extracted frequencies of reported CAE (QT prolongation, Torsade de Pointes tachycardia, and ventricular arrhythmia) and performed a ...
Source: European Journal of Clinical Pharmacology - November 23, 2020 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass in adult patients undergoing cardiac surgery
ConclusionPPK modelling with simulation may be valuable for devising a cefazolin prophylaxis protocol for patients undergoing cardiac surgery with CPB. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 19, 2020 Category: Drugs & Pharmacology Source Type: research

Association between lipid-lowering agents and severe hyponatremia: a population-based case –control study
ConclusionsUse of statins and ezetimibe was inversely correlated with severe hyponatremia. Consequently, these drugs are unlikely culprits in patients with hyponatremia, and they appear safe to initiate in hyponatremic patients. A potential protective effect warrants further studies on how statins and other lipid-lowering drugs are linked to dysnatremias. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 19, 2020 Category: Drugs & Pharmacology Source Type: research

The scientific basis of rational prescribing. A guide to precision clinical pharmacology based on the WHO 6-step method
Discussion and conclusionAs can be seen, precision clinical pharmacology aims at being highly translational, which will require very large panels of complementary skills. Interdisciplinary  collaborations, including non-clinical pharmacologists, will be key to achieve such an ambitious program. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Source Type: research

Normal fat mass cannot be reliably estimated in typical pharmacokinetic studies
ConclusionIn typical pharmacokinetic studies, NFM should be used with caution because theFfat estimates have low precision. The estimation of Ffat should always be preceded by careful study design evaluation before planning a study, to ensure that the design and sample size is sufficient to apply this potentially useful methodology. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Source Type: research

Potentially inappropriate medication in acute hospitalized elderly patients with polypharmacy: an observational study comparing PRISCUS, STOPP, and Beers criteria
ConclusionsExplicit criteria are a useful tool for identifying during hospitalization of the elderly patients. As indicated by the results, new research is needed to carry out an adaptation in our country that includes an evaluation of the strengths of the three tools to decrease PIMs and improve prescription in the elderly. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Source Type: research

Serum 4 β-hydroxycholesterol increases during fluconazole treatment
ConclusionFluconazole inhibits the 14 α-demethylation of lanosterol and 24,25-dihydrolanosterol, regulated by CYP51A1, without reduction of total cholesterol synthesis. The increased serum level of R_4β-hydroxycholesterol under fluconazole treatment is in contrast to the reductions observed under ketoconazole and itraconazole treatmen ts. The question, whether this increase is caused by induction of CYP3A4 or by inhibition of the catabolism of 4β-hydroxycholesterol, must be answered by mechanistic in vitro and in vivo studies comparing effects of various azole antifungal agents on hepatic CYP3A4 activity. (...
Source: European Journal of Clinical Pharmacology - November 17, 2020 Category: Drugs & Pharmacology Source Type: research

CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction
ConclusionIbuprofen 600  mg was very effective in controlling inflammatory pain after lower third molar surgeries, without relevant adverse reactions; although in a very subtle way, patients with poor metabolism had higher levels of pain in the first hours, and no longer after 8 h, and used pain relief medication earlier .Trial registrationThe study was registered withClinicalTrials.gov ID (NCT03169127), on March 16th, 2017. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 17, 2020 Category: Drugs & Pharmacology Source Type: research

An open-label, positron emission tomography study of the striatal D 2 /D 3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants
ConclusionBy extrapolating the observed single-dose D2/D3 receptor occupancy data in healthy participants, multiple doses of brexpiprazole 2  mg/day and above are expected to result in an efficacious brexpiprazole concentration, consistent with clinically active doses in schizophrenia and major depressive disorder.Trial registrationClinicalTrials.gov NCT00805454 December 9, 2008. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 16, 2020 Category: Drugs & Pharmacology Source Type: research

Antimicrobial stewardship: can we add pharmacovigilance networks to the toolbox?
ConclusionThe heavy toll caused by AMR will not be brought down by a singular interventional approach, it will require a multidisciplinary and multifaceted set of strategies. Closing the laboratory capacity gap will require tremendous long-term investments, but the AMR data scarcity is a question that cannot wait any longer. The global pharmacovigilance network is a robust scientific community with experience in tracking suspected adverse events caused by new and old medicinal products. As AMR becomes a global health issue, AMS programs need all available tools to address resistance data scarcity and inform appropriate of ...
Source: European Journal of Clinical Pharmacology - November 16, 2020 Category: Drugs & Pharmacology Source Type: research

The motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research
ConclusionsThe majority of healthy Chinese subjects were young, were less well educated, had low income levels, and had poor medical insurance coverage. Given the multiple sources of motivation and complex barriers to trial participation, investigators and recruitment staff should consider ethics aspects to guarantee volunteer safety and well-being. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 13, 2020 Category: Drugs & Pharmacology Source Type: research

Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients
ConclusionModel-based simulation using PK parameters from the COVID-19 patients shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side-effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics –pharmacodynamics (PK-PD) relationships for CQ when given alone or in combination with other agents to treat COVID-19. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 13, 2020 Category: Drugs & Pharmacology Source Type: research

Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department
ConclusionThe same ATC classes, antithrombotics and cytostatics, were involved in ADRs causing university clinic hospitalizations as those identified previously in drug-related hospital fatalities. It seems difficult to prevent these events totally, as the treatments are vitally important and their risk-benefit-relationships have been considered thoroughly, and as pharmacogenetic testing could have been useful in only few cases. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 13, 2020 Category: Drugs & Pharmacology Source Type: research

Appropriate use of essential medicines in the elderly: a comparison of the WHO essential medicines list and PIM criteria
ConclusionImproving medication information for the elderly in the EML and establishing an essential medicines list for the elderly will promote appropriate drug use in older people worldwide. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 12, 2020 Category: Drugs & Pharmacology Source Type: research

Predicting the presence and mechanism of busulfan drug-drug interactions in hematopoietic stem cell transplantation using pharmacokinetic interaction network –based molecular structure similarity and network pharmacology
ConclusionsThis study has successfully predicted busulfan DDIs in HSCT through PKI-based molecular structure similarity. The mechanism of busulfan DDI and DILI was attributed mostly to CYP450s, GSTs, and ABC transporters, and PXR was identified as a potential target. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 11, 2020 Category: Drugs & Pharmacology Source Type: research

Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model
ConclusionsOptimal sampling strategies derived from this model could be used in clinical practice to enhance therapeutic drug monitoring or to conduct additional pharmacokinetic studies. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 11, 2020 Category: Drugs & Pharmacology Source Type: research

Patients ’ contribution to drug safety in Catalonia: the interest of personal feelings on adverse drug reactions
ConclusionsPatients ’ report free-text section provides relevant information, mainly about symptoms description, psychobiosocial impact and feelings. Therefore, it is a section to be enhanced and analysed. These findings should encourage the strengthening of citizens reporting. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 10, 2020 Category: Drugs & Pharmacology Source Type: research

Therapeutic drug monitoring of oral targeted antineoplastic drugs
ConclusionSub-therapeutic concentrations and severe adverse events are current challenges in OAD treatment, which can both be addressed by the application of TDM-guided dosing, ensuring concentrations within the therapeutic window. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 9, 2020 Category: Drugs & Pharmacology Source Type: research

Effectiveness of hypoxia-induced factor prolyl hydroxylase inhibitor for managing anemia in chronic kidney disease: a systematic review and meta-analysis
ConclusionThe current meta-analysis recommends the use of hypoxia-induced factor prolyl hydroxylase inhibitor for managing anemia in chronic kidney disease. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 7, 2020 Category: Drugs & Pharmacology Source Type: research

Correlation between single-nucleotide polymorphisms and statin-induced myopathy: a mixed-effects model meta-analysis
ConclusionThe meta-analysis revealed that the rs4149056 and rs4363657 SNPs inSLCO1B1 and the rs9806699 SNP inGATM are correlated with the risk of SIM. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 4, 2020 Category: Drugs & Pharmacology Source Type: research

Safety, pharmacodynamic, and pharmacokinetic characterization of vericiguat: results from six phase I studies in healthy subjects
ConclusionIn general, vericiguat was well tolerated. These results supported further clinical evaluation of vericiguat QD in patients with heart failure.Registry numbersEudraCT: 2011-001627-21; EudraCT: 2012-000953-30 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 30, 2020 Category: Drugs & Pharmacology Source Type: research

Protective effect of flumazenil infusion in severe acute benzodiazepine toxicity: a pilot randomized trial
ConclusionsAdministration of flumazenil is safe in benzodiazepine-poisoned patients with appropriate indications. Flumazenil infusion can significantly decrease the need for intubation and subsequent ICU admission. Even though flumazenil is an expensive antidote, its administration may decrease the need for ICU beds in the setting of acute poisoning. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 30, 2020 Category: Drugs & Pharmacology Source Type: research

