European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity
ConclusionsThese findings hold promise for the development of effective weight loss interventions in this population group. There is a need for more phase III studies to provide sufficient clinical evidence for the effectiveness of retatrutide, as current evidence is limited to phase II studies and has yet to prove its worth in a larger population. Here, we aimed to provide an overview of retatrutide's safety and effectiveness in treating obesity. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Source Type: research

Effectiveness of paracetamol-NSAID combinations for upper and lower respiratory tract infections: a preliminary evaluation in primary care
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Source Type: research

Comparison of ticagrelor and clopidogrel in anemic patients with acute coronary syndrome: efficacy and safety outcomes over one year
ConclusionsTicagrelor and clopidogrel exhibited comparable efficacy and safety outcomes in anemic ACS patients over a one-year period. Although ticagrelor demonstrated superiority in reducing ischemic events, it is crucial to recognize the limitations of retrospective studies in informing clinical practice. This study offers valuable insights into tailoring antiplatelet therapy for anemic ACS patients and provides guidance for personalized treatment strategies, acknowledging the hypothesis-generating nature of retrospective analyses. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research

Exploratory associations of tacrolimus exposure and clinical outcomes after lung transplantation: A retrospective, single center experience
ConclusionA combination of Low C0/High IPV might be considered in categorizing patients towards risk of adverse clinical outcomes following lung transplantation. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research

Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
ConclusionCefoperazone-induced coagulopathy usually occurs on the 6th day of cefoperazone use in critically ill patients. The risk will increase in patients with an APACHE II score > 25, hepatic impairment, and cefoperazone Cmin ≥ 87.765 mg/l. Vitamin K1 is effective in preventing this adverse reaction. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Source Type: research

ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics
ConclusionThe prediction proved accurate demonstrating the value of conducting a microdose study prior to ascending dose studies.Trial registrationNCT05783830 March 24, 2023 (microdose study, retrospectively registered) and NCT05077631 October 14, 2021 (single ascending dose study). (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Source Type: research

The effect of statins on falls and physical activity in people aged 65 and older: A systematic review
ConclusionThis review did not identify a relationship between statin use and physical activity and falls risk in people aged 65 years and older. Ultimately, the risks and benefits of every medication should be considered in the context of each individual. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Source Type: research

ChatGPT for generating multiple-choice questions: Evidence on the use of artificial intelligence in automatic item generation for a rational pharmacotherapy exam
ConclusionsThe findings showed that the questions can effectively differentiate between students who perform at high and low levels, which also point out the potential of ChatGPT as an artificial intelligence tool in test development. Future studies may use the prompt to generate items in order for enhancing the external validity of the results by gathering data from diverse institutions and settings. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Source Type: research

COVID-19 and pregnancy: A European study on pre- and post-infection medication use
ConclusionOur findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research

Understanding hemoglobin contribution to high-dose methotrexate disposition —population pharmacokinetics in pediatric patients with hematological malignancies
ConclusionThe developed population pharmacokinetic model can contribute to the therapy optimization during HDMTX in pediatric patients with ALL and NHL. In addition to renal function and body weight, it describes the influence of hemoglobin on CL, allowing better understanding of its contribution to the disposition of HDMTX. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research

The safety and efficacy of dabrafenib and trametinib in patients with glioma: A systematic review and meta-analysis
ConclusionsDabrafenib and trametinib demonstrate promising anti-tumor efficacy in gliomas, particularly low-grade tumors, achieving durable disease stabilization in many patients. However, toxicity significantly limited tolerability. Additional research should further examine efficacy and refine safe administration protocols across glioma subtypes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research

Progress of PD-1/PD-L1 inhibitor combination therapy in immune treatment for HER2-positive tumors
ConclusionCombinatorial immunotherapeutic strategies involving PD-1/PD-L1 inhibitors hold considerable promise in the treatment of HER2-positive tumors. Continued research efforts and clinical trials are warranted to elucidate optimal treatment regimens that maximize therapeutic benefits while minimizing adverse effects. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 11, 2024 Category: Drugs & Pharmacology Source Type: research

Retraction Note: Graphical representation of network meta-analysis: an iconographic support to the complexity of multiple data comparisons
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 10, 2024 Category: Drugs & Pharmacology Source Type: research