European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Drug-drug interaction perpetrators of oxycodone in patients with cancer: frequency and clinical relevance
ConclusionA high frequency of pharmacologically and clinically relevant perpetrators of oxycodone was observed in our cohort. Moreover, a high number of double interactions involving oxycodone was registered. More intense monitoring of DDIs may be needed to improve medication safety of patients with cancer taking oxycodone. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 13, 2024 Category: Drugs & Pharmacology Source Type: research

Effects of an intraoperative intravenous Bolus Dose of Dexmedetomidine on postoperative catheter-related bladder discomfort in male patients undergoing transurethral resection of bladder tumors: a randomized, double-blind, controlled trial
ConclusionThe effect of intravenous bolus doses of dexmedetomidine on postoperative CRBD was dose-independent, whereas intravenous administration of 0.5 µg/kg dexmedetomidine reduced the early postoperative incidence of CRBD with minimal side effects.Trial registrationClinical trial number and registry URL: ChiCTR 2,000,034,657,http://www.chictr.org.cn, date of registration: July 14, 2020. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 13, 2024 Category: Drugs & Pharmacology Source Type: research

Autoimmune disorders reported following COVID-19 vaccination: A disproportionality analysis using the WHO database
ConclusionIn addressing the imperative to comprehend AEFI related to autoimmune disorders following COVID-19 vaccination, our study identified four potential safety signals. Thus, our research underscores the importance of proactive safety monitoring for the identification of the four AEFIs following COVID-19 vaccination, considering the associated advantages. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 12, 2024 Category: Drugs & Pharmacology Source Type: research

Effects of first-line nucleot(s)ide analogues on lipid profiles in patients with chronic hepatitis B: a network meta-analysis
ConclusionTDF was effective in lipid reduction, particularly pronounced in the older population. TAF and ETV had a neutral effect to TC, TG, LDL-C, and HDL-C. Despite a relative increase in lipids observed in patients transitioning from TDF to TAF or ETV, these changes remained within acceptable limits. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research

Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals
ConclusionThe age-related increase in C/D ratio starts in middle-aged adults and progresses up to more than twofold higher C/D ratio in the oldest old. Sertraline seems to be less prone to age-related changes in C/D ratio than the other antidepressants. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research

Antidepressant deprescribing: State of the art and recommendations —A literature overview
ConclusionsFrom the literature review, it emerged that there is no clear evidence useful to support clinicians in antidepressant deprescribing interventions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 8, 2024 Category: Drugs & Pharmacology Source Type: research

Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
ConclusionsMethotrexate dosage regimens were primarily based on body surface area and renal function. Further studies are needed to evaluate MTX pharmacokinetics and pharmacodynamics in both children (especially infants) and adults. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2024 Category: Drugs & Pharmacology Source Type: research

The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
ConclusionsThis study provided a sign that PPIs used only in the ICU, rather than throughout hospital stay, might provide more benefit for critically ill pediatric patients. Additionally, younger pediatric patients might gain relatively more benefit than older children when receiving PPIs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2024 Category: Drugs & Pharmacology Source Type: research

Effects of mirabegron on brown adipose tissue and metabolism in humans: A systematic review and meta-analysis
ConclusionThrough our meta-analysis of 6 papers, we found that mirabegron has the potential to increase human BAT activity, REE, NEFA content, body temperature, HR, blood pressure, and blood insulin content. These effects may lead to reductions in blood glucose levels in obese/overweight and diabetic patients. Additionally, the activation of BAT by mirabegron could represent a novel approach for treating obesity, diabetes, and cardiovascular disease.Trial registration number and dateCRD42023413446, 04/11/2023. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 30, 2023 Category: Drugs & Pharmacology Source Type: research

Low-dose Rivaroxaban: is it a safe alternative in Chinese older patients?
Conclusions10 mg once daily rivaroxaban may provide survival benefits for elderly patients with NVAF. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 30, 2023 Category: Drugs & Pharmacology Source Type: research