Interventions to optimize prescribed medicines and reduce their misuse in chronic non-malignant pain: a systematic review
ConclusionsA well-structured CNMP management programme to promote medicines optimization should include multi-component interventions delivered by a multidisciplinary team of healthcare professionals and target both healthcare professionals and patients. There was heterogeneity in definitions applied and interventions evaluated. There is a need for the development of clear and consistent terminology and measurement criteria to facilitate better comparisons of research evidence. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 30, 2020 Category: Drugs & Pharmacology Source Type: research

Off-label use of dexmedetomidine in paediatric anaesthesiology: an international survey of 791 (paediatric) anaesthesiologists
ConclusionThe majority of anaesthesiologists use dexmedetomidine in paediatrics for premedication, procedural sedation, ICU sedation and anaesthesia, despite the off-label use and sparse evidence. The large intercontinental differences in prescribing dexmedetomidine call for consensus and worldwide education on the optimal use in paediatric practice. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Use of tramadol and other analgesics following media attention and risk minimization actions from regulators: a Danish nationwide drug utilization study
ConclusionWe identified a decline in tramadol use coinciding with the media attention in 2017 and continuing during regulatory actions. There was generally no evidence of unintended effects on the utilization of opioids related to the media attention and regulatory actions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 28, 2020 Category: Drugs & Pharmacology Source Type: research

The PRECIS-2 tool seems not to be useful to discriminate the degree of pragmatism of medicine masked trials from that of open-label trials
ConclusionThe PRECIS-2 tool seems not to be sensitive enough to clearly discriminate between medicine masked pRCTs and open-label pRCTs. When conducting systematic reviews, it is suggested that the PRECIS-2 tool should not be used to support placing masked trials in the pragmatic side of the explanatory/pragmatic  continuum. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 26, 2020 Category: Drugs & Pharmacology Source Type: research

Switching from a traditional undergraduate programme in (clinical) pharmacology and therapeutics to a problem-based learning programme
ConclusionChanging from a traditional programme to an integrated PBL programme in pharmacology and CPT during the undergraduate medical curriculum may improve the prescribing competencies of final-year students. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 23, 2020 Category: Drugs & Pharmacology Source Type: research

Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease
This study aimed to explore the association betweenFMO3 rs1736557 polymorphism and clopidogrel response.MethodsFive hundred twenty-two Chinese CAD patients treated with dual antiplatelet therapy were recruited from Xiangya Hospital. After oral administration of 300  mg loading dose (LD) clopidogrel for 12–24 h or 75 mg daily maintenance dose (MD) clopidogrel for at least 5 days, the platelet reaction index (PRI) was determined by vasodilator-stimulated phosphoprotein-phosphorylation assay.FMO3 rs1736557,CYP2C19*2, andCYP2C19*3 polymorphisms were genotyped by polymerase chain reaction-restriction f...
Source: European Journal of Clinical Pharmacology - October 21, 2020 Category: Drugs & Pharmacology Source Type: research

Second-generation antipsychotics and pregnancy complications: the impact of confounding by indication
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 20, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic variability of phenobarbital: a systematic review of population pharmacokinetic analysis
ConclusionPhenobarbital clearance may be predicted from previously developed population pharmacokinetic models and their significant covariate-parameter relationships along with Bayesian forecasting. However, when applying these models in a target population, an external evaluation of these models using the target population is warranted, and it is recommended that future research be conducted to investigate the link between population pharmacokinetics and pharmacodynamics. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 19, 2020 Category: Drugs & Pharmacology Source Type: research

Benefits and adverse effects of ACE inhibitors in patients with heart failure with reduced ejection fraction: a systematic review and meta-analysis
ConclusionThis review focuses on clinical elements necessary in a shared decision-making process. In practice, general practitioners will be able to use these data to discuss ACE inhibitor treatment with HFrEF patients. This study was registered in the PROSPERO registry under the reference number CRD42018096930. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 17, 2020 Category: Drugs & Pharmacology Source Type: research

Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens
ConclusionThe pharmacokinetic/pharmacodynamic parameters linked to bactericidal activity should be determined for 14  g, 16 g and 20 g once-daily doses of PASER. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Source Type: research

Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials
ConclusionCoQ10 supplementation, in the tested range of doses, was shown to reduce MDA concentrations, and increase TAC and antioxidant defense system enzymes. However, there were no significant effects of CoQ10 on NO, GSH concentrations, or CAT activity. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions in infants, children and adolescents exposed to antidepressants: a French pharmacovigilance study
ConclusionThis pediatric pharmacovigilance study underscored the high prevalence of neuropsychiatric and gastrointestinal ADRs, including three unexpected cases of pancreatitis. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Source Type: research

