Activities of clinical pharmacologists across Europe: A survey by the European association of clinical pharmacology and therapeutics
ConclusionCPT comes with a plurality of backgrounds and activities, all required to embrace the different pathologies and the whole lifecycle of medicinal products, but all of them being rarely performed in any given country. The willingness to use common CPT teaching material and prescribing exams at the European level is a good sign of increasing harmonisation of our discipline Europewide. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Source Type: research

Incidence, characteristics, and risk factors of drug-associated muscle adverse reaction: a retrospective real-world study of inpatients
ConclusionHealthcare professionals should be vigilant with patients exhibiting the identified risk factors. Monitoring creatine kinase and related indices when using myotoxic drugs is crucial to preventing serious adverse reactions, ultimately preserving patients ’ quality of life. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Source Type: research

Impact of combined propranolol and oxytocin on the process and outcomes of labor: a meta-analysis of randomized controlled trials
ConclusionThe combined use of propranolol and oxytocin can significantly reduce the cesarean section rate, shorten the duration of the latent phase and the duration of the active phase on day 1, and is safe. However, due to the limitations, the conclusions of this article still need to be verified by large-sample, multicenter, rigorously designed high-quality clinical RCTs.Trial registrationRegistration number is INPLASY202390107. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research

Recommendations for the safe use of direct oral anticoagulants in patients with cirrhosis based on a systematic review of pharmacokinetic, pharmacodynamic and safety data
ConclusionDOACs can be used in patients with CTP A cirrhosis, and apixaban, dabigatran and edoxaban can also be used in CTP B. It is recommended to avoid rivaroxaban in CTP B and C. There is insufficient evidence to support safe use of other DOACs in CTP C cirrhosis. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Source Type: research

Evaluation of methods measuring medication adherence in patients with polypharmacy: a longitudinal and patient perspective
ConclusionCombining tools for measuring adherence seems feasible and can provide insight into the accordance of patients ’ actual medication use with their prescribed regimen, but also into problems contributing to non-adherence. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Source Type: research

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism
ConclusionIn conclusion, we provide evidence of potential genetic markers involved in clinical response variability to RIS therapy in ASD children. However, replication in prospective samples with greater ethnic diversity and sample sizes is necessary. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research

The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ConclusionsThis systematic review found that numerous drugs have an impact on the pharmacokinetics of linezolid, and the purported main mechanism may be that linezolid is the substrate of P-glycoprotein. In clinical practice, it is prudent to pay attention to the changes in linezolid pharmacokinetics caused by interactions. Conducting therapeutic drug monitoring (TDM) is beneficial to improve efficacy and reduce adverse reactions of linezolid. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism
ConclusionIn conclusion, we provide evidence of potential genetic markers involved in clinical response variability to RIS therapy in ASD children. However, replication in prospective samples with greater ethnic diversity and sample sizes is necessary. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research

The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ConclusionsThis systematic review found that numerous drugs have an impact on the pharmacokinetics of linezolid, and the purported main mechanism may be that linezolid is the substrate of P-glycoprotein. In clinical practice, it is prudent to pay attention to the changes in linezolid pharmacokinetics caused by interactions. Conducting therapeutic drug monitoring (TDM) is beneficial to improve efficacy and reduce adverse reactions of linezolid. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research