European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The effect of renal impairment and obesity on anti-Xa peak and trough levels in patients receiving therapeutic doses of nadroparin: a comparison with control patients
ConclusionIn renal impairment, anti-Xa peak levels after dose reduction are comparable to those in controls. Weight-based dosing is suitable for obese patients. Aiming for peak levels between 0.6 and 1.0  IU/mL in these patients would result in overexposure compared to controls. Considering the association of trough levels and bleeding risk and our findings, trough monitoring seems to be a suitable parameter to identify nadroparin accumulation. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Source Type: research

Usefulness of mirtazapine and SSRIs in late-life depression: post hoc analysis of the GUNDAM study
ConclusionThe potential usefulness of mirtazapine in elderly patients was demonstrated. The results also showed differences in the treatment response to SSRIs and mirtazapine between elderly and non-elderly patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 13, 2023 Category: Drugs & Pharmacology Source Type: research

Comparison of the efficacy and safety of hypoglycemic treatments in patients with non-alcoholic fatty liver disease and type-2 diabetes: a systematic review and Bayesian network analysis
ConclusionGLP1RA plus insulin combination therapy, GLP1RA, SGLT2i, and TZD may be the most effective therapeutic methods for patients with NAFLD and T2DM. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 8, 2023 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of bempedoic acid lipid-lowering therapy: a systematic review and meta-analysis of randomized controlled trials
ConclusionBempedoic acid reduces the risk of MACE and all-cause mortality, lowers serum total cholesterol and LDL-C levels, and has a favorable safety profile.Trial registration ClinicalTrial.gov Identifier: CRD42023412837. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 6, 2023 Category: Drugs & Pharmacology Source Type: research

Prevalence, trends, and individual patterns of long-term antidepressant medication use in the adult Swiss general population
ConclusionThe proportion of long-term users in Switzerland is high and steadily increasing. Given the ongoing debate about the confounding effects of relapse and withdrawal, more research is needed to investigate longer use of antidepressants that could indicate overprescribing. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 5, 2023 Category: Drugs & Pharmacology Source Type: research

Cost-effectiveness of brentuximab vedotin in Hodgkin lymphoma: a systematic review
ConclusionAvailable economic evaluations show that using BV as front-line treatment or consolidation therapy is not cost-effective based on specific ICER thresholds for patients with HL or R/R HL. To decide on this orphan drug, we should consider other factors such as existence of alternative treatment options, clinical benefits, and disease burden. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 1, 2023 Category: Drugs & Pharmacology Source Type: research

The beneficial use of nitric oxide during cardiopulmonary bypass on postoperative outcomes in children and adult patients: a systematic review and meta-analysis of 2897 patients
ConclusionUsing inhaled nitric oxide during cardiopulmonary bypass reduces the length of stay in the intensive care unit, and for children, it reduces the duration of mechanical ventilation. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 31, 2023 Category: Drugs & Pharmacology Source Type: research

Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies
ConclusionsThis meta-analysis revealed an independent correlation between the use of aspirin and reductions in both the incidence and mortality rates of PCa. However, randomized controlled trials did not find any association between aspirin use and PCa. Furthermore, the impact of aspirin on PCa occurrence was found to be dependent on both dosage and duration. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 30, 2023 Category: Drugs & Pharmacology Source Type: research

Effects of sacubitril/valsartan on exercise capacity: a prognostic improvement that starts during uptitration
ConclusionsA holistic and progressive HF improvement was observed with sacubitril/valsartan in parallel with quality of life. Likewise, a prognostic enhancement was observed. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research

Therapeutic drug monitoring of voriconazole and CYP2C19 phenotype for dose optimization in paediatric patients
ConclusionsThe VRC plasma trough concentration is significantly influenced by the CYP2C19 phenotype. The recommended maintenance dose for pediatric patients may not be appropriate for Chinese patients. To increase the probability of achieving the therapeutic range for VRC plasma trough concentration, the administration of VRC should consider the age of paediatric patients and the presence of CYP2C19 polymorphisms. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research

Use of overactive bladder anticholinergic medications associated with falls leading to emergency department visits: results from the ADRED study
ConclusionsAlthough falls occur multifactorial in older adults and confounding by indication cannot be ruled out, the indication for a drug treatment should be decided with caution when other, non-pharmacological treatment options have been tried.German clinical trial registerDRKS-ID: DRKS00008979, registration date 01/11/2017. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research

Beyond benzodiazepines: a meta-analysis and narrative synthesis of the efficacy and safety of alternative options for alcohol withdrawal syndrome management
ConclusionFor AWS treatments, non-BZDs are superior to or equally effective as BZDs. Non-BZD adverse events warrant further investigation. Agents that inhibit gated ion channels are promising candidates.Protocol registrationPROSPERO CRD42022384875. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research

Costs associated with adverse drug reactions in an older population admitted to hospital: a prospective cohort study
ConclusionADRs leading to hospital admission are associated with modest incremental healthcare costs during and three months after admission. Severe and possibly preventable ADRs were associated with higher costs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Source Type: research