Tocilizumab for treating COVID-19: a systemic review and meta-analysis of retrospective studies
ConclusionTocilizumab may have potential effectiveness to treat COVID-19 according to the results of this study. However, more large-scale studies are needed for more accurate conclusions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 13, 2020 Category: Drugs & Pharmacology Source Type: research

The association of GATM polymorphism with statin-induced myopathy: a systematic review and meta-analysis
ConclusionsGATM polymorphism including rs9806699 G>A, rs1719247 C>T, and rs1346268 T>C may be protective factors of SIM.GATM rs9806699 G>A may only exert protective effect on mild SIM cases. Our meta-analysis indicates thatGATM polymorphism may represent a pharmacogenomics biomarker for predicting incidence of SIM, which contributes to risk stratification and optimizing statin adherence. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 13, 2020 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients
ConclusionAccording to the estimated 50% effective concentration of lopinavir against SARS-CoV-2 virus in Vero E6 cells (16.7  mg/L), our model showed that at steady state, a dose of 400 mg b.i.d. led to 40% of patients below the minimum effective concentration while a dose of 1200 mg b.i.d. will reduce this proportion to 22%. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 13, 2020 Category: Drugs & Pharmacology Source Type: research

Presence of the aldehyde dehydrogenase 2 variant ALDH2*2 considerably increases EC 50 of nitroglycerin
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 10, 2020 Category: Drugs & Pharmacology Source Type: research

Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder
ConclusionsPatients with hematopoietic or immune-related disorder treated with oral ITZ had a higher level of serum creatinine. Although serum creatinine potentially increases in conjunction with the free plasma concentration of OH-ITZ, concomitant ITZ administration has a slight impact on the eGFR-cre level in clinical settings. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 8, 2020 Category: Drugs & Pharmacology Source Type: research

Potentially inappropriate medication in older psychiatric patients
The objective of this study was to analyze the prevalence and sort of PIM prescribing in a naturalistic, real-world psychiatric setting.MethodsThe retrospective analysis gathered data from a large pharmacovigilance study, conducted at 10 psychiatric hospitals. Data from inpatients aged ≥ 65 years were included for the analysis. The number and sort of PIM, as defined by the German PRISCUS list, were controlled by analyzing the patients’ medication profile.ResultsIn total, 4760 patient cases (59.2% female) with a mean (mean ± standard deviation (SD)) age of 77.33 ± 7.77 y...
Source: European Journal of Clinical Pharmacology - October 7, 2020 Category: Drugs & Pharmacology Source Type: research

Lipid-lowering medication use and cancer-specific survival among endometrial or lung cancer patients: an Australian nationwide cohort study
ConclusionsAmong LLM users, adherence to this drug is inversely associated with reduced cancer-specific mortality. Together with previous evidence, randomised controlled trials are called for to confirm whether LLMs could be considered as an adjuvant treatment to improve prognosis. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 7, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of histamine type-2 receptor antagonists on the anticancer efficacy of gefitinib in patients with non-small cell lung cancer
ConclusionThis study demonstrated that concomitant administration of H2RA with gefitinib does not affect the efficacy of gefitinib. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 6, 2020 Category: Drugs & Pharmacology Source Type: research

Bleeding and thromboembolism due to drug-drug interactions with non-vitamin K antagonist oral anticoagulants —a Swedish, register-based cohort study in atrial fibrillation outpatients
ConclusionIncreased risk of bleeding was seen for pharmacodynamic and pharmacokinetic interactions with NOACs. Prescribers need to be vigilant of the effect of interacting drugs on the risk profile of patients treated with NOACs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 6, 2020 Category: Drugs & Pharmacology Source Type: research

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review
AbstractBackgroundDrug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group.MethodsThe data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were “DRESS syndrome,” “...
Source: European Journal of Clinical Pharmacology - October 5, 2020 Category: Drugs & Pharmacology Source Type: research

Quality of adverse event reporting in clinical trials of remdesivir in patients with COVID-19
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 3, 2020 Category: Drugs & Pharmacology Source Type: research

Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review
ConclusionThere is need for good quality validation studies comparing multiple scales to define the best scale and to conduct a meta-analysis for the assessment of their clinical impact. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 2, 2020 Category: Drugs & Pharmacology Source Type: research